General Information |
MoonProt ID | 240 |
First appeared in release | 1.0 |
Name(s) | Tryptophanyl-tRNA synthetase
Tryptophan--tRNA ligase, cytoplasmic
Interferon-induced protein 53
IFP53
TrpRS
hWRS
Gene Name: WARS |
UniProt ID | P23381 (SYWC_HUMAN), Reviewed |
GO terms | GO:0001525 angiogenesis
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006436 tryptophanyl-tRNA aminoacylation
GO:0008285 negative regulation of cell proliferation
GO:0010467 gene expression
GO:0045765 regulation of angiogenesis
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004830 tryptophan-tRNA ligase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome |
Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal) |
Sequence length | 471 |
FASTA sequence | >sp|P23381|SYWC_HUMAN Tryptophan--tRNA ligase, cytoplasmic OS=Homo sapiens GN=WARS PE=1 SV=2
MPNSEPASLLELFNSIATQGELVRSLKAGNASKDEIDSAVKMLVSLKMSYKAAAGEDYKADCPPGNPAPTSNHGPDATEAEEDFVDPWTVQTSSAKGIDYDKLIVRFGSSKIDKELINRIERATGQRPHHFLRRGIFFSHRDMNQVLDAYENKKPFYLYTGRGPSSEAMHVGHLIPFIFTKWLQDVFNVPLVIQMTDDEKYLWKDLTLDQAYSYAVENAKDIIACGFDINKTFIFSDLDYMGMSSGFYKNVVKIQKHVTFNQVKGIFGFTDSDCIGKISFPAIQAAPSFSNSFPQIFRDRTDIQCLIPCAIDQDPYFRMTRDVAPRIGYPKPALLHSTFFPALQGAQTKMSASDPNSSIFLTDTAKQIKTKVNKHAFSGGRDTIEEHRQFGGNCDVDVSFMYLTFFLEDDDKLEQIRKDYTSGAMLTGELKKALIEVLQPLIAEHQARRKEVTDEIVKEFMTPRKLSFDFQ
|
Structure Information |
PDB ID | 2QUI,
2QUJ,
2QUK,
2QUH,
2AZX,
1R6T,
1R6U,
1ULH,
1O5T, 2AKE,
2DR2,
2QUJ |
Quaternary structure | |
SCOP | Adenine nucleotide alpha hydrolase-like |
CATH | 3.40.50.620, 1.10.240.10 |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | 1-12, 30-32, 52-82, 271, 346-352, 466-471 |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | Tryptophanyl-tRNA synthetase, enzyme
ATP + L-tryptophan + tRNA(Trp) => AMP + diphosphate + L-tryptophyl-tRNA(Trp)
protein synthesis |
References for function | |
E.C. number | 6.1.1.2 |
Location of functional site(s) | |
Cellular location of function | cytoplasm |
Comments | |
Function 2 |
Function description | forms complex with the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) and poly(ADP-ribose) polymerase 1 (PARP-1)
the complex activates p53
|
References for function | Sajish M, Zhou Q, Kishi S, Valdez DM, Kapoor M, Guo M, Lee S, Kim S, Yang XL, Schimmel P. Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN- and p53 signaling. Nat Chem Biol. 2012 Apr 15. PMID: 22504299 |
E.C. number | N/A |
Location of functional site(s) | |
Cellular location of function | nucleus |
Comments | |