General Information |
MoonProt ID | 146 |
First appeared in release | 1.0 |
Name(s) | hemagglutinin
HA |
UniProt ID | B9VJ59 (B9VJ59_9PARA), Unreviewed |
GO terms | GO:0008152 metabolic process
GO:0016032 viral process
GO:0019058 viral life cycle
GO:0019062 virion attachment to host cell
GO:0046718 viral entry into host cell
GO:0004308 exo-alpha-sialidase activity
GO:0046789 host cell surface receptor binding
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0019012 virion
GO:0019031 viral envelope
GO:0033644 host cell membrane |
Organisms for which functions have been demonstrated | Paramyxovirus (Mumps virus) |
Sequence length | 582 |
FASTA sequence | >tr|B9VJ59|B9VJ59_9MONO HN OS=Mumps rubulavirus PE=3 SV=1
MEPSKLFTISDNATFAPGPVINAADKKTFRTCFRILVLSVQAVTLILVIVTLGELVRMINDQGLSNQLPSITNKIRESATMIASAVGVMNQVIHGVTISLPLQIEGNQNQLLSTLATICTSKKQVSNCSTNIPLVNDLRFINGINKFIIEDYATHDFSIGHPLNMPSFIPTATSPNGCTRIPSFSLGKTHWCYTHNVINANCKDHTSSNQYVSMGILVQTASRYPMFKTLKIQYLSDGLNRKSCSIATVPDGCAMYCYVSTQLETDDYAGSSPPTQKLTLLFYNDTVTERTISPSGLEGNWATLVPGVGSGIYFENKLIFPAYGGVLPNSTLGVKSAREFFRPVNPYNPCSGPQQDLDQRALRSYFPSYFSNRRVQSAFLVCAWNQILVTNCELVVPSSNQTLMGAEGRVLLINNRLLYYQRSTSWWPYELLYEISFTFTNSGQSSVNMSWIPIYSFTRPGSGSCSGENVCPTACVSGVYLDPWPLTPYSHQSGINRNFYFTGALLNSSTTRVNPTLYVSALNNLTVLAPYGTQGLFASYTTTTCFQDTGDASVYCVYIMELASNIVGEFQILPVLTRLTIT |
Structure Information |
PDB ID | 1Z4V 1Z4W 1Z4X 1Z4Y 1Z4Z 1Z50 |
Quaternary structure | |
SCOP | 6-bladed beta-propeller |
CATH | 2.120.10.10 |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | 1 to 14, 61-74, 580-582 |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | hemagglutinin
binding the virus to the surface of host cells
|
References for function | Crennell S, Takimoto T, Portner A, Taylor G. Crystal structure of the multifunctional paramyxovirus hemagglutinin-neuraminidase. Nat Struct Biol. 2000 Nov. PMID: 11062565 |
E.C. number | N/A |
Location of functional site(s) | |
Cellular location of function | surface of virus |
Comments | |
Function 2 |
Function description | Neuraminidase, enzyme
cleaves the glycosidic linkages of neuraminic acids |
References for function | Crennell S, Takimoto T, Portner A, Taylor G. Crystal structure of the multifunctional paramyxovirus hemagglutinin-neuraminidase. Nat Struct Biol. 2000 Nov. PMID: 11062565 |
E.C. number | 3.2.1.18 |
Location of functional site(s) | |
Cellular location of function | surface of virus |
Comments | |