Protein Information

General Information
MoonProt ID167
First appeared in release1.0
Name(s)Arginase Gene Name:CAR1
UniProt IDP00812 (ARGI_YEAST), Reviewed
GO termsGO:0000050 urea cycle GO:0006525 arginine metabolic process GO:0019547 arginine catabolic process to ornithine GO:0090368 regulation of ornithine metabolic process GO:0004053 arginase activity GO:0005515 protein binding GO:0008270 zinc ion binding GO:0016787 hydrolase activity GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines GO:0030145 manganese ion binding GO:0046872 metal ion binding GO:0090369 ornithine carbamoyltransferase inhibitor activity GO:0005829 cytosol
Organisms for which functions have been demonstratedSaccharomyces cerevisiae (yeast, fungi)
Sequence length333
Structure Information
PDB IDClosest homologue in PDB is from Leishmania mexicana with 58.57% amino acid sequence identity; 96% query cover
Quaternary structure
TM Helix Predictionno TM helices
DisProt AnnotationNot in DisProt
Predicted Disorder Regions1 to 10, 74-82, 332-333
Connections to Disease
Function 1
Function descriptionarginase use of arginine as nitrogen source L-arginine + H2O => L-ornithine + urea Nitrogen metabolism, urea cycle
References for function
E.C. number3.5.3.1
Location of functional site(s)
Cellular location of functioncytoplasm
Function 2
Function descriptionbinds to ornithine transcarbamylase and inactivates it (OTCase, catalyzes first step in arginine biosynthesis), effectors are ornithine and arginine
References for functionBechet J, Wiame JM. Indication of a specific regulatory binding protein for ornithinetranscarbamylase in Saccharomyces cerevisiae. Biochem Biophys Res Commun. 1965 Nov 8. PMID: 5866843. Messenguy F, Wiame J. The control of ornithinetranscarbamylase activity by arginase in Saccharomyces cerevisiae. FEBS Lett. 1969 Apr. PMID: 11946965.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm