| General Information |
| MoonProt ID | 140 |
| First appeared in release | 1.0 |
| Name(s) | Thymidine phosphorylase
thymidine:phosphate deoxy-alpha-D-ribosyltransferase
TP
Gliostatin
Platelet-derived endothelial cell growth factor
PDGF
PD-ECGF
TdRPase
Gene Name: TYMP
|
| UniProt ID | P19971 (TYPH_HUMAN) Reviewed |
| GO terms | GO:0000002 mitochondrial genome maintenance
GO:0001525 angiogenesis
GO:0006206 pyrimidine nucleobase metabolic process
GO:0006213 pyrimidine nucleoside metabolic process
GO:0006220 pyrimidine nucleotide metabolic process
GO:0006260 DNA replication
GO:0006935 chemotaxis
GO:0007275 multicellular organismal development
GO:0008152 metabolic process
GO:0030154 cell differentiation
GO:0043097 pyrimidine nucleoside salvage
GO:0044281 small molecule metabolic process
GO:0046135 pyrimidine nucleoside catabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
GO:0004645 phosphorylase activity
GO:0005161 platelet-derived growth factor receptor binding GO:0008083 growth factor activity
GO:0009032 thymidine phosphorylase activity
GO:0016154 pyrimidine-nucleoside phosphorylase activity
GO:0016740 transferase activity
GO:0016757 transferase activity, transferring glycosyl groups
GO:0016763 transferase activity, transferring pentosyl groups
GO:0005829 cytosol |
| Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal) |
| Sequence length | 482 |
| FASTA sequence | >sp|P19971|TYPH_HUMAN Thymidine phosphorylase OS=Homo sapiens GN=TYMP PE=1 SV=2
MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAAVVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGGVGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQAGCCIVGQSEQLVPAEGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAAVFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPPDLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARALCSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVGAELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPPQQ |
| Structure Information |
| PDB ID | 2WK5, 2J0F |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1 to 31, 477-482 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Thymidine phosphorylase
thymidine + phosphate <=> thymine + 2-deoxy-alpha-D-ribose 1-phosphate
Pyrimidine metabolism, dTMP biosynthesis in salvage pathway |
| References for function | |
| E.C. number | 2.4.2.4 |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |
| Function 2 |
| Function description | Platelet-derived endothelial cell growth factor
|
| References for function | Furukawa T, Yoshimura A, Sumizawa T, Haraguchi M, Akiyama S, Fukui K, Ishizawa M, Yamada Y. Angiogenic factor. Nature. 1992 Apr 23. PMID: 1570012 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | extracellular, secreted |
| Comments | |