General Information |
MoonProt ID | 143 |
First appeared in release | 1.0 |
Name(s) | citrate synthase |
UniProt ID | I7MG78 |
GO terms | GO:0006099 tricarboxylic acid cycle
GO:0044262 cellular carbohydrate metabolic process
GO:0016740 transferase activity
GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer |
Organisms for which functions have been demonstrated | Tetrahymena thermophila |
Sequence length | 474 |
FASTA sequence | >tr|I7MG78|I7MG78_TETTS Citrate synthase OS=Tetrahymena thermophila (strain SB210) GN=TTHERM_00318570 PE=3 SV=1
MRKQIINCKRLYHQNQYFFNPKADLKTVLREQIPIKIQGFNEMKKKYGDRVMGEITVNQALGGMRGIRALFYDQSTVDPIDGVMFRGYSIPELHELLPKLRKPSAEDFQSDQQPLPEGLFFLLLTGELPSYHQVELIRHEWDVRGKVSDELINFINRLDNKMHPMTMLSLAILYEQKTSKFAQLYNESKLNKSNYWEYTYEDSVDLIAKLPRIAATIYRKKFKDGKPIAHKDGLDWSAQLAHMMGFEGQETLNELLRAFLTIHADHEGGEVSTHASHLVGSALGDPYLCMTTAYTGLAGPLHGLANQEVLKWILNFVEVHGYDVTNRQIEDYVNTTVLSGRLVPGYGHAVLRRPDPRFLHLYDFGNKYLRDNEMIRLLHQMTDVIPRRLRTFKNISSPYPNVDCHSGALLYQLGIQEYQFYTVLFAISRSIGCLTNLVWCRAFGLPIERPESADLAYYNNLFQNKIPKQEKDDQ |
Structure Information |
PDB ID | Closest homologue in PDB is from Sus scrofa with 45.12% amino acid sequence identity; 90% query cover |
Quaternary structure | |
SCOP | NA |
CATH | NA |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | 1 to 16, 104-110, 187-190, 463-474 |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | citrate synthase, enzyme
acetyl-CoA + oxaloacetate + H2O => citrate + CoA-SH
Citric acid cycle |
References for function | |
E.C. number | 2.3.3.1 |
Location of functional site(s) | |
Cellular location of function | |
Comments | |
Function 2 |
Function description | 14-nm cytoskeletal protein |
References for function | Numata O. Multifunctional proteins in Tetrahymena: 14-nm filament protein/citrate synthase and translation elongation factor-1 alpha. Int Rev Cytol. 1996 0. PMID: 8575889 |
E.C. number | N.A |
Location of functional site(s) | |
Cellular location of function | cytosol, cytoskeleton |
Comments | |