| General Information |
| MoonProt ID | 139 |
| First appeared in release | 1.0 |
| Name(s) | Clf1p pre-mRNA splicing factor
Pre-mRNA-splicing factor CLF1
Crooked neck-like factor 1
PRP19-associated complex protein 77
Synthetic lethal with CDC40 protein 3
Gene Name: CLF1
|
| UniProt ID | Q12309 (CLF1_YEAST), Reviewed |
| GO terms | GO:0000354 cis assembly of pre-catalytic spliceosome
GO:0006270 DNA replication initiation
GO:0006270 DNA replication initiation
GO:0006396 RNA processing
GO:0006397 mRNA processing
GO:0007049 cell cycle
GO:0008380 RNA splicing
GO:0003682 chromatin binding
GO:0003688 DNA replication origin binding
GO:0005515 protein binding
contributes to GO:0000384 first spliceosomal transesterification activity
contributes_to GO:0000386 second spliceosomal transesterification activity
GO:0000785 chromatin
GO:0000974 Prp19 complex
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005681 spliceosomal complex
GO:0071004 U2-type prespliceosome
GO:0071006 U2-type catalytic step 1 spliceosome
GO:0071007 U2-type catalytic step 2 spliceosome
GO:0071008 U2-type post-mRNA release spliceosomal complex |
| Organisms for which functions have been demonstrated | Saccharomyces cerevisiae |
| Sequence length | 687 |
| FASTA sequence | >sp|Q12309|CLF1_YEAST Pre-mRNA-splicing factor CLF1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CLF1 PE=1 SV=1
MDTLEPTAVDTHVSAEQILRDVYKKGQKARGSTNIDILDLEELREYQRRKRTEYEGYLKRNRLDMGQWIRYAQFEIEQHDMRRARSIFERALLVDSSFIPLWIRYIDAELKVKCINHARNLMNRAISTLPRVDKLWYKYLIVEESLNNVEIVRSLYTKWCSLEPGVNAWNSFVDFEIRQKNWNGVREIYSKYVMAHPQMQTWLKWVRFENRHGNTEFTRSVYSLAIDTVANLQNLQIWSDMEVAKLVNSFAHWEAAQQEYERSSALYQIAIEKWPSNQLLKAGLLDFEKQFGDINSIEETISYKRKMEYETILSNNAYDYDTWWLYLDLISESFPKQIMQTFEKAIVDSRPKELSKNVQWKRYIYLWMRYICYVELELENSLLEEELFQRLIDDIIPHKHFTFSKIWLMYAKFLIRHDDVPKARKILGKAIGLCPKAKTFKGYIELEVKLKEFDRVRKIYEKFIEFQPSDLQIWSQYGELEENLGDWDRVRGIYTIALDENSDFLTKEAKIVLLQKYITFETESQEFEKARKLYRRYLELNQYSPQSWIEFAMYQTSTPTEQQLLDLAKLQSENVDEDIEFEITDENKLEARKVFEEAIVFFKEKDDKQGRLSILEALKDYEETYGTELDQETVKKRFPKVIKKVRLQNGVEEEFVDYIFPDDIDDDKPKPSKFLELAKKWKQEQAL
|
| Structure Information |
| PDB ID | 5LJ5, 6EXN, 5LJ3, 5GMK (40% query cover), 5WSG (34% query cover) |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1 to 10, 28-32, 563-584, 683-687 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Clf1p pre-mRNA splicing factor
involved in assembly of spliceosome
|
| References for function | |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |
| Function 2 |
| Function description | Initiation of DNA replication
binds to origin of replication complex
|
| References for function | Zhu W, Rainville IR, Ding M, Bolus M, Heintz NH, Pederson DS. Evidence that the pre-mRNA splicing factor Clf1p plays a role in DNA replication in Saccharomyces cerevisiae. Genetics. 2002 Apr. PMID: 11973290 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |