Proteins

ID Protein Name Function 1 Function 2 Species Name
3SMC-3 (Structural maintenance chromosome 3), Mus musculusSMC3 interacts with SMC1 and other non-Smc subunits like Scc3 and Scc1 (also called Rad21) to form a cohesion complex, called "cohesin," that maintains proper sister chromatid cohesion throughout the cell cycle and during mitosis to ensure accurate chromosome segregation. Each Smc heterodimer associates with non-Smc subunits to form functional Smc complexes.Bamacan is a proteoglycan, and is a component of a component of the basement membrane in the Engelbreth-Holm-Swarm tumor matrix, the renal mesangial matrix, and the basement membrane of other tissues. Bamacan is involved in the control of cell growth and transformationEnteamoeba histolytica (amoeba, anaerobic eukaryote, causes amebiasis)
4FdGOGAT Glutamate synthase, Spinacia oleracea FdGOGAT Glutamate synthase, enzyme 2 L-glutamate + 2 oxidized ferredoxin => L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+. amino acid biosynthesis, L-glutamate biosynthesisSubunit of UDP-sulfoquinovose synthaseSpinacia oleracea (Spinach, a plant)
51-Cys Peroxiredoxin, Homo sapiensAcidic calcium-independent Phospholipase A2 (aiPLA2): regulation of phospholipid turnoverNon-selenium Glutathione Peroxidase Can reduce H2O2 and short chain organic, fatty acid, and phospholipid hydroperoxidesHomo sapiens (human, a mammal, OMIM number 602316 )
6Phosphoglucose Isomerase, Mus musculusCatalyzes interconversion of glucose-6-phosphate and fructose-6-phosphate in glycolysis and gluconeogenesisCytokine/growth factor, binds to target cells and causes pre-B cells to mature into antibody secreting cells, supports survival of embryonal neurons, causes differentiation of some leukemia cell linesStaphylococcus aureus (Gram positive bacterium, causes staph infections, abcesses/boils)
7Hsp60, Homo sapiens and ratHsp60 mitochondrial protein import, facilitate correct folding, promote refolding, prevent misfolding of proteins receptor for HDL affinity for apolipoprotein apoA-IIHomo sapiens and rat - (human, a mammal OMIM number 118190 612233 leukodystrophy, hypomyelinating, 4; 605280 Spastic paraplegia 13, autosomal dominant
8GroEL, Enterobacter aerogenesprotein chaperone, prevents proteins from misfolding, promotes correct refolding and assembly of polypeptides toxin, paralyzes cockroaches (produced by bacterium that is an endosymbiont of antlions, which are larvae of Myrmeleon bore)Listeria monocytogenes (Gram positive bacterium, causes listeriosis, septicemia, meningitis)
96-phosphofructokinase, Lactococcus lactis6-phosphofructokinase, enzyme ATP + D-fructose 6-phosphate => ADP + D-fructose 1,6-bisphosphate Carbohydrate degradation, glycolysis binding to invertase, a hyperglycosylated mannoprotein from Saccharomyces cerevisiaeLactococcus lactis IL1403 (Gram positive bacterium)
106-phosphofructokinase, Streptococcus oralis6-phosphofructokinase, enzyme ATP + D-fructose 6-phosphate => ADP + D-fructose 1,6-bisphosphate Carbohydrate degradation, glycolysisbinds plasminogen from host organismStreptococcus oralis LA11 - oral streptococci (Gram positive bacterium)
126-phosphogluconate dehydrogenase , Streptococcus6-phosphogluconate dehydrogenase, enzyme 6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH Carbohydrate degradation, pentose phosphate pathway adhesin - not clear to which host proteinStreptococcus pneumoniae (Gram positive bacterium)
13Alcohol dehydrogenase (ADH1), Candida albicansAlcohol dehydrogenase (ADH1), enzyme An alcohol + NAD+ => an aldehyde or ketone + NADH. binds plasminogen from humansCandida albicans (yeast, a fungi, can cause candiadiasis)
14alcohol acetaldehyde dehydrogenase, ListeriaAn enzyme: The N-terminus contains acetaldehyde dehydrogenase (ALDH) and the Cterminus an alcohol dehydrogenase (ADH) Adhesin, binds Hsp60 on surface of host cellsListeria monocytogenes (Gram positive bacterium)
15alcohol dehydrogenase (EhADH2), Enteamoeba histolytica alcohol dehydrogenase (EhADH2), enzyme Including the following 2 domains: Alcohol dehydrogenase and Acetaldehyde dehydrogenase An alcohol + NAD+ => an aldehyde or ketone + NADH Acetaldehyde + CoA + NAD+ => acetyl-CoA + NADH. demonstrated that it has both ADH and acetaldehyde dehydrogenase activity. binds fibronectin, laminin, and type II collagen Enteamoeba histolytica (amoeba, anaerobic eukaryote)
16Aspartate ammonia lyase, aspartase, Haemophilus influenzaeaspartate ammonia lyase, aspartase, enzyme L-aspartate => fumarate + NH3binds plasminogenHaemophilus influenzae (Gram negative bacterium)
17Bile salt hydrolase, Bifidobacteriumbile salt hydrolaseplasminogen bindingBifidobacterium(Bifidobacterium lactis, B. bifidum, and B. longum (Gram positive bacterium)
18DnaK, Bifidobacteriumchaperoneplasminogen bindingBifidobacterium(Bifidobacterium lactis, B. bifidum, and B. longum) (Gram positive bacterium)
19DnaK, Lactococcus lactischaperonebinding to invertase, a hyperglycosylated mannoprotein from Saccharomyces cerevisiaeLactococcus lactis IL1403 (Gram positive bacterium)
20DnaK, Neisseria meningitidischaperoneplasminogen binding proteinNeisseria meningitidis (Gram negative bacterium, causes meningitis)
21DnaK, Mycobacterium tuberculosischaperone plasminogen bindingMycobacterium tuberculosis (mycobacterium, causes tuberculosis)
22Ef-Tu, Lactobacillus johnsoniielongation factor in protein synthesisattachment to human cells and mucinsLactobacillus johnsonii NCC533 (La1) (Gram positive bacterium)
23Ef-Tu, Mycoplasma pneumoniaeelongation factor in protein synthesis during protein biosynthesis: promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes fibronectin bindingMycoplasma pneumoniae
24Ef-Tu, Pseudomonas aeruginosaelongation factor during protein synthesis during protein synthesis: promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes factor H and plasminogen bindingCandida albicans (yeast, a fungi, can cause candiadiasis)
25enolase, Aeromonas hydrophilaenolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. Carbohydrate degradation, glycolysis plasminogen binding (binds human plasminogen)Aeromonas hydrophila (soft-tissue infections, with cellulitis being most frequent)
26enolase, Bifidobacteriumenolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate Carbohydrate degradation, glycolysisplasminogen binding (binds human plasminogen)Bifidobacterium (B. longum, B. bifidum, B. breve and B. lactis) (Gram positive bacterium)
27enolase, Borrelia burgdorferi enolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. Carbohydrate degradation, glycolysisplasminogen binding (binds human plasminogen)Borrelia burgdorferi (Lyme disease)
28enolase, Candida albicansenolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Carbohydrate degradation, glycolysis plasminogen bindingCandida albicans (yeast, a fungi, can cause candiadiasis)
29Enolase, Lactobacillus crispatusEnolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O. Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate Carbohydrate degradation, glycolysis; binds plasminogen and lamininLactobacillus crispatus (Gram positive bacterium)
30Enolase, Lactobacillus johnsonii2-phospho-D-glycerate => phosphoenolpyruvate + H2O. Pathway Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate Carbohydrate degradation, glycolysisbinds plasminogen and lamininLactobacillus johnsonii (Gram positive bacterium)
31Enolase, Lactobacillus plantarumEnolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate Carbohydrate degradation, glycolysis binds fibronectinLactobacillus plantarum (Gram positive bacterium)
32Enolase, Neisseria meningitidisEnolase 2-phospho-D-glycerate => phosphoenolpyruvate + H2O. Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate Carbohydrate degradation, glycolysisplasminogen bindingNeisseria meningitidis (Gram negative bacterium, causes meningitis)
33Enolase, Onchocerca volvulusEnolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate Carbohydrate degradation, glycolysisbinds plasminogenOnchocerca volvulus (cuases river blindness)
34Enolase, Staphylococcus aureusEnolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate Carbohydrate degradation, glycolysisbinds plasminogen and lamininStaphylococcus aureus (Gram positive bacterium, causes staph infections, abcesses/boils)
35Enolase, Oral streptococci (S. anginosus, S. oralis)Enolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate Carbohydrate degradation, glycolysisplasminogen bindingOral streptococci (S. anginosus, S. oralis)
36Enolase, Streptococcus pneumoniaeenolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate Carbohydrate degradation, glycolysisbinds plasminogen Streptococcus pneumoniae (Gram positive bacterium)
37Enolase, Streptococcus pyogenesenolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate Carbohydrate degradation, glycolysisbinds plasminogen Streptococcus pyogenes(Gram positive bacterium)
38enolase, Streptococcus suisenolase 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate Carbohydrate degradation, glycolysisbinds fibronectin and plasminogenStreptococcus suis(Gram positive bacterium)
39Enolase, Streptococcus mutansEnolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate Carbohydrate degradation, glycolysisbinds plasminogenStreptococcus mutans (Gram positive bacterium)
40Enolase, Homo sapiensenolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Carbohydrate degradation, glycolysis plasminogen bindingHomo sapiens (human, a mammal, OMIM number 172430 Enolase deficiency)
41Enolase, Trichomonas vaginalisEnolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Carbohydrate degradation, glycolysisplasminogen bindingTrichomonas vaginalis
42Enolase, Rattus norvegicusEnolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Carbohydrate degradation, glycolysis plasminogen bindingRattus norvegicus (rat, a mammal)
43Enolase, Leishmania mexicanaenolase, enzyme reversible conversion of 2-phosphoglycerate to phosphoenolpyruvatebinds plasminogenLeishmania mexicana (causes human leishmaniasis)
44Enolase, Paracoccidioides brasiliensisenolase, enzyme catalyses the dehydration of 2-phospho-D-glycerate (PGA) to phosphoenolpyruvate glycolysis, gluconeogenesisfibronectin bindingParacoccidioides brasiliensis
45Enolase, Bacillus anthracisenolase, enzyme 2-phospho-D-glycerate => phosphoenolpyruvate + H2O Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate Carbohydrate degradation, glycolysisbinds plasminogen and lamininBacillus anthracis
46Fructose bisphosphate aldolase, Candida albicansFructose bisphosphate aldolase, enzyme D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis Carbohydrate degradation, glycolysis, gluconeogenesis plasminogen bindingCandida albicans (yeast, a fungi, can cause candiadiasis)
47fructose-1,6-bisphosphate aldolase, Neisseria meningitidisfructose-1,6-bisphosphate aldolase, enzymeadhesin to human cellsNeisseria meningitidis (Gram negative bacterium, causes meningitis)
49GAPDH, Lactobacillus plantarumGAPDH, enzyme Glyceraldehyde 3-phosphate dehydrogenase binds mucin and Caco-2 cellsLactobacillus plantarum (Gram positive bacterium)
50GAPDH, Lactococcus lactisglyceraldehyde 3-phosphate dehydrogenase, GAPDH, enzyme D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 1,3-bisphospho-D-glycerate + NADH. Carbohydrate degradation, glycolysisbinding to invertase, a hyperglycosylated mannoprotein from Saccharomyces cerevisiaeLactococcus lactis IL1403 (Gram positive bacterium)
51GAPDH, Paracoccidioides brasiliensisglyceraldehyde 3-phosphate dehydrogenase, enzyme D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 1,3-bisphosphoglycerate + NADH. Carbohydrate degradation, glycolysisbind to fibronectin, laminin, and type I collagenParacoccidioides brasiliensis
52GAPDH, Oral streptococci (S. anginosus and S. oralis)GAPDH, Glyceraldehyde-3-phosphate dehydrogenase, enzymeplasminogen bindingOral streptococci (S. anginosus and S. oralis) (Gram positive bacteria)
53GAPDH, Streptococcus pyogenes glyceraldehyde 3-phosphate dehydrogenase, enzyme D-glyceraldehyde 3-phosphate + phosphate + NAD+ => 1,3-bisphosphoglycerate + NADH. Carbohydrate degradation, glycolysisbinds uPAR/CD87 receptor on human cellsStreptococcus pyogenes (Gram positive bacterium)
54GAPDH, Streptococcus suisGAPDH, glyceraldehyde 3-phosphate dehydrogenase, enzymeplasminogen bindingStreptococcus suis (Gram positive bacterium)
55GAPDH, Trichomonas vaginalisGlyceraldehyde-3-phosphate dehydrogenase, enzymebinds fibronectin fibronectin binding, and plasminogen and collagenTrichomonas vaginalis
56GAPDH, Staphylococcus aureus (S. epidermidis and S. aureus)GAPDH, glyceraldehyde 3-phosphate dehydrogenase, enzymetransferrin-binding protein (also called TPN) AND also binds plasminogen involved in the acquisition of transferrin-bound ironStaphylococcus aureus (S. epidermidis and S. aureus) (Gram positive bacteria)
57GAPDH, Streptococcus pneumoniaeglyceraldehyde 3-phosphate dehydrogenase, enzymeplasminogen bindingStreptococcus pneumoniae (Gram positive bacterium)
58GAPDH, Candida albicansglyceraldehyde 3-phosphate dehydrogenase, enzyme D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 1,3-bisphosphoglycerate + NADH. Carbohydrate degradation, glycolysisplasminogen binding fibronectin and laminin binding Candida albicans (yeast, a fungi, can cause candiadiasis)
59GAPDH, Streptococcus agalactiaeGlyceraldehyde 3-phosphate dehydrogenase, enzymeplasminogen bindingStreptococcus agalactiae, Streptococcus - group B, serotype III/deltaepsilon, strain J48 (Gram positive bacterium)
60GAPDH, Bacillus anthracisglyceraldehyde 3-phosphate dehydrogenase, enzyme catalyzes the oxidative phosphorylation of D-glyceraldehyde- 3-phosphate (G-3-P) to 1,3-diphosphoglycerate in the presence of NAD+/NADP+ and inorganic phosphate (Pi)plasminogen bindingBacillus anthracis
61GAPDH, Mycoplasma genitaliumglyceraldehyde 3-phosphate dehydrogenase, enzyme D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 1,3-bisphosphoglycerate + NADH Carbohydrate degradation, glycolysisbinds mucinMycoplasma genitalium
62GAPDH, Streptococcus - group A streptococciglyceraldehyde 3-phosphate dehydrogenase, enzymePlasminogen bindingStreptococcus pyogenes serotype M4 (strain MGAS10750) (Gram positive bacterium)
63Glutamine synthetase, BifidobacteriumGlutamine synthetase, enzyme ATP + L-glutamate + NH3 => ADP + phosphate + L-glutamineplasminogen bindingBifidobacterium (Bifidobacterium lactis, B. bifidum, and B. longum)
64Glucose 6-phosphate isomerase, Lactobacillus crispatusglucose 6-phosphate isomerase, enzyme D-glucose 6-phosphate <=> D-fructose 6-phosphate Carbohydrate biosynthesis; gluconeogenesis Carbohydrate degradation; glycolysislaminin, collagen I binding (not fibronectin)Lactobacillus crispatus (Gram positive bacterium)
300Glutamine synthetase, Lactobacillus crispatusGlutamine synthetase, enzyme ATP + L-glutamate + NH3 => ADP + phosphate + L-glutamine fibronectin, laminin, collagen I binding, and plasminogen bindingLactobacillus crispatus (Gram positive bacterium)
66Glutamine synthetase, Mycobacterium tuberculosisGlutamine synthetase ATP + L-glutamate + NH3 => ADP + phosphate + L-glutamineplasminogen and fibronectin binding proteinMycobacterium tuberculosis (mycobacterium, causes tuberculosis)
67Histone H1, Mus musculusHistone H1 binds to DNA near nucleosomes aids in condensation of nucleosome chains into higher-order structured fibersthyroglobulin receptorMus musculus (Mouse, mammal)
68Hsp60, Chlamydiae pneumoniaechaperonin, assist in the correct folding of new or unfolded proteins under both normal and stress conditionsbinding to cell surface and activates pathwaysChlamydiae pneumoniae (can cause pneumonia and other diseases)
69Hsp60, Histoplasma capsulatumHsp60adhesinHistoplasma capsulatum (Hc strain G217B) - also known as Ajellomyces capsulatus, causes hostoplsmosis, Darling's disease)
70Hsp60, Legionella pneumophilachaperone - Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides adhesinLegionella pneumophila (causes Legionnaires' disease)
72Hsp60 chaperone, ListeriaHsp60 chaperoneadhesinListeria
73Hsp60, Haemophilus ducreyiHsp60, GroEL, Prevents misfolding and promotes the refolding and proper assembly of unfolded proteinsadhesin - to glycosphinngolipidsHaemophilus ducreyi (Gram negative bacterium)
74Hsp60, Lactobacillus johnsoniiHsp60, GroEL, Prevents misfolding of proteins, promotes the refolding and correct assembly of unfolded proteinsadhesin binds to mucins and epithelial cellsLactobacillus johnsonii La1 (NCC 533) (Gram positive bacterium)
75Hsp60, Lactococcus lactischaperonin, Prevents misfolding of proteins, promotes the refolding and proper assembly of unfolded proteinsbinding to invertase, a hyperglycosylated mannoprotein from Saccharomyces cerevisiaeLactococcus lactis IL1403 (Gram positive bacterium)
77Hsp60, Salmonella typhimuriumchaperonin, Prevents misfolding of proteins, promotes the refolding and proper assembly of unfolded proteins adhesinSalmonella typhimurium (Gram negative bacterium)
78Hsp60, Clostridium difficilechaperonin, Prevents protein misfolding, promotes the refolding and proper assembly of unfolded proteinsadhesinClostridium difficile (can cause diarrhea)
79Hsp60, Helicobacter pylori chaperonin, Prevents protein misfolding, promotes the refolding and proper assembly of unfolded proteinsadhesin - to host cellsHelicobacter pylori (H. pylori strain TK1029) (causes peptic ulcers and gastritis)
80Hsp65, Mycobacterium tuberculosis chaperonin, Prevents protein misfolding, promotes the refolding and proper assembly of unfolded proteinsadhesin to CD43 on macrophage surfaceMycobacterium tuberculosis (mycobacterium, causes tuberculosis)
81Malate synthase, Mycobacterium tuberculosisMalate synthase, enzyme Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA Acetyl-CoA + H2O + glyoxylate => malate + CoA Carbohydrate metabolism; glyoxylate cycle glyoxylate pathway enables bacteria to assimilate two-carbon compounds into the TCA cycle binds fibronectin and laminin and A549 lung epithelial cellsMycobacterium tuberculosis (mycobacterium, causes tuberculosis)
82Ornithine carbamoyltransferase, Staphylococcus epidermidisOrnithine carbamoyltransferase, enzyme Carbamoyl phosphate + L-ornithine => phosphate + L-citrullinebind fibronectinStaphylococcus epidermidis (Gram positive bacterium)
83Peroxiredoxin, Neisseria meningitidisPeroxiredoxin, antioxidantplasminogen bindingNeisseria meningitidis (Gram negative bacterium)
84Peroxisomal catalase (CTA1), Candida albicansPeroxisomal catalase (CTA1), protect cells from the toxic effects of hydrogen peroxide 2 H2O2 => O2 + 2 H2O plasminogen bindingCandida albicans (yeast, a fungi, can cause candiadiasis)
85Phosphoglycerate kinase, Streptococcus agalactiaePhosphoglycerate kinase ADP + 1,3-bisphosphoglycerate => ATP + 3-phosphoglycerate Carbohydrate degradation, glycolysisplasminogen bindingStreptococcus agalactiae (GBS = group B Streptococcus, strain NCS13) (Gram positive bacterium)
86Phosphoglycerate kinase, Streptococcus pneumoniaePhosphoglycerate kinase, enzyme ADP + 1,3-bisphosphoglycerate => ATP + glycerate-3-phosphate Carbohydrate degradation, glycolysisplasminogen bindingStreptococcus pneumoniae (Gram positive bacterium)
87Phosphoglycerate kinase, Candida albicansPhosphoglycerate kinase, enzyme ADP + 1,3-bisphosphoglycerate => ATP + 3-phospho-D-glycerate Carbohydrate degradation, glycolysisplasminogen binding Candida albicans (yeast, a fungi, can cause candiadiasis)
88Phosphoglycerate kinase, Streptococcus - oral streptococci (S. anginosus and S. oralis) Phosphoglycerate kinase, enzyme ADP + 1,3-bisphosphoglycerate => ATP + 3-phospho-D-glycerate Carbohydrate degradation, glycolysisplasminogen bindingStreptococcus - oral streptococci (S. anginosus and S. oralis) (Gram positive bacterium)
89Phosphoglycerate mutase, BifidobacteriumPhosphoglycerate mutase, enzyme 1,3-bisphosphoglycerate <=> 2,3-bisphosphoglycerateplasminogen bindingBifidobacterium (Bifidobacterium lactis, B. bifidum, and B. longum)
90Phosphoglycerate mutase, Streptococcus - oral streptococci (S. anginosus and S. oralis)Phosphoglycerate mutase, enzyme 1,3-bisphosphoglycerate <=> 2,3-bisphosphoglycerateplasminogen bindingStreptococcus - oral streptococci (S. anginosus and S. oralis) (Gram positive bacterium)
91Phosphoglyceromutase, Candida albicansPhosphoglyceromutase, enzyme 1,3-bisphosphoglycerate <=> 2,3-bisphosphoglycerate Carbohydrate degradation, glycolysisplasminogen bindingCandida albicans (yeast, a fungi, can cause candiadiasis)
92Pyruvate dehydrogenase, Mycoplasma pneumoniaePyruvate dehydrogenase, enzyme The pyruvate dehydrogenase complex catalyzes the overall conversion pyruvate => acetyl-CoA and CO2. Pyruvate dehydrogenase (E1) is one of the enzyme components of the complex fibrinogen bindingMycoplasma pneumoniae
93Pyruvate kinase, Lactococcus lactisPyruvate kinase, enzyme ADP + phosphoenolpyruvate => ATP + pyruvate Carbohydrate degradation, glycolysisbinding to invertase, a hyperglycosylated mannoprotein from Saccharomyces cerevisiaeLactococcus lactis IL1403 (Gram positive bacterium)
94Pyruvate-ferredoxin oxidoreductase, Trichomonas vaginalisPyruvate-ferredoxin oxidoreductase, enzyme oxidative decarboxylation of pyruvate to yield acetyl-CoA and CO2cell surface adherance proteinTrichomonas vaginalis
95Transcription elongation factor, Candida albicansTranscription elongation factor during protein biosynthesis, TEF1 promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of the ribosome plasminogen bindingCandida albicans (yeast, a fungi, can cause candiadiasis)
96Superoxide dismutase, Mycobacterium aviumSuperoxide dismutase, enzyme antioxidant convert superoxide anion radicals into O2 and H2O2adhesinMycobacterium avium (mycobacterium, causes Johne's disease, a systemic infection of the intestines)
97Thiol-specific antioxidant protein, Candida albicansThiol-specific antioxidant protein antioxidant 2 R'-SH + ROOH = R'-S-S-R' + H2O + ROH. plasminogen bindingCandida albicans (yeast, a fungi, can cause candiadiasis)
98Triose phosphate isomerase, Paracoccidioides brasiliensis Triose phosphate isomerase, enzyme D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate Carbohydrate degradation glycolysis Carbohydrate biosynthesis, gluconeogenesis adhesinParacoccidioides brasiliensis
100Triose phosphate isomerase, Staphylococcus aureusTriose phosphate isomerase, enzyme D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate Carbohydrate degradation, glycolysis Carbohydrate biosynthesis, gluconeogenesis adhesin, contact-mediated killing of CryptococcusStaphylococcus aureus (Gram positive bacterium, causes staph infections, abcesses/boils)
101Triose phosphate isomerase, Streptococcus - oral streptococci (S. anginosus and S. oralis)Triose phosphate isomerase, enzyme D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate Carbohydrate degradation, glycolysis Carbohydrate biosynthesis, gluconeogenesis plasminogen bindingStreptococcus - oral streptococci (S. anginosus and S. oralis) (Gram positive bacterium)
110Aconitase, Mycobacterium tuberculosisaconitase, enzyme catalyse the isomerization of citrate to iso-citrate in the citric acid cycleiron-responsive protein Binds to selected IREs (Iron-responsive elements)--sequences present within the UTR (untranslated regions) of M. tuberculosis mRNA Mycobacterium tuberculosis (mycobacterium, causes tuberculosis)
111Aconitase, Saccharomyces cerevisiaeaconitase, enzyme Catalyzes the conversion of citrate to aconitate in the pathway for lysine biosynthesis. Krebs cycle, Amino-acid biosynthesis, L-lysine biosynthesis mitochondrial DNA maintenance enzymatic activity and iron sulfur cluster are not needed for this roleSaccharomyces cerevisiae
112I-AniI, Emericella nidulans (Aspergillus nidulans)mRNA maturase required for splicing of the intron in the cytochrome b (cobA) gene, which contains the coding sequence for the maturase. stimulates the intrinsic ribozyme activity of the intron by binding to and stabilizing the three-dimensional structure of the RNA. homing endonuclease introduces a double-strand break at a specific location in the cobA gene and helps in the insertion of an intron containing its own coding sequence (group I intron) Emericella nidulans (Aspergillus nidulans)
113Arg5,6, Saccharomyces cerevisiaeenzyme in the arginine biosynthetic pathway N-acetyl-gamma phosphate reductase and acetyl glutamate kinaseArg5 binds to mitochondrial and nuclear DNA in vivo and regulates gene expression, regulator of transcription for several genesSaccharomyces cerevisiae
114Argininosuccinate lyase, Anas platyrhynchos Argininosuccinate lyase, enzyme Catalyzes the breakdown of argininosuccinate to produce arginine and fumarate. It is the fourth enzyme of the urea cycle. Argininosuccinase is involved in biosythesis of arginine in all species and production of urea in ureotelic organisms. 2-(N(omega)-L-arginino)succinate => fumarate + L-arginine Amino-acid biosynthesis, arginine biosynthesisDelta-2 Crystallin in the lens of the eye - only in birds and reptilesAnas platyrhynchos (duck)
115lactate dehydrogenase, Anas platyrhynchoslactate dehydrogenase, enzyme lactate + NAD+ <=> pyruvate + NADH pyruvate fermentation to lactateStructural eye lens protein (epsilon-crystallin)- also in crocodile, hummingbird, chimney swiftAnas platyrhynchos (Mallard duck) - also in reptiles, swans, geese, ostriches
116retinol binding protein 1, Lygodactylus picturatusCellular retinol-binding protein Type 1 carrier protein involved in transport of retinol from liver to peripheral tissuescrystallin Ultraviolet Filter Lens protein Lygodactylus luteopicturatus (Yellow-headed Dwarf Gecko)
117 lactate dehydrogenase A, crystallin upsilon, Ornithorhynchus anatinus Lactate dehydrogenase A, enzyme Fermentation, Pyruvate fermentation to lactate pyruvate + NADH <=> lactate + NAD+ Catalyzes the conversion of pyruvate (final product of glycolysis) to lactateLens protein crystallinOrnithorhynchus anatinus (Duckbill platypus)
118Aldehyde dehydrogenase, Elephantus edwardiiretinaldehyde dehydrogenase, enzyme an aldehyde dehydrogenase class 1 An aldehyde + NAD+ + H2O => a carboxylate + NADH. Alcohol metabolism, ethanol degradationeta crystallin Elephantus edwardii (elephant shrew)
119L-gulonate 3-dehydrogenase, Lambda-crystallin, Oryctolagus cuniculusL-gulonate 3 -dehydrogenase, enzyme L-gulonate + NAD(+) <=> 3-dehydro-L-gulonate + NADH Catalysis the NAD-linked dehydrogenation of L-gulonate into dehydro-L-gulonate in the urinate cycle. Lambda crystallin Oryctolagus cuniculus (Rabbit)
120Quinone oxidoreductase, Zeta-crystallin, Cavia porcellusQuinone oxidoreductase NADPH:quinone oxidoreductase NADPH + 2 quinone <=> NADP(+) + 2 semiquinone Zeta-crystallin (Also in camels, llamas, and tree frog)Cavia porcellus (Guinea pig)
121NADPH quinone oxidoreductase, Zeta-crystallin, Hyla japonicaNADPH:quinone oxidoreductase, enzymeZeta crystallin (Also in camel, llamas and Guinea pig)Hyla japonica (Japanese tree frog)
122Carbinolamine dehydratase, Rattus norvegicusPterin-4-alpha-carbinolamine dehydratase, enzyme convert 4a-hydroxy tetrahydropterin to quinonoid dihydrobiopterin, in phenylalanine hydroxylation reaction (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin => (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2Odimerization of hepatocyte nuclear factor 1? (HNF1A), a homeodomain transcription factor, results in transcription activation Rattus norvegicus
123Lactose synthase, Homo sapiensLactose synthase, enzyme UDP-alpha-D-galactose + D-glucose <=> UDP + lactoseGalactosyltransferase, enzyme UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1Homo sapiens (human, a mammal, P15291 OMIM number 137060 607091, Congenital disorder of glycosylation, type IId)
124DegP, Escherichia colipeptidase at higher temperatures.chaperone at low temperatures Escherichia coli (strain K12) (Gram negative bacterium)
125Albaflavenone Monooxygenase, Streptomyces coelicolorAlbaflavenone Monooxygenase (+)-epi-isozizaene + 2 NADPH + 2 O(2) <=> albaflavenone + 2 NADP(+) + 3 H(2)O Terpene synthase (2E,6E)-farnesyl diphosphate <=> (E)-beta-farnesene + diphosphatestreptomyces coelicolor A3(2)
126Delta-aminolevulinic acid dehydratase, Homo sapiens5-aminolaevulinate dehydratase, enzyme converts 2 (5-aminolevulinate) to porphobilinogen +2H20. Porphyrin-containing compound metabolism, protoporphyrin-IX biosynthesisproteasome inhibitor Noncompetitively blocks proteolysis of certain protein substrates. Homo sapiens (human, a mammal)
127FtsH, Shigella flexnerichaperoneMetalloprotease, enzyme ATP-dependent zinc metallopeptidase, hydrolyzes cytoplasmic and transmembrane proteinsShigella flexneri
128Leukotriene A-4 hydrolase, Homo sapiensLeukotriene A-4 hydrolase, enzyme epoxide hydrolase (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H(2)O <=> (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate catalyzes the last step in the biosynthesis of leukotriene B4. Lipid metabolism, leukotriene B4 biosynthesisAminopeptidase, enzyme Homo sapiens (human, a mammal)
129Lysyl hydroxylase, Homo sapiensLysyl hydroxylase isoform 3, enzyme L-lysine-[procollagen] + 2-oxoglutarate + O(2) <=> (2S,5R)-5-hydroxy-L-lysine-[procollagen] + succinate + CO(2) Important for formation of intermolecular cross-links in collagen, helps provide strength to collagen acts at -Xaa-Lys-Gly- sequences Collagen glucosyltransferase UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen = UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagenHomo sapiens (human, a mammal)
130Phosphoglycerate Kinase, Homo sapiensPhosphoglycerate Kinase, enzyme ADP + 1,3-bisphosphoglycerate => ATP + 3-phospho-D-glycerate Carbohydrate degradation, glycolysisdisulphide reductase, enzyme Inhibits angiogenesis through a disulfide reductase activity that activates plasminogen autoproteolytic activity, producing angiostatin. One or more of the PGK cysteine residues may have a role in plasmin reduction. Homo sapiens (human, a mammal)
131Prostaglandin H2 Synthase, Ovis aries Prostaglandin H2 synthase-1, enzyme Arachidonate + AH(2) + 2 O(2) <=> prostaglandin H(2) + A + H(2)O Lipid metabolism, prostaglandin biosynthesisPeroxidase and cyclo-oxygenase 2 phenolic donor + H(2)O(2) <=> 2 phenoxyl radical of the donor + 2 H(2)OOvis aries (Sheep)
132Mismatch repair endonuclease PMS2, Mus musculusPMS2 mismatch repair enzyme introduces single-strand breaks near the mismatch Hypermutation of antibody variable chainsMus musculus
133Thymosin beta-4, Homo sapiensInvolved in sequestering G-actin (monomeric actin) in human polymorphonuclear leukocytes (PMNs). secreted anti-inflammatory agent Homo sapiens (human, a mammal) and Bos taurus (cow, a mammal)
135Acetohydroxyacid isomerase, Saccharomyces cerevisiaeacetohydroxyacid reductoisomerase, enzyme Amino-acid biosynthesis, L-leucine, L-isoleucine and L-valine biosynthesis (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ => (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH (2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ => (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH Cofactor maintain mitochondrial DNA stability enzyme catalytic function not needed for this roleSaccharomyces cerevisiae (yeast, fungi)
136PutA, Salmonella typhimuriumProline dehydrogenase / Proline oxidase pyrroline-5-carboxylic acid dehydrogenase activitytranscriptional repressor of the put operonSalmonella typhimurium (and also E. coli) (Gram negative bacterium)
137GCN4 transcription factor, Saccharomyces cerevisiaetranscription factor; transcription activatorribonucleaseSaccharomyces cerevisiae
138birA biotin sythetase, Escherichia colibirA biotin synthetase, enzyme biotin--[acetyl-CoA-carboxylase] ligase ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)]. bio operon repressor repressor activity depends on cellular concentration of biotinEscherichia coli (Gram negative bacterium)
139Clf1p pre-mRNA splicing factor, Saccharomyces cerevisiaeClf1p pre-mRNA splicing factor involved in assembly of spliceosome Initiation of DNA replication binds to origin of replication complex Saccharomyces cerevisiae
140Thymidine phosphorylase, Homo sapiensThymidine phosphorylase thymidine + phosphate <=> thymine + 2-deoxy-alpha-D-ribose 1-phosphate Pyrimidine metabolism, dTMP biosynthesis in salvage pathwayPlatelet-derived endothelial cell growth factor Homo sapiens (human, a mammal)
143Citrate synthase, Tetrahymena thermophilacitrate synthase, enzyme acetyl-CoA + oxaloacetate + H2O => citrate + CoA-SH Citric acid cycle14-nm cytoskeletal proteinTetrahymena thermophila
144Galactokinase, Kluyveromyces lactisgalactokinase ATP + galactose => ADP + galactose 1-phosphate. Carbohydrate metabolism; galactose metabolismtranscriptional activator of GAL genes Kluyveromyces lactis
145Glutamate racemase, Mycobacterium tuberculosisglutamate racemase L-glutamate <=> D-glutamate Cell wall biogenesis, peptidoglycan biosynthesisDNA gyrase relieves strain when double-stranded DNA is being unwound Mycobacterium tuberculosis (mycobacterium, causes tuberculosis)
146Hemagglutinin, Paramyxovirushemagglutinin binding the virus to the surface of host cells Neuraminidase, enzyme cleaves the glycosidic linkages of neuraminic acidsParamyxovirus (Mumps virus)
147Transketolase, Escherichi colitransketolase, enzyme Pentose Phosphate Pathway Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-ribose 5-phosphate + D-xylulose 5-phosphate. Transcriptional regulator derepresses the marRAB multiple antibiotic resistance operon by binding to the MarR repressor a "trigger enzyme"Escherichia coli (Gram negative bacterium)
148Tyrosyl tRNA synthetase, Neurospora crassa tyrosyl tRNA synthetase, enzyme attaches tyrosine to tRNA(Tyr) ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr)promotes folding of group 1 intronsNeurospora crassa
149Ag85A, Mycobacterium tuberculosismycolyltransferase, enzyme cell wall assembly Transesterification of mycolic acidsfibronectin-bindingMycobacterium tuberculosis (mycobacterium, causes tuberculosis)
150Aconitase, Bos taurusaconitase, enzyme 4Fe-4S cluster in active site when cellular iron levels are high Citrate <=> isocitrate Citric acid cycleiron responsive element binding protein when cellular iron concentrations are low, loses 4Fe-4S cluster and binds to iron-responsive elements (IRES) in mRNA that encodes proteins that are involved in iron uptake and use Bos taurus (bovine, a mammal)
151Folate receptor, Mus musculusfolate receptor binds folate and derivatives and brings them into the cell during endocytosis transcription factor Mus musculus (Mouse, mammal)
152Dihydroxyacetone kinase, Escherichia colidihydroxyacetone kinase, enzyme ATP + glycerone <=> ADP + glycerone phosphate (glycerone also called dihydroxyacetone)controls gene expression by binding to transcription factor DhaR, a trigger enzymeEscherichia coli (Gram negative bacterium)
153Aaa autolysin, Staphylococcus aureusAaa autolysin peptidoglycan hydrolase, enzyme in cell division, cell separation, and cell wall turnover also bacteriolytic activity cleaves some cell wall glycopeptides, hydrolyzes the link between L-amino acid residues and N-acetylmuramoyl residues fibronectin binding, adhesinStaphylococcus aureus (Gram positive bacterium)
154Aae autolysin, Staphylococcus epidermidisAae autolysin peptidoglycan hydrolase in cell-wall turnover and cell division bacteriolytic activity binds fibrinogen, fibronectin and vitronectinStaphylococcus epidermis (Gram positive bacterium)
155AtlC, Staphylococcus capraeautolysin, enzyme N-acetylmuramoyl-L-alanine amidase hydrolyze peptidoglycan in cell wallfibronectin bindingStaphylococcus caprae (Gram positive bacterium)
156Ami autolysin, Listeria monocytogenesautolysin, enzyme cleaves cell wall glycopeptides, at the link between the L-amino acid residues and the N-acetylmuramoyl residues adherence to eukaryotic cellsListeria monocytogenes (Gram positive bacterium, causes listeriosis, septicemia, meningitis)
157Ag85B, Mycobacterium tuberculosismycolyltransferase, enzyme cell wall assembly Transesterification of mycolic acidsfibronectin bindingMycobacterium tuberculosis (mycobacterium, causes tuberculosis)
158Ag85C, Mycobacterium tuberculosismycolyltransferase, enzyme cell wall assembly Transesterification of mycolic acidsfibronectin bindingMycobacterium tuberculosis (mycobacterium, causes tuberculosis)
159Thioredoxin, Escherichia colithioredoxin antioxidant aids the reduction of other proteins by cysteine thiol-disulfide exchangeSubunit of T7 DNA polymerase ****maybe not strictly considered moonlighting because adopted by a phage to be part of a protein complex*****Escherichia coli (Gram negative bacterium)
160Lymphotactin, Homo sapienscytokine agonist for XCR1, the specific G-protein-coupled receptor for lymphotactinbinding to cell-surface glycosaminoglycans **a Metamorphic protein - different fold than when cytokine***Homo sapiens (human, a mammal, OMIM number 600250 )
161ATF2, Homo sapiensATF2 activating transcription factor bZIP family of transcription factors binds DNA as a dimer, homodimerization or heterodimerization, sometimes with c-Jun recruiting Mre11 to IR-induced foci (IRIF) in the DNA damage response, this function does not require DNA binding domain or dimerization with c-JunHomo sapiens (human, a mammal) and Mus musculus (mouse a mammal)
162ATF2, Mus musculusATF2 activating transcription factor bZIP family of transcription factors binds DNA as a dimer, homodimerization or heterodimerization, sometimes with c-Jun recruiting Mre11 to IR-induced foci (IRIF) in the DNA damage response, this function does not require DNA binding domain or dimerization with c-Jun Mus musculus (Mouse, mammal)
163Glutamine synthetase, Bacillus subtilis glutamine synthetase catalyzes the synthesis of glutamine from glutamate and ammonia ATP + L-glutamate + NH3 => ADP + phosphate + L-glutaminebinds to transcription factor TnrA, a global regulator of transcription, and prevents it from binding to DNABacillus subtilis
164Glutamate dehydrogenase, Bacillus subtilisglutamate dehydrogenase deaminates glutamate to form ?-ketoglutarate L-glutamate + H2O + NAD+ => 2-oxoglutarate + NH3 + NADH.interacts directly with GltC, a LysR-type transcription factorBacillus subtilis
165High mobility group protein B1, Rattus norvegicus binds heparin involved in extension of neurite-type cytoplasmic processes DNA binding protein, without sequence specificity associates with chromatin, may play structural role bends DNA Rattus norvegicus (Rat, a mammal)
166Arg82, Saccharomyces cerevisiaekinase, enzyme phosphorylates inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,5-tetrakisphosphate (Ins(1,3,4,5)P4) 2 ATP + 1D-myo-inositol 1,4,5-trisphosphate => 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate. stabilizes transcription factors ARG80 and MCM1 Saccharomyces cerevisiae (yeast, fungi)
167Arginase, Saccharomyces cerevisiaearginase use of arginine as nitrogen source L-arginine + H2O => L-ornithine + urea Nitrogen metabolism, urea cyclebinds to ornithine transcarbamylase and inactivates it (OTCase, catalyzes first step in arginine biosynthesis), effectors are ornithine and arginine Saccharomyces cerevisiae (yeast, fungi)
168Epimorphin, Syntaxin-2, Homo sapiensepimorphin - mediates epithelial tissue morphogenesis outside the cell syntaxin 2 controls protein secretion from endoplasmic reticulumGolgi-derived vesicles it is a target SNARE (t-SNARE) on the cytoplasmic side of the plasma membranes that aids in fusion of the plasma membrane with vesicles that carry the appropriate vesicle SNARE (v-SNARE) proteinsHomo sapiens (human, a mammal, OMIM number 132350 )
169Calreticulin, Homo sapienschaperone promotes protein folding and assembly of oligomers involved in protein quality control adhesin Homo sapiens (human, a mammal)
170Erk2, Homo sapiensErk2 kinase, enzyme Serine/threonine kinase ATP + a protein => ADP + a phosphoprotein.transcriptional repressor represses expression of interferon gamma-induced genesHomo sapiens (human, a mammal, OMIM number 176948 )
171L13a, Homo sapienribosome protein, part of 60S subunit of ribosome translation inhibition Component of the GAIT complex (gamma interferon-activated inhibitor of translation) Homo sapiens (human, a mammal)
172Glutamyl-prolyl tRNA synthetase, Homo sapiensglutamyl-prolyl tRNA synthetase, enzyme an aminoacyl-tRNA synthetase catalyze the attachment of amino acids to cognate tRNAs ATP + L-glutamate + tRNA(Glu) => AMP + diphosphate + L-glutamyl-tRNA(Glu) ATP + L-proline + tRNA(Pro) => AMP + diphosphate + L-prolyl-tRNA(Pro)translation inhibition part of GAIT complex: interferon (IFN)-gamma-activated inhibitor of translation silences ceruloplasmin mRNA translation Homo sapiens (human, a mammal)
173Glyceraldehyde-3-phosphate dehydrogenase, Homo sapiensglyceraldehyde-3-phosphate dehydrogenase, enzyme D-glyceraldehyde 3-phosphate + phosphate + NAD+ => 1,3-bis-phosphogycerate + NADH Carbohydrate degradation, glycolysistranslation inhibition part of GAIT complex: interferon (IFN)-gamma-activated inhibitor of translation that silences ceruloplasmin mRNA translation Homo sapiens (human, a mammal, OMIM number 138400)
174L7 ribosomal, Methanococcus jannaschiipart of the ribosomesRNP core protein binds the box C/D snoRNA core motif, homologue of eukaryotic 15.5kD proteinMethanococcus jannaschii
175RACK1, Saccharomyces cerevisiaeComponent of the 40S (small) ribosomal subunitscaffold in cytoplasmic signal transduction pathwaysSaccharomyces cerevisiae (yeast, fungi)
177L10 ribosomal protein, Homo sapiensComponent of the large subunit (60S) of the ribosome negative regulator of c-Jun in transcriptionHomo sapiens (human, a mammal)
178L32, Saccharomyces cerevisiaeComponent of the ribosome large subunit (60S)inhibits the splicing of the transcript of its own gene, RPL32Saccharomyces cerevisiae (yeast, fungi)
179S14 ribosomal protein, Saccharomyces cerevisiaeComponent of the ribosome small subunit (40S)represses expression of RPS14B gene rpS14 binds directly to RNA, binds to an RNA stem-loop structure in RPS14B pre-mRNA Saccharomyces cerevisiae (yeast, fungi)
180L2 ribosomal protein, Saccharomyces cerevisiaeComponent of the ribosome large subunit (60S). regulates accumulation of L2 mRNA, shortens half-life of L2 mRNA Saccharomyces cerevisiae (yeast, fungi)
181S28 Ribosomal protein, Saccharomyces cerevisiaeComponent of the ribosome small subunit (40S)shortens half-life of own mRNA binds to hairpin structure in 3' UTR and also to the decapping machinerySaccharomyces cerevisiae (yeast, fungi)
182L12 ribosomal protein, Caenorhabditis elegansribosomal protein Binds RNA directly (26S rRNA)inhibits splicing of its own RNACaenorhabditis elegans (nematode, worm)
183S13 ribosomal protein, Homo sapiensribosomal protein, part of the ribosomeinhibits splicing of own RNA transcript inhibit removal of intron 1 from rpS13 pre-mRNA Homo sapiens (human, a mammal)
184L11 ribosomal protein, Mus musculusribosomal protein, part of 60S subunitBinds to and inhibits HDM2, a ubiquitin ligase, which results in stabilization of p53 tumor suppressor proteinMus musculus (Mouse, mammal)
185L11 ribosomal protein, Homo sapiensribosomal protein, part of 60S subunitBinds to and inhibits HDM2, a ubiquitin ligase, which results in stabilization of p53 tumor suppressor proteinHomo sapiens (human, a mammal)
186L5 ribosomal protein, Homo sapiensribosomal protein, part of the 60S subunitBinds to and inhibits HDM2, a ubiquitin ligase, which results in stabilization of the p53 tumor suppressor proteinHomo sapiens (human, a mammal)
187S7 ribosomal protein, Homo sapiensribosomal protein, part of 40S subunitBinds to and inhibits HDM2, a ubiquitin ligase, which results in stabilization of the p53 tumor suppressor proteinHomo sapiens (human, a mammal)
188L26 ribosomal protein, Homo sapiensribosomal protein, part of 60S subunitregulates (increases) translation of p53 tumor suppressor protein after DNA damage, leading to cell cycle arrest and apoptosis binds 5' UTR of p53 mRNAHomo sapiens (human, a mammal)
189Nucleolin, Homo sapienssynthesis and maturation of ribosomesregulates (decreases) translation of p53 tumor suppressor protein binds 5' UTR of p53 mRNAHomo sapiens (human, a mammal)
190L23 ribosomal protein, Homo sapiensribosomal protein, part of 60S subunitBinds to and inhibits HDM2, a ubiquitin ligase, which results in stabilization of p53 tumor suppressor protein Homo sapiens (human, a mammal)
191L10 ribosomal protein, Arabidopsis thalianaribosomal protein, part of 40S subunit Involved in NSP-interacting kinase (NIK) receptor-mediated defense pathway to defend against geminivirus substrate and binding partner of NIK1 Arabidopsis thaliana (Mouse-ear cress, a plant)
192S3 ribosomal protein, Drosophila melanogasterribosomal protein, part of 40S subunitDNA repair activity cleaves DNA at apurinic/apyrimidinic sites Drosophila melanogaster (fruit fly, an insect)
11S3 ribosomal protein, Homo sapienribosomal protein, part of the 40S subunita subunit of a DNA binding complex involved in NF-kappaB-mediated transcriptionHomo sapiens (human, a mammal, OMIM number 600454 )
193EF-G, Streptococcus gordoniielongation factor in translation catalyzes translocation step, uses GTPadhesin, binds salivary mucin MUC7Streptococcus gordonii (Gram positive bacterium)
194L4 ribosomal protein, Escherichia coliribosomal protein, part of the 50S subunittranscriptional repressor causes premature termination of transcription within S10 operonEscherichia coli (Gram negative bacterium)
195Enolase, Streptococcus gordoniienolase, enzyme Catalyzes the interconversion of 2-phosphoglycerate and phosphoenolpyruvate 2-phospho-D-glycerate <=> phosphoenolpyruvate + H2O Carbohydrate degradation, glycolysisadhesin, binds salivary mucin MUC7Streptococcus gordonii (Gram positive bacterium)
196Fructose-1,6-bisphosphate aldolase/phosphatase, Sulfolobus tokodaiifructose-1,6-bisphosphatase, enzyme dephosphorylation of FBP to fructose-6-phosphate fructose-1,6-bisphosphate aldolase, enzyme reversible aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to FBPSulfolobus tokodaii
197Fructose-1,6-bisphosphate aldolase/phosphatase, Thermoproteus neutrophilusfructose-1,6-bisphosphatase, enzyme dephosphorylation of FBP to fructose-6-phosphate fructose-1,6-bisphosphate aldolase, enzyme reversible aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to FBPThermoproteus neutrophilus
2RfaH, Escherichia coliaids in transcription elongation of long RNA chains, reduces pausing and inhibits termination translational regulatorEscherichia coli (Gram negative bacterium)
198DegQ, Escherichia colipeptidase, enzyme chaperone, aids in folding of proteins Escherichia coli (Gram negative bacterium)
199Cdt1, Homo sapienshelps load proteins onto chromatin to create the pre-replication complex for initiating DNA replication role in mitosis localizes to kinetochores through binding to the Hec1 component of the Ndc80 complex Homo sapiens (human, a mammal, OMIM number 605525 Meier-Gorlin Syndrome)
200MalY, Escherichia colibeta-cystathionase, enzyme cleavage of cystathionine to homocysteine, ammonia, and pyruvate L-cystathionine + H2O => L-homocysteine + NH3 + pyruvate Amino-acid biosynthesis, methionine biosynthesis transcription regulation binds to MalT activator of mal regulon and prevents its actionEscherichia coli (Gram negative bacterium)
201Hexokinase, Saccharomyces cerevisiaehexokinase, enzyme ATP + D-hexose => ADP + D-hexose 6-phosphate. Carbohydrate metabolism, hexose metabolism, glycolysisHxk2 interacts directly with Mig1, a transcriptional repressor that binds to promoters of genes that are repressed by glucose high glucose causes Hxk2 to move to the nucleusSaccharomyces cerevisiae (yeast, fungi)
202GmaR, Listeria monocytogenesO-GlcNAc transferase glycosyltransferase that mediates beta-O-linked GlcNAc modification of flagellin (FlaA)transcriptional regulator anti-repressor, target is MogR (a transcriptional repressor), binds to MogR and prevents it from binding to DNAListeria monocytogenes (Gram positive bacterium, causes listeriosis, septicemia, meningitis)
203Pyruvate carboxylase, Hansenula poymorphaPyruvate carboxylase, enzyme ATP + pyruvate + HCO3- => ADP + phosphate + oxaloacetate. Carbohydrate biosynthesis, gluconeogenesis assembly of peroxisomal alcohol oxidase (AOX) may mediate FAD binding to AOX monomers in cytoplasm, which enables them to be transported to the peroxisome where they can assemble into the active octomeric formHansenula poymorpha (Pichia angusta) (Yeast)
65Phosphofructokinase, Pichia pastorisphosphofructokinase, enzyme ATP + D-fructose 6-phosphate => ADP + D-fructose 1,6-bisphosphate Glycolysisprotein, but not catalytic function, is required for microautophagy (vacuolar degradation of peroxisomes) only alpha subunit of phosphofructokinase plays this roleKomagataella pastoris (Yeast) (Pichia pastoris)
71Enolase 1, Saccharomyces cerevisiaeenolase, enzyme 2-phospho-D-glycerate <=> phosphoenolpyruvate + H2O Glycolysisrequired for vacuole homotypic membrane fusion and protein trafficking to the vacuole enzyme catalytic activity not needed for this roleSaccharomyces cerevisiae (yeast, fungi)
204PyrH, Escherichia coliUMP kinase, enzyme phosphorylates UMP to UDP ATP + UMP <=> ADP + UDP de novo biosynthetic pathway of pyrimidine nucleotidestranscriptional regulator involved in pyrimidine-specific repression of the carAB operon binds to PepA Escherichia coli (Gram negative bacterium)
76Enolase 2, Saccharomyces cerevisiaeenolase, enzyme 2-phospho-D-glycerate <=> phosphoenolpyruvate + H2O Glycolysisrequired for vacuole homotypic membrane fusion and protein trafficking to the vacuole enzyme catalytic activity not needed for this roleSaccharomyces cerevisiae (yeast, fungi)
205CysK, Bacillus subtilisCysteine synthase, enzyme O-acetyl-serine + H2S = cysteine + acetate Amino-acid biosynthesis, biosynthesis of cysteinetranscriptional regulator regulates activity of CymR transcription factor forms complex with CymR that represses transcription of the CymR regulon Bacillus subtilis
99Fructose 1,6-Bisphosphate Aldolase, Saccharomyces cerevisiaeAldolase, enzyme D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate Glycolysis, Gluconeogenesisbinds to vacuolar H+-ATPase and is needed for its assembly enzymatic catalytic activity not needed for this functionSaccharomyces cerevisiae (yeast, fungi)
134Ure2, Saccharomyces cerevisiaefunctions in nitrogen catabolite repression binds to and inhibits GATA transcriptional activators GLN3 and GAT1, keeps them in the cytoplasm, prevents transcription of their target genes glutathione peroxidase, enzyme also thiol:disulfide oxidoreductase 2 glutathione + H2O2 => glutathione disulfide + 2 H2OSaccharomyces cerevisiae (yeast, fungi)
206Aes, Escherichia coliesterase, enzyme esterase of short chain fatty esters with up to 8 carbons in acyl chaintranscription regulation binds to MalT activator of mal regulon and prevents its actionEscherichia coli (Gram negative bacterium)
207PutA, Escherichia coliProline dehydrogenase / Proline oxidase, enzyme L-proline + a quinone => (S)-1-pyrroline-5-carboxylate + a quinol L-glutamate 5-semialdehyde + NAD+ + H2O => L-glutamate + NADH Amino-acid degradation, L-proline degradation into L-glutamatetranscriptional repressor of the put operon Escherichia coli (Gram negative bacterium)
208NadR, Escherichia colinicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase activities, enzyme ATP + nicotinamide ribonucleotide => diphosphate + NAD+ ATP + 1-(beta-D-ribofuranosyl)-nicotinamide => ADP + beta-nicotinamide D-ribonucleotide NAD biosynthesisTranscriptional repressor binds to the nadB operator DNA sequence Increasing NAD causes an increase in the affinity of NadR for the nadB operator regions of nadA, nadB, and pncB Escherichia coli (Gram negative bacterium)
209PepA, Escherichia coliaminopeptidase, enzyme removes amino-terminal amino acid, preferentially if it is Leu transcriptional repressor binds DNA, binds car operator DNA represses the carAB operon Escherichia coli (Gram negative bacterium)
210Glucose permease, Escherichia coliphosphorylates glucose, enzyme sugars are phosphorylated during transport through the channel subunit of the protein complex IIB subunit binds and sequesters Mlc transcription repressor in presence of glucoseEscherichia coli (Gram negative bacterium)
211MalK, Escherichia coliATP binding/hydrolysis protein of MalEFGK maltose/maltodextrin transporter (importer) an ABC transporter ATP + H2O = ADP + phosphate transcription regulation binds to MalT activator of mal regulon and prevents its actionEscherichia coli (Gram negative bacterium)
212DhaK, Escherichia colisubunit of dihydroxyacetone kinase, enzyme phosphorylates dihydroxyacetone contains the Dha binding site corepressor of DhaR transcription activator binds to DhaR affects transcription of the dhaKLM operon Escherichia coli (Gram negative bacterium)
213DhaL, Escherichia colisubunit of dihydroxyacetone kinase, enzyme phosphorylates dihydroxyacetone contains the ADP-binding site coactivator of DhaR transcription activator binds to DhaR affects transcription of the dhaKLM operon Escherichia coli (Gram negative bacterium)
215Formiminotransferase, Thermoplasma acidophilumformiminotransferase, enzyme histidine breakdown5-formyltetrahydrofolate cycloligase ATP + 5-formyltetrahydrofolate <=> ADP + phosphate + 5,10-methenyltetrahydrofolateThermoplasma acidophilum
216Sarcosine oxidase alpha subunit, Thermococcus kodakarensisSarcosine oxidase, enzyme oxidation of the methyl group in sarcosine and transfer to folate oxidative demethylation of sarcosine to yield glycine and 5,10-CH2-tetrahydrofolate NADH dehydrogenase NADH + H+ + acceptor <=> NAD+ + reduced acceptor Thermococcus kodakarensis
217Sarcosine oxidase beta subunit, Thermococcus kodakarensisSarcosine oxidase, enzyme oxidation of the methyl group in sarcosine and transfer to folate oxidative demethylation of sarcosine to yield glycine and 5,10-CH2-tetrahydrofolate L-proline dehydrogenase, enzyme L-proline + acceptor <=> (S)-1-pyrroline-5-carboxylate + reduced acceptor Thermococcus kodakarensis
218TreX, Sulfologus solfataricusalpha-1,4-transferase, enzyme alpha-1,6-glucosidase, enzymeSulfologus solfataricus
219Thymidylate synthase, Homo sapiensthymidylate synthase, enzyme de novo synthesis of thymidylate, a DNA precursor 5,10-methylenetetrahydrofolate + dUMP <=> dihydrofolate + dTMP Pyrimidine metabolism, dTTP biosynthesismRNA translation inhibition regulation of human TS mRNA translation does not bind to unrelated mRNAs Homo sapiens (human, a mammal, OMIM number 188350 )
220Thymidylate synthase, Plasmodium falciparumDihydrofolate reductase and Thymidylate synthase, enzyme 5,6,7,8-tetrahydrofolate + NADP+ <=> 7,8-dihydrofolate + NADPH 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP Tetrahydrofolate biosynthesismRNA translation inhibition regulation of plasmodium TS-DHFR mRNA translation Plasmodium falciparum
222Dihydrofolate reductase, Homo sapiensdihydrofolate reductase, enzyme 5,6,7,8-tetrahydrofolate + NADP+ => 7,8-dihydrofolate + NADPH tetrahydrofolate biosynthesisbinds DHFR mRNA regulation of DHFR synthesis methotrexate inhibits interaction Homo sapiens (human, a mammal)
223Serine hydroxymethyltransferase, Homo sapiensserine hydroxymethyltransferase, enzyme 5,10-methylenetetrahydrofolate + glycine + H2O <=> tetrahydrofolate + L-serine One-carbon metabolism, tetrahydrofolate interconversionbinds mRNA binds the 5' untranslated region (UTR) of its own mRNA Homo sapiens (human, a mammal)
224Uracil phosphoribosyltransferase, Bacillus caldolyticusuracil phosphoribosyltransferase, enzyme UMP + diphosphate <=> uracil + 5-phospho-alpha-D-ribose 1-diphosphate binds mRNA transcriptional attenuation of the pyrimidine nucleotide biosynthetic (pyr) operon binds upstream of the genes being regulated Bacillus caldolyticus
225Creatine kinase, Rattus norvegicuscreatine kinase, enzyme transfers phosphoryl group between ATP and various phosphogens (e.g. creatine phosphate) ATP + creatine <=> ADP + phosphocreatinebinds mRNA translation regulator binds 3' untranslated region (3' UTR) of mRNA of alpha myosin heavy chain (alphaMyHC) Rattus norvegicus (rat, a mammal)
226Mevalonate kinase, Rattus norvegicusMevalonate kinase, enzyme ATP + (R)-mevalonate => ADP + (R)-5-phosphomevalonate Isoprenoid biosynthesis, mevalonate pathwaymRNA binding cytosolic luteinizing hormone receptor mRNA binding protein increases LH receptor mRNA degradation Rattus norvegicus (rat, a mammal)
227Threonyl-tRNA synthetase, Escherichia coliThreonine-tRNA ligase, enzyme ATP + L-threonine + tRNA(Thr) => AMP + diphosphate + L-threonyl-tRNA(Thr)binds mRNA binds mRNA encoding threonyl-tRNA synthetase, controls expression of its own gene at the translational level Escherichia coli (Gram negative bacterium)
229Enolase, Mycoplasma fermentansenolase, enzyme 2-phospho-D-glycerate <=> phosphoenolpyruvate + H2O Carbohydrate degradation, glycolysisplasminogen binding Mycoplasma fermentans (mycobacterium)
230GroEL1, Mycobacterium tuberculosisprotein chaperone prevents proteins from misfolding, promotes correct refolding and assembly of polypeptidesbinds DNA low specificity but high affinity nucleoid-associated protein condenses DNA into a compact structure Mycobacterium tuberculosis (mycobacterium, causes tuberculosis)
231Gephryn, Homo sapiensconnects membrane proteins to cytoskeleton microtubule binding protein anchors transmembrane receptors needed for clustering of inhibitory glycine receptors in postsynaptic membranes in the rat central nervous system Molybdopterin adenylyltransferase and Molybdopterin molybdenumtransferase, enzyme biosynthesis of the molybdenum cofactor catalyzes two steps ATP + molybdopterin => diphosphate + adenylyl-molybdopterin. Adenylyl-molybdopterin + molybdate => molybdenum cofactor + AMP. Cofactor biosynthesis, molybdopterin biosynthesis Homo sapiens (human, a mammal)
232Cytochrome C, Equus caballusElectron carrier protein component of the mitochondrial electron-transport chain binding to apoptosis protease activation factor-1 (Apaf-1) promotes apoptosis release from mitochondria allows interaction with apoptosis proteins Equus caballus (Horse, a mammal)
233Cytochrome C, Saccharomyces cerevisiaeElectron carrier protein component of the mitochondrial electron-transport chain binding to apoptosis protease activation factor-1 (Apaf-1) promotes apoptosis release from mitochondria allows interaction with apoptosis proteins Saccharomyces cerevisiae (yeast, fungi)
234Aconitase, Homo sapiensaconitase, enzyme 4Fe-4S cluster in active site when cellular iron levels are high Citrate <=> isocitrate Citric acid cycleiron responsive element binding protein when cellular iron concentrations are low, loses 4Fe-4S cluster and binds to iron-responsive elements (IRES) in mRNA that encodes proteins that are involved in iron uptake and use Homo sapiens (human, a mammal)
235Alaninyl-tRNA syntetase, Escherichia coliAlanyl-tRNA synthetase, enzyme attaches alanine to tRNA(Ala) ATP + L-alanine + tRNA(Ala) => AMP + diphosphate + L-alanyl-tRNA(Ala)transcription regulator represses transcription of its own gene increased repression with increased alanine concentrations binds DNA Escherichia coli (Gram negative bacterium)
236Leucyl-tRNA synthetase, Saccharomyces cerevisiaeLeucyl-tRNA synthetase, enzyme ATP + L-leucine + tRNA(Leu) => AMP + diphosphate + L-leucyl-tRNA(Leu) protein synthesisintron splicing, RNA splicing group I intron splicing Saccharomyces cerevisiae (yeast, fungi)
237Leucyl-tRNA synthetase, Homo sapiensLeucyl-tRNA synthetase, enzyme attaches leucine to its cognate tRNA ATP + L-leucine + tRNA(Leu) => AMP + diphosphate + L-leucyl-tRNA(Leu) protein synthesis GTPase-activating protein (GAP) senses intracellular leucing concentration and binds to Rag GTPase Rag signals to mTORC1 promotes translocation of mTORC1 to the lysosomal membraneHomo sapiens (human, a mammal)
238Glutaminyl-tRNA synthetase, Homo sapiensGlutaminyl-tRNA synthetase, enzyme ATP + L-glutamine + tRNA(Gln) => AMP + diphosphate + L-glutaminyl-tRNA(Gln) protein synthesis interacts with ASK1 (Fas ligation activated apoptosis signal-regulating kinase 1) to inhibit apoptosis induced by ASK1 protein-protein interaction increased under conditions of increased glutamine concentration Homo sapiens (human, a mammal)
239Lysyl-tRNA synthetase, Rattus norvegicusLysyl-tRNA synthetase, enzyme ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys) protein synthesissynthesis of diadenosine tetraphosphate (diadenosine-5',5'''-P1,P4-tetraphosphate, Ap(4)A, AppppA) Ap4A then regulates transcription of MITF target genes Rattus norvegicus (rat, a mammal)
240Tryptophanyl-tRNA synthetase, Homo sapiensTryptophanyl-tRNA synthetase, enzyme ATP + L-tryptophan + tRNA(Trp) => AMP + diphosphate + L-tryptophyl-tRNA(Trp) protein synthesisforms complex with the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) and poly(ADP-ribose) polymerase 1 (PARP-1) the complex activates p53 Homo sapiens (human, a mammal)
241MSCp43, Mus musculusscaffold protein in the multisynthase complex forms a multi-protein complex with glutamyl-, prolyl-, isoelucyl-, leucyl-, methionyl-, glutaminyl-, lysyl-, arginyl-, and aspartyl-tRNA synthetases, AIMP2/p38, and AIMP3/p18cytokine roles in angiogenesis - inducing endothelial cell migration induces maturation of dendritic cells induces monocyte cell adhesion Mus musculus (Mouse, mammal)
242MSCp38, Mus musculusscaffold protein in the multisynthase complex forms a multi-protein complex with glutamyl-, prolyl-, isoelucyl-, leucyl-, methionyl-, glutaminyl-, lysyl-, arginyl-, and aspartyl-tRNA synthetases, AIMP1/p24, and AIMP3/p18binds to FUSE-binding protein (FBP), a transcriptional activator of c-myc the protein-protein interaction causes an increase in the ubiquitination and degradation of FBP, which results in downregulation of c-myc differentiation of lung cells Mus musculus (Mouse, mammal)
243MSCp18, Mus musculusscaffold protein in the multisynthase complex forms a multi-protein complex with glutamyl-, prolyl-, isoelucyl-, leucyl-, methionyl-, glutaminyl-, lysyl-, arginyl-, and aspartyl-tRNA synthetases, AIMP2/p38, and AIMP3/p24protein-protein interaction with ATM/ATR that results in p53 activation translocates to nucleus and plays a role in DNA repair Mus musculus (Mouse, mammal)
244Lysyl-tRNA synthetase, Homo sapiensLysyl-tRNA synthetase, enzyme ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys) protein synthesis cytokine binds to macrophages and peripheral blood mononuclear cells increases TNF-alpha production by target cells increases target cell migration Homo sapiens (human, a mammal)
245Methionyl-tRNA synthetase, Homo sapiensMethionyl-tRNA synthetase, enzyme ATP + L-methionine + tRNA(Met) => AMP + diphosphate + L-methionyl-tRNA(Met) protein synthesisbiogenesis of rRNA in nucleoli translocation to nucleolus triggered by growth factors Homo sapiens (human, a mammal)
246L1 ribosomal protein, Escherichia coliribosomal protein, part of the 50S subunit translational repressor binds to the mRNA of the L11 operon Escherichia coli (Gram negative bacterium)
247S4 ribosomal protein, Escherichia coliS4 ribosomal protein part of the 30S subunit, helps nucleate assembly of the 30S subunit by binding directly to the 16S rRNA translational repressor binds mRNA of operon encoding S3, S11, S4Escherichia coli (Gram negative bacterium)
248S8 ribosomal protein, Escherichia coliS8 ribosomal protein part of the 30S subunit binds to 16S rRNA translational repressor inhibits expression of some proteins encoded by the spc operon Escherichia coli (Gram negative bacterium)
249Argonaute4, Arabidopsis thalianaComponent of the RISC complex RNA-directed DNA methylation, involves small interfering RNA (siRNA) RNA-directed gene silencing cleaves RNA transcripts, enzyme generates small interfering RNAs (siRNAs) Arabidopsis thaliana (Mouse-ear cress, a plant)
250Ubp6, Saccharomyces cerevisiaedeubiquitinase, enzyme associated with proteasome releases ubiquitin from ubiquitinated proteins that bind to the proteasome inhibits proteasome activity delays the degradation of ubiquitinated proteins by the proteasome enables gradual deubiquitination of the substrate Saccharomyces cerevisiae (yeast, fungi)
251hRoDH-E2, Homo sapiensretinol dehydrogenase, enzyme all-trans-retinol + NAD+ <=> all-trans-retinal + NADH. Cofactor metabolism, retinol metabolism transcriptional repressor represses profilaggrin promoter activity by adjusting the activity of Sp1 and other activators Homo sapiens (human, a mammal)
252Pyruvate kinase, Rattus norvegicusPyruvate kinase, enzyme ATP + pyruvate => ADP + phosphoenolpyruvate Carbohydrate degradation, glycolysis enzyme as tetramerthyroid hormone binding activity monomer binds 3,3',5-triiodo-L-thyronine (T3) Rattus norvegicus (rat, a mammal)
253Sulfite reductase, Pisum sativumSulfite reductase, enzyme Hydrogen sulfide + 6 oxidized ferredoxin + 3 H2O <=> sulfite + 6 reduced ferredoxin + 6 H+ compact DNA in nucleoids of plastids method to regulate transcription Pisum sativum (garden pea)
254Band 3 anion exchanger, Homo sapiensBand 3 anion exchanger transports inorganic anions across the plasma membrane in a 1:1 exchange scaffold protein providing binding sites for glycolytic enzymes involved in regulation of catalytic activity of glycolytic enzymes site of binding is N-terminal cytoplasmic domain of Band 3Homo sapiens (human, a mammal)
255Hal3, Saccharomyces cerevisiaeSubunit of phosphopantothenoylcysteine decarboxylase (PPCDC) coenzyme A biosynthesis pathway inhibitory subunit of protein phosphatase PPZ1 Saccharomyces cerevisiae (yeast, fungi)
256Vhs3, Saccharomyces cerevisiaeSubunit of phosphopantothenoylcysteine decarboxylase (PPCDC) coenzyme A biosynthesis pathway inhibitory subunit of protein phosphatase PPZ1 Saccharomyces cerevisiae (yeast, fungi)
257I-Tev1 endonuclease, bacteriophage T4homing endonuclease, enzyme intron-encoded binds cognate intronless alleles transcriptional autorepressor bacteriophage T4
258Pth2/Bit1, Homo sapiensPeptidyl-tRNA hydrolase, enzyme aminoacyl-tRNA + H2O => amino acid + tRNA releases tRNA from the premature translation termination product inhibitor of transcription protein-protein interactionHomo sapiens (human, a mammal)
259CFTR, Homo sapienschloride transporter ATP + H2O => ADP + phosphate contains nucleotide binding domains that bind and hydrolyze ATPregulator of other ion channelsHomo sapiens (human, a mammal,OMIM number 602421 Cystic Fibrosis)
260MDR1, Homo sapienstransmembrane transporter efflux pump, uses ATP for energy expels drugs and other small molecule compounds ATP + H2O + xenobiotic(Inside) => ADP + phosphate + xenobiotic(Outside)regulator of volume-activated chloride channels Homo sapiens (human, a mammal)
261Atla autolysin, Streptococcus mutansautolysin, enzyme cleaves cell wall peptidoglycanbinds fibronectinStreptococcus mutans
262Peroxiredoxin 1, Saccharomyces cerevisiaeperoxiredoxin peroxidase antioxidant 2 R'-SH + ROOH => R'-S-S-R' + H2O + ROH. molecular chaperones helps proteins foldSaccharomyces cerevisiae (yeast, fungi)
263Peroxiredoxin 2, Saccharomyces cerevisiaeperoxiredoxin peroxidase antioxidant 2 R'-SH + ROOH => R'-S-S-R' + H2O + ROHmolecular chaperones helps proteins foldSaccharomyces cerevisiae (yeast, fungi)
266Vps22, Drosophila melanogasterComponent of the ESCRT-II complex (ensodomal sorting complex required for transport II) complex needed for sorting ubiquitinated endosomal proteins into multivesicular bodies important for transport of transmembrane proteins to the lysosome for degradationwith other members of the ESCRT complex, binds to the localization element in the 3' untranslated region (UTR) of bicoid mRNA functions in localizing bicoid mRNA to the anterior of the Drosophila egg Drosophila melanogaster (fruit fly, an insect)
267Vps36, Drosphila melanogasterComponent of the ESCRT-II complex (ensodomal sorting complex required for transport II) complex needed for sorting ubiquitinated endosomal proteins into multivesicular bodies important for transport of transmembrane proteins to the lysosome for degradation mRNA binding binds to the localization element in the 3' untranslated region (UTR) of bicoid mRNA functions in localizing bicoid mRNA to the anterior of the Drosophila egg Drosophila melanogaster (fruit fly, an insect)
265Vps25, Drosophila melanogasterComponent of the ESCRT-II complex (ensodomal sorting complex required for transport II) complex needed for sorting ubiquitinated endosomal proteins into multivesicular bodies important for transport of transmembrane proteins to the lysosome for degradation with other members of the ESCRT complex, binds to the localization element in the 3' untranslated region (UTR) of bicoid mRNA functions in localizing bicoid mRNA to the anterior of the Drosophila egg Drosophila melanogaster (fruit fly, an insect)
268Aspartate receptor, Escherichia coliaspartate receptor binds aspartate transmembrane receptor for aspartatebinds maltose binding protein maltose receptor transmembrane receptor for maltose binding protein Escherichia coli (Gram negative bacterium)
269L14 ribosomal protein, Escherichia coliribosomal protein part of the 30S subunit binds to the 23S rRNA binds DNA stimulates unwinding of DNA by Rep helicase protein Escherichia coli (Gram negative bacterium)
270S14 ribosomal protein, Homo sapiensribosomal protein inhibits S14 mRNA transcription negative effector of transcription of its own RNA Homo sapiens (human, a mammal, OMIM number 130620 Macrocytic anemia)
271STAT3, Mus musculustranscription factor, binds DNA in response to cytokines (IL-6, and other growth factors) binds promoters containing IL-6 responsive elements modulates the activities of complexes I and II of the electron transport chain (ETC) in the mitochondriaMus musculus (Mouse, mammal)
273Fructose-bisphosphate aldolase, Plasmodium bergheiFructose-bisphosphate aldolase, enzyme D-fructose 1,6-bisphosphate => dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate Carbohydrate degradation, glycolysisattaches actin filaments to TRAP proteins (transmembrane adhesive proteins of the thrombospondin-related anonymous protein) and transduces the motor force across the surface of the plasmodium Plasmodium berghei
274Fructose-bisphosphate aldolase, Toxoplasma gondiiFructose-bisphosphate aldolase, enzyme D-fructose 1,6-bisphosphate => dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate Carbohydrate degradation, glycolysisprotein-protein interactions couples actin cytoskeleton filaments in the cytoplasm to the surface adhesin microneme protein 2 (MIC2)Toxoplasma gondii
275Gpx4, Homo sapiensPhospholipid hydroperoxide glutathione peroxidase, enzyme removes membrane lipid peroxidation, cell protection 2 glutathione + a lipid hydroperoxide => glutathione disulfide + lipid + 2 H2Ostructural role in capsule in mature spermatozoa Homo sapiens (human, a mammal, OMIM number 138322 Spondylometaphyseal dysplasia)
276Lactose synthetase, Bos taurusLactose synthetase, enzyme UDP-alpha-D-galactose + D-glucose => UDP + lactose UDP-galactose: N-acetylglucosamine galactosyltransferase, enzyme UDP-alpha-D-galactose + N-acetyl-D-glucosamine => UDP + N-acetyllactosamineBos taurus (cow, a mammal)
277Isocitrate dehydrogenase 1, Saccharomyces cerevisiaeIsocitrate dehydrogenase, enzyme Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH Citric acid cyclebinds mRNA binds specifically to 5'-untranslated leaders of mitochondrial mRNAs Saccharomyces cerevisiae (yeast, fungi)
278Isocitrate dehydrogenase 2, Saccharomyces cerevisiaeIsocitrate dehydrogenase, enzyme Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH Citric acid cyclebinds mRNA binds specifically to 5'-untranslated leaders of mitochondrial mRNAs Saccharomyces cerevisiae (yeast, fungi)
279Germin, Hordeum vulgareOxalate oxidase, enzyme Oxalate + O2 + 2 H+ => 2 CO2 + H2O2superoxide dismutase, enzyme 2 superoxide (O2-) + 2 H(+) <=> O(2) + H(2)O(2)Hordeum vulgare
280S10 ribosomal protein, Escherichia coliribosomal protein part of the 30S subunitpart of an antitermination apparatus antitermination of Rho-dependent and Rho-independent terminators Escherichia coli (Gram negative bacterium)
282P0 ribosomal protein, Drosophila melanogasterP0 ribosomal protein part of the 60S subunitApurinic-apyrimidinic endonuclease, enzyme functions in DNA repair act on AP DNA, cleaves 5' of a baseless site Drosophila melanogaster (fruit fly, an insect)
283L10 ribosomal protein, Escherichia coliribosomal protein part of the 50S subunit translation inhibitor autogenous regulation of translation Escherichia coli (Gram negative bacterium)
473Arogenate dehydratase/prephenate dehydratase 2arogenate dehydratase. Converts the prephenate produced from the shikimate-chorismate pathway into phenylalanine.component of the chloroplast division machinery. .Arabidopsis thaliana (Mouse-ear cress, a plant)
284S7 ribosomal protein, Escherichia coliribosomal protein binds to 16S rRNA part of the 30S subunittranslational repressor regulates the expression of two proteins encoded by the str operon Escherichia coli (Gram negative bacterium)
470H3 histone, Xenopus laevisHistonecopper reductase. The histone H3-H4 tetramer is a copper reductase enzyme.Xenopus laevis (African clawed frog, an amphibian)
471Histone H4, Xenopus laevisHistone. Core component of nucleosome.copper reductase. The histone H3-H4 tetramer is a copperreductase enzyme.Xenopus laevis (African clawed frog, an amphibian)
472Myo-inositol 1-phosphate synthase 1myo-inositol phosphate synthase.Interact with the histone methyltransferases ATXR5 and ATXR6.Arabidopsis thaliana (Mouse-ear cress, a plant)
286Matrix metaloproteinase 12, Mus musculusMatrix metaloproteinase, enzyme cleaves elastin, IFN-?promotes transcription binds to the NFKBIA promoter Mus musculus (Mouse, mammal)
287dCTP deaminase, Methanocaldococcus jannaschiidCTP deaminase deamination of the cytosine moiety in dCTP dCTP + 2 H2O => dUMP + diphosphate + NH3 Pyrimidine metabolism, dUMP biosynthesishydrolysis of the triphosphate moiety forming dUMP dUTP => dUMPMethanocaldococcus jannaschii
288Penicillin binding protein 4, Escherichia colicarboxypeptidase, enzyme Cell wall biogenesis, peptidoglycan biosynthesisendopeptidase, enzymeEscherichia coli (Gram negative bacterium)
290RNase P protein 1, Homo sapiensMitochondrial ribonuclease P protein 1, noncatalytic subunit cleaves tRNA molecules in their 5'-ends subunit of ribonuclease P, not catalytic subunit for this function required for ribonuclease P activity tRNA methyltransferase, enzyme Homo sapiens (human, a mammal, OMIM number 615423 Combined oxidative phosphorylation deficiency 30)
291Zuotin, Saccharomyces cerevisiaecomponent of a chaperone complex component of the ribosome-associated complex (RAC) that helps in folding of nascent polypeptide chainsactivator of a transcription factor activates Pdr1 transcription factor Saccharomyces cerevisiae (yeast, fungi)
302aldehyde-alcohol dehydrogenase Ealdehyde alcohol dehydrogenase, alcohol dehydrogenase, acetaldehyde-CoA dehydrogenase, and pyruvate formate-lyase (PFL) deactivase activitiesbinds to ribosome and affects translation, RNA unwinding activity, RNA helicaseEscherichia coli (Gram negative bacterium)
303fructose-1,6-bisphosphate aldolasealdolase, cleavage of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate, in glycolysisActivation of mouse (host) macrophage protein tyrosine phosphatase-1 (SHP-1), causes macrophage disfunction
304fructose-1,6-bisphosphate aldolasealdolase, in glycolysis and gluconeogenesis, reversible cleavage of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate.bind to and regulate insulin-dependent glucose transporter GLUT4Mus musculus (Mouse, mammal)
305Fructose-bisphosphate aldolase Aaldolase, cleavage of carbon-carbon bonds, in glycolysis, gluconeogenesis, and fructose metabolism, D-fructose 1,6-bisphosphate => dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate.sequesters WASP, Wiskott–Aldrich Syndrome Protein, which is involved in controlling actin dynamics, inihibits actin polymerization, only binds to active from of WASP, inhibits WA?stimulated Arp2/3?dependent actin?polymerization reactionOryctolagus cuniculus (Rabbit. a mammal)
306fructose 1,6-bisphosphate aldolasefructose bisphosphate aldolase, enzyme, in glycolysis and gluconeogenesis, D-fructose 1,6-bisphosphate -> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphateadhesin, binds to receptor on host cells, binds to host Flamingo cadherin receptor (FCR)Streptococcus pneumoniae (Gram positive bacterium)
307Fructose-bisphosphate aldolase Aaldolase, D-fructose 1,6-bisphosphate-> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate, in glycolysisinteractions with zona pellucida proteins of eggHomo sapiens (human, a mammal)
308alpha-ketoglutarate dehydrogenase E2alpha-ketoglutarate dehydrogenase E2, in Krebs cycle, dihydrolipoyl succinyltransferasemitochondrial DNA inheritanceTrypanosoma brucei
309Ask1part of DASH complex, which binds to microtubules and kinetochores and regulates their associationtranscriptional regulatorTuber melanosporum
310Beta-arrestin-1cytosolic regulator and scaffold of GPCR signaling, interacts with activated receptors at cell membrane, resulting in receptor endocytosis and attenuation of receptor signallingregulation of histone acetylation and gene transcription, helps recruit histone acetyltransferase p300 to specific promoters, resulting in enhanced acetylation of histone H4 and transcription of those genesHomo sapiens (human, a mammal)
311beta-arrestin-2uncouple activated seven-transmembrane receptors from heterotrimeric G proteins, mediate the endocytosis of most G-protein-coupled receptors (GPCRs)regulates transcription Homo sapiens (human, a mammal)
312Streptococcal C5a peptidaseprotease, peptidase, endopeptidase, cleaves and inactivates C5a (a component of the human complement system), helps GBS evade phagocytosisfibronectin binding, adhesinStreptococcus agalactiae, group B streptococci (GBS) (Gram positive bacterium)
313Phosphatidylinositol-binding clathrin assembly proteinbinds clathrin in endocytosis, assembly protein helps bring clathrin and adapter protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assemblytranscription activationHomo sapiens (human, a mammal)
314COP9 signalosome complex subunit 7part of COP9 signalosome (CSN), in ubiquitin-mediated protein degradation, CSN removes the ubiquitin-like protein Nedd8 from the cullin subunit of cullin-RING E3 ligase (CRL) Drosophila melanogaster (fruit fly, an insect)
315chloroplast dihydrolipoamide acetyltransferaseenzyme, pyruvate dehydrogenase complex subunit in chloroplast, dihydrolipoamide acetyltransferase (DLA2), helps provide acetyl-CoA for fatty acid synthesisChlamydomonas reinhardtii (unicellular green alga)(Chlamydomonas smithii)
316DPP4, dipeptidyl peptidase 4serine exopeptidase, dipeptidyl peptidase, regulates several physiological processes by cleaving peptides in the blood, i.e. chemokines, growth factors, neuropeptides, removes N-terminal dipeptides from proteins with unsubstituted N-termini as long as the second residue is prolineglycoprotein receptor, involved in T-cell activation, binds ADA, CAV1, IGF2R, and PTPRCHomo sapiens (human, a mammal)
317DPP10, dipeptidyl peptidase 10enzyme, dipeptidyl peptidase activity with Gly-Pro-MCA (glycyl-L-proline 4-methylcoumaryl-7-amide) as a substrateancillary subunit of Kv4 channels, bind to pore-forming subunits of voltage-gated K+ channels, causes negative shifts in voltage dependence of channel activation and steady state inactivationDrosophila melanogaster (fruit fly, an insect)
318EF-1-alphaelongation factorregulate cell motility by assembling actin filamentDictyostelium discoideium (slime mold)
319Eukaryotic elongation factor 1 A-1translation elongation factorbinds and severs microtubulesHomo sapiens (human, a mammal)
320elongation factor 1-alphatranslation elongation factor, the rate and fidelity of protein translationbinds to and activates Src homology 2 domain containing tyrosine phosphatase-1 (SHP-1) in host macrophages, inhibits activity of infected macrophagesLeishmania donovani
321Elongation factor 1-alpha 1translation elongation factorbinds and severs microtubulesOryctolagus cuniculus (rabbit)
322elongation factor 1 alphatranslation elongation factorbinds and severs microtubulesXenopus laevis (African clawed frog)
323translation elongation factor Tutranslation elongation factor TuMucin (MUC7)-binding proteinStreptococcus gordonii (Gram positive bacterium)
324Eukaryotic translation initiation factor 3 subunit Apart of eIF3 13-subunit complex that organizes initiation factor and ribosome interactions required for productive translation, protein scaffold for formation of initiation complexes, binds to proteins of small ribosomal subunitbinds to 5' untranslated regions of specific mRNA for translational activation, subunits a, b, d, g, binding site on mRNA for c-Jun is required for efficient translation of c-JUNHomo sapiens (human, a mammal)
325Eukaryotic translation initiation factor 3 subunit Bpart of eIF3 13-subunit complex that organizes initiation factor and ribosome interactions required for productive translation, protein scaffold for formation of initiation complexes, binds to proteins of small ribosomal subunitbinds to 5' untranslated regions of specific mRNA for translational activation, subunits a, b, d, g, binding site on mRNA for c-Jun is required for efficient translation of c-JUNHomo sapiens (human, a mammal)
326Eukaryotic translation initiation factor 3 subunit Dpart of eIF3 13-subunit complex that organizes initiation factor and ribosome interactions required for productive translation, protein scaffold for formation of initiation complexes, binds to proteins of small ribosomal subunitbinds to 5' untranslated regions of specific mRNA for translational activation, subunits a, b, d, g, binding site on mRNA for c-Jun is required for efficient translation of c-JUNHomo sapiens (human, a mammal)
327Eukaryotic translation initiation factor 3 subunit Gpart of eIF3 13-subunit complex that organizes initiation factor and ribosome interactions required for productive translation, protein scaffold for formation of initiation complexes, binds to proteins of small ribosomal subunitbinds to 5' untranslated regions of specific mRNA for translational activation, subunits a, b, d, g, binding site on mRNA for c-Jun is required for efficient translation of c-JUNHomo sapiens (human, a mammal)
328elongation factor 2translation elongation factorbinding partner for Akt2 signalling moleculeHomo sapiens (human, a mammal)
329endopeptidase Oendopeptidase, metalloendopeptidaseplasminogen binding protein, fibronectin binding proteinStreptococcus pneumoniae (Gram positive bacterium)
330enolase, 2-phospho-D-glycerate hydrolaseenolase, catalyze the conversion of 2-phosphoglycerate (2-PGA) to phosphoenolpyruvate (PEP), in glycosisplasminogen and fibronectin bindingMycoplasma synoviae
331enolase, 2-phospho-D-glycerate hydro-lyaseenolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase, 2-phospho-D-glycerate -> phosphoenolpyruvate, in glycolysisplasminogen binding, also maybe EBP binding, also maybe adhesin Plasmodium falciparum
332enolase, 2-phospho-D-glycerate hydro-lyaseenolase, in glycolysis, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydrataseplasminogen bindingStreptococcus canis, group G Streptococci (Gram positive bacterium)
333enolase, 2-phospho-D-glycerate hydro-lyaseenolase, enzyme, in glycolysis, 2-phosphoglycerate => phosphoenolpyruvatebinds Cytokeratin 8 (CK8) of host cellsStreptococcus gallolyticus (Gram positive bacterium)
334enolaseenolaseantiphagocytic activity of host (insect), affects host immune system, host immune suppressionSteinernema glaseri (nematode, a wor,)
335Methylglutaconyl-CoA hydratase3-methylglutaconyl-CoA hydratase that catalyzes the conversion of 3-methylglutaconyl-CoA to 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) in leucine catabolismRNA bindingHomo sapiens (human, a mammal)
336Epidermal growth factor receptor substrate 15binds clathrin, clathrin adapter in post-Golgi trafficking, also role in assembly of clathrin-coated pitstranscription activationHomo sapiens (human, a mammal)
337Fructose-1,6-bisphosphatasefructose-1,6-bisphosphatase 1, enzyme in gluconeogenesis, D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + phosphatebinds to HIF (hypoxia inducible factor) protein and inhibits nuclear HIF actionHomo sapiens (human, a mammal)
338Glyceraldehyde-3-phosphate dehydrogenaseglyceraldehyde 3-phosphate dehydrogenase, enzyme, D-glyceraldehyde 3-phosphate + phosphate + NAD+ => 3-phospho-D-glyceroyl phosphate + NADHsingle stranded DNA binding (SSB), effects on the DNA-polymerase-alpha- primase complexBos taurus (cow, a mammal)
339glyceraldehyde-3-phosphate dehydrogenaseenzyme, glyceraldehyde 3-phosphate dehydrogenase, D-glyceraldehyde 3-phosphate (G3P) -> 3-phospho-D-glyceroyl phosphate, in glycolysistransferrin receptor, iron uptakeCricetulus griseus, hamster (Chinese hamster, CHO cells, mammal)
340glyceraldehyde-3-phosphate dehydrogenaseGAPDH, glyceraldehyde-3-phosphate dehydrogenase, in glycolysis, D-glyceraldehyde 3-phosphate + phosphate + NAD+ -> 3-phospho-D-glyceroyl phosphate + NADHbinding alternative complement pathway protein C3, inhibit complement cascade, evade host immunityHaemonchus contortus (Barber pole worm)
341glyceraldehyde-3-phosphate dehydrogenaseglyceraldehyde-3-phosphate dehydrogenase, enzyme in glycolysis, oxidative phosphorylation of G3P (glyceraldehyde 3-phosphate) to 1, 3-bisphosphoglycerate in the presence ofNADH/NADPH and inorganic phosphatemucin bindingLactobacillus acidophilus (Gram positive bacterium)
344glyceraldehyde-3-phosphate dehydrogenaseglyceraldehyde 3-phosphate dehydrogenase, in glycolysis, D-glyceraldehyde 3-phosphate (G3P) <-> 3-phospho-D-glyceroyl phosphatebind mRNA AU-rich element (ARE), regulation of cyclo-oxygenase-2 (COX-2) expressio, binding to COX-2 mRNAMus musculus (Mouse, mammal)
345Glyceraldehyde-3-phosphate dehydrogenaseGlyceraldehyde-3-phosphate dehydrogenase, GAPDH, in glycolysis, conversion of glyceraldehyde 3-phosphate into glycerate 1,3-bisphosphateheme binding protein, required for the insertion of cellular heme into inducible nitric oxide synthaseOryctolagus cuniculus (rabbit , a mammal) Also human and S. suis
346glyceraldehyde 3-phosphage dehydrogenaseGAPDH, in glycolysis, catalyzing the phosphorylation of glyceraldehyde-3-phosphate to D-glycerate 1,3-bisphosphateadhesinTalaromyces marneffei (Penicillium marneffei)
347Glyceraldehyde-3-phosphate dehydrogenaseGAPDH, converts D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate, enzyme in glycolysis, glyceraldehyde 3-phosphate + phosphate + NAD+ => 3-phospho-D-glyceroyl phosphate + NADHbinds to Siah1, involved in apoptosisRattus norvegicus (rat, a mammal)
348Glyceraldehyde-3-phosphate dehydrogenase 3GAPDH, glyceraldehyde 3-phosphate dehydrogenasebinds to Sir2, regulates gene silencing by influencing Sir2’s association with chromatin, especially near telomeresSaccharomyces cerevisiae (yeast, fungi)
349glutathione S-transferase M3glutathione S-transferasebinds to rhZP4, in head of sperm, interactions with zona pellucida proteins of eggHomo sapiens (human, a mammal)
350glutathione S-transferaseglutathione S-transferase, detoxify electrophilic compoundsbinds ZP3 protein component of zona pellucida, serves as a gamete recognition molecule, binds specifically to zona pellucida (of egg) during the first phase of sperm–oocyte interactionsCapra hircus (goat, a mammal)
352glycerol 3-phosphate dehydrogenaseglycerol 3-phosphate dehydrogenase, functions in glycerol accumulationplasminogen bindingCandida albicans (yeast, a fungi, can cause candiadiasis)
353glycyl-tRNA synthetaseglycyl-tRNA synthetase, catalyze the formation of glycyl-tRNAGly as a substrate for ribosomal protein synthesis, P41250 (SYG_HUMAN), ATP + glycine + tRNA(Gly) => AMP + diphosphate + glycyl-tRNA(Gly) AND P1,P(4)-bis(5'-guanosyl) tetraphosphate + H2O => GTP + GMPbinds to NEDD8, E1, and E2 (Ubc12) in neddylation pathway, binds the APPBP1 subunit of E1 and captures and protects (like a chaperone) activated E2 (NEDD8-conjugated Ubc12) before the activated E2 reaches a downstream targetHomo sapiens (human, a mammal)
354glycyl tRNA synthetaseglycyl tRNA synthetase, catalyzes attachment of glycine to its cognate tRNA, ATP + glycine + tRNA(Gly) => AMP + diphosphate + glycyl-tRNA(Gly) AND P1,P(4)-bis(5'-guanosyl) tetraphosphate + H2O => GTP + GMP****NEOMORPHIC MOONLIGHTING PROTEIN***, mutant forms have protein binding activity, bind to neuropilin 1 (Nrp1) recpeptor, directly antagonizes binding of the ligand VEGF (vascular endothelial growth factor) to Nrp1, which is an essential signaling pathway in survival of motor neuronMus musculus (Mouse, mammal)
355hydroxyacyl-CoA dehydrogenase, subunit betaenzyme, 3-ketoacyl-CoA thiolase activityRNA binding, binds 3'UTR of REN mRNA which results in regulation of renin expression, destabilizes REN mRNAHomo sapiens (human, a mammal)
356phosphopantothenoylcysteine decarboxylasephosphopantothenoylcysteine decarboxylase, decarboxylation of phosphopahtothenoyl-L-cysteine, in CoA biosynthesis, PPCDCinhibitor of serine/threoinine phosphatase Pzh1Schizosaccharomyces pombe
357Protein deglycase 1chaperoneglyoxylase III, enzyme, catalyses the conversion of methylglyoxal (MG) to D-lactateEscherichia coli (Gram negative bacterium)
358hexokinase-1hexokinase, enzyme, in glycolysis, ATP + D-hexose => D-hexose 6-phosphate + ADPreceptor for bacterial NAG (N-acetylglucosamine), activates inflammasome responseMus musculus (Mouse, mammal)
359hexokinase 1hexokinase, ATP + D-hexose => ADP + D-hexose 6-phosphatebinds to vacuolar H+-ATPase B1 (VHA-B1) and the 19S regulatory particle of proteasome subunit (RPT5B) to modulate transcription of specific target genesArabidopsis thaliana (Mouse-ear cress, a plant)
360high-affinity glucose transporter 1sugar transporter, glucose transportercomplement inhibitor, binds complement regulator FH, binds complement regulator C4BP, protects cells from host complement cascade, complement evasion resulting in reduced formation of the potentially lytic terminal complex (TCC)Candida albicans (yeast, a fungi, can cause candiadiasis)
361LYS20homocitrate synthase, enzyme, lysine biosynthetic pathwayDNA damage repair, helps in INO80 accumulation at DNA breaks to aid in histone evictionSaccharomyces cerevisiae (yeast, fungi)
362Hsp60chaperoninbinds DNA, bind the template strand of active mtDNA ori sequences in vitro, involved in structure and transmission of mitochondrial DNA nucleoids to daughter cellsSaccharomyces cerevisiae (yeast, fungi)
364Inositol-pentakisphosphate 2-kinasekinase, ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate => ADP + 1D-myo-inositol hexakisphosphate.scaffold, binds protein kinase CK2, TCOF1, and upstream-binding-factor (UBF)Homo sapiens (human, a mammal)
365lactate dehydrogenase isozyme Menzyme, lactate + NAD+ -> pyruvate + NADHRNA binding protein, post-transcriptional regulation of gene expression, AU-rich element (ARE, binding to these kinds of elements can be involved in affecting RNA stability) binding protein (AUBP), role may also involve binding to AUF1 protein, binds the 3 -UTR of GM-CSF RNAMus musculus (Mouse, mammal)
366lactate dehydrogenase isozyme Menzyme, lactate + NAD+ -> pyruvate + NADHRNA binding protein, post-transcriptional regulation of gene expression, AU-rich element (ARE, binding to these kinds of elements can be involved in affecting RNA stability) binding protein (AUBP), role may also involve binding to AUF1 protein, binds the 3 -UTR of GM-CSF RNAMus musculus (Mouse, mammal)
367nuclear cytoplasmic O-GlcNAcase and acetyltransferaseO-GlcNase, which removes regulatory O-GlcNAc modifications on proteinshistone acetyltransferase (HAT), add acetyl groups to histonesMus musculus (Mouse, mammal)
368outer dense fiber protein 2component of sperm tail outer dense fibersinteractions with zona pellucida proteins of eggHomo sapiens (human, a mammal)
369phosphoadenosine-phosphosulfate reductasephosphoadenosine-phosphosulfate reductase (thioredoxin), enzyme in sulfur assimilation, conversion of activated sulfate (PAPS) to sulfite, adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide <-> 3'-phosphoadenylyl sulfate + thioredoxintranscription factorTuber melanosporum (Perigord black truffle, filamentous mycorrhizal ascomycetous fungus)
370mitochondrial 2-cysteine peroxiredoxinperoxidase activity, detoxification of reactive oxygen species (ROS), removal of peroxide, use redox active cysteine residue (peroxidatic Cys) to reduce substrates like H2O2chaperone and activators of signal transduction cascades, prevents thermal aggregation of citrate synthase in vitro, lack of expression makes promastigoes more sensitive to temperature in the mammalian host (37°C)Leishmania infantum
372peroxiredoxin 5peroxiredoxinsperm plasma membrane protein interacting with zona pellucida proteinsSus scrofa (pig)
373Alkyl Hydroperoxide Reductase Cperoxiredoxin, hydroxyperoxidase activityheme binding proteinStreptococcus agalactiae, group B Streptococcus (Gram positive bacterium)
374phosphofructokinase 1phosphofructokinase, enzyme in glycolysis, first committed step of glycolysis, by phosphorylating F6P into fructose-1,6-bisphosphate (F1,6P), ATP + D-fructose 6-phosphate => ADP + D-fructose 1,6-bisphosphatebinds TEADs proteins and promotes their interaction with YAP/TAX transcription factorsHomo sapiens (human, a mammal)
375phosphoglycerate kinase 1phosphoglycerate kinase, enzyme, reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglyceratebinds mRNA, regulates expression of urokinase receptor, "Overexpression in H157 lung squamous carcinoma cells reduced cell surface uPAR expression as well as uPAR-mediated cellular functions at the post-transcriptional level."Homo sapiens (human, a mammal)
376phosphoglycerate kinaseenzyme, phosphoglycerate kinase, in glycolysis, ATP + 3-phospho-D-glycerate -> ADP + 3-phospho-D-glyceroyl phosphatebinding to actin filament in insect vector (Circulifer haemotoceps, leafhopper) during invasionSpiroplasma citri, a plant bacterial pathogen transmitted by insects
377glutathione peroxidase 4phospholipid hydroperoxide glutathione peroxidase, 2 glutathione + a hydroperoxy-fatty-acyl-[lipid] -> glutathione disulfide + a hydroxy-fatty-acyl-[lipid]interactions with zona pellucida proteins of eggHomo sapiens (human, a mammal)
378pinintranscriptional activatorbinds RNA, involved in splicing of pre-mRNAsHomo sapiens (human, a mammal)
379pyruvate kinase 3, isoform 2pyruvate kinase, ATP + pyruvate -> ADP + phosphoenolpyruvate, in glycolysisinteractions with zona pellucida proteins of eggHomo sapiens (human, a mammal)
380pyruvate decarboxylasepyruvate decarboxylase, 2-oxo acid -> an aldehyde + CO2transcriptional regulator but might not bind DNA directly (possibly by sequestering Rag3 in the cytoplasm), inhibits transcription from PDC1 and PDC5 promotersKluyveromyces lactis
381pyruvate dehydrogenase E2 subunitpyruvate dehydrogenase E2 subunit, dihydrolipoamide acetyltransferaseDNA binding, transcription regulationBacillus thuringiensis
382pyruvate kinase 1pyruvate kinase, ATP + pyruvate <=> ADP + phosphoenolpyruvate.histone kinase, phosphorylates H3T11, protein kinase, part of SESAME complexSaccharomyces cerevisiae (yeast, fungi)
383pyruvate kinase isozyme type M2pyruvate kinase, enzyme, glycolysis, ATP + pyruvate <=> ADP + phosphoenolpyruvateregulates transcription, binds to Oct-4 proteinHomo sapiens (human, a mammal)
385Leucyl aminopeptidase leucine aminopeptidase (LAP) binds to heparinMycoplasma hyopneumoniae
387DNA-directed RNA polymerase beta subunitbeta subunit of DNA-directed RNA polymeraseMuc7 binding proteinStreptococcus gordonii (Gram positive bacterium)
388Regulatory particle triple-A ATPase subunit 5bpart of the regulatory ATPase complex of the 26S proteasome, confers substrate specificity and need for ATP to the proteaseomebinds to hexokinase 1 and VHA B1 to modulate transcription of specific target genesArabidopsis thaliana (Mouse-ear cress, a plant)
390succinate dehydrogenase subunit 3subunit of succinate dehydrogenase in the respiratory chain, electron transport in respiratory complex IIpart of TIM22 complex (carrier translocase, mitochondrial inner membrane translocase) in mitochondria, helps in biogenesis and assembly of membrane-integral subunits of TIM22 complexSaccharomyces cerevisiae (yeast, fungi)
391superoxide dismutasesuperoxide dismutase, catalysis of superoxide (O2-) to hydrogen peroxide (H2O2), remove reactive oxygen species, 2 superoxide -> oxygen and H2O2binds DNA, transcription factor in response to H2O2, a reactive oxygen species (ROS), regulates expression of genes involved in oxidative resistance and DNA damage repair, ROS treatment increases Sod1 binding to the promoters of RNR3 and GRE2Saccharomyces cerevisiae (yeast, fungi)
392Threonine-tRNA ligasethreonyl aminoacyl-tRNA synthetase, attaches threonine to tRNA, early step in protein synthesis, ATP + L-threonine + tRNA(Thr) -> AMP + diphosphate + L-threonyl-tRNA(Thr)promotes vascular development, demostrated this is separate from role in protein synthesisDanio rerio (Zebrafish) (Brachydanio rerio)
393Threonine-tRNA ligasethreonyl aminoacyl-tRNA synthetase, attaches threonine to tRNA, early step in protein synthesis, ATP + L-threonine + tRNA(Thr) -> AMP + diphosphate + L-threonyl-tRNA(Thr)promotes vascular development, demostrated this is separate from role in protein synthesisHomo sapiens (human, a mammal)
394 triose-phosphate isomerasetriosephosphate isomerase, D-glyceraldehyde 3-phosphate <-> dihydroxyacetone phosphate, in glycolysis and gluconeogenesisinteract with rhZP3 and rhZP4, interactions with zona pellucida proteins of eggHomo sapiens (human, a mammal)
395VDAC-2voltage-dependent anion channel 2 (VDAC2), transports adenine nucleotides, Ca2+ and other metabolites, voltage-dependentbinds to rhZP2 or rhZP3, zona pellucida proteins of eggHomo sapiens (human, a mammal)
396VHA-B1subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase functions in acidifying several intracellular compartments in eukaryotic cellsbinds to hexokinase 1 and the 19S regulatory particle of proteasome subunit (RPT5B) to modulate transcription of specific target genesArabidopsis thaliana (Mouse-ear cress, a plant)
397VPS22component of ESCRT-II (endosomal sorting complex required for transport), functions in exosomal sorting pathway that sorts ubiquitinated endosomal proteins into internal vesiclesbind bicoid mRNA to cause localization to anterior of eggDrosophila melanogaster (fruit fly, an insect)
398ESCRT-II complex subunit VPS25component of ESCRT-II (endosomal sorting complex required for transport), functions in exosomal sorting pathway that sorts ubiquitinated endosomal proteins into internal vesiclesbind bicoid mRNA to cause localization to anterior of eggDrosophila melanogaster (fruit fly, an insect)
399ESCRT-II complex subunit VPS36component of ESCRT-II (endosomal sorting complex required for transport), functions in exosomal sorting pathway that sorts ubiquitinated endosomal proteins into internal vesiclesbind bicoid mRNA to cause localization to anterior of egg, binding directly and specifically to stem-loop V of the bicoid 39 UTRDrosophila melanogaster (fruit fly, an insect)
400ADP/ATP Translocase 2, Human mediates transmembrane exchange of ADP and ATP, providing ADP to the mitochondrial ATPase ANT promotes mitophagy independently of its ADP/ATP exchange activityHomo sapiens (human, a mammal)
401Perodoxin 1, Humanperoxidase (Sm-Prxl-LMW), thioredoxin-dependent peroxidase in the absence of oxidative stress, uses redox-active cysteine to reduce H2O2chaperone, ATP-independent holdases at high hydrogen peroxide concentrations, prevent protein aggregation by quarantining client proteinshuman parasite Schistosoma mansoni(Blood fluke)
402Thioredoxin 3, Humandisulfide reductase, involved in activation of ribonucleotide reductase, modulation of transcription factors, promotion of a variety of tumors, and photosynthetic activity of plant cellsChaperone, involved in assembly of the T7 DNA polymerase complex and the formation of fila- mentous phageArabidopsis thaliana (Mouse-ear cress, a plant)
403Elongation Factor 2, YeastElongation factor in protein synthesis Interaction with contact system proteins HK, FXII, and PPKCandida albicans (yeast, a fungi, can cause candiadiasis)
4046-phosphogluconate dehydrogenase, YeastCatalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.binding to plasma proteins, interacting with components of contact systemCandida albicans (yeast, a fungi, can cause candiadiasis)
405HSP70, Yeastchaperone protein, intracellular functioninducing endocytosis, belongs to heat shock protein 70 (Hsp 70) familyCandida albicans (yeast, a fungi, can cause candiadiasis)
406Peroxisomal Catalase, Yeastcatalase activityHPG-bindingCandida albicans (yeast, a fungi, can cause candiadiasis)
407Peroxiredoxin 2, MousePeroxiredoxinregulate proinflammatory responses, vascular remodeling, and global oxidative stressMus musculus (Mouse, mammal)
408Autoimmune regulator, MouseAutoimmune regulator; Transcription factor that regulates the expression of many tissue restricted antigens (TRA)Binds to several spindle proteins including AURKB, CEP55, CNTROB, HAUS5, HAUS8, CLASP1, and CLASP2 Mus musculus (Mouse, mammal)
409Microtubule organization protein AKNA, Mouselocalizes to the distal part of the subdistal appendages of the mother centriole in interphase and dissociates from centrosomes during mitosis upon increased phosphorylation; re-associates with the centrosomes during late telophase/early G1interacts with components of the gamma-tubulin ring complex (gamma-TuRC), and MT binding proteins such as EB1, P150-Glued (DCTN1), and dynein.Mus musculus (Mouse, mammal)
410Cyclic AMP-dependent transcription factor ATF-5, Humanaccumulation at the centrosomes from G1 through anaphase and dissociation during late telophase; interacts with centrosomal proteins, including gamma-tubulin and pericentrin (PCNT),centriolar fragmentation and formation of multipolar spindles during downregulation of ATF5 (RNAi-mediated)Homo sapiens (human, a mammal)
411BRCA1, Humanassociates with RNA polymerase II holoenzyme and some transcription factors, including TFIIF/GTF2F1, TFIIE/GTF2E1, and TFIIH/GTF2H1, acting as a transcription regulator interacts with the BRCA1-associated RING domain protein (BARD1) and the Obg-like ATPase (OLA1), forming a complex with E3 ligase activity that binds and ubiquinates gamma-tubulinHomo sapiens (human, a mammal)
412BRCA1, Xenopus laevis physically interacts with BARD1 and spindle-associated proteins TPX2, NuMa, and XRHAMM, required for spindle formation induced by nuclei in cytoplasmic extracts from Xenopus laevis eggsRING-type E3 ubiquitin transferase BRCA1Xenopus laevis (African clawed frog)
413Angiotensin-converting enzyme 2, HumanCarboxypeptidase enzyme chaperone for BoAT in amino acid transportHomo sapiens (Human)
414Adenine nucleotide translocator 2, Humanmediates transmembrane exchange of ADP and ATP, providing ADP to the mitochondrial ATPase (complex V)ANT promotes mitophagy independently of its ADP/ATP exchange activityHomo sapiens (human, a mammal)
415Adenine nucleotide translocator 2, Mousemediates transmembrane exchange of ADP and ATP, providing ADP to the mitochondrial ATPase (complex V)ANT promotes mitophagy independently of its ADP/ATP exchange activityMus musculus (Mouse, mammal)
416Anoctamin-6, MouseCa2+-dependent scrambling of phospholipidsSmall-conductance calcium-activated nonselective cation (SCAN) channelMus musculus (Mouse, mammal)
417Core-binding factor subunit beta, Humannon-DNA-binding regulatory subunit; binds RUNX (RUNX1, RUNX2, or RUNX3) to form different versions of CBF; it allosterically enhances the sequence-specific DNA-binding capacity of RUNXAlso binds RUNX & binds with mitotic proteins MRLC3; allows for completion of cytokinesis Homo sapiens (human, a mammal)
418Glucose-6-phosphate isomerase, YeastGlycose-6-phosphate Isomerasecell wall-associating protein that is immunoreactive during fungal infectionCandida albicans (yeast, a fungi, can cause candiadiasis)
419Glutathione reductaseReductase ActivityBinding to plasma proteinsCandida albicans (yeast, a fungi, can cause candiadiasis)
420Integrin-like protein, Yeastinhibits opsonization and phagocytosis due to competition with CR3adhesin, contributes to significant increase in yeast cell adhesion to human epithelial and endothelial cellsCandida albicans (yeast, a fungi, can cause candiadiasis)
421VP40Interacts with cell membrane, when dimerNeeded for virus budding, when linear hexamerEbola virus (virus)
422Peroxiredoxin 6, RatPeroxiredoxin activity ChapteroneRattus norvegicus (Rat, mammal))
423Peroxiredoxin-5, Mouseperoxidase, thiol-dependentsignaling moleculeMus musculus (Mouse, mammal)
424POU domain, class 2, transcription factor 1 Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR.Interacts with BRCA1, binds PARP-1 and APC1Homo sapiens (human, a mammal)
425Peroxiredoxin 2; Prx2, Thioredoxin peroxidase; Thioredoxin peroxidase 2; gene: TPx-2Peroxiredoxinregulator of host Th2 modulated immune response when secretedSchistosoma mansoni, blook fluke
426Phosphotransferase, YeastphosphotransferaseBinding of Plasma ProteinsCandida albicans (yeast, a fungi, can cause candiadiasis)
427POU domain class 2 transcription factor 1, FrogTranscription factor that binds to an octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and histone H2B.Interacts with BRCA1, binds PARP-1 and APC1Xenopus laevis (African clawed frog)
428Anoctamin, Drosophila melanogasterCalcium activated chloride channelCaPLSase, Upon Ca2 binding, TMEM16F–CaPLSase mediates the rapid flip-flopping of phospholipids across cell membranes and thus dissipates the asymmetric distribution of membrane phospholipids. During platelet activation, TMEM16F–CaPLSase–induced phosphatidylserine (PS) externalization is essential for prothrombinase assembly, subsequent thrombin generation, and blood coagulationDrosophila melanogaster (fruit fly, an insect)
429Transaldolase, Yeasttransaldolase, Enzyme, second step of pentose-phosphate pathway; D-glyceraldehyde 3-phosphate + D-sedoheptulose 7-phosphate = beta-D-fructose 6-phosphate + D-erythrose 4-phosphatebinding to kininogen, binding to ECM proteins (Fibronectin, Laminin and Vitronectin)Candida tropicalis (yeast, a fungi)
430Transcriptional coactivator YAP1, HumanTranscriptional regulator; the downstream regulatory target in the Hippo signaling pathway that plays a role in organ size control and tumor suppression by restricting proliferation and promoting apoptosisBinds RUNX proteins, binds PATJ, in cytokinesis Homo sapiens (human, a mammal)
431Y-box-binding protein 1, HumanDNA and RNA binding,has roles in transcription, translation, and splicing, binds gamma-tubulin and PCNT Homo sapiens (human, a mammal)
432Superoxide dismutase 3, Yeastremoves radicals, 2 H+ + 2 superoxide = H2O2 + O2binds to 3 plasma proteins: high-molecular-mass kininogen (HK), factor XII (FXII) and prekallikrein (PPK)Candida albicans (yeast, a fungi, can cause candiadiasis)
433Thioredoxin peroxidase, Fasciola hepaticaThioredoxin peroxidase, protection against ROS, antioxidant, oxidoreductasecytokine, Regulates alternative activation of macrophages, inducing Th2 response Fasciola hepatica
434Adenine nucleotide translocator 1, Mouseadenine nucleotide translocator, ADP/ATP exchanger, mitochondriaInteracts with TIM44 protein and affects the activity of the TIM23 complexMus musculus (Mouse, mammal)
435Adenine nucleotide translocator 1, Humanadenine nucleotide translocator, ADP/ATP exchanger, mitochondriaInteracts with TIM44 protein and affects the activity of the TIM23 complexHomo sapiens (human, a mammal)
436Heat shock protein SSA2, YeastChaperone; helps adapt to temperature variations Binds HTN3/histatin-5, a peptide from human salivaCandida albicans (yeast, a fungi)
4372-cys peroxiredoxin, Schistosoma mansoniperoxidase (Sm-Prxl-LMW), thioredoxin-dependent peroxidase in the absence of oxidative stress, uses redox-active cysteine to reduce H2O2chaperone, ATP-independent holdases at high hydrogen peroxide concentrations, prevent protein aggregation by quarantining client proteinsSchistosoma mansoni(Blood fluke), human parasite
438Fructose-bisphosphate aldolase, Candida tropicalis Glycolytic enzyme; fructose bisphosphate aldolasebinds fibronectin, vitronectin, and lamininCandida tropicalis (yeast, a fungi)
439Enolase 1, Candida tropicalis Enolase 1 ECM protein binding (fibronectin, vitronectin and laminin)Candida tropicalis (yeast, a fungi)
440Wilms tumor proteinTranscription factor, binds DNAbinds MAD2, without it see Accelerated metaphase-to-anaphase transition; defective chromosome segregationHomo sapiens (human, a mammal)
441 IIH helicase subunit XPBATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complexbinds gamma-tubulinHomo sapiens (human, a mammal)
442KAT8 regulatory NSL complex subunit 1part of the NSL complex, which acetylates nucleosomal histone H4 on lysine residuesKANSL1 and KANSL3 bind MT minus ends, also bind TPX2, MCAKHomo sapiens (human, a mammal)
443KAT8 regulatory NSL complex subunit 3part of the NSL complex, which acetylates nucleosomal histone H4 on lysine residuesKANSL1 and KANSL3 bind MT minus ends, also bind TPX2, MCAKHomo sapiens (human, a mammal)
444Microspherule protein 1part of the NSL complex, which acetylates nucleosomal histone H4 on lysine residuescomponent of KANSL complex located at Spindle poles; KANSL1 and KANSL3 bind MT minus endsHomo sapiens (human, a mammal)
445WD repeat-containing protein 5part of the MLL1/MLL complex, which methylates and dimethylates lysine 4 of histone H3binds to KIF2A, PRC1, MKLP1, CYK4, and CEP55Homo sapiens (human, a mammal)
446Pre-mRNA-splicing factor SPF27component of spliceosome, conserved Prp19 (pre-RNA processing 19) complex is required for pre-mRNA splicing in eukaryotic nucleiwithout it see Defective chromatin-MT interaction; morphologically abnormal spindles in Xenopus egg extractsXenopus tropicalis (Western clawed frog) (Silurana tropicalis)
453Transglutaminase-2, MouseTransglutaminase (catalyze protein crosslinking via transamidation of glutamine residues to lysine residues in a Ca2+-dependent manner)GTPase, GTP binding proteinMus musculus (Mouse, mammal)
448Peroxiredoxin, Fasciola hepatica Peroxiredoxin, antioxidant activity, reduction of H2O2, protection from ROScytokine, Induces expression and production of Ym1 in macrophages, promotes polarization of Th2 responseFasciola hepatica
503LD47455pcomponent of spliceosomebinds Ndc80, Mitch, and Nuf2 (Ndc80 complex) without it see Reduced accumulation of Ndc80 at kinetochores and severe defects in chromosome alignment Drosophila melanogaster (fruit fly, an insect)
451Matrix metalloproteinase-3, RatMetalloprotease (degrades fibronectin, gelatin, proteoglycans, denatured type I collagen, laminin, and other extracellular matrix components)transcription factor Rattus norvegicus (Rat, mammal)
504Pre-mRNA-processing factor 31component of spliceosomebinds Ndc80, Mitch, and Nuf2 (Ndc80 complex) without it see Reduced accumulation of Ndc80 at kinetochores and severe defects in chromosome alignmentDrosophila melanogaster (fruit fly, an insect)
452Transglutaminase-2, HumanTransglutaminase (catalyze protein crosslinking via transamidation of glutamine residues to lysine residues in a Ca2+-dependent manner) GTPase, GTP binding proteinHomo sapiens (human, a mammal)
501Splicing factor 3A subunit 2pre-mRNA splicing, a component of the splicing factor SF3A complexbinds Ndc80/HEC1, without it see Morphologically irregular spindles; defective chromosome congression at metaphaseHomo sapiens (human, a mammal)
449Matrix metalloproteinase-3, MouseMetalloprotease (degrades fibronectin, gelatin, proteoglycans, denatured type I collagen, laminin, and other extracellular matrix components)transcription factorMus musculus (Mouse, mammal)
502U4/U6 small nuclear ribonucleoprotein Prp31component of the spliceosomebinds Ndc80/HEC1, without it see Morphologically irregular spindles; defective chromosome congression at metaphaseHomo sapiens (human, a mammal)
450Matrix metalloproteinase-3, HumanMetalloprotease (degrades fibronectin, gelatin, proteoglycans, denatured type I collagen, laminin, and other extracellular matrix components)transcription factorHomo sapiens (human, a mammal)
454Protease 7, E coliProteaseAdhesin to human cellsEscherichia coli (Gram negative bacterium)
455L-asparaginase 2 , E. Coliasparaginaseinhibits T-lymphocyte proliferationEscherichia coli (Gram negative bacterium)
457GroEL chaperoneBinds mucinBifidobacterium longum (strain NCC 2705) (Gram positive bacterium)
456PhosphoketolasePhosphoketolaseBinds mucinBifidobacterium longum (strain NCC 2705) (Gram positive bacterium)
458EF-Tu, Bifidobacterium longumelognation factorbinds mucinBifidobacterium longum (strain NCC 2705) (Gram positive bacterium)
459phosphoglycerate kinase, Bifidobacterium longumPhosphoglycerate kinase. This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.binds mucinBifidobacterium longum (strain NCC 2705) (Gram positive bacterium)
469phosphoglucosamine mutase, Listeriaphosphoglucosamine mutase. Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate.Forms a complex with CdaA and inhibits the diadenylate cyclaseactivity.Listeria monocytogenes (Gram positive bacterium, causes listeriosis, septicemia, meningitis)
460Transaldolase, bifidobacterium longumTransferase. Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.Binds mucinBifidobacterium longum (strain NCC 2705) (Gram positive bacterium)
461Heat shock protein, Bifidobacterium longumheat shock proteinbinds mucinBifidobacterium longum (strain NCC 2705) (Gram positive bacterium)
462Probable 23S rRNA methyltransferase Erm23S rRNA Methyltransferase. The 179-amino-acid long protein deduced from Rv1988 presents similarity with the Erm protein family, members of which confer macrolide, lincosamide, streptogramin B resistance by methylation of the 23S rRNA at a highly conserved adenine nucleotide (A2058 [E. coli numbering]). Dimethylates arginine 42 of histone H3 in host cellsMycobacterium tuberculosis (mycobacterium, causes tuberculosis)
463glyceraldehyde-3-phosphate dehydrogenase, Arabidopsis thalianaglyceraldehyde-3-phosphate dehydrogenaseBinds NF-YC10 (nuclear factor Y subunit C10). GAPC interacts with a transcription factor to promote the expression of heat-inducible genes and heat tolerance in Arabidopsis. Screening of Arabidopsis transcription factors identifies nuclear factor Y subunit C10 (NF-YC10) as a GAPC-binding protein.Arabidopsis thaliana (Mouse-ear cress, a plant)
464Intraflagellar transport protein 88 homolog, MusMouse ciliary protein. Involved in primary cilium biogenesis.regulates NFkappaB signalingMus musculus (Mouse, mammal)
465Kinesin-like protein KIF3A, MouseMouse ciliary protein.regulates NFkappaB signalingMus musculus (Mouse, mammal)
466Tau-tubulin kinase 2, MusMouse ciliary protein. Serine/threonine kinase that acts as a key regulator of ciliogenesis.regulates NFkappaB signalingMus musculus (Mouse, mammal)
467Nephrocystin-4, MouseMouse ciliary protien. Required for building functional cilia.regulates NFkappaB signalingMus musculus (Mouse, mammal)
468Phosphoinositide-3-kinase catalytic gamma polypeptide, Mousephosphoinositide 3-kinaseregulator of phosphodiesterase 4, a non-catalytic functionMus musculus (Mouse, mammal)
474Arogenate dehydratase 5Arogenate dehydratase.transcriptional regulator.Arabidopsis thaliana (Mouse-ear cress, a plant)
475Developmental protein eyes absenttranscriptional coactivator.tyrosine phosphataseDrosophila melanogaster (fruit fly, an insect)
476Threonine phosphatasetranscription factorphosphataseNicotiana tabacum (Common tobacco, a plant)
477DNA protection during starvation proteinferritinDNA binding protein.Campylobacter jejuni
478Riboflavin kinaseCTP-dependent riboflavin kinaseDNA binding protein. Transcriptional regulator of riboflavin metabolism, PF12802 archael.Metallosphaera yellowstonensis MK1
479Riboflavin kinase, Pyrobaculum yellowstonensis WP30CTP-dependent riboflavin kinaseDNA binding protein. Transcriptional regulator of riboflavin metabolism, PF12802 archael.Pyrobaculum yellowstonensis WP30
480NAD-dependent protein deacetylase Sir2.1, C. Elegansdeacetylase transcription regulationCaenorhabditis elegans
481NAD-dependent protein deacetylase Sir1deacetylase transcription regulationHomo sapiens (Human)
482PARP-1, Humanpoly[ADP-ribose]polymerase 1Transcription factorHomo sapiens (Human)
483PARP-1, Mousepoly[ADP-ribose]polymerase 1Transcription factorMus musculus
484DNA apurinic endonuclease, HumanDNA repair redox regulation of transcriptional factorsHomo sapiens (Human)
485DNA apurinic endonuclease, RatDNA repairredox regulation of transcriptional factorsRattus norvegicus (Rat)
486Bifunctional NAD(P)H-hydrate repair enzymecatalyzes the epimerization of the S- and R-forms of NAD(P)HXcatalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMPMetallosphaera yellowstonensis MK1
487FMN adenylyltransferaseCatalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FADCorynebacterium ammoniagenes (Brevibacterium ammoniagenes)Corynebacterium ammoniagenes (Brevibacterium ammoniagenes)
488FMN adenylyltransferaseCatalyzes the phosphorylation of riboflavin to FMN followed by the adenylation of FMN to FADFMN adenylyltransferaseMycoplasma gallisepticum
489Riboflavin biosynthesis protein, E ColiRibD diaminohydroxyphosphoribosylaminopyrimidine deaminase 5-amino-6-(5-phosphoribosylamino)uracil reductase Escherichia coli (strain K12)
490Asparaginyl endopeptidase 2 Asparaginyl endopeptidases (AEPs), N-terminal excisionC-terminal cyclization of cyclotide precursorsMomordica cochinchinensis (Spiny bitter cucumber) (Muricia cochinchinensis)
491FMN adenylyltransferase, E ColiATP-dependent riboflavin kinaseFAD synthetaseEscherichia coli (strain K12)
492Bifunctional riboflavin kinaseBifunctional riboflavin kinaseFMN adenylyltransferaseBacillus subtilis (strain 168)
493Riboflavin biosynthesis protein RibD deaminasereductaseBacillus subtilis (strain 168)
494Tudor-interacting repair regulator protein Syndesmos, interacts with p53 binding protein 1 (53BP1) and regulates its recruitment to chromatin. Binds RNAHomo sapiens (Human)
495Mevalonate kinase Mevalonate kinaseSecreted and modulates cell invasion, binds to receptorTrypanosoma cruzi (strain CL Brener)
496Calgranulin-Bbinds to receptor, amplifies inflammation via Toll-like receptor four TLR4.part of a heterocomplex with S100A8 to drive inflammation, antimicrobialHomo sapiens (Human)
497S100 calcium-binding protein A9binds toToll-like receptor four TLR4, amplifies inflammationpart of a heterocomplex with S100A8 to drive inflammation, antimicrobialMus musculus (Mouse)
498Glyceraldehyde-3-phosphate dehydrogenase Aglyceraldehyde-3-phosphate dehydrogenasethiol-disulfide exchange with CP12Chlamydomonas reinhardtii (Chlamydomonas smithii)
499Cell division protein YtfB Cell division proteinadhesinEscherichia coli (strain K12)
500Asparaginyl endopeptidase 2 Asparaginyl endopeptidasecyclaseMomordica cochinchinensis (Spiny bitter cucumber) (Muricia cochinchinensis)
505Citrate synthase CitAcitrate synthasecell cycle control (enzyme function not needed)Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus)
506Fibroblast growth factor 2 fibroblast growth factor, binds receptormediates phosphorylation of ERK1/2Homo sapiens (Human)
507Phosphoinositide phospholipase C-beta-1phospholipaseinhibit protein translationHomo sapiens (Human)
508Large tumor suppressor homolog 1kinasescaffold function.Homo sapiens (Human)
509Interleukin-1 alpha, Humanbinds receptor, A cytokine of the interleukin 1 family. It can stimulate thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity.Regulation of transcription. The precursor form of IL-1 alphais an intracrine proinflammatory activator of transcription.Homo sapiens (Human)
510 Fibroblast growth factor 1, Human growth factornuclear anti-apoptotic factorHomo sapiens (Human)
511Aminoacyl tRNA synthase complex-interacting multifunctional protein 1 a proinflammatory cytokine.Non-catalytic component of tRNA multisynthetase complex in protein translation. Stimulates the catalytic activity of cytoplasmic arginyl-tRNA synthase.Homo sapiens (Human)
512High mobility group protein 1One of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability.In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Homo sapiens (Human)