| General Information |
| MoonProt ID | 148 |
| First appeared in release | 1.0 |
| Name(s) | tyrosyl tRNA synthetase
Tyrosine-tRNA ligase, mitochondrial
TyrRS
Gene Name: cyt-18 |
| UniProt ID | P12063 (SYYM_NEUCR), Reviewed |
| GO terms | GO:0006397 mRNA processing
GO:0006412 translation
GO:0006418 tRNA aminoacylation for protein translation
GO:0006437 tyrosyl-tRNA aminoacylation
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004831 tyrosine-tRNA ligase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix |
| Organisms for which functions have been demonstrated | Neurospora crassa |
| Sequence length | 669 |
| FASTA sequence | >sp|P12063|SYYM_NEUCR Tyrosine--tRNA ligase, mitochondrial OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) GN=cyt-18 PE=1 SV=2
MLLRTKALIRSGGSIAKYAAANPSCFILQRRGLRREFGPKYTAKINEAEENWQARAEAIKKGKKQNTWDLFEERGYVKDTAGTKEHIAELMRTRRIGAYVGIDPTAPSLHVGHLLPLMPLFWMYLEGYKAFTLIGGSTAKIGDPTGRLKSRDHLSSSDATMNMTKIHYQLKKLWENVDTQMRARGYEADWARKRGIVNNNHWWNKQPMLEVLRRVGHALRIGPMLSRDTVKNKMTQGDGVSFAEFTYPIMQGWDWFELFYQQGVQMQIGGSDQYGNIISGLEVVKAARESEPDPQERKYVTPKTALDECVGFTVPLLTDSSGAKFGKSAGNAIWLDPYQTSVFDFYGYFVRRSDQEVENLLKLFTFMPISEITKTMEEHIKDPSKRVAQHTLAREVVTLVHGKQEASAAEDQHRMMYTGQMTIPQVSRAKDAATGGDQYKTISDQPVTLNNAPRIDMILPESLIMGKSIGRILYAAGLASSTTEGHKLAAAQGCYVGGAHRAGGENVTMNPDLISFMPVKLWFPGETQRYLINGNLLILRKGKHNVRVIQMVSDVEYAASGQTYPGQSFTGAVRKLNEIMKNLKEKKLTPEEAKNAVNELQKSSQEKQQGQQIIFPEEKSRQKKDMETKLKQEMIASVKTIDGMMDEKPSVRGDGVKKQTQDDRDPYKW
|
| Structure Information |
| PDB ID | 1Y42 2RKJ |
| Quaternary structure | |
| SCOP | NA |
| CATH | 3.40.50.620, 1.10.240.10 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1 to 17, 19-20, 148-151, 293-303, 421-451, 499-508, 563-573, 584-630, 643-669 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | tyrosyl tRNA synthetase, enzyme
attaches tyrosine to tRNA(Tyr)
ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr) |
| References for function | |
| E.C. number | 6.1.1.1 |
| Location of functional site(s) | |
| Cellular location of function | mitochondrion |
| Comments | |
| Function 2 |
| Function description | promotes folding of group 1 introns |
| References for function | Caprara MG, Mohr G, Lambowitz AM. A tyrosyl-tRNA synthetase protein induces tertiary folding of the group I intron catalytic core. J Mol Biol. 1996 Apr 5. PMID: 8648621 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | mitochondrion |
| Comments | |