Publications

Moonprot Database original release article:

Chen, C., Zabad, S., Liu, H., Wang, W., & Jeffery, C. (2017). MoonProt 2.0: an expansion and update of the moonlighting proteins database. Nucleic acids research46(D1), D640-D644. PMID: 29126295

Mani, M., Chen, C., Amblee, V., Liu, H., Mathur, T., Zwicke, G., … & Jeffery, C. J. (2014). MoonProt: a database for proteins that are known to moonlight. Nucleic acids research43(D1), D277-D282. PMID: 25324305

Review Articles about Moonlighting Proteins:

Jeffery, C. J. (2017). What is Protein Moonlighting and Why is it Important?. Moonlighting Proteins: Novel Virulence Factors in Bacterial Infections, 1-19. PMID: 29203708

Wang, W., & Jeffery, C. J. (2016). An analysis of surface proteomics results reveals novel candidates for intracellular/surface moonlighting proteins in bacteria. Molecular BioSystems12(5), 1420-1431. PMID: 26938107

Jeffery, C. J. (2015). Why study moonlighting proteins?. Frontiers in genetics6. PMID: 26150826

Jeffery, C. J. (2014). An introduction to protein moonlighting. PMID: 25399589

Guo M, Schimmel P. (2013) Essential nontranslational functions of tRNA synthetases. Nat Chem Biol., 9,145-53. PMID: 23416400

Jia B, Cheong GW, Zhang S. (2013) Multifunctional enzymes in archaea: promiscuity and moonlight. Extremophiles. 17(2):193-203. doi: 10.1007/s00792-012-0509-1. PMID: 23283522

Henderson B, Martin A. (2013) Bacterial moonlighting proteins and bacterial virulence. Curr Top Microbiol Immunol. 358:155-213. doi: 10.1007/82_2011_188. PMID: 22143554

Henderson B, Martin A. (2011) Bacterial virulence in the moonlight: multitasking bacterial moonlighting proteins are virulence determinants in infectious disease. Infect Immun. 79(9):3476-91. doi: 10.1128/IAI.00179-11. PMID: 21646455

Jeffery CJ. (2011) Proteins with neomorphic moonlighting functions in disease. IUBMB Life.;63(7):489-94. doi: 10.1002/iub.504. PMID: 21698752

Huberts DH, van der Klei IJ. (2010) Moonlighting proteins: an intriguing mode of multitasking. Biochim Biophys Acta. 1803(4):520-5. doi: 10.1016/j.bbamcr.2010.01.022. PMID: 20144902

Henderson B, Pockley AG. (2010) Molecular chaperones and protein-folding catalysts as intercellular signaling regulators in immunity and inflammation. J Leukoc Biol. 88(3):445-62. doi: 10.1189/jlb.1209779. PMID: 20445014

Henderson B, Lund PA, Coates AR. (2010) Multiple moonlighting functions of mycobacterial molecular chaperones. Tuberculosis (Edinb). 90(2):119-24. doi: 10.1016/j.tube.2010.01.004. PMID: 20338810

Collingridge PW, Brown RW, Ginger ML. (2010) Moonlighting enzymes in parasitic protozoa. Parasitology.137(9):1467-75. doi: 10.1017/S0031182010000259. PMID: 20233494

Jeffery CJ. (2009) Moonlighting proteins–an update. Mol Biosyst. 5(4):345-50. PMID: 19396370

Radisky DC, Stallings-Mann M, Hirai Y, Bissell MJ. (2009) Single proteins might have dual but related functions in intracellular and extracellular microenvironments. Nat Rev Mol Cell Biol. 10(3):228-34. doi: 10.1038/nrm2633. PMID: 19190671

Gancedo,C. and Flores,C.L. (2008) Moonlighting proteins in yeasts. Microbiol. Mol. Biol. Rev., 72, 197–210. PMID: 18322039

Commichau FM, Stülke J. (2008) Trigger enzymes: bifunctional proteins active in metabolism and in controlling gene expression. Mol Microbiol. 67(4):692-702. PMID: 18086213

Piatigorsky,J. (2007) Gene Sharing and Evolution. Harvard University Press, Cambridge, MA.

Jeffery, C. J. (2005) Mass Spectrometry and the Search for Moonlighting Proteins. Mass Spectrometry Reviews. 24:772-82. PMID: 15605385

Tompa P, Szász C, Buday L. (2005) Structural disorder throws new light on moonlighting. Trends Biochem Sci. 30(9):484-9. PMID: 16054818

Jeffery, C. J. (2005) Moonlighting Proteins: Proteins with Multiple Functions. In The Extracellular Biology of Molecular Chaperones. Edited by Brian Henderson and A. Graham Pockley. Cambridge University Press. New York. Pp. 61-77.

Kim JW, Dang CV. (2005) Multifaceted roles of glycolytic enzymes. Trends Biochem Sci. 30(3):142-50. PMID: 15752986

Jeffery CJ. (2004) Molecular mechanisms for multitasking: recent crystal structures of moonlighting proteins. Curr Opin Struct Biol. 14(6):663-8. PMID: 15582389

Jeffery, C. J. (2004) Moonlighting Proteins: Complications and Implications for Proteomics Research. Drug Discovery Today Targets. 3: 71-78. DOI: 10.1016/S1741-8372(04)02405-3

Copley SD. (2003) Enzymes with extra talents: moonlighting functions and catalytic promiscuity. Curr Opin Chem Biol. 7(2):265-72. PMID: 12714060

Jeffery CJ. (2003) Moonlighting proteins: old proteins learning new tricks. Trends Genet. 19(8):415-7. PMID: 12902157

Piatigorsky, J. (2003) Crystallin genes: specialization by changes in gene regulation may precede gene duplication. J. Struct. Funct. Genomics 3, 131–137. PMID: 12836692

Jeffery CJ. (2003) Multifunctional proteins: examples of gene sharing. Ann Med. 35(1):28-35. PMID: 12693610

Jeffery CJ, Bahnson BJ, Chien W, Ringe D, Petsko GA. (2000) Crystal structure of rabbit phosphoglucose isomerase, a glycolytic enzyme that moonlights as neuroleukin, autocrine motility factor, and differentiation mediator. Biochemistry. 39(5):955-64. PMID: 10653639

Jeffery CJ. (1999) Moonlighting proteins. Trends Biochem Sci. 24(1):8-11. PMID: 10087914

Piatigorsky, J. (1998) Multifunctional lens crystallins and corneal enzymes. More than meets the eye. Ann. N. Y. Acad. Sci. 842, 7–15. PMID: 9599288

Nobeli,I., Favia,A.D. Wool,I.G. (1996) Extraribosomal functions of ribosomal proteins. Trends Biochem. Sci., 21, 164–165.

Wistow, G. and Kim, H. (1991) Lens protein expression in mammals: taxon-specificity and the recruitment of crystallins. J. Mol. Evol. 32, 262–269. PMID: 1904503

Piatigorsky J, Wistow GJ. (1989) Enzyme/crystallins: gene sharing as an evolutionary strategy. Cell. 57(2):197-9. PMID: 2649248