| General Information |
| MoonProt ID | 1 |
| First appeared in release | 4.0 |
| Name(s) | L-lactate dehydrogenase, ldh |
| UniProt ID | P78007 |
| GO terms | GO:0003824 catalytic activity, GO:0004459 L-lactate dehydrogenase (NAD+) activity, GO:0005515 protein binding, GO:0016491 oxidoreductase activity, GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor, GO:0006089 lactate metabolic process, GO:0006096 glycolytic process, GO:0019752 carboxylic acid metabolic process, GO:0005737 cytoplasm, GO:0016020 membrane |
| Organisms for which functions have been demonstrated | Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1) (Mycoplasmoides pneumoniae) Mycoplasma pneumoniae, a human pathogen known for causing Mycoplasma pnuemonia, major cause of community acquires respiratory infections |
| Sequence length | 312.0 |
| FASTA sequence | >sp|P78007|LDH_MYCPN L-lactate dehydrogenase OS=Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1) OX=272634 GN=ldh PE=1 SV=1 MKSLKVALIGSGAVGTSFLYAAMSRGLASEYMVIDINEKSQVGNVFDLQDAVPSSPQYSK VIAGDYKQLKDYDFIFIGAGRPQKQGGETRLQLLEGNVEIMKNIAKAVKESGFKGITLIA SNPVDIMAYTYLKVTGFEPNKVIGSGTLLDSARLKFAIAEKYGMSSRDVQAYVLGEHGDS SVSIISSAKIAGLPLKHFSKASDIEKEFAEIDHFIRRRAYEIIERKGATFYGIGEATAEV AELILRDTKEVRVVASLINGQYGAKDVMFGTPCVLGRNGVEKILEIELSATEKAGLDKSI QVLKDNIKLAKL |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | Homotetramer |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | entries not found |
| Predicted Disorder Regions | N-terminus AA 1-3, 310-312 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enzyme, lactate dehydrogenase |
| References for function | Gründel A, Jacobs E, Dumke R. Interactions of surface-displayed glycolytic enzymes of Mycoplasma pneumoniae with components of the human extracellular matrix. Int J Med Microbiol. 2016 Dec;306(8):675-685. doi: 10.1016/j.ijmm.2016.09.001. Epub 2016 Sep 3. PMID: 27616280. |
| E.C. number | EC:1.1.1.27 |
| Location of functional site(s) | |
| Cellular location of function | cytosol |
| Comments | |
| Function 2 |
| Function description | adhesin, binds host ECM, binds laminin, vitronectin, fibrinogen, |
| References for function | Gründel A, Jacobs E, Dumke R. Interactions of surface-displayed glycolytic enzymes of Mycoplasma pneumoniae with components of the human extracellular matrix. Int J Med Microbiol. 2016 Dec;306(8):675-685. doi: 10.1016/j.ijmm.2016.09.001. Epub 2016 Sep 3. PMID: 27616280. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |