| General Information |
| MoonProt ID | 156 |
| First appeared in release | 1.0 |
| Name(s) | Ami autolysin |
| UniProt ID | O33983 (O33983_LISMN), Unreviewed |
| GO terms | GO:0009253 peptidoglycan catabolic process
GO:0008745 N-acetylmuramoyl-L-alanine amidase activity |
| Organisms for which functions have been demonstrated | Listeria monocytogenes (Gram positive bacterium, causes listeriosis, septicemia, meningitis) |
| Sequence length | 917 |
| FASTA sequence | >gi|2340115|gb|AAC45605.1| AMI [Listeria monocytogenes]
MKKLVKSAVVFAGLVFIGTSATMITEKASAASTDPVQKVDGQATYIPKGVRDGTATEEHDGFEDGTNSVLQQVPLLRATTGYPDVNAYIKSNKFSTAKIEKQLKSQFPKFNYRNGYGKPEGIVIHETANNSSTITGEINYMSTNYNNAFVHAFVDKSRIIQIHPTENGVWGAGQYANARFIQVELVRSKTFDEFARSINNYAYYAAYLLDQYNLPVDSAHSDGKGTVWSHDAVTRYLGGTTHTDPVAYFNQWGYNFNNFVSLINEKYKAMQVNYEKIEYDKAITAYSRVKTATGNSVWTKPNKTEGAKLVNPLSSYSGKNLRIIREAKTSGGTIWYQFSVGGKTIGWVDSKALNTFYTPSMEKTITGTRYVLPSKQTVHYYGLPVEDSAIDRGPLSKFNGQALTLQREATIEGQLWYRVKDLGWVKAVNLTTTKYDLIEYDKAITAYSRVKTAAGNYVWSKPNKTEGAKQGSALSTYSGKNMRIIREAKTSSGTIWYQFSIDGKTIGWVDTKALNTFYTPSMEKNLTATRYVAPGQETQHYYGLPVADSAIDRGPLSKFAGQTLTVQREATIEGQLWYRVKDLGWTKASTLTATQYDKLEYDKAITAYSRVKTATGNSVWTKPYRTSGYKLVNPLSSYAGKNLRIIREAKTSSGIWYQFSVGGKTIGWVDSKALNTFYTPSMEKTITGTRYVLPSKQTVHYYGLPVEDSAIDRGPLSKFNGQALTLQREATIEGQLWYRVKDLGWVKAANLTTTKYDTLSYDKAITAYSRVKTATGNSVWTKPNKIEGAQKISALSTYSGKNMRILREAKTSSGTIWYQFSVGGKTIGWVETKALNTFYTPSMEKNLTATRYVLTSKKNEHYYGLPVVDSAIDRGPLSKFSGKTLTVQREATIEGQLWYRVKDLGWTKAANLSAKKQ
|
| Structure Information |
| PDB ID | Closest homologue in PDB is from Staphylococcus aureus with 55.19% amino acid sequence identity; 19% query cover |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | 1(7-24) signal sequence |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1 to 11, 21-42, 50-64, 908-917 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | autolysin, enzyme
cleaves cell wall glycopeptides, at the link between the L-amino acid residues and the N-acetylmuramoyl residues |
| References for function | |
| E.C. number | 3.5.1.28 |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |
| Function 2 |
| Function description | adherence to eukaryotic cells |
| References for function | Milohanic E1, Pron B, Berche P, Gaillard JL. Identification of new loci involved in adhesion of Listeria monocytogenes to eukaryotic cells. European Listeria Genome Consortium. Microbiology. 2000 Mar;146 ( Pt 3):731-9.
10746777
|
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |