| General Information |
| MoonProt ID | 152 |
| First appeared in release | 1.0 |
| Name(s) | dihydroxyacetone kinase
glycerone kinase
|
| UniProt ID | Q8XDH4 (Q8XDH4_ECO57), Unreviewed |
| GO terms | GO:0006071 glycerol metabolic process
GO:0016310 phosphorylation
GO:0051156 glucose 6-phosphate metabolic process
GO:0004340 glucokinase activity
GO:0004371 glycerone kinase activity
GO:0016301 kinase activity
GO:0016740 transferase activity
|
| Organisms for which functions have been demonstrated | Escherichia coli (Gram negative bacterium) |
| Sequence length | 366 |
| FASTA sequence | >gi|13361170|dbj|BAB35128.1| dihydroxyacetone kinase [Escherichia coli O157:H7 str. Sakai]
MPYRNCWSKIMKKLINDVQDVLDEQLAGLAKAHPSLTLHQDPVYVTRADAPVAGKVALLSGGGSGHEPMHCGYIGQGMLSGACPGEIFTSPTPDKIFECAMQVDGGEGVLLIIKNYTGDILNFETATELLHDSGVKVTTVVIDDDVAVKDSLYTAGRRGVANTVLIEKLVGAAAERGDSLDACAELGRKLNNQGHSIGIALGACTVPAAGKPSFTLADNEMEFGVGIHGEPGIDRRPFSSLDQTVDEMFDTLLENGSYHRTLRFWDYQQGSWQEEPQTKQPLQSGDGVIALVNNLGATPLSELYGVYNRLTTRCQQAGLTIERNLIGAYCTSLDMTGFSITLLKVDDETLALWDAPVHTPALNWGK |
| Structure Information |
| PDB ID | 1OI2 1OI3 1UOD 1UOE 4LRX 3PNK 3PNL 4LRY 3PNO 3PNQ 3PNM |
| Quaternary structure | |
| SCOP | DAK1/DegV-like |
| CATH | 3.40.50.10440, 3.30.1180.20 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1 to 5, 254-255 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | dihydroxyacetone kinase, enzyme
ATP + glycerone <=> ADP + glycerone phosphate
(glycerone also called dihydroxyacetone) |
| References for function | |
| E.C. number | 2.7.1.29 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | controls gene expression by binding to transcription factor DhaR, a trigger enzyme |
| References for function | B?chler C, Schneider P, B?hler P, Lustig A, Erni B. Escherichia coli dihydroxyacetone kinase controls gene expression by binding to transcription factor DhaR. EMBO J. 2005 Jan 26. PMID: 15616579 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | binding to DNA |
| Comments | |