| General Information |
| MoonProt ID | 514 |
| First appeared in release | 4.0 |
| Name(s) | Transferrin |
| UniProt ID | H2F490 |
| GO terms | GO:0005615 extracellular space |
| Organisms for which functions have been demonstrated | Periplaneta americana |
| Sequence length | 714 amino acids |
| FASTA sequence | >tr|H2F490|H2F490_PERAM Transferrin OS=Periplaneta americana OX=6978 PE=2 SV=1
MSKLSLLLLLQLPAALLLAIPTPHVYKVCVPDGALNDCEQMASETALHMHCVPARDRTACLDKIQHHDADFVPVDPEDIFLASKITNQSFIVFKEIRTKEEPDEEFRYEAVAVIHKNQNITSVQGLRGLKSCHTGVGRNVGYKIPITKLRKMGVLTNLNDPDMTPRENELHALSQLFSKACLVGKWAPDPAQNQALKERYPNLCALCEHPEQCDYPDKYSGYDGALRCLAENGGEVAWTKVYYVKKHFGLPIGAGEAVPTGEDPDNYAFLCPDGTKKPITGRPCIWAARPWQGYITNTDVEDMSELRSQISLADNIGETEHAAWLSKVLDLNNKTVAVDNGGPFSPQQYLDKANYTDVIERDTGDPHRPVRFCVTSDTELEKCHVLRRAAFSRDIRPAFDCVQESTNQDCMATVRDNGADVITLDGGDVFTAMREYNLKPIIAEQYGEHGSMYYAVAVVKKSSSYQSIADLRGAKSCHTGYGRTAGWNVPLYLLLNQSLISRTSCPYSEAVSTFFSGGSCVPGVPHGPELLCSLCAGNLDTGDRTYACSASNNESFFGYTGAFRCLASGAGDVAFVKHTTVAENTDGNNTAAWAAGLHSSDFELLCPNGGRAPVEQYSRCHLAEVPPHMVVTSNDKSDNVLNEIRHAVLAAGDLYSRRPDLFKLFGDFDGTKDLLFKNSATGLRAVDTGTPVMQHYTEMLDVIRTCENQTPAQE |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | NA |
| SCOP | |
| CATH | |
| TM Helix Prediction | |
| DisProt Annotation | |
| Predicted Disorder Regions | |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Iron transport |
| References for function | 1. Geiser, D. L., & Winzerling, J. J. (2012). Insect transferrins: multifunctional proteins. Biochimica et biophysica acta, 1820(3), 437–451. https://doi.org/10.1016/j.bbagen.2011.07.011 2. Najera, D. G., Dittmer, N. T., Weber, J. J., Kanost, M. R., & Gorman, M. J. (2021). Phylogenetic and sequence analyses of insect transferrins suggest that only transferrin 1 has a role in iron homeostasis. Insect science, 28(2), 495–508. https://doi.org/10.1111/1744-7917.12783 3. Xiao, G., Liu, Z.-H., Zhao, M., Wang, H.-L., & Zhou, B. (2019). Transferrin 1 Functions in Iron Trafficking and Genetically Interacts with Ferritin in Drosophila melanogaster. Cell Reports, 26(3), 748–758.e5. doi:10.1016/j.celrep.2018.12.053 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | Extracellular space of cell |
| Comments | |
| Function 2 |
| Function description | Antibacterial and Antiviral action |
| References for function | 1. Sagar S, Javle V. R. K, Chunduri J. R. In Silico Modelling of Antibacterial Protein Transferrin from Periplaneta americana and its Interaction Analysis with Membrane Protein of MRSA. Biosc.Biotech.Res.Comm. 2020;13(2). DOI: http://dx.doi.org/10.21786/bbrc/13.2/42
2.Siddharth Sagar, Jayaprada Rao Chunduri and Vyomesh Javle (2020); AN ASSESSMENT OF THE INTERACTION BETWEEN INSECT BRAIN PROTEIN AND NON-STRUCTURAL PROTEIN OF CORONAVIRUS USING IN-SILICO ANALYSES Int. J. of Adv. Res. 8 (May). 436-452. DOI URL: http://dx.doi.org/10.21474/IJAR01/10945 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | Extracellular space |
| Comments | |