| General Information |
| MoonProt ID | 11 |
| First appeared in release | 1.0 |
| Name(s) | 40S ribosomal protein S3
Gene Name:RPS3 |
| UniProt ID | P23396 (RS3_HUMAN), Reviewed |
| GO terms | GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000737 DNA catabolic process, endonucleolytic
GO:0002181 cytoplasmic translation
GO:0006412 translation
GO:0006413 translational initiation
GO:0006414 translational elongation
GO:0006415 translational termination
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0006974 cellular response to DNA damage stimulus
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0019058 viral life cycle
GO:0019083 viral transcription
GO:0044267 cellular protein metabolic process
GO:0045738 negative regulation of DNA repair
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:1902546 positive regulation of DNA N-glycosylase activity GO:2001235 positive regulation of apoptotic signaling pathway
GO:0003684 damaged DNA binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0003735 structural constituent of ribosome
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity GO:0004519 endonuclease activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0044822 poly(A) RNA binding
GO:0051018 protein kinase A binding
GO:0051059 NF-kappaB binding
GO:0051536 iron-sulfur cluster binding
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015935 small ribosomal subunit
GO:0022627 cytosolic small ribosomal subunit
GO:0030529 ribonucleoprotein complex
GO:0032587 ruffle membrane
GO:0070062 extracellular vesicular exosome
colocalizes_with GO:0071159 NF-kappaB complex |
| Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal, OMIM number 600454 ) |
| Sequence length | 243 |
| FASTA sequence | >sp|P23396|RS3_HUMAN 40S ribosomal protein S3 OS=Homo sapiens GN=RPS3 PE=1 SV=2
MAVQISKKRKFVADGIFKAELNEFLTRELAEDGYSGVEVRVTPTRTEIIILATRTQNVLGEKGRRIRELTAVVQKRFGFPEGSVELYAEKVATRGLCAIAQAESLRYKLLGGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRGQRAKSMKFVDGLMIHSGDPVNYYVDTAVRHVLLRQGVLGIKVKIMLPWDPTGKIGPKKPLPDHVSIVEPKDEILPTTPISEQKGGKPEPPAMPQPVPTA |
| Structure Information |
| PDB ID | 2ZKQ, 3J3A,
4KZX,
4KZY,
4KZZ |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1 to 4, 215-243 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | ribosomal protein, part of the 40S subunit |
| References for function | |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | a subunit of a DNA binding complex involved in NF-kappaB-mediated transcription |
| References for function | Wan F, Anderson DE, Barnitz RA, Snow A, Bidere N, Zheng L, Hegde V, Lam LT, Staudt LM, Levens D, Deutsch WA, Lenardo MJ. Ribosomal protein S3: a KH domain subunit in NF-kappaB complexes that mediates selective gene regulation. Cell. 2007 Nov 30. PMID: 18045535 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm, nucleus |
| Comments | |