General Information |
MoonProt ID | 129 |
First appeared in release | 1.0 |
Name(s) | Lysyl hydroxylase 3
Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
LH3
lysine hydroxylase
Lysine,2-oxoglutarate 5-dioxygenase
Gene Name: PLOD3 |
UniProt ID | O60568 (PLOD3_HUMAN) Reviewed |
GO terms | GO:0001701 in utero embryonic development
GO:0001886 endothelial cell morphogenesis
GO:0006464 cellular protein modification process
GO:0008104 protein localization
GO:0021915 neural tube development
GO:0030198 extracellular matrix organization
GO:0030199 collagen fibril organization
GO:0032870 cellular response to hormone stimulus
GO:0042311 vasodilation
GO:0048730 epidermis morphogenesis
GO:0055114 oxidation-reduction process
GO:0060425 lung morphogenesis
GO:0070831 basement membrane assembly
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0008475 procollagen-lysine 5-dioxygenase activity
GO:0016491 oxidoreductase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
GO:0031418 L-ascorbic acid binding
GO:0033823 procollagen glucosyltransferase activity
GO:0046872 metal ion binding
GO:0050211 procollagen galactosyltransferase activity
GO:0051213 dioxygenase activity
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0030867 rough endoplasmic reticulum membrane
GO:0070062 extracellular vesicular exosome |
Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal) |
Sequence length | 738 |
FASTA sequence | >sp|O60568|PLOD3_HUMAN Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 OS=Homo sapiens GN=PLOD3 PE=1 SV=1
MTSSGPGPRFLLLLPLLLPPAASASDRPRGRDPVNPEKLLVITVATAETEGYLRFLRSAEFFNYTVRTLGLGEEWRGGDVARTVGGGQKVRWLKKEMEKYADREDMIIMFVDSYDVILAGSPTELLKKFVQSGSRLLFSAESFCWPEWGLAEQYPEVGTGKRFLNSGGFIGFATTIHQIVRQWKYKDDDDDQLFYTRLYLDPGLREKLSLNLDHKSRIFQNLNGALDEVVLKFDRNRVRIRNVAYDTLPIVVHGNGPTKLQLNYLGNYVPNGWTPEGGCGFCNQDRRTLPGGQPPPRVFLAVFVEQPTPFLPRFLQRLLLLDYPPDRVTLFLHNNEVFHEPHIADSWPQLQDHFSAVKLVGPEEALSPGEARDMAMDLCRQDPECEFYFSLDADAVLTNLQTLRILIEENRKVIAPMLSRHGKLWSNFWGALSPDEYYARSEDYVELVQRKRVGVWNVPYISQAYVIRGDTLRMELPQRDVFSGSDTDPDMAFCKSFRDKGIFLHLSNQHEFGRLLATSRYDTEHLHPDLWQIFDNPVDWKEQYIHENYSRALEGEGIVEQPCPDVYWFPLLSEQMCDELVAEMEHYGQWSGGRHEDSRLAGGYENVPTVDIHMKQVGYEDQWLQLLRTYVGPMTESLFPGYHTKARAVMNFVVRYRPDEQPSLRPHHDSSTFTLNVALNHKGLDYEGGGCRFLRYDCVISSPRKGWALLHPGRLTHYHEGLPTTWGTRYIMVSFVDP |
Structure Information |
PDB ID | 6FXK |
Quaternary structure | |
SCOP | NA |
CATH | NA |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | 1-9, 24-34, 360-370, 601-605, 737-738 |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | Lysyl hydroxylase isoform 3, enzyme
L-lysine-[procollagen] + 2-oxoglutarate + O(2) <=> (2S,5R)-5-hydroxy-L-lysine-[procollagen] + succinate + CO(2)
Important for formation of intermolecular cross-links in collagen, helps provide strength to collagen
acts at -Xaa-Lys-Gly- sequences
|
References for function | Valtavaara M, Szpirer C, Szpirer J, Myllyl? R. Primary structure, tissue distribution, and chromosomal localization of a novel isoform of lysyl hydroxylase (lysyl hydroxylase 3. J Biol Chem. 1998 May 22. PMID: 9582318 |
E.C. number | 1.14.11.4 |
Location of functional site(s) | |
Cellular location of function | Endoplasmic Reticulum, Cytoplasmic membrane |
Comments | |
Function 2 |
Function description | Collagen glucosyltransferase UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen = UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen |
References for function | Heikkinen J, Risteli M, Wang C, Latvala J, Rossi M, Valtavaara M, Myllyl? R. Lysyl hydroxylase 3 is a multifunctional protein possessing collagen glucosyltransferase activity. J Biol Chem. 2000 Nov 17. PMID: 10934207 |
E.C. number | 2.4.1.66 |
Location of functional site(s) | |
Cellular location of function | Plasma membrane |
Comments | |