General Information |
MoonProt ID | 159 |
First appeared in release | 1.0 |
Name(s) | thioredoxin
Gene Name:trxA |
UniProt ID | D3QX74 (D3QX74_ECOCB), Unreviewed |
GO terms | GO:0006662 glycerol ether metabolic process
GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process
GO:0015035 protein disulfide oxidoreductase activity |
Organisms for which functions have been demonstrated | Escherichia coli (Gram negative bacterium) |
Sequence length | 127 |
FASTA sequence | >tr|D3QX74|D3QX74_ECOCB Thioredoxin OS=Escherichia coli O55:H7 (strain CB9615 / EPEC) GN=trxA PE=3 SV=1
MLHQQRNQHARLIPVELYMSDKIIHLTDDSFDTDVLKADGAILVDFWAEWCGPCKMIAPILDEIADEYQGKLTVAKLNIDQNPGTAPKYGIRGIPTLLLFKNGEVAATKVGALSKGQLKEFLDANLA |
Structure Information |
PDB ID | 3DXB,
2TRX, 1T7P, 1SKR, 1SKS, 1SKW, 1SL0, 1SL1, 1SL2, 1TK0, 1TK5, 1TK8, 1TKD, 1T8E, 1X9M, 1X9S, 1X9W, 2BTO, 1ZYQ, 2AJQ, 2H6X, 1ZZY, 3DYR, 2H76, 2H71, 2H75, 2H70, 2H74, 2H73, 2TIR, 2H6Z, 2H72, 2H6Y, 2FCH |
Quaternary structure | |
SCOP | NA |
CATH | NA |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | 1 to 12, 125-127 |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | thioredoxin
antioxidant
aids the reduction of other proteins by cysteine thiol-disulfide exchange |
References for function | |
E.C. number | N/A |
Location of functional site(s) | |
Cellular location of function | cytoplasm |
Comments | |
Function 2 |
Function description | Subunit of T7 DNA polymerase
****maybe not strictly considered moonlighting because adopted by a phage to be part of a protein complex***** |
References for function | Mark DF, Richardson CC. Escherichia coli thioredoxin: a subunit of bacteriophage T7 DNA polymerase. Proc Natl Acad Sci U S A. 1976 Mar. PMID: 768986 |
E.C. number | N/A |
Location of functional site(s) | |
Cellular location of function | binding to DNA |
Comments | |