General Information |
MoonProt ID | 111 |
First appeared in release | 1.0 |
Name(s) | aconitase
Aconitate hydratase
Homocitrate dehydratase
Aconitase 2
Gene Name: ACO2
|
UniProt ID | P39533 (ACON2_YEAST), Reviewed |
GO terms | GO:0006099 tricarboxylic acid cycle
GO:0008150 biological_process
GO:0008152 metabolic process
GO:0008652 cellular amino acid biosynthetic process
GO:0009085 lysine biosynthetic process
GO:0019878 lysine biosynthetic process via aminoadipic acid
GO:0003994 aconitate hydratase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0005739 mitochondrion |
Organisms for which functions have been demonstrated | Saccharomyces cerevisiae |
Sequence length | 789 |
FASTA sequence | >sp|P39533|ACON2_YEAST Homocitrate dehydratase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ACO2 PE=1 SV=1
MLSSANRFYIKRHLATHANMFPSVSKNFQTKVPPYAKLLTNLDKIKQITNNAPLTLAEKILYSHLCDPEESITSSDLSTIRGNKYLKLNPDRVAMQDASAQMALLQFMTTGLNQTSVPASIHCDHLIVGKDGETKDLPSSIATNQEVFDFLESCAKRYGIQFWGPGSGIIHQIVLENFSAPGLMMLGTDSHTPNAGGLGAIAIGVGGADAVDALTGTPWELKAPKILGVKLTGKLNGWSTPKDVITKLAGLLTVRGGTGYIVEYFGEGVSTLSCTGMATICNMGAEIGATTSTFPYQEAHKRYLQATNRAEVAEAADVALNKFNFLRADKDAQYDKVIEIDLSAIEPHVNGPFTPDLSTPISQYAEKSLKENWPQKVSAGLIGSCTNSSYQDMSRVVDLVKQASKAGLKPRIPFFVTPGSEQIRATLERDGIIDIFQENGAKVLANACGPCIGQWNREDVSKTSKETNTIFTSFNRNFRARNDGNRNTMNFLTSPEIVTAMSYSGDAQFNPLTDSIKLPNGKDFKFQPPKGDELPKRGFEHGRDKFYPEMDPKPDSNVEIKVDPNSDRLQLLEPFKPWNGKELKTNVLLKVEGKCTTDHISAAGVWLKYKGHLENISYNTLIGAQNKETGEVNKAYDLDGTEYDIPGLMMKWKSDGRPWTVIAEHNYGEGSAREHAALSPRFLGGEILLVKSFARIHETNLKKQGVLPLTFANESDYDKISSGDVLETLNLVDMIAKDGNNGGEIDVKITKPNGESFTIKAKHTMSKDQIDFFKAGSAINYIGNIRRNE
|
Structure Information |
PDB ID | closest is Bos taurs at 54% amino acid sequence identity |
Quaternary structure | |
SCOP | NA |
CATH | NA |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | 1-11, 389-454, 722-725, 935-938 |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | aconitase, enzyme
Catalyzes the conversion of citrate to aconitate in the pathway for lysine biosynthesis.
Krebs cycle, Amino-acid biosynthesis, L-lysine biosynthesis |
References for function | |
E.C. number | EC=4.2.1.- |
Location of functional site(s) | |
Cellular location of function | mitochondrion |
Comments | |
Function 2 |
Function description | mitochondrial DNA maintenance
enzymatic activity and iron sulfur cluster are not needed for this role |
References for function | X.J. Chen, X. Wang, B.A. Kaufman, et al. (2005) Aconitase Couples Metabolic Regulation to Mitochondrial DNA maintenance. Science. 2005 Feb 4;307(5710):714-7.
PMID: 15692048 |
E.C. number | N/A |
Location of functional site(s) | |
Cellular location of function | mitochondrion |
Comments | |