| General Information |
| MoonProt ID | 100 |
| First appeared in release | 1.0 |
| Name(s) | Triose phosphate isomerase
TIM
Triose-phosphate isomerase
tpiA
Gene Name: tpi
|
| UniProt ID | Q6GIL6 |
| GO terms | GO:0006094 gluconeogenesis
GO:0006096 glycolysis
GO:0006098 pentose-phosphate shunt
GO:0008152 metabolic process
GO:0003824 catalytic activity
GO:0004807 triose-phosphate isomerase activity
GO:0016853 isomerase activity
GO:0005737 cytoplasm |
| Organisms for which functions have been demonstrated | Staphylococcus aureus (Gram positive bacterium, causes staph infections, abcesses/boils) |
| Sequence length | 253 aa |
| FASTA sequence | >sp|Q6GIL6|TPIS_STAAR Triosephosphate isomerase OS=Staphylococcus aureus (strain MRSA252) GN=tpiA PE=1 SV=1
MRTPIIAGNWKMNKTVQEAKDFVNALPTLPDSKEVESVICAPAIQLDALTTAVKEGKAQGLEIGAQNTYFEDNGAFTGETSPVALADLGVKYVVIGHSERRELFHETDEEINKKAHAIFKHGMTPIICVGETDEERESGKANDVVGEQVKKAVAGLSEDQLKSVVIAYEPIWAIGTGKSSTSEDANEMCAFVRQTIADLSSKEVSEATRIQYGGSVKPNNIKEYMAQTDIDGALVGGASLKVEDFVQLLEGAK
|
| Structure Information |
| PDB ID | 3M9Y 3UWU 3UWV 3UWW 3UWZ |
| Quaternary structure | |
| SCOP | TIM beta/alpha-barrel |
| CATH | 3.20.20.70 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Triose phosphate isomerase, enzyme
D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate
Carbohydrate degradation, glycolysis
Carbohydrate biosynthesis, gluconeogenesis
|
| References for function | |
| E.C. number | 5.3.1.1 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | adhesin, contact-mediated killing of Cryptococcus |
| References for function | Yamaguchi M, Ikeda R, Nishimura M, Kawamoto S. Localization by scanning immunoelectron microscopy of triosephosphate isomerase, the molecules responsible for contact-mediated killing of Cryptococcus, on the surface of Staphylococcus. Microbiol Immunol. 2010 Jun. PMID: 20536736 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |