General Information |
MoonProt ID | 167 |
First appeared in release | 1.0 |
Name(s) | Arginase
Gene Name:CAR1 |
UniProt ID | P00812 (ARGI_YEAST), Reviewed |
GO terms | GO:0000050 urea cycle
GO:0006525 arginine metabolic process
GO:0019547 arginine catabolic process to ornithine
GO:0090368 regulation of ornithine metabolic process
GO:0004053 arginase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0090369 ornithine carbamoyltransferase inhibitor activity
GO:0005829 cytosol |
Organisms for which functions have been demonstrated | Saccharomyces cerevisiae (yeast, fungi) |
Sequence length | 333 |
FASTA sequence | >gi|171161|gb|AAA34469.1| arginase [Saccharomyces cerevisiae]
METGPHYNYYKNRELSIVLAPFSGGQGKLGVEKGPKYMLKHGLQTSIEDLGWSTELEPSMDEAQFVGKLKMEKDSTTGGSSVMIDGVKAKRADLVGEATKLVYNSVSKVVQANRFPLTLGGDHSIAIGTVSAVLDKYPDAGLLWIDAHADINTIESTPSGNLHGCPVSFLMGLNKDVPHCPESLKWVPGNLSPKKIAYIGLRDVDAGEKKILKDLGIAAFSMYHVDKYGINAVIEMAMKAVHPETNGEGPIMCSYDVDGVDPLYIPATGTPVRGGLTLREGLFLVERLAESGNLIALDVVECNPDLAIHDIHVSNTISAGCAIARCALGETLL |
Structure Information |
PDB ID | Closest homologue in PDB is from Leishmania mexicana with 58.57% amino acid sequence identity; 96% query cover |
Quaternary structure | |
SCOP | NA |
CATH | NA |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | 1 to 10, 74-82, 332-333 |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | arginase
use of arginine as nitrogen source
L-arginine + H2O => L-ornithine + urea
Nitrogen metabolism, urea cycle |
References for function | |
E.C. number | 3.5.3.1 |
Location of functional site(s) | |
Cellular location of function | cytoplasm |
Comments | |
Function 2 |
Function description | binds to ornithine transcarbamylase and inactivates it (OTCase, catalyzes first step in arginine biosynthesis), effectors are ornithine and arginine
|
References for function | Bechet J, Wiame JM. Indication of a specific regulatory binding protein for ornithinetranscarbamylase in Saccharomyces cerevisiae. Biochem Biophys Res Commun. 1965 Nov 8. PMID: 5866843.
Messenguy F, Wiame J. The control of ornithinetranscarbamylase activity by arginase in Saccharomyces cerevisiae. FEBS Lett. 1969 Apr. PMID: 11946965. |
E.C. number | N/A |
Location of functional site(s) | |
Cellular location of function | cytoplasm |
Comments | |