| General Information |
| MoonProt ID | 111 |
| First appeared in release | 1.0 |
| Name(s) | aconitase
Aconitate hydratase
Homocitrate dehydratase
Aconitase 2
Gene Name: ACO2
|
| UniProt ID | P39533 (ACON2_YEAST), Reviewed |
| GO terms | GO:0006099 tricarboxylic acid cycle
GO:0008150 biological_process
GO:0008152 metabolic process
GO:0008652 cellular amino acid biosynthetic process
GO:0009085 lysine biosynthetic process
GO:0019878 lysine biosynthetic process via aminoadipic acid
GO:0003994 aconitate hydratase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
GO:0051539 4 iron, 4 sulfur cluster binding
GO:0005739 mitochondrion |
| Organisms for which functions have been demonstrated | Saccharomyces cerevisiae |
| Sequence length | 789 |
| FASTA sequence | >sp|P39533|ACON2_YEAST Homocitrate dehydratase, mitochondrial OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ACO2 PE=1 SV=1
MLSSANRFYIKRHLATHANMFPSVSKNFQTKVPPYAKLLTNLDKIKQITNNAPLTLAEKILYSHLCDPEESITSSDLSTIRGNKYLKLNPDRVAMQDASAQMALLQFMTTGLNQTSVPASIHCDHLIVGKDGETKDLPSSIATNQEVFDFLESCAKRYGIQFWGPGSGIIHQIVLENFSAPGLMMLGTDSHTPNAGGLGAIAIGVGGADAVDALTGTPWELKAPKILGVKLTGKLNGWSTPKDVITKLAGLLTVRGGTGYIVEYFGEGVSTLSCTGMATICNMGAEIGATTSTFPYQEAHKRYLQATNRAEVAEAADVALNKFNFLRADKDAQYDKVIEIDLSAIEPHVNGPFTPDLSTPISQYAEKSLKENWPQKVSAGLIGSCTNSSYQDMSRVVDLVKQASKAGLKPRIPFFVTPGSEQIRATLERDGIIDIFQENGAKVLANACGPCIGQWNREDVSKTSKETNTIFTSFNRNFRARNDGNRNTMNFLTSPEIVTAMSYSGDAQFNPLTDSIKLPNGKDFKFQPPKGDELPKRGFEHGRDKFYPEMDPKPDSNVEIKVDPNSDRLQLLEPFKPWNGKELKTNVLLKVEGKCTTDHISAAGVWLKYKGHLENISYNTLIGAQNKETGEVNKAYDLDGTEYDIPGLMMKWKSDGRPWTVIAEHNYGEGSAREHAALSPRFLGGEILLVKSFARIHETNLKKQGVLPLTFANESDYDKISSGDVLETLNLVDMIAKDGNNGGEIDVKITKPNGESFTIKAKHTMSKDQIDFFKAGSAINYIGNIRRNE
|
| Structure Information |
| PDB ID | closest is Bos taurs at 54% amino acid sequence identity |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-11, 389-454, 722-725, 935-938 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | aconitase, enzyme
Catalyzes the conversion of citrate to aconitate in the pathway for lysine biosynthesis.
Krebs cycle, Amino-acid biosynthesis, L-lysine biosynthesis |
| References for function | |
| E.C. number | EC=4.2.1.- |
| Location of functional site(s) | |
| Cellular location of function | mitochondrion |
| Comments | |
| Function 2 |
| Function description | mitochondrial DNA maintenance
enzymatic activity and iron sulfur cluster are not needed for this role |
| References for function | X.J. Chen, X. Wang, B.A. Kaufman, et al. (2005) Aconitase Couples Metabolic Regulation to Mitochondrial DNA maintenance. Science. 2005 Feb 4;307(5710):714-7.
PMID: 15692048 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | mitochondrion |
| Comments | |