| General Information |
| MoonProt ID | 134 |
| First appeared in release | 1.0 |
| Name(s) | Transcriptional regulator URE2
Disulfide reductase
Glutathione peroxidase
Gene Name:URE2 |
| UniProt ID | P23202 (URE2_YEAST), Reviewed |
| GO terms | GO:0006808 regulation of nitrogen utilization
GO:0010044 response to aluminum ion
GO:0032447 protein urmylation
GO:0042128 nitrate assimilation
GO:0042994 cytoplasmic sequestering of transcription factor
GO:0055114 oxidation-reduction process
GO:2001141 regulation of RNA biosynthetic process
GO:0003714 transcription corepressor activity
GO:0004602 glutathione peroxidase activity
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0051219 phosphoprotein binding
GO:0005737 cytoplasm
GO:0005829 cytosol |
| Organisms for which functions have been demonstrated | Saccharomyces cerevisiae (yeast, fungi) |
| Sequence length | 354 |
| FASTA sequence | >sp|P23202|URE2_YEAST Transcriptional regulator URE2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=URE2 PE=1 SV=1
MMNNNGNQVSNLSNALRQVNIGNRNSNTTTDQSNINFEFSTGVNNNNNNNSSSNNNNVQNNNSGRNGSQNNDNENNIKNTLEQHRQQQQAFSDMSHVEYSRITKFFQEQPLEGYTLFSHRSAPNGFKVAIVLSELGFHYNTIFLDFNLGEHRAPEFVSVNPNARVPALIDHGMDNLSIWESGAILLHLVNKYYKETGNPLLWSDDLADQSQINAWLFFQTSGHAPMIGQALHFRYFHSQKIASAVERYTDEVRRVYGVVEMALAERREALVMELDTENAAAYSAGTTPMSQSRFFDYPVWLVGDKLTIADLAFVPWNNVVDRIGINIKIEFPEVYKWTKHMMRRPAVIKALRGE
|
| Structure Information |
| PDB ID | 1G6W
1G6Y
1JZR
1K0A
1K0B
1K0C
1K0D
1HQO |
| Quaternary structure | |
| SCOP | GST C-terminal domain-like, Thioredoxin fold |
| CATH | 3.40.30.10, 1.20.1050.10 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | 31.64%, 1 - 89; 1 - 90; 273 - 294, |
| Predicted Disorder Regions | 1-12, 23-30, 45-99, 276-283, 351-354 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | functions in nitrogen catabolite repression
binds to and inhibits GATA transcriptional activators GLN3 and GAT1, keeps them in the cytoplasm, prevents transcription of their target genes |
| References for function | Coschigano PW, Magasanik B. The URE2 gene product of Saccharomyces cerevisiae plays an important role in the cellular response to the nitrogen source and has homology to glutathione s-transferases. Mol Cell Biol. 1991 Feb. PMID: 1990286.
Blinder D, Coschigano PW, Magasanik B. Interaction of the GATA factor Gln3p with the nitrogen regulator Ure2p in Saccharomyces cerevisiae. J Bacteriol. 1996 Aug. PMID: 8755910.
Courchesne WE, Magasanik B. Regulation of nitrogen assimilation in Saccharomyces cerevisiae: roles of the URE2 and GLN3 genes. J Bacteriol. 1988 Feb. PMID: 2892826. |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | glutathione peroxidase, enzyme
also thiol:disulfide oxidoreductase
2 glutathione + H2O2 => glutathione disulfide + 2 H2O |
| References for function | Bai M, Zhou JM, Perrett S. The yeast prion protein Ure2 shows glutathione peroxidase activity in both native and fibrillar forms. J Biol Chem. 2004 Nov 26. PMID: 15371425 |
| E.C. number | 1.8.4.- |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |