| General Information |
| MoonProt ID | 130 |
| First appeared in release | 4.0 |
| Name(s) | malate synthase |
| UniProt ID | Q5YLB8 |
| GO terms | "GO:0003824 catalytic activity
GO:0004474 malate synthase activity
GO:0016740 transferase activity
GO:0006097 glyoxylate cycle
GO:0006099 tricarboxylic acid cycle
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0005782 peroxisomal matrix" |
| Organisms for which functions have been demonstrated | Paracoccidioides brasiliensis |
| Sequence length | 539.0 |
| FASTA sequence | >tr|Q5YLB8|Q5YLB8_PARBR Malate synthase OS=Paracoccidioides brasiliensis OX=121759 PE=2 SV=2 MAYVDTLLKDVAILGPLNGTRRKILTKEATAFLALLHRTFNPTRKALLQRRSDRQAELDR GSLLDFLPETKHIRDNDAWKGAPPAPGLVDRRVEITGPTDRKMVVNALNSDVYTYMADFE DSSAPTWDNMVNGQVNLYDAIRRQVDFKQGGKDYKLRTDRKLPTLIARARGWHLDEKHLT VDGEPMSGSLFDFGLYFFHNAKELVKRGAGPYFYLPKMESHLEARMWNDVYNLAQDYIGM PRGTIRATVLIETISAAFEMDEIIYELRDHSSGLNCGRWDYIFSFIKKFRQNPSFVLPDR SDVTMTVPFMDAYVKLLIKTCHRRGVHAMGGMAAQIPIKDDPKANEAAMASVRADKLREV RAGHDGTWVGHPALAKIATDVFDQYMPTPNQLFVRREDVHITANDLLNTNVPGRITEDGI RKNLNIGLSYMEGWLRGVGCIPINYLMEDAATAEVSRSQLWQWVKHNVTTAEGKRVDKAY ALKLLQEQTDELASKAPKGNRYQLAARYFAGQVAGEDYADFLTSLLYNEISAPGSAAKL |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | NA |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | not in DisProt |
| Predicted Disorder Regions | Predicted disorder N terminus (aa 1-2), middle regions (aa 77-82, 89-94), and C terminus (aa 537-541). |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enzyme, malate synthase |
| References for function | da Silva Neto BR, de Fátima da Silva J, Mendes-Giannini MJ, Lenzi HL, de Almeida Soares CM, Pereira M. The malate synthase of Paracoccidioides brasiliensis is a linked surface protein that behaves as an anchorless adhesin. BMC Microbiol. 2009 Dec 24;9:272. doi: 10.1186/1471-2180-9-272. PMID: 20034376; PMCID: PMC2807876. |
| E.C. number | EC:2.3.3.9 |
| Location of functional site(s) | |
| Cellular location of function | peroxisome |
| Comments | |
| Function 2 |
| Function description | adhesin |
| References for function | da Silva Neto BR, de Fátima da Silva J, Mendes-Giannini MJ, Lenzi HL, de Almeida Soares CM, Pereira M. The malate synthase of Paracoccidioides brasiliensis is a linked surface protein that behaves as an anchorless adhesin. BMC Microbiol. 2009 Dec 24;9:272. doi: 10.1186/1471-2180-9-272. PMID: 20034376; PMCID: PMC2807876. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |