General Information |
MoonProt ID | 212 |
First appeared in release | 1.0 |
Name(s) | dihydroxyacetone kinase
PTS-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit DhaK
Gene Name:dhaK
|
UniProt ID | P76015 (DHAK_ECOLI), Reviewed |
GO terms | GO:0006071 glycerol metabolic process
GO:0006974 cellular response to DNA damage stimulus
GO:0016310 phosphorylation
GO:0019563 glycerol catabolic process
GO:0042182 ketone catabolic process
GO:0046365 monosaccharide catabolic process
GO:0004371 glycerone kinase activity
GO:0005515 protein binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0047324 phosphoenolpyruvate-glycerone phosphotransferase activity
GO:0005829 cytosol |
Organisms for which functions have been demonstrated | Escherichia coli (Gram negative bacterium) |
Sequence length | 356 |
FASTA sequence | >sp|P76015|DHAK_ECOLI PTS-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit DhaK OS=Escherichia coli (strain K12) GN=dhaK PE=1 SV=2
MKKLINDVQDVLDEQLAGLAKAHPSLTLHQDPVYVTRADAPVAGKVALLSGGGSGHEPMHCGYIGQGMLSGACPGEIFTSPTPDKIFECAMQVDGGEGVLLIIKNYTGDILNFETATELLHDSGVKVTTVVIDDDVAVKDSLYTAGRRGVANTVLIEKLVGAAAERGDSLDACAELGRKLNNQGHSIGIALGACTVPAAGKPSFTLADNEMEFGVGIHGEPGIDRRPFSSLDQTVDEMFDTLLVNGSYHRTLRFWDYQQGSWQEEQQTKQPLQSGDRVIALVNNLGATPLSELYGVYNRLTTRCQQAGLTIERNLIGAYCTSLDMTGFSITLLKVDDETLALWDAPVHTPALNWGK
|
Structure Information |
PDB ID | 1OI2
1OI3
1UID
3PNK
3PNL
4LRY
3PNO
3PNQ
3PNM
1UOE
|
Quaternary structure | |
SCOP | NA |
CATH | |
TM Helix Prediction | No TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | 258-266, 355-356 |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | subunit of dihydroxyacetone kinase, enzyme
phosphorylates dihydroxyacetone
contains the Dha binding site
|
References for function | |
E.C. number | 2.7.-.- |
Location of functional site(s) | |
Cellular location of function | cytoplasm |
Comments | |
Function 2 |
Function description | corepressor of DhaR transcription activator
binds to DhaR
affects transcription of the dhaKLM operon
|
References for function | B?chler C, Schneider P, B?hler P, Lustig A, Erni B. Escherichia coli dihydroxyacetone kinase controls gene expression by binding to transcription factor DhaR. EMBO J. 2005 Jan 26. PMID: 15616579 |
E.C. number | N/A |
Location of functional site(s) | |
Cellular location of function | cytoplasm |
Comments | |