| General Information |
| MoonProt ID | 118 |
| First appeared in release | 1.0 |
| Name(s) | Aldehyde dehydrogenase, cytosolic 1
ALDH class 1
eta-crystallin
Gene Name: ALDH1 |
| UniProt ID | Q28399 (ALDH1_ELEED) Reviewed |
| GO terms | GO:0006068 ethanol catabolic process
GO:0008152 metabolic process
GO:0055114 oxidation-reduction process
GO:0004029 aldehyde dehydrogenase (NAD) activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0005737 cytoplasm
|
| Organisms for which functions have been demonstrated | Elephantus edwardii (elephant shrew) |
| Sequence length | 501 |
| FASTA sequence | >sp|Q28399|ALDH1_ELEED Aldehyde dehydrogenase, cytosolic 1 OS=Elephantulus edwardii GN=ALDH1 PE=1 SV=1 MSSSGMPDLPAPLTNIKIQHTKLFINNEWHESVSGKTFPVFNPATEEKICEVEEADKEDVDKAVKAAREAFQMGSPWRTMDASERGQLIYKLADLIERDRLLLATLESINAGKVFASAYLMDLDYCIKALRYCAGWADKIQGRTIPVDGEFFSYTRHEPIGVCGLIFPWNAPMILLACKIGPALCCGNTVIVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYGPTAGAAISSHMDVDKVAFTGSTEVGKMIQEAAAKSNLKRVTLELGAKNPCIVFADADLDSAVEFAHQGVFTNQGQSCIAASKLFVEEAIYDEFVQRSVERAKKYVFGNPLTPGVNHGPQINKAQHNKIMELIESGKKEGAKLECGGGPWGNKGYFIQPTVFSNVTDDMRIAKEEIFGPVQQIMKFKSLDEVIKRANNTYYGLVAGVFTKDLDKAVTVSSALQAGTVWVNCYLAASAQSPAGGFKMSGHGREMGEYGIHEYTEVKTVTMKISEKNS |
| Structure Information |
| PDB ID | 1O9J |
| Quaternary structure | |
| SCOP | ALDH-like |
| CATH | 3.40.605.10, 3.40.309.10 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-11, 497-501 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | retinaldehyde dehydrogenase, enzyme
an aldehyde dehydrogenase class 1
An aldehyde + NAD+ + H2O => a carboxylate + NADH.
Alcohol metabolism, ethanol degradation |
| References for function | Bateman OA, Purkiss AG, van Montfort, Slingsby C, Graham C, Wistow G. Crystal structure of eta-crystallin: adaptation of a class 1 aldehyde dehydrogenase for a new role in the eye lens. Biochemistry. 2003 Apr 22. PMID: 12693930 |
| E.C. number | 1.2.1.3 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | eta crystallin
|
| References for function | Bateman OA, Purkiss AG, van Montfort, Slingsby C, Graham C, Wistow G. Crystal structure of eta-crystallin: adaptation of a class 1 aldehyde dehydrogenase for a new role in the eye lens. Biochemistry. 2003 Apr 22. PMID: 12693930 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm of eye lens |
| Comments | |