| General Information |
| MoonProt ID | 125 |
| First appeared in release | 1.0 |
| Name(s) | Albaflavenone Monooxygenase
Albaflavenone synthase
CYP170A1
Cytochrome P450
Epi-isozizaene 5-monooxygenase/(E)-beta-fernesene synthase
terpene synthase
Cytochrome P450 170A1
|
| UniProt ID | Q9K498 (EIZFM_STRCO), Reviewed |
| GO terms | GO:0055114 oxidation-reduction process
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0010333 terpene synthase activity
GO:0016491 oxidoreductase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016829 lyase activity
GO:0020037 heme binding
GO:0046872 metal ion binding |
| Organisms for which functions have been demonstrated | streptomyces coelicolor A3(2) |
| Sequence length | 461 |
| FASTA sequence | >sp|Q9K498|EIZFM_STRCO Epi-isozizaene 5-monooxygenase/(E)-beta-farnesene synthase OS=Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145) GN=SCO5223 PE=1 SV=1
MTVESVNPETRAPAAPGAPELREPPVAGGGVPLLGHGWRLARDPLAFMSQLRDHGDVVRIKLGPKTVYAVTNPELTGALALNPDYHIAGPLWESLEGLLGKEGVATANGPLHRRQRRTIQPAFRLDAIPAYGPIMEEEAHALTERWQPGKTVDATSESFRVAVRVAARCLLRGQYMDERAERLCVALATVFRGMYRRMVVPLGPLYRLPLPANRRFNDALADLHLLVDEIIAERRASGQKPDDLLTALLEAKDDNGDPIGEQEIHDQVVAILTPGSETIASTIMWLLQALADHPEHADRIRDEVEAVTGGRPVAFEDVRKLRHTGNVIVEAMRLRPAVWVLTRRAVAESELGGYRIPAGADIIYSPYAIQRDPKSYDDNLEFDPDRWLPERAANVPKYAMKPFSAGKRKCPSDHFSMAQLTLITAALATKYRFEQVAGSNDAVRVGITLRPHDLLVRPVAR
|
| Structure Information |
| PDB ID | 3DBG 3EL3 |
| Quaternary structure | |
| SCOP | NA |
| CATH | 1.10.630.10 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-22, 458-461 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Albaflavenone Monooxygenase (+)-epi-isozizaene + 2 NADPH + 2 O(2) <=> albaflavenone + 2 NADP(+) + 3 H(2)O |
| References for function | Zhao B, Lin X, Lei L, Lamb DC, Kelly SL, Waterman MR, Cane DE. Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor A3(2). J Biol Chem. 2008 Mar 28. PMID: 18234666 |
| E.C. number | 1.14.13.106 |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |
| Function 2 |
| Function description | Terpene synthase (2E,6E)-farnesyl diphosphate <=> (E)-beta-farnesene + diphosphate |
| References for function | Zhao B, Lei L, Vassylyev DG, Lin X, Cane DE, Kelly SL, Yuan H, Lamb DC, Waterman MR. Crystal structure of albaflavenone monooxygenase containing a moonlighting terpene synthase active site. J Biol Chem. 2009 Dec 25. PMID: 19858213 |
| E.C. number | 4.2.3.47 |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |