| 3 | SMC-3 (Structural maintenance chromosome 3), Mus musculus | SMC3 interacts with SMC1 and other non-Smc subunits like Scc3 and Scc1 (also called Rad21) to form a cohesion complex, called "cohesin," that maintains proper sister chromatid cohesion throughout the cell cycle and during mitosis to ensure accurate chromosome segregation.
Each Smc heterodimer associates with non-Smc subunits to form functional Smc complexes. | Bamacan is a proteoglycan, and is a component of a component of the basement membrane in the Engelbreth-Holm-Swarm tumor matrix, the renal mesangial matrix, and the basement membrane of other tissues.
Bamacan is involved in the control of cell growth and transformation | Enteamoeba histolytica (amoeba, anaerobic eukaryote, causes amebiasis) |
| 4 | FdGOGAT Glutamate synthase, Spinacia oleracea | FdGOGAT Glutamate synthase, enzyme
2 L-glutamate + 2 oxidized ferredoxin => L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+.
amino acid biosynthesis, L-glutamate biosynthesis | Subunit of UDP-sulfoquinovose synthase | Spinacia oleracea (Spinach, a plant) |
| 5 | 1-Cys Peroxiredoxin, Homo sapiens | Acidic calcium-independent Phospholipase A2 (aiPLA2):
regulation of phospholipid turnover | Non-selenium Glutathione Peroxidase
Can reduce H2O2 and short chain organic, fatty acid, and phospholipid hydroperoxides | Homo sapiens (human, a mammal, OMIM number 602316 ) |
| 6 | Phosphoglucose Isomerase, Mus musculus | Catalyzes interconversion of glucose-6-phosphate and fructose-6-phosphate in glycolysis and gluconeogenesis | Cytokine/growth factor, binds to target cells and causes pre-B cells to mature into antibody secreting cells, supports survival of embryonal neurons, causes differentiation of some leukemia cell lines | Staphylococcus aureus (Gram positive bacterium, causes staph infections, abcesses/boils) |
| 7 | Hsp60, Homo sapiens and rat | Hsp60
mitochondrial protein import, facilitate correct folding, promote refolding, prevent misfolding of proteins
| receptor for HDL
affinity for apolipoprotein apoA-II | Homo sapiens and rat - (human, a mammal OMIM number 118190 612233 leukodystrophy, hypomyelinating, 4; 605280 Spastic paraplegia 13, autosomal dominant |
| 8 | GroEL, Enterobacter aerogenes | protein chaperone,
prevents proteins from misfolding, promotes correct refolding and assembly of polypeptides | toxin, paralyzes cockroaches
(produced by bacterium that is an endosymbiont of antlions, which are larvae of Myrmeleon bore) | Listeria monocytogenes (Gram positive bacterium, causes listeriosis, septicemia, meningitis) |
| 9 | 6-phosphofructokinase, Lactococcus lactis | 6-phosphofructokinase, enzyme
ATP + D-fructose 6-phosphate => ADP + D-fructose 1,6-bisphosphate
Carbohydrate degradation, glycolysis
| binding to invertase, a hyperglycosylated
mannoprotein from Saccharomyces cerevisiae | Lactococcus lactis IL1403 (Gram positive bacterium) |
| 10 | 6-phosphofructokinase, Streptococcus oralis | 6-phosphofructokinase, enzyme
ATP + D-fructose 6-phosphate => ADP + D-fructose 1,6-bisphosphate
Carbohydrate degradation, glycolysis | binds plasminogen from host organism | Streptococcus oralis LA11 - oral streptococci (Gram positive bacterium) |
| 12 | 6-phosphogluconate dehydrogenase , Streptococcus | 6-phosphogluconate dehydrogenase, enzyme
6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH
Carbohydrate degradation, pentose phosphate pathway
| adhesin - not clear to which host protein | Streptococcus pneumoniae (Gram positive bacterium) |
| 13 | Alcohol dehydrogenase (ADH1), Candida albicans | Alcohol dehydrogenase (ADH1), enzyme
An alcohol + NAD+ => an aldehyde or ketone + NADH.
| binds plasminogen from humans | Candida albicans (yeast, a fungi, can cause candiadiasis) |
| 14 | alcohol acetaldehyde dehydrogenase, Listeria | An enzyme: The N-terminus contains acetaldehyde dehydrogenase (ALDH) and the Cterminus an alcohol dehydrogenase (ADH)
| Adhesin, binds Hsp60 on surface of host cells | Listeria monocytogenes (Gram positive bacterium) |
| 15 | alcohol dehydrogenase (EhADH2), Enteamoeba histolytica | alcohol dehydrogenase (EhADH2), enzyme
Including the following 2 domains: Alcohol dehydrogenase and Acetaldehyde dehydrogenase
An alcohol + NAD+ => an aldehyde or ketone + NADH
Acetaldehyde + CoA + NAD+ => acetyl-CoA + NADH.
demonstrated that it has both ADH and acetaldehyde dehydrogenase activity. | binds fibronectin, laminin, and type II collagen
| Enteamoeba histolytica (amoeba, anaerobic eukaryote) |
| 16 | Aspartate ammonia lyase, aspartase, Haemophilus influenzae | aspartate ammonia lyase, aspartase, enzyme
L-aspartate => fumarate + NH3 | binds plasminogen | Haemophilus influenzae (Gram negative bacterium) |
| 17 | Bile salt hydrolase, Bifidobacterium | bile salt hydrolase | plasminogen binding | Bifidobacterium(Bifidobacterium lactis, B. bifidum, and B. longum (Gram positive bacterium) |
| 18 | DnaK, Bifidobacterium | chaperone | plasminogen binding | Bifidobacterium(Bifidobacterium lactis, B. bifidum, and B. longum) (Gram positive bacterium) |
| 19 | DnaK, Lactococcus lactis | chaperone | binding to invertase, a hyperglycosylated mannoprotein from Saccharomyces cerevisiae | Lactococcus lactis IL1403 (Gram positive bacterium) |
| 20 | DnaK, Neisseria meningitidis | chaperone | plasminogen binding protein | Neisseria meningitidis (Gram negative bacterium, causes meningitis) |
| 21 | DnaK, Mycobacterium tuberculosis | chaperone
| plasminogen binding | Mycobacterium tuberculosis (mycobacterium, causes tuberculosis) |
| 22 | Ef-Tu, Lactobacillus johnsonii | elongation factor in protein synthesis | attachment to human cells and mucins | Lactobacillus johnsonii NCC533 (La1) (Gram positive bacterium) |
| 23 | Ef-Tu, Mycoplasma pneumoniae | elongation factor in protein synthesis
during protein biosynthesis: promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes | fibronectin binding | Mycoplasma pneumoniae |
| 24 | Ef-Tu, Pseudomonas aeruginosa | elongation factor during protein synthesis
during protein synthesis: promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes | factor H and plasminogen binding | Candida albicans (yeast, a fungi, can cause candiadiasis) |
| 25 | enolase, Aeromonas hydrophila | enolase, enzyme
2-phospho-D-glycerate => phosphoenolpyruvate + H2O
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.
Carbohydrate degradation, glycolysis
| plasminogen binding
(binds human plasminogen) | Aeromonas hydrophila (soft-tissue infections, with cellulitis being most frequent) |
| 26 | enolase, Bifidobacterium | enolase, enzyme
2-phospho-D-glycerate => phosphoenolpyruvate + H2O
reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate
Carbohydrate degradation, glycolysis | plasminogen binding
(binds human plasminogen) | Bifidobacterium (B. longum, B. bifidum, B. breve and B. lactis) (Gram positive bacterium) |
| 27 | enolase, Borrelia burgdorferi | enolase, enzyme
2-phospho-D-glycerate => phosphoenolpyruvate + H2O
reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. Carbohydrate degradation, glycolysis | plasminogen binding
(binds human plasminogen) | Borrelia burgdorferi (Lyme disease) |
| 28 | enolase, Candida albicans | enolase, enzyme
2-phospho-D-glycerate => phosphoenolpyruvate + H2O
Carbohydrate degradation, glycolysis
| plasminogen binding | Candida albicans (yeast, a fungi, can cause candiadiasis) |
| 29 | Enolase, Lactobacillus crispatus | Enolase, enzyme
2-phospho-D-glycerate => phosphoenolpyruvate + H2O.
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate
Carbohydrate degradation, glycolysis;
| binds plasminogen and laminin | Lactobacillus crispatus (Gram positive bacterium) |
| 30 | Enolase, Lactobacillus johnsonii | 2-phospho-D-glycerate => phosphoenolpyruvate + H2O.
Pathway
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate
Carbohydrate degradation, glycolysis | binds plasminogen and laminin | Lactobacillus johnsonii (Gram positive bacterium) |
| 31 | Enolase, Lactobacillus plantarum | Enolase, enzyme
2-phospho-D-glycerate => phosphoenolpyruvate + H2O
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate
Carbohydrate degradation, glycolysis
| binds fibronectin | Lactobacillus plantarum (Gram positive bacterium) |
| 32 | Enolase, Neisseria meningitidis | Enolase
2-phospho-D-glycerate => phosphoenolpyruvate + H2O.
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate
Carbohydrate degradation, glycolysis | plasminogen binding | Neisseria meningitidis (Gram negative bacterium, causes meningitis) |
| 33 | Enolase, Onchocerca volvulus | Enolase, enzyme
2-phospho-D-glycerate => phosphoenolpyruvate + H2O
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate
Carbohydrate degradation, glycolysis | binds plasminogen | Onchocerca volvulus (cuases river blindness) |
| 34 | Enolase, Staphylococcus aureus | Enolase, enzyme
2-phospho-D-glycerate => phosphoenolpyruvate + H2O
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate
Carbohydrate degradation, glycolysis | binds plasminogen and laminin | Staphylococcus aureus (Gram positive bacterium, causes staph infections, abcesses/boils) |
| 35 | Enolase, Oral streptococci (S. anginosus, S. oralis) | Enolase, enzyme
2-phospho-D-glycerate => phosphoenolpyruvate + H2O
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate
Carbohydrate degradation, glycolysis | plasminogen binding | Oral streptococci (S. anginosus, S. oralis) |
| 36 | Enolase, Streptococcus pneumoniae | enolase, enzyme
2-phospho-D-glycerate => phosphoenolpyruvate + H2O
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate
Carbohydrate degradation, glycolysis | binds plasminogen | Streptococcus pneumoniae (Gram positive bacterium) |
| 37 | Enolase, Streptococcus pyogenes | enolase, enzyme
2-phospho-D-glycerate => phosphoenolpyruvate + H2O
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate
Carbohydrate degradation, glycolysis | binds plasminogen | Streptococcus pyogenes(Gram positive bacterium) |
| 38 | enolase, Streptococcus suis | enolase
2-phospho-D-glycerate => phosphoenolpyruvate + H2O
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate
Carbohydrate degradation, glycolysis | binds fibronectin and plasminogen | Streptococcus suis(Gram positive bacterium) |
| 39 | Enolase, Streptococcus mutans | Enolase, enzyme
2-phospho-D-glycerate => phosphoenolpyruvate + H2O
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate
Carbohydrate degradation, glycolysis | binds plasminogen | Streptococcus mutans (Gram positive bacterium) |
| 40 | Enolase, Homo sapiens | enolase, enzyme
2-phospho-D-glycerate => phosphoenolpyruvate + H2O
Carbohydrate degradation, glycolysis
| plasminogen binding | Homo sapiens (human, a mammal, OMIM number 172430 Enolase deficiency) |
| 41 | Enolase, Trichomonas vaginalis | Enolase, enzyme
2-phospho-D-glycerate => phosphoenolpyruvate + H2O
Carbohydrate degradation, glycolysis | plasminogen binding | Trichomonas vaginalis |
| 42 | Enolase, Rattus norvegicus | Enolase, enzyme
2-phospho-D-glycerate => phosphoenolpyruvate + H2O
Carbohydrate degradation, glycolysis
| plasminogen binding | Rattus norvegicus (rat, a mammal) |
| 43 | Enolase, Leishmania mexicana | enolase, enzyme
reversible conversion of 2-phosphoglycerate to phosphoenolpyruvate | binds plasminogen | Leishmania mexicana (causes human leishmaniasis) |
| 44 | Enolase, Paracoccidioides brasiliensis | enolase, enzyme
catalyses the dehydration of 2-phospho-D-glycerate (PGA) to phosphoenolpyruvate
glycolysis, gluconeogenesis | fibronectin binding | Paracoccidioides brasiliensis |
| 45 | Enolase, Bacillus anthracis | enolase, enzyme
2-phospho-D-glycerate => phosphoenolpyruvate + H2O
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate
Carbohydrate degradation, glycolysis | binds plasminogen and laminin | Bacillus anthracis |
| 46 | Fructose bisphosphate aldolase, Candida albicans | Fructose bisphosphate aldolase, enzyme
D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate
Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis
Carbohydrate degradation, glycolysis, gluconeogenesis
| plasminogen binding | Candida albicans (yeast, a fungi, can cause candiadiasis) |
| 47 | fructose-1,6-bisphosphate aldolase, Neisseria meningitidis | fructose-1,6-bisphosphate aldolase, enzyme | adhesin to human cells | Neisseria meningitidis (Gram negative bacterium, causes meningitis) |
| 49 | GAPDH, Lactobacillus plantarum | GAPDH, enzyme
Glyceraldehyde 3-phosphate dehydrogenase | binds mucin and Caco-2 cells | Lactobacillus plantarum (Gram positive bacterium) |
| 50 | GAPDH, Lactococcus lactis | glyceraldehyde 3-phosphate dehydrogenase, GAPDH, enzyme
D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 1,3-bisphospho-D-glycerate + NADH.
Carbohydrate degradation, glycolysis | binding to invertase, a hyperglycosylated mannoprotein from Saccharomyces cerevisiae | Lactococcus lactis IL1403 (Gram positive bacterium) |
| 51 | GAPDH, Paracoccidioides brasiliensis | glyceraldehyde 3-phosphate dehydrogenase, enzyme
D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 1,3-bisphosphoglycerate + NADH.
Carbohydrate degradation, glycolysis | bind to fibronectin, laminin, and type I collagen | Paracoccidioides brasiliensis |
| 52 | GAPDH, Oral streptococci (S. anginosus and S. oralis) | GAPDH, Glyceraldehyde-3-phosphate dehydrogenase, enzyme | plasminogen binding | Oral streptococci (S. anginosus and S. oralis) (Gram positive bacteria) |
| 53 | GAPDH, Streptococcus pyogenes | glyceraldehyde 3-phosphate dehydrogenase, enzyme
D-glyceraldehyde 3-phosphate + phosphate + NAD+ => 1,3-bisphosphoglycerate + NADH.
Carbohydrate degradation, glycolysis | binds uPAR/CD87 receptor on human cells | Streptococcus pyogenes (Gram positive bacterium) |
| 54 | GAPDH, Streptococcus suis | GAPDH, glyceraldehyde 3-phosphate dehydrogenase, enzyme | plasminogen binding | Streptococcus suis (Gram positive bacterium) |
| 55 | GAPDH, Trichomonas vaginalis | Glyceraldehyde-3-phosphate dehydrogenase, enzyme | binds fibronectin
fibronectin binding, and plasminogen and collagen | Trichomonas vaginalis |
| 56 | GAPDH, Staphylococcus aureus (S. epidermidis and S. aureus) | GAPDH, glyceraldehyde 3-phosphate dehydrogenase, enzyme | transferrin-binding protein (also called TPN) AND also binds plasminogen
involved in the acquisition of transferrin-bound iron | Staphylococcus aureus (S. epidermidis and S. aureus) (Gram positive bacteria) |
| 57 | GAPDH, Streptococcus pneumoniae | glyceraldehyde 3-phosphate dehydrogenase, enzyme | plasminogen binding | Streptococcus pneumoniae (Gram positive bacterium) |
| 58 | GAPDH, Candida albicans | glyceraldehyde 3-phosphate dehydrogenase, enzyme
D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 1,3-bisphosphoglycerate + NADH.
Carbohydrate degradation, glycolysis | plasminogen binding
fibronectin and laminin binding
| Candida albicans (yeast, a fungi, can cause candiadiasis) |
| 59 | GAPDH, Streptococcus agalactiae | Glyceraldehyde 3-phosphate dehydrogenase, enzyme | plasminogen binding | Streptococcus agalactiae, Streptococcus - group B, serotype III/deltaepsilon, strain J48 (Gram positive bacterium) |
| 60 | GAPDH, Bacillus anthracis | glyceraldehyde 3-phosphate dehydrogenase, enzyme
catalyzes the oxidative phosphorylation of D-glyceraldehyde-
3-phosphate (G-3-P) to 1,3-diphosphoglycerate in the presence of
NAD+/NADP+ and inorganic phosphate (Pi) | plasminogen binding | Bacillus anthracis |
| 61 | GAPDH, Mycoplasma genitalium | glyceraldehyde 3-phosphate dehydrogenase, enzyme
D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 1,3-bisphosphoglycerate + NADH
Carbohydrate degradation, glycolysis | binds mucin | Mycoplasma genitalium |
| 62 | GAPDH, Streptococcus - group A streptococci | glyceraldehyde 3-phosphate dehydrogenase, enzyme | Plasminogen binding | Streptococcus pyogenes serotype M4 (strain MGAS10750) (Gram positive bacterium) |
| 63 | Glutamine synthetase, Bifidobacterium | Glutamine synthetase, enzyme
ATP + L-glutamate + NH3 => ADP + phosphate + L-glutamine | plasminogen binding | Bifidobacterium (Bifidobacterium lactis, B. bifidum, and B. longum) |
| 64 | Glucose 6-phosphate isomerase, Lactobacillus crispatus | glucose 6-phosphate isomerase, enzyme
D-glucose 6-phosphate <=> D-fructose 6-phosphate
Carbohydrate biosynthesis; gluconeogenesis
Carbohydrate degradation; glycolysis | laminin, collagen I binding (not fibronectin) | Lactobacillus crispatus (Gram positive bacterium) |
| 300 | Glutamine synthetase, Lactobacillus crispatus | Glutamine synthetase, enzyme
ATP + L-glutamate + NH3 => ADP + phosphate + L-glutamine | fibronectin, laminin, collagen I binding, and plasminogen binding | Lactobacillus crispatus (Gram positive bacterium) |
| 66 | Glutamine synthetase, Mycobacterium tuberculosis | Glutamine synthetase
ATP + L-glutamate + NH3 => ADP + phosphate + L-glutamine | plasminogen and fibronectin binding protein | Mycobacterium tuberculosis (mycobacterium, causes tuberculosis) |
| 67 | Histone H1, Mus musculus | Histone H1
binds to DNA near nucleosomes
aids in condensation of nucleosome chains into higher-order structured fibers | thyroglobulin receptor | Mus musculus (Mouse, mammal) |
| 68 | Hsp60, Chlamydiae pneumoniae | chaperonin, assist in the correct folding of new or unfolded proteins under both normal and stress conditions | binding to cell surface and activates pathways | Chlamydiae pneumoniae (can cause pneumonia and other diseases) |
| 69 | Hsp60, Histoplasma capsulatum | Hsp60 | adhesin | Histoplasma capsulatum (Hc strain G217B) - also known as Ajellomyces capsulatus, causes hostoplsmosis, Darling's disease) |
| 70 | Hsp60, Legionella pneumophila | chaperone - Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides | adhesin | Legionella pneumophila (causes Legionnaires' disease) |
| 72 | Hsp60 chaperone, Listeria | Hsp60 chaperone | adhesin | Listeria |
| 73 | Hsp60, Haemophilus ducreyi | Hsp60, GroEL, Prevents misfolding and promotes the refolding and proper assembly of unfolded proteins | adhesin - to glycosphinngolipids | Haemophilus ducreyi (Gram negative bacterium) |
| 74 | Hsp60, Lactobacillus johnsonii | Hsp60, GroEL, Prevents misfolding of proteins, promotes the refolding and correct assembly of unfolded proteins | adhesin
binds to mucins and epithelial cells | Lactobacillus johnsonii La1 (NCC 533) (Gram positive bacterium) |
| 75 | Hsp60, Lactococcus lactis | chaperonin, Prevents misfolding of proteins, promotes the refolding and proper assembly of unfolded proteins | binding to invertase, a hyperglycosylated mannoprotein from Saccharomyces cerevisiae | Lactococcus lactis IL1403 (Gram positive bacterium) |
| 77 | Hsp60, Salmonella typhimurium | chaperonin, Prevents misfolding of proteins, promotes the refolding and proper assembly of unfolded proteins
| adhesin | Salmonella typhimurium (Gram negative bacterium) |
| 78 | Hsp60, Clostridium difficile | chaperonin, Prevents protein misfolding, promotes the refolding and proper assembly of unfolded proteins | adhesin | Clostridium difficile (can cause diarrhea) |
| 79 | Hsp60, Helicobacter pylori | chaperonin, Prevents protein misfolding, promotes the refolding and proper assembly of unfolded proteins | adhesin - to host cells | Helicobacter pylori (H. pylori strain TK1029) (causes peptic ulcers and gastritis) |
| 80 | Hsp65, Mycobacterium tuberculosis | chaperonin, Prevents protein misfolding, promotes the refolding and proper assembly of unfolded proteins | adhesin to CD43 on macrophage surface | Mycobacterium tuberculosis (mycobacterium, causes tuberculosis) |
| 81 | Malate synthase, Mycobacterium tuberculosis | Malate synthase, enzyme
Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Acetyl-CoA + H2O + glyoxylate => malate + CoA
Carbohydrate metabolism; glyoxylate cycle
glyoxylate pathway enables bacteria to assimilate two-carbon
compounds into the TCA cycle
| binds fibronectin and laminin and A549 lung epithelial cells | Mycobacterium tuberculosis (mycobacterium, causes tuberculosis) |
| 82 | Ornithine carbamoyltransferase, Staphylococcus epidermidis | Ornithine carbamoyltransferase, enzyme
Carbamoyl phosphate + L-ornithine => phosphate + L-citrulline | bind fibronectin | Staphylococcus epidermidis (Gram positive bacterium) |
| 83 | Peroxiredoxin, Neisseria meningitidis | Peroxiredoxin, antioxidant | plasminogen binding | Neisseria meningitidis (Gram negative bacterium) |
| 84 | Peroxisomal catalase (CTA1), Candida albicans | Peroxisomal catalase (CTA1), protect cells from the toxic effects of hydrogen peroxide
2 H2O2 => O2 + 2 H2O
| plasminogen binding | Candida albicans (yeast, a fungi, can cause candiadiasis) |
| 85 | Phosphoglycerate kinase, Streptococcus agalactiae | Phosphoglycerate kinase
ADP + 1,3-bisphosphoglycerate => ATP + 3-phosphoglycerate
Carbohydrate degradation, glycolysis | plasminogen binding | Streptococcus agalactiae (GBS = group B Streptococcus, strain NCS13) (Gram positive bacterium) |
| 86 | Phosphoglycerate kinase, Streptococcus pneumoniae | Phosphoglycerate kinase, enzyme
ADP + 1,3-bisphosphoglycerate => ATP + glycerate-3-phosphate
Carbohydrate degradation, glycolysis | plasminogen binding | Streptococcus pneumoniae (Gram positive bacterium) |
| 87 | Phosphoglycerate kinase, Candida albicans | Phosphoglycerate kinase, enzyme
ADP + 1,3-bisphosphoglycerate => ATP + 3-phospho-D-glycerate
Carbohydrate degradation, glycolysis | plasminogen binding | Candida albicans (yeast, a fungi, can cause candiadiasis) |
| 88 | Phosphoglycerate kinase, Streptococcus - oral streptococci (S. anginosus and S. oralis) | Phosphoglycerate kinase, enzyme
ADP + 1,3-bisphosphoglycerate => ATP + 3-phospho-D-glycerate
Carbohydrate degradation, glycolysis | plasminogen binding | Streptococcus - oral streptococci (S. anginosus and S. oralis) (Gram positive bacterium) |
| 89 | Phosphoglycerate mutase, Bifidobacterium | Phosphoglycerate mutase, enzyme
1,3-bisphosphoglycerate <=> 2,3-bisphosphoglycerate | plasminogen binding | Bifidobacterium (Bifidobacterium lactis, B. bifidum, and B. longum) |
| 90 | Phosphoglycerate mutase, Streptococcus - oral streptococci (S. anginosus and S. oralis) | Phosphoglycerate mutase, enzyme
1,3-bisphosphoglycerate <=> 2,3-bisphosphoglycerate | plasminogen binding | Streptococcus - oral streptococci (S. anginosus and S. oralis) (Gram positive bacterium) |
| 91 | Phosphoglyceromutase, Candida albicans | Phosphoglyceromutase, enzyme
1,3-bisphosphoglycerate <=> 2,3-bisphosphoglycerate
Carbohydrate degradation, glycolysis | plasminogen binding | Candida albicans (yeast, a fungi, can cause candiadiasis) |
| 92 | Pyruvate dehydrogenase, Mycoplasma pneumoniae | Pyruvate dehydrogenase, enzyme
The pyruvate dehydrogenase complex catalyzes the overall conversion pyruvate => acetyl-CoA and CO2.
Pyruvate dehydrogenase (E1) is one of the enzyme components of the complex
| fibrinogen binding | Mycoplasma pneumoniae |
| 93 | Pyruvate kinase, Lactococcus lactis | Pyruvate kinase, enzyme
ADP + phosphoenolpyruvate => ATP + pyruvate
Carbohydrate degradation, glycolysis | binding to invertase, a hyperglycosylated mannoprotein from Saccharomyces cerevisiae | Lactococcus lactis IL1403 (Gram positive bacterium) |
| 94 | Pyruvate-ferredoxin oxidoreductase, Trichomonas vaginalis | Pyruvate-ferredoxin oxidoreductase, enzyme
oxidative decarboxylation of pyruvate to yield acetyl-CoA and CO2 | cell surface adherance protein | Trichomonas vaginalis |
| 95 | Transcription elongation factor, Candida albicans | Transcription elongation factor
during protein biosynthesis, TEF1 promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of the ribosome | plasminogen binding | Candida albicans (yeast, a fungi, can cause candiadiasis) |
| 96 | Superoxide dismutase, Mycobacterium avium | Superoxide dismutase, enzyme
antioxidant
convert superoxide anion radicals into O2 and H2O2 | adhesin | Mycobacterium avium (mycobacterium, causes Johne's disease, a systemic infection of the intestines) |
| 97 | Thiol-specific antioxidant protein, Candida albicans | Thiol-specific antioxidant protein
antioxidant
2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH.
| plasminogen binding | Candida albicans (yeast, a fungi, can cause candiadiasis) |
| 98 | Triose phosphate isomerase, Paracoccidioides brasiliensis | Triose phosphate isomerase, enzyme
D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate
Carbohydrate degradation glycolysis
Carbohydrate biosynthesis, gluconeogenesis
| adhesin | Paracoccidioides brasiliensis |
| 100 | Triose phosphate isomerase, Staphylococcus aureus | Triose phosphate isomerase, enzyme
D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate
Carbohydrate degradation, glycolysis
Carbohydrate biosynthesis, gluconeogenesis
| adhesin, contact-mediated killing of Cryptococcus | Staphylococcus aureus (Gram positive bacterium, causes staph infections, abcesses/boils) |
| 101 | Triose phosphate isomerase, Streptococcus - oral streptococci (S. anginosus and S. oralis) | Triose phosphate isomerase, enzyme
D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate
Carbohydrate degradation, glycolysis
Carbohydrate biosynthesis, gluconeogenesis
| plasminogen binding | Streptococcus - oral streptococci (S. anginosus and S. oralis) (Gram positive bacterium) |
| 110 | Aconitase, Mycobacterium tuberculosis | aconitase, enzyme
catalyse the isomerization of citrate to iso-citrate in the citric acid cycle | iron-responsive protein
Binds to selected IREs (Iron-responsive elements)--sequences present within the UTR (untranslated regions) of M. tuberculosis mRNA
| Mycobacterium tuberculosis (mycobacterium, causes tuberculosis) |
| 111 | Aconitase, Saccharomyces cerevisiae | aconitase, enzyme
Catalyzes the conversion of citrate to aconitate in the pathway for lysine biosynthesis.
Krebs cycle, Amino-acid biosynthesis, L-lysine biosynthesis | mitochondrial DNA maintenance
enzymatic activity and iron sulfur cluster are not needed for this role | Saccharomyces cerevisiae |
| 112 | I-AniI, Emericella nidulans (Aspergillus nidulans) | mRNA maturase
required for splicing of the intron in the cytochrome b (cobA) gene, which contains the coding sequence for the maturase.
stimulates the intrinsic ribozyme activity of the intron by binding to and stabilizing the three-dimensional structure of the RNA. | homing endonuclease
introduces a double-strand break at a specific location in the cobA gene and helps in the insertion of an intron containing its own coding sequence (group I intron)
| Emericella nidulans (Aspergillus nidulans) |
| 113 | Arg5,6, Saccharomyces cerevisiae | enzyme in the arginine biosynthetic pathway
N-acetyl-gamma phosphate reductase and acetyl glutamate kinase | Arg5 binds to mitochondrial and nuclear DNA in vivo and regulates gene expression, regulator of transcription for several genes | Saccharomyces cerevisiae |
| 114 | Argininosuccinate lyase, Anas platyrhynchos | Argininosuccinate lyase, enzyme
Catalyzes the breakdown of argininosuccinate to produce arginine and fumarate. It is the fourth enzyme of the urea cycle. Argininosuccinase is involved in biosythesis of arginine in all species and production of urea in ureotelic organisms. 2-(N(omega)-L-arginino)succinate => fumarate + L-arginine
Amino-acid biosynthesis, arginine biosynthesis | Delta-2 Crystallin in the lens of the eye - only in birds and reptiles | Anas platyrhynchos (duck) |
| 115 | lactate dehydrogenase, Anas platyrhynchos | lactate dehydrogenase, enzyme
lactate + NAD+ <=> pyruvate + NADH
pyruvate fermentation to lactate | Structural eye lens protein (epsilon-crystallin)- also in crocodile, hummingbird, chimney swift | Anas platyrhynchos (Mallard duck) - also in reptiles, swans, geese, ostriches |
| 116 | retinol binding protein 1, Lygodactylus picturatus | Cellular retinol-binding protein Type 1
carrier protein involved in transport of retinol from liver to peripheral tissues | crystallin
Ultraviolet Filter Lens protein | Lygodactylus luteopicturatus (Yellow-headed Dwarf Gecko) |
| 117 | lactate dehydrogenase A, crystallin upsilon, Ornithorhynchus anatinus | Lactate dehydrogenase A, enzyme
Fermentation, Pyruvate fermentation to lactate
pyruvate + NADH <=> lactate + NAD+
Catalyzes the conversion of pyruvate (final product of glycolysis) to lactate | Lens protein crystallin | Ornithorhynchus anatinus (Duckbill platypus) |
| 118 | Aldehyde dehydrogenase, Elephantus edwardii | retinaldehyde dehydrogenase, enzyme
an aldehyde dehydrogenase class 1
An aldehyde + NAD+ + H2O => a carboxylate + NADH.
Alcohol metabolism, ethanol degradation | eta crystallin
| Elephantus edwardii (elephant shrew) |
| 119 | L-gulonate 3-dehydrogenase, Lambda-crystallin, Oryctolagus cuniculus | L-gulonate 3 -dehydrogenase, enzyme
L-gulonate + NAD(+) <=> 3-dehydro-L-gulonate + NADH
Catalysis the NAD-linked dehydrogenation of L-gulonate into dehydro-L-gulonate in the urinate cycle.
| Lambda crystallin
| Oryctolagus cuniculus (Rabbit) |
| 120 | Quinone oxidoreductase, Zeta-crystallin, Cavia porcellus | Quinone oxidoreductase
NADPH:quinone oxidoreductase
NADPH + 2 quinone <=> NADP(+) + 2 semiquinone
| Zeta-crystallin
(Also in camels, llamas, and tree frog) | Cavia porcellus (Guinea pig) |
| 121 | NADPH quinone oxidoreductase, Zeta-crystallin, Hyla japonica | NADPH:quinone oxidoreductase, enzyme | Zeta crystallin
(Also in camel, llamas and Guinea pig) | Hyla japonica (Japanese tree frog) |
| 122 | Carbinolamine dehydratase, Rattus norvegicus | Pterin-4-alpha-carbinolamine dehydratase, enzyme
convert 4a-hydroxy tetrahydropterin to quinonoid dihydrobiopterin, in phenylalanine hydroxylation reaction
(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin => (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O | dimerization of hepatocyte nuclear factor 1? (HNF1A), a homeodomain transcription factor, results in transcription activation
| Rattus norvegicus |
| 123 | Lactose synthase, Homo sapiens | Lactose synthase, enzyme
UDP-alpha-D-galactose + D-glucose <=> UDP + lactose | Galactosyltransferase, enzyme
UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1 | Homo sapiens (human, a mammal, P15291 OMIM number 137060 607091, Congenital disorder of glycosylation, type IId) |
| 124 | DegP, Escherichia coli | peptidase at higher temperatures. | chaperone at low temperatures | Escherichia coli (strain K12) (Gram negative bacterium) |
| 125 | Albaflavenone Monooxygenase, Streptomyces coelicolor | Albaflavenone Monooxygenase (+)-epi-isozizaene + 2 NADPH + 2 O(2) <=> albaflavenone + 2 NADP(+) + 3 H(2)O | Terpene synthase (2E,6E)-farnesyl diphosphate <=> (E)-beta-farnesene + diphosphate | streptomyces coelicolor A3(2) |
| 126 | Delta-aminolevulinic acid dehydratase, Homo sapiens | 5-aminolaevulinate dehydratase, enzyme
converts 2 (5-aminolevulinate) to porphobilinogen +2H20.
Porphyrin-containing compound metabolism, protoporphyrin-IX biosynthesis | proteasome inhibitor
Noncompetitively blocks proteolysis of certain protein substrates. | Homo sapiens (human, a mammal) |
| 127 | FtsH, Shigella flexneri | chaperone | Metalloprotease, enzyme
ATP-dependent zinc metallopeptidase, hydrolyzes cytoplasmic and transmembrane proteins | Shigella flexneri |
| 128 | Leukotriene A-4 hydrolase, Homo sapiens | Leukotriene A-4 hydrolase, enzyme
epoxide hydrolase
(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H(2)O <=> (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate
catalyzes the last step in the biosynthesis of leukotriene B4.
Lipid metabolism, leukotriene B4 biosynthesis | Aminopeptidase, enzyme | Homo sapiens (human, a mammal) |
| 129 | Lysyl hydroxylase, Homo sapiens | Lysyl hydroxylase isoform 3, enzyme
L-lysine-[procollagen] + 2-oxoglutarate + O(2) <=> (2S,5R)-5-hydroxy-L-lysine-[procollagen] + succinate + CO(2)
Important for formation of intermolecular cross-links in collagen, helps provide strength to collagen
acts at -Xaa-Lys-Gly- sequences
| Collagen glucosyltransferase UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen = UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | Homo sapiens (human, a mammal) |
| 130 | Phosphoglycerate Kinase, Homo sapiens | Phosphoglycerate Kinase, enzyme
ADP + 1,3-bisphosphoglycerate => ATP + 3-phospho-D-glycerate
Carbohydrate degradation, glycolysis | disulphide reductase, enzyme
Inhibits angiogenesis through a disulfide reductase activity that activates plasminogen autoproteolytic activity, producing angiostatin. One or more of the PGK cysteine residues may have a role in plasmin reduction. | Homo sapiens (human, a mammal) |
| 131 | Prostaglandin H2 Synthase, Ovis aries | Prostaglandin H2 synthase-1, enzyme
Arachidonate + AH(2) + 2 O(2) <=> prostaglandin H(2) + A + H(2)O
Lipid metabolism, prostaglandin biosynthesis | Peroxidase and cyclo-oxygenase 2 phenolic donor + H(2)O(2) <=> 2 phenoxyl radical of the donor + 2 H(2)O | Ovis aries (Sheep) |
| 132 | Mismatch repair endonuclease PMS2, Mus musculus | PMS2 mismatch repair enzyme
introduces single-strand breaks near the mismatch | Hypermutation of antibody variable chains | Mus musculus |
| 133 | Thymosin beta-4, Homo sapiens | Involved in sequestering G-actin (monomeric actin) in human polymorphonuclear leukocytes (PMNs).
| secreted anti-inflammatory agent | Homo sapiens (human, a mammal) and Bos taurus (cow, a mammal) |
| 135 | Acetohydroxyacid isomerase, Saccharomyces cerevisiae | acetohydroxyacid reductoisomerase, enzyme
Amino-acid biosynthesis, L-leucine, L-isoleucine and L-valine biosynthesis
(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ => (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH
(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ => (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH
Cofactor
| maintain mitochondrial DNA stability
enzyme catalytic function not needed for this role | Saccharomyces cerevisiae (yeast, fungi) |
| 136 | PutA, Salmonella typhimurium | Proline dehydrogenase / Proline oxidase
pyrroline-5-carboxylic acid dehydrogenase activity | transcriptional repressor of the put operon | Salmonella typhimurium (and also E. coli) (Gram negative bacterium) |
| 137 | GCN4 transcription factor, Saccharomyces cerevisiae | transcription factor; transcription activator | ribonuclease | Saccharomyces cerevisiae |
| 138 | birA biotin sythetase, Escherichia coli | birA biotin synthetase, enzyme
biotin--[acetyl-CoA-carboxylase] ligase
ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)]. | bio operon repressor
repressor activity depends on cellular concentration of biotin | Escherichia coli (Gram negative bacterium) |
| 139 | Clf1p pre-mRNA splicing factor, Saccharomyces cerevisiae | Clf1p pre-mRNA splicing factor
involved in assembly of spliceosome
| Initiation of DNA replication
binds to origin of replication complex
| Saccharomyces cerevisiae |
| 140 | Thymidine phosphorylase, Homo sapiens | Thymidine phosphorylase
thymidine + phosphate <=> thymine + 2-deoxy-alpha-D-ribose 1-phosphate
Pyrimidine metabolism, dTMP biosynthesis in salvage pathway | Platelet-derived endothelial cell growth factor
| Homo sapiens (human, a mammal) |
| 143 | Citrate synthase, Tetrahymena thermophila | citrate synthase, enzyme
acetyl-CoA + oxaloacetate + H2O => citrate + CoA-SH
Citric acid cycle | 14-nm cytoskeletal protein | Tetrahymena thermophila |
| 144 | Galactokinase, Kluyveromyces lactis | galactokinase
ATP + galactose => ADP + galactose 1-phosphate.
Carbohydrate metabolism; galactose metabolism | transcriptional activator of GAL genes
| Kluyveromyces lactis |
| 145 | Glutamate racemase, Mycobacterium tuberculosis | glutamate racemase
L-glutamate <=> D-glutamate
Cell wall biogenesis, peptidoglycan biosynthesis | DNA gyrase
relieves strain when double-stranded DNA is being unwound | Mycobacterium tuberculosis (mycobacterium, causes tuberculosis) |
| 146 | Hemagglutinin, Paramyxovirus | hemagglutinin
binding the virus to the surface of host cells
| Neuraminidase, enzyme
cleaves the glycosidic linkages of neuraminic acids | Paramyxovirus (Mumps virus) |
| 147 | Transketolase, Escherichi coli | transketolase, enzyme
Pentose Phosphate Pathway
Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-ribose 5-phosphate + D-xylulose 5-phosphate. | Transcriptional regulator
derepresses the marRAB multiple antibiotic resistance operon by binding to the MarR repressor
a "trigger enzyme" | Escherichia coli (Gram negative bacterium) |
| 148 | Tyrosyl tRNA synthetase, Neurospora crassa | tyrosyl tRNA synthetase, enzyme
attaches tyrosine to tRNA(Tyr)
ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr) | promotes folding of group 1 introns | Neurospora crassa |
| 149 | Ag85A, Mycobacterium tuberculosis | mycolyltransferase, enzyme
cell wall assembly
Transesterification of mycolic acids | fibronectin-binding | Mycobacterium tuberculosis (mycobacterium, causes tuberculosis) |
| 150 | Aconitase, Bos taurus | aconitase, enzyme
4Fe-4S cluster in active site when cellular iron levels are high Citrate <=> isocitrate
Citric acid cycle | iron responsive element binding protein
when cellular iron concentrations are low, loses 4Fe-4S cluster and binds to iron-responsive elements (IRES) in mRNA that encodes proteins that are involved in iron uptake and use | Bos taurus (bovine, a mammal) |
| 151 | Folate receptor, Mus musculus | folate receptor
binds folate and derivatives and brings them into the cell during endocytosis
| transcription factor
| Mus musculus (Mouse, mammal) |
| 152 | Dihydroxyacetone kinase, Escherichia coli | dihydroxyacetone kinase, enzyme
ATP + glycerone <=> ADP + glycerone phosphate
(glycerone also called dihydroxyacetone) | controls gene expression by binding to transcription factor DhaR, a trigger enzyme | Escherichia coli (Gram negative bacterium) |
| 153 | Aaa autolysin, Staphylococcus aureus | Aaa autolysin
peptidoglycan hydrolase, enzyme
in cell division, cell separation, and cell wall turnover
also bacteriolytic activity
cleaves some cell wall glycopeptides, hydrolyzes the link between L-amino acid residues and N-acetylmuramoyl residues | fibronectin binding, adhesin | Staphylococcus aureus (Gram positive bacterium) |
| 154 | Aae autolysin, Staphylococcus epidermidis | Aae autolysin
peptidoglycan hydrolase in cell-wall turnover and cell division
bacteriolytic activity
| binds fibrinogen, fibronectin and vitronectin | Staphylococcus epidermis (Gram positive bacterium) |
| 155 | AtlC, Staphylococcus caprae | autolysin, enzyme
N-acetylmuramoyl-L-alanine amidase
hydrolyze peptidoglycan in cell wall | fibronectin binding | Staphylococcus caprae (Gram positive bacterium) |
| 156 | Ami autolysin, Listeria monocytogenes | autolysin, enzyme
cleaves cell wall glycopeptides, at the link between the L-amino acid residues and the N-acetylmuramoyl residues | adherence to eukaryotic cells | Listeria monocytogenes (Gram positive bacterium, causes listeriosis, septicemia, meningitis) |
| 157 | Ag85B, Mycobacterium tuberculosis | mycolyltransferase, enzyme
cell wall assembly
Transesterification of mycolic acids | fibronectin binding | Mycobacterium tuberculosis (mycobacterium, causes tuberculosis) |
| 158 | Ag85C, Mycobacterium tuberculosis | mycolyltransferase, enzyme
cell wall assembly
Transesterification of mycolic acids | fibronectin binding | Mycobacterium tuberculosis (mycobacterium, causes tuberculosis) |
| 159 | Thioredoxin, Escherichia coli | thioredoxin
antioxidant
aids the reduction of other proteins by cysteine thiol-disulfide exchange | Subunit of T7 DNA polymerase
****maybe not strictly considered moonlighting because adopted by a phage to be part of a protein complex***** | Escherichia coli (Gram negative bacterium) |
| 160 | Lymphotactin, Homo sapiens | cytokine
agonist for XCR1, the specific G-protein-coupled receptor for lymphotactin | binding to cell-surface glycosaminoglycans
**a Metamorphic protein - different fold than when cytokine*** | Homo sapiens (human, a mammal, OMIM number 600250 ) |
| 161 | ATF2, Homo sapiens | ATF2 activating transcription factor
bZIP family of transcription factors
binds DNA as a dimer, homodimerization or heterodimerization, sometimes with c-Jun
| recruiting Mre11 to IR-induced foci (IRIF) in the DNA damage response, this function does not require DNA binding domain or dimerization with c-Jun | Homo sapiens (human, a mammal) and Mus musculus (mouse a mammal) |
| 162 | ATF2, Mus musculus | ATF2 activating transcription factor bZIP family of transcription factors binds DNA as a dimer, homodimerization or heterodimerization, sometimes with c-Jun
| recruiting Mre11 to IR-induced foci (IRIF) in the DNA damage response, this function does not require DNA binding domain or dimerization with c-Jun
| Mus musculus (Mouse, mammal) |
| 163 | Glutamine synthetase, Bacillus subtilis | glutamine synthetase
catalyzes the synthesis of glutamine from glutamate and ammonia
ATP + L-glutamate + NH3 => ADP + phosphate + L-glutamine | binds to transcription factor TnrA, a global regulator of transcription, and prevents it from binding to DNA | Bacillus subtilis |
| 164 | Glutamate dehydrogenase, Bacillus subtilis | glutamate dehydrogenase
deaminates glutamate to form ?-ketoglutarate
L-glutamate + H2O + NAD+ => 2-oxoglutarate + NH3 + NADH. | interacts directly with GltC, a LysR-type transcription factor | Bacillus subtilis |
| 165 | High mobility group protein B1, Rattus norvegicus | binds heparin
involved in extension of neurite-type cytoplasmic processes | DNA binding protein, without sequence specificity
associates with chromatin, may play structural role
bends DNA | Rattus norvegicus (Rat, a mammal) |
| 166 | Arg82, Saccharomyces cerevisiae | kinase, enzyme
phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4)
2 ATP + 1D-myo-inositol 1,4,5-trisphosphate => 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.
| stabilizes transcription factors ARG80 and MCM1 | Saccharomyces cerevisiae (yeast, fungi) |
| 167 | Arginase, Saccharomyces cerevisiae | arginase
use of arginine as nitrogen source
L-arginine + H2O => L-ornithine + urea
Nitrogen metabolism, urea cycle | binds to ornithine transcarbamylase and inactivates it (OTCase, catalyzes first step in arginine biosynthesis), effectors are ornithine and arginine
| Saccharomyces cerevisiae (yeast, fungi) |
| 168 | Epimorphin, Syntaxin-2, Homo sapiens | epimorphin - mediates epithelial tissue morphogenesis outside the cell
| syntaxin 2
controls protein secretion from endoplasmic reticulumGolgi-derived vesicles
it is a target SNARE (t-SNARE) on the cytoplasmic side of the plasma membranes that aids in fusion of the plasma membrane with vesicles that carry the appropriate vesicle SNARE (v-SNARE) proteins | Homo sapiens (human, a mammal, OMIM number 132350 ) |
| 169 | Calreticulin, Homo sapiens | chaperone
promotes protein folding and assembly of oligomers
involved in protein quality control
| adhesin
| Homo sapiens (human, a mammal) |
| 170 | Erk2, Homo sapiens | Erk2 kinase, enzyme
Serine/threonine kinase
ATP + a protein => ADP + a phosphoprotein. | transcriptional repressor
represses expression of interferon gamma-induced genes | Homo sapiens (human, a mammal, OMIM number 176948 ) |
| 171 | L13a, Homo sapien | ribosome protein,
part of 60S subunit of ribosome
| translation inhibition
Component of the GAIT complex (gamma interferon-activated inhibitor of translation)
| Homo sapiens (human, a mammal) |
| 172 | Glutamyl-prolyl tRNA synthetase, Homo sapiens | glutamyl-prolyl tRNA synthetase, enzyme
an aminoacyl-tRNA synthetase
catalyze the attachment of amino acids to cognate tRNAs
ATP + L-glutamate + tRNA(Glu) => AMP + diphosphate + L-glutamyl-tRNA(Glu)
ATP + L-proline + tRNA(Pro) => AMP + diphosphate + L-prolyl-tRNA(Pro) | translation inhibition
part of GAIT complex: interferon (IFN)-gamma-activated inhibitor of translation
silences ceruloplasmin mRNA translation
| Homo sapiens (human, a mammal) |
| 173 | Glyceraldehyde-3-phosphate dehydrogenase, Homo sapiens | glyceraldehyde-3-phosphate dehydrogenase, enzyme
D-glyceraldehyde 3-phosphate + phosphate + NAD+ => 1,3-bis-phosphogycerate + NADH
Carbohydrate degradation, glycolysis | translation inhibition
part of GAIT complex: interferon (IFN)-gamma-activated inhibitor of translation that silences ceruloplasmin mRNA translation
| Homo sapiens (human, a mammal, OMIM number 138400) |
| 174 | L7 ribosomal, Methanococcus jannaschii | part of the ribosome | sRNP core protein
binds the box C/D snoRNA core motif, homologue of eukaryotic 15.5kD protein | Methanococcus jannaschii |
| 175 | RACK1, Saccharomyces cerevisiae | Component of the 40S (small) ribosomal subunit | scaffold in cytoplasmic signal transduction pathways | Saccharomyces cerevisiae (yeast, fungi) |
| 177 | L10 ribosomal protein, Homo sapiens | Component of the large subunit (60S) of the ribosome
| negative regulator of c-Jun in transcription | Homo sapiens (human, a mammal) |
| 178 | L32, Saccharomyces cerevisiae | Component of the ribosome large subunit (60S) | inhibits the splicing of the transcript of its own gene, RPL32 | Saccharomyces cerevisiae (yeast, fungi) |
| 179 | S14 ribosomal protein, Saccharomyces cerevisiae | Component of the ribosome small subunit (40S) | represses expression of RPS14B gene
rpS14 binds directly to RNA, binds to an RNA stem-loop structure in RPS14B pre-mRNA | Saccharomyces cerevisiae (yeast, fungi) |
| 180 | L2 ribosomal protein, Saccharomyces cerevisiae | Component of the ribosome large subunit (60S). | regulates accumulation of L2 mRNA, shortens half-life of L2 mRNA
| Saccharomyces cerevisiae (yeast, fungi) |
| 181 | S28 Ribosomal protein, Saccharomyces cerevisiae | Component of the ribosome small subunit (40S) | shortens half-life of own mRNA
binds to hairpin structure in 3' UTR and also to the decapping machinery | Saccharomyces cerevisiae (yeast, fungi) |
| 182 | L12 ribosomal protein, Caenorhabditis elegans | ribosomal protein
Binds RNA directly (26S rRNA) | inhibits splicing of its own RNA | Caenorhabditis elegans (nematode, worm) |
| 183 | S13 ribosomal protein, Homo sapiens | ribosomal protein, part of the ribosome | inhibits splicing of own RNA transcript
inhibit removal of intron 1 from rpS13 pre-mRNA | Homo sapiens (human, a mammal) |
| 184 | L11 ribosomal protein, Mus musculus | ribosomal protein, part of 60S subunit | Binds to and inhibits HDM2, a ubiquitin ligase, which results in stabilization of p53 tumor suppressor protein | Mus musculus (Mouse, mammal) |
| 185 | L11 ribosomal protein, Homo sapiens | ribosomal protein, part of 60S subunit | Binds to and inhibits HDM2, a ubiquitin ligase, which results in stabilization of p53 tumor suppressor protein | Homo sapiens (human, a mammal) |
| 186 | L5 ribosomal protein, Homo sapiens | ribosomal protein, part of the 60S subunit | Binds to and inhibits HDM2, a ubiquitin ligase, which results in stabilization of the p53 tumor suppressor protein | Homo sapiens (human, a mammal) |
| 187 | S7 ribosomal protein, Homo sapiens | ribosomal protein, part of 40S subunit | Binds to and inhibits HDM2, a ubiquitin ligase, which results in stabilization of the p53 tumor suppressor protein | Homo sapiens (human, a mammal) |
| 188 | L26 ribosomal protein, Homo sapiens | ribosomal protein, part of 60S subunit | regulates (increases) translation of p53 tumor suppressor protein after DNA damage, leading to cell cycle arrest and apoptosis
binds 5' UTR of p53 mRNA | Homo sapiens (human, a mammal) |
| 189 | Nucleolin, Homo sapiens | synthesis and maturation of ribosomes | regulates (decreases) translation of p53 tumor suppressor protein
binds 5' UTR of p53 mRNA | Homo sapiens (human, a mammal) |
| 190 | L23 ribosomal protein, Homo sapiens | ribosomal protein, part of 60S subunit | Binds to and inhibits HDM2, a ubiquitin ligase, which results in stabilization of p53 tumor suppressor protein
| Homo sapiens (human, a mammal) |
| 191 | L10 ribosomal protein, Arabidopsis thaliana | ribosomal protein, part of 40S subunit
| Involved in NSP-interacting kinase (NIK) receptor-mediated defense pathway to defend against geminivirus
substrate and binding partner of NIK1
| Arabidopsis thaliana (Mouse-ear cress, a plant) |
| 192 | S3 ribosomal protein, Drosophila melanogaster | ribosomal protein, part of 40S subunit | DNA repair activity
cleaves DNA at apurinic/apyrimidinic sites
| Drosophila melanogaster (fruit fly, an insect) |
| 11 | S3 ribosomal protein, Homo sapien | ribosomal protein, part of the 40S subunit | a subunit of a DNA binding complex involved in NF-kappaB-mediated transcription | Homo sapiens (human, a mammal, OMIM number 600454 ) |
| 193 | EF-G, Streptococcus gordonii | elongation factor in translation
catalyzes translocation step, uses GTP | adhesin, binds salivary mucin MUC7 | Streptococcus gordonii (Gram positive bacterium) |
| 194 | L4 ribosomal protein, Escherichia coli | ribosomal protein, part of the 50S subunit | transcriptional repressor
causes premature termination of transcription within S10 operon | Escherichia coli (Gram negative bacterium) |
| 195 | Enolase, Streptococcus gordonii | enolase, enzyme
Catalyzes the interconversion of 2-phosphoglycerate and phosphoenolpyruvate
2-phospho-D-glycerate <=> phosphoenolpyruvate + H2O
Carbohydrate degradation, glycolysis | adhesin, binds salivary mucin MUC7 | Streptococcus gordonii (Gram positive bacterium) |
| 196 | Fructose-1,6-bisphosphate aldolase/phosphatase, Sulfolobus tokodaii | fructose-1,6-bisphosphatase, enzyme
dephosphorylation of FBP to fructose-6-phosphate | fructose-1,6-bisphosphate aldolase, enzyme
reversible aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to FBP | Sulfolobus tokodaii |
| 197 | Fructose-1,6-bisphosphate aldolase/phosphatase, Thermoproteus neutrophilus | fructose-1,6-bisphosphatase, enzyme
dephosphorylation of FBP to fructose-6-phosphate | fructose-1,6-bisphosphate aldolase, enzyme
reversible aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to FBP | Thermoproteus neutrophilus |
| 2 | RfaH, Escherichia coli | aids in transcription elongation of long RNA chains,
reduces pausing and inhibits termination
| translational regulator | Escherichia coli (Gram negative bacterium) |
| 198 | DegQ, Escherichia coli | peptidase, enzyme
| chaperone, aids in folding of proteins
| Escherichia coli (Gram negative bacterium) |
| 199 | Cdt1, Homo sapiens | helps load proteins onto chromatin to create the pre-replication complex for initiating DNA replication
| role in mitosis
localizes to kinetochores through binding to the Hec1 component of the Ndc80 complex
| Homo sapiens (human, a mammal, OMIM number 605525 Meier-Gorlin Syndrome) |
| 200 | MalY, Escherichia coli | beta-cystathionase, enzyme
cleavage of cystathionine to homocysteine, ammonia, and pyruvate
L-cystathionine + H2O => L-homocysteine + NH3 + pyruvate
Amino-acid biosynthesis, methionine biosynthesis | transcription regulation binds to MalT activator of mal regulon and prevents its action | Escherichia coli (Gram negative bacterium) |
| 201 | Hexokinase, Saccharomyces cerevisiae | hexokinase, enzyme
ATP + D-hexose => ADP + D-hexose 6-phosphate.
Carbohydrate metabolism, hexose metabolism, glycolysis | Hxk2 interacts directly with Mig1, a transcriptional repressor that binds to promoters of genes that are repressed by glucose
high glucose causes Hxk2 to move to the nucleus | Saccharomyces cerevisiae (yeast, fungi) |
| 202 | GmaR, Listeria monocytogenes | O-GlcNAc transferase
glycosyltransferase that mediates beta-O-linked GlcNAc modification of flagellin (FlaA) | transcriptional regulator
anti-repressor, target is MogR (a transcriptional repressor), binds to MogR and prevents it from binding to DNA | Listeria monocytogenes (Gram positive bacterium, causes listeriosis, septicemia, meningitis) |
| 203 | Pyruvate carboxylase, Hansenula poymorpha | Pyruvate carboxylase, enzyme
ATP + pyruvate + HCO3- => ADP + phosphate + oxaloacetate.
Carbohydrate biosynthesis, gluconeogenesis
| assembly of peroxisomal alcohol oxidase (AOX)
may mediate FAD binding to AOX monomers in cytoplasm, which enables them to be transported to the peroxisome where they can assemble into the active octomeric form | Hansenula poymorpha (Pichia angusta) (Yeast) |
| 65 | Phosphofructokinase, Pichia pastoris | phosphofructokinase, enzyme
ATP + D-fructose 6-phosphate => ADP + D-fructose 1,6-bisphosphate Glycolysis | protein, but not catalytic function, is required for microautophagy (vacuolar degradation of peroxisomes)
only alpha subunit of phosphofructokinase plays this role | Komagataella pastoris (Yeast) (Pichia pastoris) |
| 71 | Enolase 1, Saccharomyces cerevisiae | enolase, enzyme
2-phospho-D-glycerate <=> phosphoenolpyruvate + H2O
Glycolysis | required for vacuole homotypic membrane fusion and protein trafficking to the vacuole
enzyme catalytic activity not needed for this role | Saccharomyces cerevisiae (yeast, fungi) |
| 204 | PyrH, Escherichia coli | UMP kinase, enzyme
phosphorylates UMP to UDP
ATP + UMP <=> ADP + UDP
de novo biosynthetic pathway of pyrimidine nucleotides | transcriptional regulator
involved in pyrimidine-specific repression of the carAB operon
binds to PepA | Escherichia coli (Gram negative bacterium) |
| 76 | Enolase 2, Saccharomyces cerevisiae | enolase, enzyme
2-phospho-D-glycerate <=> phosphoenolpyruvate + H2O
Glycolysis | required for vacuole homotypic membrane fusion and protein trafficking to the vacuole
enzyme catalytic activity not needed for this role | Saccharomyces cerevisiae (yeast, fungi) |
| 205 | CysK, Bacillus subtilis | Cysteine synthase, enzyme
O-acetyl-serine + H2S = cysteine + acetate
Amino-acid biosynthesis, biosynthesis of cysteine | transcriptional regulator
regulates activity of CymR transcription factor
forms complex with CymR that represses transcription of the CymR regulon
| Bacillus subtilis |
| 99 | Fructose 1,6-Bisphosphate Aldolase, Saccharomyces cerevisiae | Aldolase, enzyme
D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate
Glycolysis, Gluconeogenesis | binds to vacuolar H+-ATPase and is needed for its assembly
enzymatic catalytic activity not needed for this function | Saccharomyces cerevisiae (yeast, fungi) |
| 134 | Ure2, Saccharomyces cerevisiae | functions in nitrogen catabolite repression
binds to and inhibits GATA transcriptional activators GLN3 and GAT1, keeps them in the cytoplasm, prevents transcription of their target genes | glutathione peroxidase, enzyme
also thiol:disulfide oxidoreductase
2 glutathione + H2O2 => glutathione disulfide + 2 H2O | Saccharomyces cerevisiae (yeast, fungi) |
| 206 | Aes, Escherichia coli | esterase, enzyme
esterase of short chain fatty esters with up to 8 carbons in acyl chain | transcription regulation
binds to MalT activator of mal regulon and prevents its action | Escherichia coli (Gram negative bacterium) |
| 207 | PutA, Escherichia coli | Proline dehydrogenase / Proline oxidase, enzyme
L-proline + a quinone => (S)-1-pyrroline-5-carboxylate + a quinol
L-glutamate 5-semialdehyde + NAD+ + H2O => L-glutamate + NADH
Amino-acid degradation, L-proline degradation into L-glutamate | transcriptional repressor of the put operon
| Escherichia coli (Gram negative bacterium) |
| 208 | NadR, Escherichia coli | nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase activities, enzyme
ATP + nicotinamide ribonucleotide => diphosphate + NAD+
ATP + 1-(beta-D-ribofuranosyl)-nicotinamide => ADP + beta-nicotinamide D-ribonucleotide
NAD biosynthesis | Transcriptional repressor
binds to the nadB operator DNA sequence
Increasing NAD causes an increase in the affinity of NadR for the nadB operator regions of nadA, nadB, and pncB | Escherichia coli (Gram negative bacterium) |
| 209 | PepA, Escherichia coli | aminopeptidase, enzyme
removes amino-terminal amino acid, preferentially if it is Leu
| transcriptional repressor
binds DNA, binds car operator DNA
represses the carAB operon
| Escherichia coli (Gram negative bacterium) |
| 210 | Glucose permease, Escherichia coli | phosphorylates glucose, enzyme
sugars are phosphorylated during transport through the channel subunit of the protein complex
| IIB subunit binds and sequesters Mlc transcription repressor in presence of glucose | Escherichia coli (Gram negative bacterium) |
| 211 | MalK, Escherichia coli | ATP binding/hydrolysis protein of MalEFGK maltose/maltodextrin transporter (importer)
an ABC transporter
ATP + H2O = ADP + phosphate
| transcription regulation
binds to MalT activator of mal regulon and prevents its action | Escherichia coli (Gram negative bacterium) |
| 212 | DhaK, Escherichia coli | subunit of dihydroxyacetone kinase, enzyme
phosphorylates dihydroxyacetone
contains the Dha binding site
| corepressor of DhaR transcription activator
binds to DhaR
affects transcription of the dhaKLM operon
| Escherichia coli (Gram negative bacterium) |
| 213 | DhaL, Escherichia coli | subunit of dihydroxyacetone kinase, enzyme
phosphorylates dihydroxyacetone
contains the ADP-binding site
| coactivator of DhaR transcription activator
binds to DhaR
affects transcription of the dhaKLM operon
| Escherichia coli (Gram negative bacterium) |
| 215 | Formiminotransferase, Thermoplasma acidophilum | formiminotransferase, enzyme
histidine breakdown | 5-formyltetrahydrofolate cycloligase
ATP + 5-formyltetrahydrofolate <=> ADP + phosphate + 5,10-methenyltetrahydrofolate | Thermoplasma acidophilum |
| 216 | Sarcosine oxidase alpha subunit, Thermococcus kodakarensis | Sarcosine oxidase, enzyme
oxidation of the methyl group in sarcosine and transfer to folate
oxidative demethylation of sarcosine to yield glycine and 5,10-CH2-tetrahydrofolate
| NADH dehydrogenase
NADH + H+ + acceptor <=> NAD+ + reduced acceptor
| Thermococcus kodakarensis |
| 217 | Sarcosine oxidase beta subunit, Thermococcus kodakarensis | Sarcosine oxidase, enzyme
oxidation of the methyl group in sarcosine and transfer to folate oxidative demethylation of sarcosine to yield glycine and 5,10-CH2-tetrahydrofolate | L-proline dehydrogenase, enzyme
L-proline + acceptor <=> (S)-1-pyrroline-5-carboxylate + reduced acceptor
| Thermococcus kodakarensis |
| 218 | TreX, Sulfologus solfataricus | alpha-1,4-transferase, enzyme
| alpha-1,6-glucosidase, enzyme | Sulfologus solfataricus |
| 219 | Thymidylate synthase, Homo sapiens | thymidylate synthase, enzyme
de novo synthesis of thymidylate, a DNA precursor
5,10-methylenetetrahydrofolate + dUMP <=> dihydrofolate + dTMP
Pyrimidine metabolism, dTTP biosynthesis | mRNA translation inhibition
regulation of human TS mRNA translation
does not bind to unrelated mRNAs
| Homo sapiens (human, a mammal, OMIM number 188350 ) |
| 220 | Thymidylate synthase, Plasmodium falciparum | Dihydrofolate reductase and Thymidylate synthase, enzyme
5,6,7,8-tetrahydrofolate + NADP+ <=> 7,8-dihydrofolate + NADPH
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP
Tetrahydrofolate biosynthesis | mRNA translation inhibition
regulation of plasmodium TS-DHFR mRNA translation | Plasmodium falciparum |
| 222 | Dihydrofolate reductase, Homo sapiens | dihydrofolate reductase, enzyme
5,6,7,8-tetrahydrofolate + NADP+ => 7,8-dihydrofolate + NADPH
tetrahydrofolate biosynthesis | binds DHFR mRNA
regulation of DHFR synthesis
methotrexate inhibits interaction
| Homo sapiens (human, a mammal) |
| 223 | Serine hydroxymethyltransferase, Homo sapiens | serine hydroxymethyltransferase, enzyme
5,10-methylenetetrahydrofolate + glycine + H2O <=> tetrahydrofolate + L-serine
One-carbon metabolism, tetrahydrofolate interconversion | binds mRNA
binds the 5' untranslated region (UTR) of its own mRNA
| Homo sapiens (human, a mammal) |
| 224 | Uracil phosphoribosyltransferase, Bacillus caldolyticus | uracil phosphoribosyltransferase, enzyme
UMP + diphosphate <=> uracil + 5-phospho-alpha-D-ribose 1-diphosphate
| binds mRNA
transcriptional attenuation of the pyrimidine nucleotide biosynthetic (pyr) operon
binds upstream of the genes being regulated | Bacillus caldolyticus |
| 225 | Creatine kinase, Rattus norvegicus | creatine kinase, enzyme
transfers phosphoryl group between ATP and various phosphogens (e.g. creatine phosphate)
ATP + creatine <=> ADP + phosphocreatine | binds mRNA
translation regulator
binds 3' untranslated region (3' UTR) of mRNA of alpha myosin heavy chain (alphaMyHC)
| Rattus norvegicus (rat, a mammal) |
| 226 | Mevalonate kinase, Rattus norvegicus | Mevalonate kinase, enzyme
ATP + (R)-mevalonate => ADP + (R)-5-phosphomevalonate
Isoprenoid biosynthesis, mevalonate pathway | mRNA binding
cytosolic luteinizing hormone receptor mRNA binding protein
increases LH receptor mRNA degradation | Rattus norvegicus (rat, a mammal) |
| 227 | Threonyl-tRNA synthetase, Escherichia coli | Threonine-tRNA ligase, enzyme
ATP + L-threonine + tRNA(Thr) => AMP + diphosphate + L-threonyl-tRNA(Thr) | binds mRNA
binds mRNA encoding threonyl-tRNA synthetase, controls expression of its own gene at the translational level
| Escherichia coli (Gram negative bacterium) |
| 229 | Enolase, Mycoplasma fermentans | enolase, enzyme
2-phospho-D-glycerate <=> phosphoenolpyruvate + H2O
Carbohydrate degradation, glycolysis | plasminogen binding
| Mycoplasma fermentans (mycobacterium) |
| 230 | GroEL1, Mycobacterium tuberculosis | protein chaperone
prevents proteins from misfolding, promotes correct refolding and assembly of polypeptides | binds DNA
low specificity but high affinity
nucleoid-associated protein
condenses DNA into a compact structure
| Mycobacterium tuberculosis (mycobacterium, causes tuberculosis) |
| 231 | Gephryn, Homo sapiens | connects membrane proteins to cytoskeleton
microtubule binding protein
anchors transmembrane receptors
needed for clustering of inhibitory glycine receptors in postsynaptic membranes in the rat central nervous system
| Molybdopterin adenylyltransferase and Molybdopterin molybdenumtransferase, enzyme
biosynthesis of the molybdenum cofactor
catalyzes two steps
ATP + molybdopterin => diphosphate + adenylyl-molybdopterin.
Adenylyl-molybdopterin + molybdate => molybdenum cofactor + AMP.
Cofactor biosynthesis, molybdopterin biosynthesis
| Homo sapiens (human, a mammal) |
| 232 | Cytochrome C, Equus caballus | Electron carrier protein
component of the mitochondrial electron-transport chain
| binding to apoptosis protease activation factor-1 (Apaf-1)
promotes apoptosis
release from mitochondria allows interaction with apoptosis proteins
| Equus caballus (Horse, a mammal) |
| 233 | Cytochrome C, Saccharomyces cerevisiae | Electron carrier protein component of the mitochondrial electron-transport chain | binding to apoptosis protease activation factor-1 (Apaf-1) promotes apoptosis release from mitochondria allows interaction with apoptosis proteins | Saccharomyces cerevisiae (yeast, fungi) |
| 234 | Aconitase, Homo sapiens | aconitase, enzyme
4Fe-4S cluster in active site when cellular iron levels are high Citrate <=> isocitrate
Citric acid cycle | iron responsive element binding protein
when cellular iron concentrations are low, loses 4Fe-4S cluster and binds to iron-responsive elements (IRES) in mRNA that encodes proteins that are involved in iron uptake and use | Homo sapiens (human, a mammal) |
| 235 | Alaninyl-tRNA syntetase, Escherichia coli | Alanyl-tRNA synthetase, enzyme
attaches alanine to tRNA(Ala)
ATP + L-alanine + tRNA(Ala) => AMP + diphosphate + L-alanyl-tRNA(Ala) | transcription regulator
represses transcription of its own gene
increased repression with increased alanine concentrations
binds DNA
| Escherichia coli (Gram negative bacterium) |
| 236 | Leucyl-tRNA synthetase, Saccharomyces cerevisiae | Leucyl-tRNA synthetase, enzyme
ATP + L-leucine + tRNA(Leu) => AMP + diphosphate + L-leucyl-tRNA(Leu)
protein synthesis | intron splicing, RNA splicing
group I intron splicing
| Saccharomyces cerevisiae (yeast, fungi) |
| 237 | Leucyl-tRNA synthetase, Homo sapiens | Leucyl-tRNA synthetase, enzyme
attaches leucine to its cognate tRNA
ATP + L-leucine + tRNA(Leu) => AMP + diphosphate + L-leucyl-tRNA(Leu)
protein synthesis
| GTPase-activating protein (GAP)
senses intracellular leucing concentration and binds to Rag GTPase
Rag signals to mTORC1
promotes translocation of mTORC1 to the lysosomal membrane | Homo sapiens (human, a mammal) |
| 238 | Glutaminyl-tRNA synthetase, Homo sapiens | Glutaminyl-tRNA synthetase, enzyme
ATP + L-glutamine + tRNA(Gln) => AMP + diphosphate + L-glutaminyl-tRNA(Gln)
protein synthesis
| interacts with ASK1 (Fas ligation activated apoptosis signal-regulating kinase 1) to inhibit apoptosis induced by ASK1
protein-protein interaction increased under conditions of increased glutamine concentration
| Homo sapiens (human, a mammal) |
| 239 | Lysyl-tRNA synthetase, Rattus norvegicus | Lysyl-tRNA synthetase, enzyme
ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)
protein synthesis | synthesis of diadenosine tetraphosphate (diadenosine-5',5'''-P1,P4-tetraphosphate, Ap(4)A, AppppA)
Ap4A then regulates transcription of MITF target genes
| Rattus norvegicus (rat, a mammal) |
| 240 | Tryptophanyl-tRNA synthetase, Homo sapiens | Tryptophanyl-tRNA synthetase, enzyme
ATP + L-tryptophan + tRNA(Trp) => AMP + diphosphate + L-tryptophyl-tRNA(Trp)
protein synthesis | forms complex with the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) and poly(ADP-ribose) polymerase 1 (PARP-1)
the complex activates p53
| Homo sapiens (human, a mammal) |
| 241 | MSCp43, Mus musculus | scaffold protein in the multisynthase complex
forms a multi-protein complex with glutamyl-, prolyl-, isoelucyl-, leucyl-, methionyl-, glutaminyl-, lysyl-, arginyl-, and aspartyl-tRNA synthetases, AIMP2/p38, and AIMP3/p18 | cytokine
roles in angiogenesis - inducing endothelial cell migration
induces maturation of dendritic cells
induces monocyte cell adhesion
| Mus musculus (Mouse, mammal) |
| 242 | MSCp38, Mus musculus | scaffold protein in the multisynthase complex forms a multi-protein complex with glutamyl-, prolyl-, isoelucyl-, leucyl-, methionyl-, glutaminyl-, lysyl-, arginyl-, and aspartyl-tRNA synthetases, AIMP1/p24, and AIMP3/p18 | binds to FUSE-binding protein (FBP), a transcriptional activator of c-myc
the protein-protein interaction causes an increase in the ubiquitination and degradation of FBP, which results in downregulation of c-myc
differentiation of lung cells
| Mus musculus (Mouse, mammal) |
| 243 | MSCp18, Mus musculus | scaffold protein in the multisynthase complex forms a multi-protein complex with glutamyl-, prolyl-, isoelucyl-, leucyl-, methionyl-, glutaminyl-, lysyl-, arginyl-, and aspartyl-tRNA synthetases, AIMP2/p38, and AIMP3/p24 | protein-protein interaction with ATM/ATR that results in p53 activation
translocates to nucleus and plays a role in DNA repair
| Mus musculus (Mouse, mammal) |
| 244 | Lysyl-tRNA synthetase, Homo sapiens | Lysyl-tRNA synthetase, enzyme
ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)
protein synthesis
| cytokine
binds to macrophages and peripheral blood mononuclear cells
increases TNF-alpha production by target cells
increases target cell migration
| Homo sapiens (human, a mammal) |
| 245 | Methionyl-tRNA synthetase, Homo sapiens | Methionyl-tRNA synthetase, enzyme
ATP + L-methionine + tRNA(Met) => AMP + diphosphate + L-methionyl-tRNA(Met)
protein synthesis | biogenesis of rRNA in nucleoli
translocation to nucleolus triggered by growth factors
| Homo sapiens (human, a mammal) |
| 246 | L1 ribosomal protein, Escherichia coli | ribosomal protein, part of the 50S subunit
| translational repressor
binds to the mRNA of the L11 operon | Escherichia coli (Gram negative bacterium) |
| 247 | S4 ribosomal protein, Escherichia coli | S4 ribosomal protein
part of the 30S subunit, helps nucleate assembly of the 30S subunit by binding directly to the 16S rRNA
| translational repressor
binds mRNA of operon encoding S3, S11, S4 | Escherichia coli (Gram negative bacterium) |
| 248 | S8 ribosomal protein, Escherichia coli | S8 ribosomal protein
part of the 30S subunit
binds to 16S rRNA
| translational repressor
inhibits expression of some proteins encoded by the spc operon | Escherichia coli (Gram negative bacterium) |
| 249 | Argonaute4, Arabidopsis thaliana | Component of the RISC complex
RNA-directed DNA methylation, involves small interfering RNA (siRNA)
RNA-directed gene silencing
| cleaves RNA transcripts, enzyme
generates small interfering RNAs (siRNAs)
| Arabidopsis thaliana (Mouse-ear cress, a plant) |
| 250 | Ubp6, Saccharomyces cerevisiae | deubiquitinase, enzyme
associated with proteasome
releases ubiquitin from ubiquitinated proteins that bind to the proteasome
| inhibits proteasome activity
delays the degradation of ubiquitinated proteins by the proteasome
enables gradual deubiquitination of the substrate
| Saccharomyces cerevisiae (yeast, fungi) |
| 251 | hRoDH-E2, Homo sapiens | retinol dehydrogenase, enzyme
all-trans-retinol + NAD+ <=> all-trans-retinal + NADH.
Cofactor metabolism, retinol metabolism
| transcriptional repressor
represses profilaggrin promoter activity by adjusting the activity of Sp1 and other activators
| Homo sapiens (human, a mammal) |
| 252 | Pyruvate kinase, Rattus norvegicus | Pyruvate kinase, enzyme
ATP + pyruvate => ADP + phosphoenolpyruvate
Carbohydrate degradation, glycolysis
enzyme as tetramer | thyroid hormone binding activity
monomer binds 3,3',5-triiodo-L-thyronine (T3)
| Rattus norvegicus (rat, a mammal) |
| 253 | Sulfite reductase, Pisum sativum | Sulfite reductase, enzyme
Hydrogen sulfide + 6 oxidized ferredoxin + 3 H2O <=> sulfite + 6 reduced ferredoxin + 6 H+
| compact DNA in nucleoids of plastids
method to regulate transcription
| Pisum sativum (garden pea) |
| 254 | Band 3 anion exchanger, Homo sapiens | Band 3 anion exchanger
transports inorganic anions across the plasma membrane in a 1:1 exchange
| scaffold protein providing binding sites for glycolytic enzymes
involved in regulation of catalytic activity of glycolytic enzymes
site of binding is N-terminal cytoplasmic domain of Band 3 | Homo sapiens (human, a mammal) |
| 255 | Hal3, Saccharomyces cerevisiae | Subunit of phosphopantothenoylcysteine decarboxylase (PPCDC)
coenzyme A biosynthesis pathway
| inhibitory subunit of protein phosphatase PPZ1
| Saccharomyces cerevisiae (yeast, fungi) |
| 256 | Vhs3, Saccharomyces cerevisiae | Subunit of phosphopantothenoylcysteine decarboxylase (PPCDC)
coenzyme A biosynthesis pathway | inhibitory subunit of protein phosphatase PPZ1 | Saccharomyces cerevisiae (yeast, fungi) |
| 257 | I-Tev1 endonuclease, bacteriophage T4 | homing endonuclease, enzyme
intron-encoded
binds cognate intronless alleles
| transcriptional autorepressor
| bacteriophage T4 |
| 258 | Pth2/Bit1, Homo sapiens | Peptidyl-tRNA hydrolase, enzyme
aminoacyl-tRNA + H2O => amino acid + tRNA
releases tRNA from the premature translation termination product
| inhibitor of transcription
protein-protein interaction | Homo sapiens (human, a mammal) |
| 259 | CFTR, Homo sapiens | chloride transporter
ATP + H2O => ADP + phosphate
contains nucleotide binding domains that bind and hydrolyze ATP | regulator of other ion channels | Homo sapiens (human, a mammal,OMIM number 602421 Cystic Fibrosis) |
| 260 | MDR1, Homo sapiens | transmembrane transporter
efflux pump, uses ATP for energy
expels drugs and other small molecule compounds
ATP + H2O + xenobiotic(Inside) => ADP + phosphate + xenobiotic(Outside) | regulator of volume-activated chloride channels
| Homo sapiens (human, a mammal) |
| 261 | Atla autolysin, Streptococcus mutans | autolysin, enzyme
cleaves cell wall peptidoglycan | binds fibronectin | Streptococcus mutans |
| 262 | Peroxiredoxin 1, Saccharomyces cerevisiae | peroxiredoxin
peroxidase
antioxidant
2 R'-SH + ROOH => R'-S-S-R' + H2O + ROH.
| molecular chaperones
helps proteins fold | Saccharomyces cerevisiae (yeast, fungi) |
| 263 | Peroxiredoxin 2, Saccharomyces cerevisiae | peroxiredoxin
peroxidase
antioxidant
2 R'-SH + ROOH => R'-S-S-R' + H2O + ROH | molecular chaperones
helps proteins fold | Saccharomyces cerevisiae (yeast, fungi) |
| 266 | Vps22, Drosophila melanogaster | Component of the ESCRT-II complex (ensodomal sorting complex required for transport II)
complex needed for sorting ubiquitinated endosomal proteins into multivesicular bodies
important for transport of transmembrane proteins to the lysosome for degradation | with other members of the ESCRT complex, binds to the localization element in the 3' untranslated region (UTR) of bicoid mRNA
functions in localizing bicoid mRNA to the anterior of the Drosophila egg | Drosophila melanogaster (fruit fly, an insect) |
| 267 | Vps36, Drosphila melanogaster | Component of the ESCRT-II complex (ensodomal sorting complex required for transport II) complex
needed for sorting ubiquitinated endosomal proteins into multivesicular bodies
important for transport of transmembrane proteins to the lysosome for degradation | mRNA binding
binds to the localization element in the 3' untranslated region (UTR) of bicoid mRNA
functions in localizing bicoid mRNA to the anterior of the Drosophila egg | Drosophila melanogaster (fruit fly, an insect) |
| 265 | Vps25, Drosophila melanogaster | Component of the ESCRT-II complex (ensodomal sorting complex required for transport II)
complex needed for sorting ubiquitinated endosomal proteins into multivesicular bodies
important for transport of transmembrane proteins to the lysosome for degradation | with other members of the ESCRT complex, binds to the localization element in the 3' untranslated region (UTR) of bicoid mRNA
functions in localizing bicoid mRNA to the anterior of the Drosophila egg | Drosophila melanogaster (fruit fly, an insect) |
| 268 | Aspartate receptor, Escherichia coli | aspartate receptor
binds aspartate
transmembrane receptor for aspartate | binds maltose binding protein
maltose receptor
transmembrane receptor for maltose binding protein
| Escherichia coli (Gram negative bacterium) |
| 269 | L14 ribosomal protein, Escherichia coli | ribosomal protein
part of the 30S subunit
binds to the 23S rRNA
| binds DNA
stimulates unwinding of DNA by Rep helicase protein
| Escherichia coli (Gram negative bacterium) |
| 270 | S14 ribosomal protein, Homo sapiens | ribosomal protein
| inhibits S14 mRNA transcription
negative effector of transcription of its own RNA
| Homo sapiens (human, a mammal, OMIM number 130620 Macrocytic anemia) |
| 271 | STAT3, Mus musculus | transcription factor, binds DNA
in response to cytokines (IL-6, and other growth factors)
binds promoters containing IL-6 responsive elements
| modulates the activities of complexes I and II of the electron transport chain (ETC) in the mitochondria | Mus musculus (Mouse, mammal) |
| 273 | Fructose-bisphosphate aldolase, Plasmodium berghei | Fructose-bisphosphate aldolase, enzyme
D-fructose 1,6-bisphosphate => dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate
Carbohydrate degradation, glycolysis | attaches actin filaments to TRAP proteins (transmembrane adhesive proteins of the thrombospondin-related anonymous protein) and transduces the motor force across the surface of the plasmodium
| Plasmodium berghei |
| 274 | Fructose-bisphosphate aldolase, Toxoplasma gondii | Fructose-bisphosphate aldolase, enzyme
D-fructose 1,6-bisphosphate => dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate
Carbohydrate degradation, glycolysis | protein-protein interactions
couples actin cytoskeleton filaments in the cytoplasm to the surface adhesin microneme protein 2 (MIC2) | Toxoplasma gondii |
| 275 | Gpx4, Homo sapiens | Phospholipid hydroperoxide glutathione peroxidase, enzyme
removes membrane lipid peroxidation, cell protection
2 glutathione + a lipid hydroperoxide => glutathione disulfide + lipid + 2 H2O | structural role in capsule in mature spermatozoa
| Homo sapiens (human, a mammal, OMIM number 138322 Spondylometaphyseal dysplasia) |
| 276 | Lactose synthetase, Bos taurus | Lactose synthetase, enzyme
UDP-alpha-D-galactose + D-glucose => UDP + lactose
| UDP-galactose: N-acetylglucosamine galactosyltransferase, enzyme
UDP-alpha-D-galactose + N-acetyl-D-glucosamine => UDP + N-acetyllactosamine | Bos taurus (cow, a mammal) |
| 277 | Isocitrate dehydrogenase 1, Saccharomyces cerevisiae | Isocitrate dehydrogenase, enzyme
Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH
Citric acid cycle | binds mRNA
binds specifically to 5'-untranslated leaders of mitochondrial mRNAs | Saccharomyces cerevisiae (yeast, fungi) |
| 278 | Isocitrate dehydrogenase 2, Saccharomyces cerevisiae | Isocitrate dehydrogenase, enzyme
Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH
Citric acid cycle | binds mRNA binds specifically to 5'-untranslated leaders of mitochondrial mRNAs | Saccharomyces cerevisiae (yeast, fungi) |
| 279 | Germin, Hordeum vulgare | Oxalate oxidase, enzyme
Oxalate + O2 + 2 H+ => 2 CO2 + H2O2 | superoxide dismutase, enzyme
2 superoxide (O2-) + 2 H(+) <=> O(2) + H(2)O(2) | Hordeum vulgare |
| 280 | S10 ribosomal protein, Escherichia coli | ribosomal protein
part of the 30S subunit | part of an antitermination apparatus
antitermination of Rho-dependent and Rho-independent terminators
| Escherichia coli (Gram negative bacterium) |
| 282 | P0 ribosomal protein, Drosophila melanogaster | P0 ribosomal protein
part of the 60S subunit | Apurinic-apyrimidinic endonuclease, enzyme
functions in DNA repair
act on AP DNA, cleaves 5' of a baseless site
| Drosophila melanogaster (fruit fly, an insect) |
| 283 | L10 ribosomal protein, Escherichia coli | ribosomal protein
part of the 50S subunit
| translation inhibitor
autogenous regulation of translation
| Escherichia coli (Gram negative bacterium) |
| 473 | Arogenate dehydratase/prephenate dehydratase 2 | arogenate dehydratase.
Converts the prephenate produced from the shikimate-chorismate pathway into phenylalanine. | component of the chloroplast division machinery. . | Arabidopsis thaliana (Mouse-ear cress, a plant) |
| 284 | S7 ribosomal protein, Escherichia coli | ribosomal protein
binds to 16S rRNA
part of the 30S subunit | translational repressor
regulates the expression of two proteins encoded by the str operon
| Escherichia coli (Gram negative bacterium) |
| 470 | H3 histone, Xenopus laevis | Histone | copper reductase.
The histone H3-H4 tetramer is a copper reductase enzyme. | Xenopus laevis (African clawed frog, an amphibian) |
| 471 | Histone H4, Xenopus laevis | Histone.
Core component of nucleosome. | copper reductase.
The histone H3-H4 tetramer is a copperreductase enzyme. | Xenopus laevis (African clawed frog, an amphibian) |
| 472 | Myo-inositol 1-phosphate synthase 1 | myo-inositol phosphate synthase. | Interact with the histone methyltransferases ATXR5 and ATXR6. | Arabidopsis thaliana (Mouse-ear cress, a plant) |
| 286 | Matrix metaloproteinase 12, Mus musculus | Matrix metaloproteinase, enzyme
cleaves elastin, IFN-? | promotes transcription
binds to the NFKBIA promoter
| Mus musculus (Mouse, mammal) |
| 287 | dCTP deaminase, Methanocaldococcus jannaschii | dCTP deaminase
deamination of the cytosine moiety in dCTP
dCTP + 2 H2O => dUMP + diphosphate + NH3
Pyrimidine metabolism, dUMP biosynthesis | hydrolysis of the triphosphate moiety forming dUMP
dUTP => dUMP | Methanocaldococcus jannaschii |
| 288 | Penicillin binding protein 4, Escherichia coli | carboxypeptidase, enzyme
Cell wall biogenesis, peptidoglycan biosynthesis | endopeptidase, enzyme | Escherichia coli (Gram negative bacterium) |
| 290 | RNase P protein 1, Homo sapiens | Mitochondrial ribonuclease P protein 1, noncatalytic subunit
cleaves tRNA molecules in their 5'-ends
subunit of ribonuclease P, not catalytic subunit for this function
required for ribonuclease P activity
| tRNA methyltransferase, enzyme
| Homo sapiens (human, a mammal, OMIM number 615423 Combined oxidative phosphorylation deficiency 30) |
| 291 | Zuotin, Saccharomyces cerevisiae | component of a chaperone complex
component of the ribosome-associated complex (RAC) that helps in folding of nascent polypeptide chains | activator of a transcription factor
activates Pdr1 transcription factor
| Saccharomyces cerevisiae (yeast, fungi) |
| 302 | aldehyde-alcohol dehydrogenase E | aldehyde alcohol dehydrogenase, alcohol dehydrogenase,
acetaldehyde-CoA dehydrogenase, and pyruvate formate-lyase (PFL) deactivase activities | binds to ribosome and affects translation, RNA unwinding activity, RNA helicase | Escherichia coli (Gram negative bacterium) |
| 303 | fructose-1,6-bisphosphate aldolase | aldolase, cleavage of fructose-1,6-bisphosphate to
glyceraldehyde 3-phosphate and dihydroxyacetone phosphate, in glycolysis | Activation of mouse (host) macrophage protein tyrosine phosphatase-1 (SHP-1), causes macrophage disfunction | |
| 304 | fructose-1,6-bisphosphate aldolase | aldolase, in glycolysis and gluconeogenesis, reversible cleavage of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. | bind to and regulate insulin-dependent glucose transporter GLUT4 | Mus musculus (Mouse, mammal) |
| 305 | Fructose-bisphosphate aldolase A | aldolase, cleavage of carbon-carbon bonds, in glycolysis, gluconeogenesis, and fructose metabolism, D-fructose 1,6-bisphosphate => dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate. | sequesters WASP, Wiskott–Aldrich Syndrome Protein, which is involved in controlling actin dynamics, inihibits actin polymerization, only binds to active from of WASP, inhibits WA?stimulated Arp2/3?dependent actin?polymerization reaction | Oryctolagus cuniculus (Rabbit. a mammal) |
| 306 | fructose 1,6-bisphosphate aldolase | fructose bisphosphate aldolase, enzyme, in glycolysis and gluconeogenesis, D-fructose 1,6-bisphosphate -> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate | adhesin, binds to receptor on host cells, binds to host Flamingo cadherin receptor (FCR) | Streptococcus pneumoniae (Gram positive bacterium) |
| 307 | Fructose-bisphosphate aldolase A | aldolase, D-fructose 1,6-bisphosphate-> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate, in glycolysis | interactions with zona pellucida proteins of egg | Homo sapiens (human, a mammal) |
| 308 | alpha-ketoglutarate dehydrogenase E2 | alpha-ketoglutarate dehydrogenase E2, in Krebs cycle, dihydrolipoyl succinyltransferase | mitochondrial DNA inheritance | Trypanosoma brucei |
| 309 | Ask1 | part of DASH complex, which binds to microtubules and kinetochores and regulates their association | transcriptional regulator | Tuber melanosporum |
| 310 | Beta-arrestin-1 | cytosolic regulator and scaffold of GPCR signaling, interacts with activated receptors at cell membrane, resulting in receptor endocytosis and attenuation of receptor signalling | regulation of histone acetylation and gene transcription, helps recruit histone acetyltransferase p300 to specific promoters, resulting in enhanced acetylation of histone H4 and transcription of those genes | Homo sapiens (human, a mammal) |
| 311 | beta-arrestin-2 | uncouple activated seven-transmembrane receptors from heterotrimeric G proteins, mediate the endocytosis of most G-protein-coupled receptors (GPCRs) | regulates transcription
| Homo sapiens (human, a mammal) |
| 312 | Streptococcal C5a peptidase | protease, peptidase, endopeptidase, cleaves and inactivates C5a (a component of the human complement system), helps GBS evade phagocytosis | fibronectin binding, adhesin | Streptococcus agalactiae, group B streptococci (GBS) (Gram positive bacterium) |
| 313 | Phosphatidylinositol-binding clathrin assembly protein | binds clathrin in endocytosis, assembly protein helps bring clathrin and adapter protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly | transcription activation | Homo sapiens (human, a mammal) |
| 314 | COP9 signalosome complex subunit 7 | part of COP9 signalosome (CSN), in ubiquitin-mediated protein degradation, CSN removes the ubiquitin-like protein Nedd8 from the cullin subunit of cullin-RING E3 ligase (CRL) | | Drosophila melanogaster (fruit fly, an insect) |
| 315 | chloroplast dihydrolipoamide acetyltransferase | enzyme, pyruvate dehydrogenase complex subunit in chloroplast, dihydrolipoamide acetyltransferase (DLA2), helps provide acetyl-CoA for fatty acid synthesis | | Chlamydomonas reinhardtii (unicellular green alga)(Chlamydomonas smithii) |
| 316 | DPP4, dipeptidyl peptidase 4 | serine exopeptidase, dipeptidyl peptidase, regulates several physiological processes by cleaving peptides in the blood, i.e. chemokines, growth factors, neuropeptides, removes N-terminal dipeptides from proteins with unsubstituted N-termini as long as the second residue is proline | glycoprotein receptor, involved in T-cell activation, binds ADA, CAV1, IGF2R, and PTPRC | Homo sapiens (human, a mammal) |
| 317 | DPP10, dipeptidyl peptidase 10 | enzyme, dipeptidyl peptidase activity with Gly-Pro-MCA (glycyl-L-proline 4-methylcoumaryl-7-amide) as a substrate | ancillary subunit of Kv4 channels, bind to pore-forming subunits of voltage-gated K+ channels, causes negative shifts in voltage dependence of channel activation and steady state inactivation | Drosophila melanogaster (fruit fly, an insect) |
| 318 | EF-1-alpha | elongation factor | regulate cell motility by assembling actin filament | Dictyostelium discoideium (slime mold) |
| 319 | Eukaryotic elongation factor 1 A-1 | translation elongation factor | binds and severs microtubules | Homo sapiens (human, a mammal) |
| 320 | elongation factor 1-alpha | translation elongation factor, the rate and fidelity of protein translation | binds to and activates Src homology 2 domain containing tyrosine phosphatase-1 (SHP-1) in host macrophages, inhibits activity of infected macrophages | Leishmania donovani |
| 321 | Elongation factor 1-alpha 1 | translation elongation factor | binds and severs microtubules | Oryctolagus cuniculus (rabbit) |
| 322 | elongation factor 1 alpha | translation elongation factor | binds and severs microtubules | Xenopus laevis (African clawed frog) |
| 323 | translation elongation factor Tu | translation elongation factor Tu | Mucin (MUC7)-binding protein | Streptococcus gordonii (Gram positive bacterium) |
| 324 | Eukaryotic translation initiation factor 3 subunit A | part of eIF3 13-subunit complex that organizes initiation factor and ribosome interactions required for productive translation, protein scaffold for formation of initiation complexes, binds to proteins of small ribosomal subunit | binds to 5' untranslated regions of specific mRNA for translational activation, subunits a, b, d, g, binding site on mRNA for c-Jun is required for efficient translation of c-JUN | Homo sapiens (human, a mammal) |
| 325 | Eukaryotic translation initiation factor 3 subunit B | part of eIF3 13-subunit complex that organizes initiation factor and ribosome interactions required for productive translation, protein scaffold for formation of initiation complexes, binds to proteins of small ribosomal subunit | binds to 5' untranslated regions of specific mRNA for translational activation, subunits a, b, d, g, binding site on mRNA for c-Jun is required for efficient translation of c-JUN | Homo sapiens (human, a mammal) |
| 326 | Eukaryotic translation initiation factor 3 subunit D | part of eIF3 13-subunit complex that organizes initiation factor and ribosome interactions required for productive translation, protein scaffold for formation of initiation complexes, binds to proteins of small ribosomal subunit | binds to 5' untranslated regions of specific mRNA for translational activation, subunits a, b, d, g, binding site on mRNA for c-Jun is required for efficient translation of c-JUN | Homo sapiens (human, a mammal) |
| 327 | Eukaryotic translation initiation factor 3 subunit G | part of eIF3 13-subunit complex that organizes initiation factor and ribosome interactions required for productive translation, protein scaffold for formation of initiation complexes, binds to proteins of small ribosomal subunit | binds to 5' untranslated regions of specific mRNA for translational activation, subunits a, b, d, g, binding site on mRNA for c-Jun is required for efficient translation of c-JUN | Homo sapiens (human, a mammal) |
| 328 | elongation factor 2 | translation elongation factor | binding partner for Akt2 signalling molecule | Homo sapiens (human, a mammal) |
| 329 | endopeptidase O | endopeptidase, metalloendopeptidase | plasminogen binding protein, fibronectin binding protein | Streptococcus pneumoniae (Gram positive bacterium) |
| 330 | enolase, 2-phospho-D-glycerate hydrolase | enolase, catalyze the conversion of 2-phosphoglycerate (2-PGA) to phosphoenolpyruvate (PEP), in glycosis | plasminogen and fibronectin binding | Mycoplasma synoviae |
| 331 | enolase, 2-phospho-D-glycerate hydro-lyase | enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase, 2-phospho-D-glycerate -> phosphoenolpyruvate, in glycolysis | plasminogen binding, also maybe EBP binding, also maybe adhesin | Plasmodium falciparum |
| 332 | enolase, 2-phospho-D-glycerate hydro-lyase | enolase, in glycolysis, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase | plasminogen binding | Streptococcus canis, group G Streptococci (Gram positive bacterium) |
| 333 | enolase, 2-phospho-D-glycerate hydro-lyase | enolase, enzyme, in glycolysis, 2-phosphoglycerate => phosphoenolpyruvate | binds Cytokeratin 8 (CK8) of host cells | Streptococcus gallolyticus (Gram positive bacterium) |
| 334 | enolase | enolase | antiphagocytic activity of host (insect), affects host immune system, host immune suppression | Steinernema glaseri (nematode, a wor,) |
| 335 | Methylglutaconyl-CoA hydratase | 3-methylglutaconyl-CoA hydratase that catalyzes the conversion of 3-methylglutaconyl-CoA to 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) in leucine catabolism | RNA binding | Homo sapiens (human, a mammal) |
| 336 | Epidermal growth factor receptor substrate 15 | binds clathrin, clathrin adapter in post-Golgi trafficking, also role in assembly of clathrin-coated pits | transcription activation | Homo sapiens (human, a mammal) |
| 337 | Fructose-1,6-bisphosphatase | fructose-1,6-bisphosphatase 1, enzyme in gluconeogenesis, D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + phosphate | binds to HIF (hypoxia inducible factor) protein and inhibits nuclear HIF action | Homo sapiens (human, a mammal) |
| 338 | Glyceraldehyde-3-phosphate dehydrogenase | glyceraldehyde 3-phosphate dehydrogenase, enzyme, D-glyceraldehyde 3-phosphate + phosphate + NAD+ => 3-phospho-D-glyceroyl phosphate + NADH | single stranded DNA binding (SSB), effects on the DNA-polymerase-alpha- primase complex | Bos taurus (cow, a mammal) |
| 339 | glyceraldehyde-3-phosphate dehydrogenase | enzyme, glyceraldehyde 3-phosphate dehydrogenase, D-glyceraldehyde 3-phosphate (G3P) -> 3-phospho-D-glyceroyl phosphate, in glycolysis | transferrin receptor, iron uptake | Cricetulus griseus, hamster (Chinese hamster, CHO cells, mammal) |
| 340 | glyceraldehyde-3-phosphate dehydrogenase | GAPDH, glyceraldehyde-3-phosphate dehydrogenase, in glycolysis, D-glyceraldehyde 3-phosphate + phosphate + NAD+ -> 3-phospho-D-glyceroyl phosphate + NADH | binding alternative complement pathway protein C3, inhibit complement cascade, evade host immunity | Haemonchus contortus (Barber pole worm) |
| 341 | glyceraldehyde-3-phosphate dehydrogenase | glyceraldehyde-3-phosphate dehydrogenase, enzyme in glycolysis, oxidative phosphorylation of G3P (glyceraldehyde 3-phosphate) to 1, 3-bisphosphoglycerate in the presence ofNADH/NADPH and inorganic phosphate | mucin binding | Lactobacillus acidophilus (Gram positive bacterium) |
| 344 | glyceraldehyde-3-phosphate dehydrogenase | glyceraldehyde 3-phosphate dehydrogenase, in glycolysis, D-glyceraldehyde 3-phosphate (G3P) <-> 3-phospho-D-glyceroyl phosphate | bind mRNA AU-rich element (ARE), regulation of cyclo-oxygenase-2 (COX-2) expressio, binding to COX-2 mRNA | Mus musculus (Mouse, mammal) |
| 345 | Glyceraldehyde-3-phosphate dehydrogenase | Glyceraldehyde-3-phosphate dehydrogenase, GAPDH, in glycolysis, conversion of glyceraldehyde 3-phosphate into glycerate 1,3-bisphosphate | heme binding protein, required for the insertion of cellular heme
into inducible nitric oxide synthase | Oryctolagus cuniculus (rabbit , a mammal) Also human and S. suis |
| 346 | glyceraldehyde 3-phosphage dehydrogenase | GAPDH, in glycolysis, catalyzing the phosphorylation of glyceraldehyde-3-phosphate to D-glycerate 1,3-bisphosphate | adhesin | Talaromyces marneffei (Penicillium marneffei) |
| 347 | Glyceraldehyde-3-phosphate dehydrogenase | GAPDH, converts D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate, enzyme in glycolysis, glyceraldehyde 3-phosphate + phosphate + NAD+ => 3-phospho-D-glyceroyl phosphate + NADH | binds to Siah1, involved in apoptosis | Rattus norvegicus (rat, a mammal) |
| 348 | Glyceraldehyde-3-phosphate dehydrogenase 3 | GAPDH, glyceraldehyde 3-phosphate dehydrogenase | binds to Sir2, regulates gene silencing by influencing Sir2’s association with chromatin, especially near telomeres | Saccharomyces cerevisiae (yeast, fungi) |
| 349 | glutathione S-transferase M3 | glutathione S-transferase | binds to rhZP4, in head of sperm, interactions with zona pellucida proteins of egg | Homo sapiens (human, a mammal) |
| 350 | glutathione S-transferase | glutathione S-transferase, detoxify electrophilic compounds | binds ZP3 protein component of zona pellucida, serves as a gamete recognition molecule, binds specifically to zona pellucida (of egg) during the first phase of sperm–oocyte interactions | Capra hircus (goat, a mammal) |
| 352 | glycerol 3-phosphate dehydrogenase | glycerol 3-phosphate dehydrogenase, functions in glycerol accumulation | plasminogen binding | Candida albicans (yeast, a fungi, can cause candiadiasis) |
| 353 | glycyl-tRNA synthetase | glycyl-tRNA synthetase, catalyze the formation of glycyl-tRNAGly as a substrate for ribosomal protein synthesis, P41250 (SYG_HUMAN), ATP + glycine + tRNA(Gly) => AMP + diphosphate + glycyl-tRNA(Gly) AND
P1,P(4)-bis(5'-guanosyl) tetraphosphate + H2O => GTP + GMP | binds to NEDD8, E1, and E2 (Ubc12) in neddylation pathway, binds the APPBP1 subunit of E1 and captures and protects (like a chaperone) activated E2 (NEDD8-conjugated Ubc12) before the activated E2 reaches a downstream target | Homo sapiens (human, a mammal) |
| 354 | glycyl tRNA synthetase | glycyl tRNA synthetase, catalyzes attachment of glycine to its cognate tRNA, ATP + glycine + tRNA(Gly) => AMP + diphosphate + glycyl-tRNA(Gly) AND P1,P(4)-bis(5'-guanosyl) tetraphosphate + H2O => GTP + GMP | ****NEOMORPHIC MOONLIGHTING PROTEIN***, mutant forms have protein binding activity, bind to neuropilin 1 (Nrp1) recpeptor, directly antagonizes binding of the ligand VEGF (vascular endothelial growth factor) to Nrp1, which is an essential signaling pathway in survival of motor neuron | Mus musculus (Mouse, mammal) |
| 355 | hydroxyacyl-CoA dehydrogenase, subunit beta | enzyme, 3-ketoacyl-CoA thiolase activity | RNA binding, binds 3'UTR of REN mRNA which results in regulation of renin expression, destabilizes REN mRNA | Homo sapiens (human, a mammal) |
| 356 | phosphopantothenoylcysteine decarboxylase | phosphopantothenoylcysteine decarboxylase, decarboxylation of phosphopahtothenoyl-L-cysteine, in CoA biosynthesis, PPCDC | inhibitor of serine/threoinine phosphatase Pzh1 | Schizosaccharomyces pombe |
| 357 | Protein deglycase 1 | chaperone | glyoxylase III, enzyme, catalyses the conversion of methylglyoxal
(MG) to D-lactate | Escherichia coli (Gram negative bacterium) |
| 358 | hexokinase-1 | hexokinase, enzyme, in glycolysis, ATP + D-hexose => D-hexose 6-phosphate + ADP | receptor for bacterial NAG (N-acetylglucosamine), activates inflammasome response | Mus musculus (Mouse, mammal) |
| 359 | hexokinase 1 | hexokinase, ATP + D-hexose => ADP + D-hexose 6-phosphate | binds to vacuolar H+-ATPase B1 (VHA-B1) and the 19S regulatory particle of proteasome subunit (RPT5B) to modulate transcription of specific target genes | Arabidopsis thaliana (Mouse-ear cress, a plant) |
| 360 | high-affinity glucose transporter 1 | sugar transporter, glucose transporter | complement inhibitor, binds complement regulator FH, binds complement regulator C4BP, protects cells from host complement cascade, complement evasion resulting in reduced formation of the potentially lytic terminal complex (TCC) | Candida albicans (yeast, a fungi, can cause candiadiasis) |
| 361 | LYS20 | homocitrate synthase, enzyme, lysine biosynthetic pathway | DNA damage repair, helps in INO80 accumulation at DNA breaks to aid in histone eviction | Saccharomyces cerevisiae (yeast, fungi) |
| 362 | Hsp60 | chaperonin | binds DNA, bind the template strand of active mtDNA ori sequences in vitro, involved in structure and transmission of mitochondrial DNA nucleoids to daughter cells | Saccharomyces cerevisiae (yeast, fungi) |
| 364 | Inositol-pentakisphosphate 2-kinase | kinase, ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate => ADP + 1D-myo-inositol hexakisphosphate. | scaffold, binds protein kinase CK2, TCOF1, and upstream-binding-factor (UBF) | Homo sapiens (human, a mammal) |
| 365 | lactate dehydrogenase isozyme M | enzyme, lactate + NAD+ -> pyruvate + NADH | RNA binding protein, post-transcriptional regulation of gene expression, AU-rich element (ARE, binding to these kinds of elements can be involved in affecting RNA stability) binding protein (AUBP), role may also involve binding to AUF1 protein, binds the 3 -UTR of GM-CSF RNA | Mus musculus (Mouse, mammal) |
| 366 | lactate dehydrogenase isozyme M | enzyme, lactate + NAD+ -> pyruvate + NADH | RNA binding protein, post-transcriptional regulation of gene expression, AU-rich element (ARE, binding to these kinds of elements can be involved in affecting RNA stability) binding protein (AUBP), role may also involve binding to AUF1 protein, binds the 3 -UTR of GM-CSF RNA | Mus musculus (Mouse, mammal) |
| 367 | nuclear cytoplasmic O-GlcNAcase and acetyltransferase | O-GlcNase, which removes regulatory O-GlcNAc modifications on proteins | histone acetyltransferase (HAT), add acetyl groups to histones | Mus musculus (Mouse, mammal) |
| 368 | outer dense fiber protein 2 | component of sperm tail outer dense fibers | interactions with zona pellucida proteins of egg | Homo sapiens (human, a mammal) |
| 369 | phosphoadenosine-phosphosulfate reductase | phosphoadenosine-phosphosulfate reductase (thioredoxin), enzyme in sulfur assimilation, conversion of activated sulfate (PAPS) to sulfite, adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide <-> 3'-phosphoadenylyl sulfate + thioredoxin | transcription factor | Tuber melanosporum (Perigord black truffle, filamentous mycorrhizal ascomycetous fungus) |
| 370 | mitochondrial 2-cysteine peroxiredoxin | peroxidase activity, detoxification of reactive oxygen species (ROS), removal of peroxide, use redox active cysteine residue (peroxidatic Cys) to reduce substrates like H2O2 | chaperone and activators of signal transduction cascades, prevents thermal aggregation of citrate synthase in vitro, lack of expression makes promastigoes more sensitive to temperature in the mammalian host (37°C) | Leishmania infantum |
| 372 | peroxiredoxin 5 | peroxiredoxin | sperm plasma membrane protein interacting with zona pellucida proteins | Sus scrofa (pig) |
| 373 | Alkyl Hydroperoxide Reductase C | peroxiredoxin, hydroxyperoxidase activity | heme binding protein | Streptococcus agalactiae, group B Streptococcus (Gram positive bacterium) |
| 374 | phosphofructokinase 1 | phosphofructokinase, enzyme in glycolysis, first committed step of
glycolysis, by phosphorylating F6P into fructose-1,6-bisphosphate
(F1,6P), ATP + D-fructose 6-phosphate => ADP + D-fructose 1,6-bisphosphate | binds TEADs proteins and promotes their interaction with YAP/TAX transcription factors | Homo sapiens (human, a mammal) |
| 375 | phosphoglycerate kinase 1 | phosphoglycerate kinase, enzyme, reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate | binds mRNA, regulates expression of urokinase receptor, "Overexpression in H157 lung squamous carcinoma cells reduced cell surface uPAR expression as well as uPAR-mediated cellular functions at the post-transcriptional level." | Homo sapiens (human, a mammal) |
| 376 | phosphoglycerate kinase | enzyme, phosphoglycerate kinase, in glycolysis, ATP + 3-phospho-D-glycerate -> ADP + 3-phospho-D-glyceroyl phosphate | binding to actin filament in insect vector (Circulifer haemotoceps, leafhopper) during invasion | Spiroplasma citri, a plant bacterial pathogen transmitted by insects |
| 377 | glutathione peroxidase 4 | phospholipid hydroperoxide glutathione peroxidase, 2 glutathione + a hydroperoxy-fatty-acyl-[lipid] -> glutathione disulfide + a hydroxy-fatty-acyl-[lipid] | interactions with zona pellucida proteins of egg | Homo sapiens (human, a mammal) |
| 378 | pinin | transcriptional activator | binds RNA, involved in splicing of pre-mRNAs | Homo sapiens (human, a mammal) |
| 379 | pyruvate kinase 3, isoform 2 | pyruvate kinase, ATP + pyruvate -> ADP + phosphoenolpyruvate, in glycolysis | interactions with zona pellucida proteins of egg | Homo sapiens (human, a mammal) |
| 380 | pyruvate decarboxylase | pyruvate decarboxylase, 2-oxo acid -> an aldehyde + CO2 | transcriptional regulator but might not bind DNA directly (possibly by sequestering Rag3 in the cytoplasm), inhibits transcription from PDC1 and PDC5 promoters | Kluyveromyces lactis |
| 381 | pyruvate dehydrogenase E2 subunit | pyruvate dehydrogenase E2 subunit, dihydrolipoamide acetyltransferase | DNA binding, transcription regulation | Bacillus thuringiensis |
| 382 | pyruvate kinase 1 | pyruvate kinase, ATP + pyruvate <=> ADP + phosphoenolpyruvate. | histone kinase, phosphorylates H3T11, protein kinase, part of SESAME complex | Saccharomyces cerevisiae (yeast, fungi) |
| 383 | pyruvate kinase isozyme type M2 | pyruvate kinase, enzyme, glycolysis, ATP + pyruvate <=> ADP + phosphoenolpyruvate | regulates transcription, binds to Oct-4 protein | Homo sapiens (human, a mammal) |
| 385 | Leucyl aminopeptidase | leucine aminopeptidase (LAP) | binds to heparin | Mycoplasma hyopneumoniae |
| 387 | DNA-directed RNA polymerase beta subunit | beta subunit of DNA-directed RNA polymerase | Muc7 binding protein | Streptococcus gordonii (Gram positive bacterium) |
| 388 | Regulatory particle triple-A ATPase subunit 5b | part of the regulatory ATPase complex of the 26S proteasome, confers substrate specificity and need for ATP to the proteaseome | binds to hexokinase 1 and VHA B1 to modulate transcription of specific target genes | Arabidopsis thaliana (Mouse-ear cress, a plant) |
| 390 | succinate dehydrogenase subunit 3 | subunit of succinate dehydrogenase in the respiratory chain, electron transport in respiratory complex II | part of TIM22 complex (carrier translocase, mitochondrial inner membrane translocase) in mitochondria, helps in biogenesis and assembly of membrane-integral subunits of TIM22 complex | Saccharomyces cerevisiae (yeast, fungi) |
| 391 | superoxide dismutase | superoxide dismutase, catalysis of superoxide (O2-) to hydrogen peroxide (H2O2), remove reactive oxygen species, 2 superoxide -> oxygen and H2O2 | binds DNA, transcription factor in response to H2O2, a reactive oxygen species (ROS), regulates expression of genes involved in oxidative resistance and DNA damage repair, ROS treatment increases Sod1 binding to the promoters of RNR3 and GRE2 | Saccharomyces cerevisiae (yeast, fungi) |
| 392 | Threonine-tRNA ligase | threonyl aminoacyl-tRNA synthetase, attaches threonine to tRNA, early step in protein synthesis, ATP + L-threonine + tRNA(Thr) -> AMP + diphosphate + L-threonyl-tRNA(Thr) | promotes vascular development, demostrated this is separate from role in protein synthesis | Danio rerio (Zebrafish) (Brachydanio rerio) |
| 393 | Threonine-tRNA ligase | threonyl aminoacyl-tRNA synthetase, attaches threonine to tRNA, early step in protein synthesis, ATP + L-threonine + tRNA(Thr) -> AMP + diphosphate + L-threonyl-tRNA(Thr) | promotes vascular development, demostrated this is separate from role in protein synthesis | Homo sapiens (human, a mammal) |
| 394 | triose-phosphate isomerase | triosephosphate isomerase, D-glyceraldehyde 3-phosphate <-> dihydroxyacetone phosphate, in glycolysis and gluconeogenesis | interact with rhZP3 and rhZP4, interactions with zona pellucida proteins of egg | Homo sapiens (human, a mammal) |
| 395 | VDAC-2 | voltage-dependent anion channel 2 (VDAC2), transports adenine nucleotides, Ca2+ and other metabolites, voltage-dependent | binds to rhZP2 or rhZP3, zona pellucida proteins of egg | Homo sapiens (human, a mammal) |
| 396 | VHA-B1 | subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase functions in acidifying several intracellular compartments in eukaryotic cells | binds to hexokinase 1 and the 19S regulatory particle of proteasome subunit (RPT5B) to modulate transcription of specific target genes | Arabidopsis thaliana (Mouse-ear cress, a plant) |
| 397 | VPS22 | component of ESCRT-II (endosomal sorting complex required for transport), functions in exosomal sorting pathway that sorts ubiquitinated endosomal proteins into internal vesicles | bind bicoid mRNA to cause localization to anterior of egg | Drosophila melanogaster (fruit fly, an insect) |
| 398 | ESCRT-II complex subunit VPS25 | component of ESCRT-II (endosomal sorting complex required for transport), functions in exosomal sorting pathway that sorts ubiquitinated endosomal proteins into internal vesicles | bind bicoid mRNA to cause localization to anterior of egg | Drosophila melanogaster (fruit fly, an insect) |
| 399 | ESCRT-II complex subunit VPS36 | component of ESCRT-II (endosomal sorting complex required for transport), functions in exosomal sorting pathway that sorts ubiquitinated endosomal proteins into internal vesicles | bind bicoid mRNA to cause localization to anterior of egg, binding
directly and specifically to stem-loop V of the bicoid 39 UTR | Drosophila melanogaster (fruit fly, an insect) |
| 400 | ADP/ATP Translocase 2, Human | mediates transmembrane exchange of ADP and ATP, providing ADP to the mitochondrial ATPase | ANT promotes mitophagy independently of its ADP/ATP exchange activity | Homo sapiens (human, a mammal) |
| 401 | Perodoxin 1, Human | peroxidase (Sm-Prxl-LMW), thioredoxin-dependent peroxidase in the absence of oxidative stress, uses redox-active cysteine to reduce H2O2 | chaperone, ATP-independent holdases at high hydrogen peroxide concentrations, prevent protein aggregation by quarantining client proteins | human parasite Schistosoma mansoni(Blood fluke) |
| 402 | Thioredoxin 3, Human | disulfide reductase, involved in activation of ribonucleotide reductase, modulation of transcription factors, promotion of a variety of tumors, and photosynthetic activity of plant cells | Chaperone, involved in assembly of the T7 DNA polymerase complex and the formation of fila- mentous phage | Arabidopsis thaliana (Mouse-ear cress, a plant) |
| 403 | Elongation Factor 2, Yeast | Elongation factor in protein synthesis | Interaction with contact system proteins HK, FXII, and PPK | Candida albicans (yeast, a fungi, can cause candiadiasis) |
| 404 | 6-phosphogluconate dehydrogenase, Yeast | Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH. | binding to plasma proteins, interacting with components of contact system | Candida albicans (yeast, a fungi, can cause candiadiasis) |
| 405 | HSP70, Yeast | chaperone protein, intracellular function | inducing endocytosis, belongs to heat shock protein 70 (Hsp 70) family | Candida albicans (yeast, a fungi, can cause candiadiasis) |
| 406 | Peroxisomal Catalase, Yeast | catalase activity | HPG-binding | Candida albicans (yeast, a fungi, can cause candiadiasis) |
| 407 | Peroxiredoxin 2, Mouse | Peroxiredoxin | regulate proinflammatory responses, vascular remodeling, and global oxidative stress | Mus musculus (Mouse, mammal) |
| 408 | Autoimmune regulator, Mouse | Autoimmune regulator; Transcription factor that regulates the expression of many tissue restricted antigens (TRA) | Binds to several spindle proteins including AURKB, CEP55, CNTROB, HAUS5, HAUS8, CLASP1, and CLASP2 | Mus musculus (Mouse, mammal) |
| 409 | Microtubule organization protein AKNA, Mouse | localizes to the distal part of the subdistal appendages of the mother centriole in interphase and dissociates from centrosomes during mitosis upon increased phosphorylation; re-associates with the centrosomes during late telophase/early G1 | interacts with components of the gamma-tubulin ring complex (gamma-TuRC), and MT binding proteins such as EB1, P150-Glued (DCTN1), and dynein. | Mus musculus (Mouse, mammal) |
| 410 | Cyclic AMP-dependent transcription factor ATF-5, Human | accumulation at the centrosomes from G1 through anaphase and dissociation during late telophase; interacts with centrosomal proteins, including gamma-tubulin and pericentrin (PCNT), | centriolar fragmentation and formation of multipolar spindles during downregulation of ATF5 (RNAi-mediated) | Homo sapiens (human, a mammal) |
| 411 | BRCA1, Human | associates with RNA polymerase II holoenzyme and some transcription factors, including TFIIF/GTF2F1, TFIIE/GTF2E1, and TFIIH/GTF2H1, acting as a transcription regulator | interacts with the BRCA1-associated RING domain protein (BARD1) and the Obg-like ATPase (OLA1), forming a complex with E3 ligase activity that binds and ubiquinates gamma-tubulin | Homo sapiens (human, a mammal) |
| 412 | BRCA1, Xenopus laevis | physically interacts with BARD1 and spindle-associated proteins TPX2, NuMa, and XRHAMM, required for spindle formation induced by nuclei in cytoplasmic extracts from Xenopus laevis eggs | RING-type E3 ubiquitin transferase BRCA1 | Xenopus laevis (African clawed frog) |
| 413 | Angiotensin-converting enzyme 2, Human | Carboxypeptidase enzyme | chaperone for BoAT in amino acid transport | Homo sapiens (Human) |
| 414 | Adenine nucleotide translocator 2, Human | mediates transmembrane exchange of ADP and ATP, providing ADP to the mitochondrial ATPase (complex V) | ANT promotes mitophagy independently of its ADP/ATP exchange activity | Homo sapiens (human, a mammal) |
| 415 | Adenine nucleotide translocator 2, Mouse | mediates transmembrane exchange of ADP and ATP, providing ADP to the mitochondrial ATPase (complex V) | ANT promotes mitophagy independently of its ADP/ATP exchange activity | Mus musculus (Mouse, mammal) |
| 416 | Anoctamin-6, Mouse | Ca2+-dependent scrambling of phospholipids | Small-conductance calcium-activated nonselective cation (SCAN) channel | Mus musculus (Mouse, mammal) |
| 417 | Core-binding factor subunit beta, Human | non-DNA-binding regulatory subunit; binds RUNX (RUNX1, RUNX2, or RUNX3) to form different versions of CBF; it allosterically enhances the sequence-specific DNA-binding capacity of RUNX | Also binds RUNX & binds with mitotic proteins MRLC3; allows for completion of cytokinesis | Homo sapiens (human, a mammal) |
| 418 | Glucose-6-phosphate isomerase, Yeast | Glycose-6-phosphate Isomerase | cell wall-associating protein that is immunoreactive during fungal infection | Candida albicans (yeast, a fungi, can cause candiadiasis) |
| 419 | Glutathione reductase | Reductase Activity | Binding to plasma proteins | Candida albicans (yeast, a fungi, can cause candiadiasis) |
| 420 | Integrin-like protein, Yeast | inhibits opsonization and phagocytosis due to competition with CR3 | adhesin, contributes to significant increase in yeast cell adhesion to human epithelial and endothelial cells | Candida albicans (yeast, a fungi, can cause candiadiasis) |
| 421 | VP40 | Interacts with cell membrane, when dimer | Needed for virus budding, when linear hexamer | Ebola virus (virus) |
| 422 | Peroxiredoxin 6, Rat | Peroxiredoxin activity | Chapterone | Rattus norvegicus (Rat, mammal)) |
| 423 | Peroxiredoxin-5, Mouse | peroxidase, thiol-dependent | signaling molecule | Mus musculus (Mouse, mammal) |
| 424 | POU domain, class 2, transcription factor 1 | Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR. | Interacts with BRCA1, binds PARP-1 and APC1 | Homo sapiens (human, a mammal) |
| 425 | Peroxiredoxin 2; Prx2, Thioredoxin peroxidase; Thioredoxin peroxidase 2; gene: TPx-2 | Peroxiredoxin | regulator of host Th2 modulated immune response when secreted | Schistosoma mansoni, blook fluke |
| 426 | Phosphotransferase, Yeast | phosphotransferase | Binding of Plasma Proteins | Candida albicans (yeast, a fungi, can cause candiadiasis) |
| 427 | POU domain class 2 transcription factor 1, Frog | Transcription factor that binds to an octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and histone H2B. | Interacts with BRCA1, binds PARP-1 and APC1 | Xenopus laevis (African clawed frog) |
| 428 | Anoctamin, Drosophila melanogaster | Calcium activated chloride channel | CaPLSase, Upon Ca2 binding, TMEM16F–CaPLSase mediates the rapid flip-flopping of phospholipids across cell membranes and thus dissipates the asymmetric distribution of membrane phospholipids. During platelet activation, TMEM16F–CaPLSase–induced phosphatidylserine (PS) externalization is essential for prothrombinase assembly, subsequent thrombin generation, and blood coagulation | Drosophila melanogaster (fruit fly, an insect) |
| 429 | Transaldolase, Yeast | transaldolase, Enzyme, second step of pentose-phosphate pathway; D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphate | binding to kininogen, binding to ECM proteins (Fibronectin, Laminin and Vitronectin) | Candida tropicalis (yeast, a fungi) |
| 430 | Transcriptional coactivator YAP1, Human | Transcriptional regulator; the downstream regulatory target in the Hippo signaling pathway that plays a role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis | Binds RUNX proteins, binds PATJ, in cytokinesis | Homo sapiens (human, a mammal) |
| 431 | Y-box-binding protein 1, Human | DNA and RNA binding,has roles in transcription, translation, and splicing, | binds gamma-tubulin and PCNT | Homo sapiens (human, a mammal) |
| 432 | Superoxide dismutase 3, Yeast | removes radicals, 2 H+ + 2 superoxide = H2O2 + O2 | binds to 3 plasma proteins: high-molecular-mass kininogen (HK), factor XII (FXII) and prekallikrein (PPK) | Candida albicans (yeast, a fungi, can cause candiadiasis) |
| 433 | Thioredoxin peroxidase, Fasciola hepatica | Thioredoxin peroxidase, protection against ROS, antioxidant, oxidoreductase | cytokine, Regulates alternative activation of macrophages, inducing Th2 response | Fasciola hepatica |
| 434 | Adenine nucleotide translocator 1, Mouse | adenine nucleotide translocator, ADP/ATP exchanger, mitochondria | Interacts with TIM44 protein and affects the activity of the TIM23 complex | Mus musculus (Mouse, mammal) |
| 435 | Adenine nucleotide translocator 1, Human | adenine nucleotide translocator, ADP/ATP exchanger, mitochondria | Interacts with TIM44 protein and affects the activity of the TIM23 complex | Homo sapiens (human, a mammal) |
| 436 | Heat shock protein SSA2, Yeast | Chaperone; helps adapt to temperature variations | Binds HTN3/histatin-5, a peptide from human saliva | Candida albicans (yeast, a fungi) |
| 437 | 2-cys peroxiredoxin, Schistosoma mansoni | peroxidase (Sm-Prxl-LMW), thioredoxin-dependent peroxidase in the absence of oxidative stress, uses redox-active cysteine to reduce H2O2 | chaperone, ATP-independent holdases at high hydrogen peroxide concentrations, prevent protein aggregation by quarantining client proteins | Schistosoma mansoni(Blood fluke), human parasite |
| 438 | Fructose-bisphosphate aldolase, Candida tropicalis | Glycolytic enzyme; fructose bisphosphate aldolase | binds fibronectin, vitronectin, and laminin | Candida tropicalis (yeast, a fungi) |
| 439 | Enolase 1, Candida tropicalis | Enolase 1 | ECM protein binding (fibronectin, vitronectin and laminin) | Candida tropicalis (yeast, a fungi) |
| 440 | Wilms tumor protein | Transcription factor, binds DNA | binds MAD2, without it see Accelerated metaphase-to-anaphase transition; defective chromosome segregation | Homo sapiens (human, a mammal) |
| 441 | IIH helicase subunit XPB | ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex | binds gamma-tubulin | Homo sapiens (human, a mammal) |
| 442 | KAT8 regulatory NSL complex subunit 1 | part of the NSL complex, which acetylates nucleosomal histone H4 on lysine residues | KANSL1 and KANSL3 bind MT minus ends, also bind TPX2, MCAK | Homo sapiens (human, a mammal) |
| 443 | KAT8 regulatory NSL complex subunit 3 | part of the NSL complex, which acetylates nucleosomal histone H4 on lysine residues | KANSL1 and KANSL3 bind MT minus ends, also bind TPX2, MCAK | Homo sapiens (human, a mammal) |
| 444 | Microspherule protein 1 | part of the NSL complex, which acetylates nucleosomal histone H4 on lysine residues | component of KANSL complex located at Spindle poles; KANSL1 and KANSL3 bind MT minus ends | Homo sapiens (human, a mammal) |
| 445 | WD repeat-containing protein 5 | part of the MLL1/MLL complex, which methylates and dimethylates lysine 4 of histone H3 | binds to KIF2A, PRC1, MKLP1, CYK4, and CEP55 | Homo sapiens (human, a mammal) |
| 446 | Pre-mRNA-splicing factor SPF27 | component of spliceosome, conserved Prp19 (pre-RNA processing 19) complex is required for pre-mRNA splicing in eukaryotic nuclei | without it see Defective chromatin-MT interaction; morphologically abnormal spindles in Xenopus egg extracts | Xenopus tropicalis (Western clawed frog) (Silurana tropicalis) |
| 453 | Transglutaminase-2, Mouse | Transglutaminase (catalyze protein crosslinking via transamidation of glutamine residues to lysine residues in a Ca2+-dependent manner) | GTPase, GTP binding protein | Mus musculus (Mouse, mammal) |
| 448 | Peroxiredoxin, Fasciola hepatica | Peroxiredoxin, antioxidant activity, reduction of H2O2, protection from ROS | cytokine, Induces expression and production of Ym1 in macrophages, promotes polarization of Th2 response | Fasciola hepatica |
| 503 | LD47455p | component of spliceosome | binds Ndc80, Mitch, and Nuf2 (Ndc80 complex) without it see Reduced accumulation of Ndc80 at kinetochores and severe defects in chromosome alignment | Drosophila melanogaster (fruit fly, an insect) |
| 451 | Matrix metalloproteinase-3, Rat | Metalloprotease (degrades fibronectin, gelatin, proteoglycans, denatured type I collagen, laminin, and other extracellular matrix components) | transcription factor | Rattus norvegicus (Rat, mammal) |
| 504 | Pre-mRNA-processing factor 31 | component of spliceosome | binds Ndc80, Mitch, and Nuf2 (Ndc80 complex) without it see Reduced accumulation of Ndc80 at kinetochores and severe defects in chromosome alignment | Drosophila melanogaster (fruit fly, an insect) |
| 452 | Transglutaminase-2, Human | Transglutaminase (catalyze protein crosslinking via transamidation of glutamine residues to lysine residues in a Ca2+-dependent manner) | GTPase, GTP binding protein | Homo sapiens (human, a mammal) |
| 501 | Splicing factor 3A subunit 2 | pre-mRNA splicing, a component of the splicing factor SF3A complex | binds Ndc80/HEC1, without it see Morphologically irregular spindles; defective chromosome congression at metaphase | Homo sapiens (human, a mammal) |
| 449 | Matrix metalloproteinase-3, Mouse | Metalloprotease (degrades fibronectin, gelatin, proteoglycans, denatured type I collagen, laminin, and other extracellular matrix components) | transcription factor | Mus musculus (Mouse, mammal) |
| 502 | U4/U6 small nuclear ribonucleoprotein Prp31 | component of the spliceosome | binds Ndc80/HEC1, without it see Morphologically irregular spindles; defective chromosome congression at metaphase | Homo sapiens (human, a mammal) |
| 450 | Matrix metalloproteinase-3, Human | Metalloprotease (degrades fibronectin, gelatin, proteoglycans, denatured type I collagen, laminin, and other extracellular matrix components) | transcription factor | Homo sapiens (human, a mammal) |
| 454 | Protease 7, E coli | Protease | Adhesin to human cells | Escherichia coli (Gram negative bacterium) |
| 455 | L-asparaginase 2 , E. Coli | asparaginase | inhibits T-lymphocyte proliferation | Escherichia coli (Gram negative bacterium) |
| 457 | GroEL | chaperone | Binds mucin | Bifidobacterium longum (strain NCC 2705) (Gram positive bacterium) |
| 456 | Phosphoketolase | Phosphoketolase | Binds mucin | Bifidobacterium longum (strain NCC 2705) (Gram positive bacterium) |
| 458 | EF-Tu, Bifidobacterium longum | elognation factor | binds mucin | Bifidobacterium longum (strain NCC 2705) (Gram positive bacterium) |
| 459 | phosphoglycerate kinase, Bifidobacterium longum | Phosphoglycerate kinase.
This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate. | binds mucin | Bifidobacterium longum (strain NCC 2705) (Gram positive bacterium) |
| 469 | phosphoglucosamine mutase, Listeria | phosphoglucosamine mutase.
Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. | Forms a complex with CdaA and inhibits the diadenylate cyclaseactivity. | Listeria monocytogenes (Gram positive bacterium, causes listeriosis, septicemia, meningitis) |
| 460 | Transaldolase, bifidobacterium longum | Transferase.
Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. | Binds mucin | Bifidobacterium longum (strain NCC 2705) (Gram positive bacterium) |
| 461 | Heat shock protein, Bifidobacterium longum | heat shock protein | binds mucin | Bifidobacterium longum (strain NCC 2705) (Gram positive bacterium) |
| 462 | Probable 23S rRNA methyltransferase Erm | 23S rRNA Methyltransferase.
The 179-amino-acid long protein deduced from Rv1988 presents similarity with the Erm protein family, members of which confer macrolide, lincosamide, streptogramin B resistance by methylation of the 23S rRNA at a highly conserved adenine nucleotide (A2058 [E. coli numbering]). | Dimethylates arginine 42 of histone H3 in host cells | Mycobacterium tuberculosis (mycobacterium, causes tuberculosis) |
| 463 | glyceraldehyde-3-phosphate dehydrogenase, Arabidopsis thaliana | glyceraldehyde-3-phosphate dehydrogenase | Binds NF-YC10 (nuclear factor Y subunit C10).
GAPC interacts with a transcription factor to promote the expression of heat-inducible genes and heat tolerance in Arabidopsis.
Screening of Arabidopsis transcription factors identifies nuclear factor Y subunit C10 (NF-YC10) as a GAPC-binding protein. | Arabidopsis thaliana (Mouse-ear cress, a plant) |
| 464 | Intraflagellar transport protein 88 homolog, Mus | Mouse ciliary protein.
Involved in primary cilium biogenesis. | regulates NFkappaB signaling | Mus musculus (Mouse, mammal) |
| 465 | Kinesin-like protein KIF3A, Mouse | Mouse ciliary protein. | regulates NFkappaB signaling | Mus musculus (Mouse, mammal) |
| 466 | Tau-tubulin kinase 2, Mus | Mouse ciliary protein.
Serine/threonine kinase that acts as a key regulator of ciliogenesis. | regulates NFkappaB signaling | Mus musculus (Mouse, mammal) |
| 467 | Nephrocystin-4, Mouse | Mouse ciliary protien.
Required for building functional cilia. | regulates NFkappaB signaling | Mus musculus (Mouse, mammal) |
| 468 | Phosphoinositide-3-kinase catalytic gamma polypeptide, Mouse | phosphoinositide 3-kinase | regulator of phosphodiesterase 4, a non-catalytic function | Mus musculus (Mouse, mammal) |
| 474 | Arogenate dehydratase 5 | Arogenate dehydratase. | transcriptional regulator. | Arabidopsis thaliana (Mouse-ear cress, a plant) |
| 475 | Developmental protein eyes absent | transcriptional coactivator. | tyrosine phosphatase | Drosophila melanogaster (fruit fly, an insect) |
| 476 | Threonine phosphatase | transcription factor | phosphatase | Nicotiana tabacum (Common tobacco, a plant) |
| 477 | DNA protection during starvation protein | ferritin | DNA binding protein. | Campylobacter jejuni |
| 478 | Riboflavin kinase | CTP-dependent riboflavin kinase | DNA binding protein.
Transcriptional regulator of riboflavin metabolism, PF12802 archael. | Metallosphaera yellowstonensis MK1 |
| 479 | Riboflavin kinase, Pyrobaculum yellowstonensis WP30 | CTP-dependent riboflavin kinase | DNA binding protein.
Transcriptional regulator of riboflavin metabolism, PF12802 archael. | Pyrobaculum yellowstonensis WP30 |
| 480 | NAD-dependent protein deacetylase Sir2.1, C. Elegans | deacetylase | transcription regulation | Caenorhabditis elegans |
| 513 | Malate dehydrogenase 2 | malate dehydrogenase, enzyme | mRNA binding | Homo sapeins (human) |
| 481 | NAD-dependent protein deacetylase Sir1 | deacetylase | transcription regulation | Homo sapiens (Human) |
| 482 | PARP-1, Human | poly[ADP-ribose]polymerase 1 | Transcription factor | Homo sapiens (Human) |
| 483 | PARP-1, Mouse | poly[ADP-ribose]polymerase 1 | Transcription factor | Mus musculus |
| 484 | DNA apurinic endonuclease, Human | DNA repair | redox regulation of transcriptional factors | Homo sapiens (Human) |
| 485 | DNA apurinic endonuclease, Rat | DNA repair | redox regulation of transcriptional factors | Rattus norvegicus (Rat) |
| 486 | Bifunctional NAD(P)H-hydrate repair enzyme | catalyzes the epimerization of the S- and R-forms of NAD(P)HX | catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP | Metallosphaera yellowstonensis MK1 |
| 487 | FMN adenylyltransferase | Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD | Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) | Corynebacterium ammoniagenes (Brevibacterium ammoniagenes) |
| 488 | FMN adenylyltransferase | Catalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FAD | FMN adenylyltransferase | Mycoplasma gallisepticum |
| 489 | Riboflavin biosynthesis protein, E Coli | RibD diaminohydroxyphosphoribosylaminopyrimidine deaminase | 5-amino-6-(5-phosphoribosylamino)uracil reductase | Escherichia coli (strain K12) |
| 490 | Asparaginyl endopeptidase 2 | Asparaginyl endopeptidases (AEPs), N-terminal excision | C-terminal cyclization of cyclotide precursors | Momordica cochinchinensis (Spiny bitter cucumber) (Muricia cochinchinensis) |
| 491 | FMN adenylyltransferase, E Coli | ATP-dependent riboflavin kinase | FAD synthetase | Escherichia coli (strain K12) |
| 492 | Bifunctional riboflavin kinase | Bifunctional riboflavin kinase | FMN adenylyltransferase | Bacillus subtilis (strain 168) |
| 493 | Riboflavin biosynthesis protein RibD | deaminase | reductase | Bacillus subtilis (strain 168) |
| 494 | Tudor-interacting repair regulator protein | Syndesmos, interacts with p53 binding protein 1 (53BP1) and regulates its recruitment to chromatin. | Binds RNA | Homo sapiens (Human) |
| 495 | Mevalonate kinase | Mevalonate kinase | Secreted and modulates cell invasion, binds to receptor | Trypanosoma cruzi (strain CL Brener) |
| 496 | Calgranulin-B | binds to receptor, amplifies inflammation via Toll-like receptor four TLR4. | part of a heterocomplex with S100A8 to drive inflammation, antimicrobial | Homo sapiens (Human) |
| 497 | S100 calcium-binding protein A9 | binds toToll-like receptor four TLR4, amplifies inflammation | part of a heterocomplex with S100A8 to drive inflammation, antimicrobial | Mus musculus (Mouse) |
| 498 | Glyceraldehyde-3-phosphate dehydrogenase A | glyceraldehyde-3-phosphate dehydrogenase | thiol-disulfide exchange with CP12 | Chlamydomonas reinhardtii (Chlamydomonas smithii) |
| 499 | Cell division protein YtfB | Cell division protein | adhesin | Escherichia coli (strain K12) |
| 500 | Asparaginyl endopeptidase 2 | Asparaginyl endopeptidase | cyclase | Momordica cochinchinensis (Spiny bitter cucumber) (Muricia cochinchinensis) |
| 505 | Citrate synthase CitA | citrate synthase | cell cycle control (enzyme function not needed) | Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus) |
| 506 | Fibroblast growth factor 2 | fibroblast growth factor, binds receptor | mediates phosphorylation of ERK1/2 | Homo sapiens (Human) |
| 507 | Phosphoinositide phospholipase C-beta-1 | phospholipase | inhibit protein translation | Homo sapiens (Human) |
| 508 | Large tumor suppressor homolog 1 | kinase | scaffold function. | Homo sapiens (Human) |
| 509 | Interleukin-1 alpha, Human | binds receptor, A cytokine of the interleukin 1 family. It can stimulate thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. | Regulation of transcription. The precursor form of IL-1 alphais an intracrine proinflammatory activator of transcription. | Homo sapiens (Human) |
| 510 | Fibroblast growth factor 1, Human | growth factor | nuclear anti-apoptotic factor | Homo sapiens (Human) |
| 511 | Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 | a proinflammatory cytokine. | Non-catalytic component of tRNA multisynthetase complex in protein translation. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase. | Homo sapiens (Human) |
| 512 | High mobility group protein 1 | One of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. | In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. | Homo sapiens (Human) |
| 514 | Transferrin | Iron transport | Antibacterial and Antiviral action | Periplaneta americana |
| 515 | Glyceraldehyde-3-phosphate dehydrogenase | glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) | Antibacterial and Antiviral action | Periplaneta americana |