Protein Information

General Information
MoonProt ID162
First appeared in release1.0
Name(s)Cyclic AMP-dependent transcription factor ATF-2 cAMP-dependent transcription factor ATF-2 Activating transcription factor 2 MXBP protein Cyclic AMP-responsive element-binding protein 2 CREB-2 cAMP-responsive element-binding protein 2 HB16 Histone acetyltransferase ATF2 cAMP response element-binding protein CRE-BP1 Gene Name:Atf2
UniProt IDP16951 (ATF2_MOUSE), Reviewed
GO termsGO:0003151 outflow tract morphogenesis GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006970 response to osmotic stress GO:0006974 cellular response to DNA damage stimulus GO:0016573 histone acetylation GO:0031573 intra-S DNA damage checkpoint GO:0032915 positive regulation of transforming growth factor beta2 production GO:0045444 fat cell differentiation GO:0045944 positive regulation of transcription from RNA polymerase II promoter GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0060612 adipose tissue development GO:1902110 positive regulation of mitochondrial membrane permeability involved in apoptotic process GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001102 RNA polymerase II activating transcription factor binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003682 chromatin binding GO:0003700 sequence-specific DNA binding transcription factor activity GO:0004402 histone acetyltransferase activity GO:0005515 protein binding GO:0008140 cAMP response element binding protein binding GO:0016740 transferase activity GO:0019901 protein kinase binding GO:0035497 cAMP response element binding GO:0043565 sequence-specific DNA binding GO:0046872 metal ion binding GO:0046982 protein heterodimerization activity GO:0005634 nucleus GO:0005737 cytoplasm GO:0005739 mitochondrion GO:0005741 mitochondrial outer membrane GO:0016020 membrane GO:0035861 site of double-strand break
Organisms for which functions have been demonstratedMus musculus (Mouse, mammal)
Sequence length487
Structure Information
PDB IDsmall fragment
Quaternary structure
TM Helix Predictionno TM helices
DisProt AnnotationNot in DisProt
Predicted Disorder Regions1 to 8, 39-44, 79-192, 214-224, 235-338, 407-449, 461-487
Connections to Disease
Function 1
Function descriptionATF2 activating transcription factor bZIP family of transcription factors binds DNA as a dimer, homodimerization or heterodimerization, sometimes with c-Jun
References for function
E.C. numberN/A
Location of functional site(s)
Cellular location of functionnucleus
Function 2
Function descriptionrecruiting Mre11 to IR-induced foci (IRIF) in the DNA damage response, this function does not require DNA binding domain or dimerization with c-Jun
References for functionBhoumik A, Takahashi S, Breitweiser W, Shiloh Y, Jones N, Ronai Z. ATM-dependent phosphorylation of ATF2 is required for the DNA damage response. Mol Cell. 2005 May 27. PMID: 15916964
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm