| General Information |
| MoonProt ID | 171 |
| First appeared in release | 1.0 |
| Name(s) | 60S ribosomal protein L13a
23 kDa highly basic protein
Gene Name: RPL13A |
| UniProt ID | P40429 (RL13A_HUMAN), Reviewed |
| GO terms | GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412 translation
GO:0006413 translational initiation
GO:0006414 translational elongation
GO:0006415 translational termination
GO:0006417 regulation of translation
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0017148 negative regulation of translation
GO:0019058 viral life cycle
GO:0019083 viral transcription
GO:0044267 cellular protein metabolic process
GO:0071346 cellular response to interferon-gamma
GO:1901194 negative regulation of formation of translation preinitiation complex
GO:0003735 structural constituent of ribosome
GO:0044822 poly(A) RNA binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0015934 large ribosomal subunit
GO:0022625 cytosolic large ribosomal subunit
GO:0030529 ribonucleoprotein complex
GO:0097452 GAIT complex |
| Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal) |
| Sequence length | 203 |
| FASTA sequence | >sp|P40429|RL13A_HUMAN 60S ribosomal protein L13a OS=Homo sapiens GN=RPL13A PE=1 SV=2
MAEVQVLVLDGRGHLLGRLAAIVAKQVLLGRKVVVVRCEGINISGNFYRNKLKYLAFLRKRMNTNPSRGPYHFRAPSRIFWRTVRGMLPHKTKRGQAALDRLKVFDGIPPPYDKKKRMVVPAALKVVRLKPTRKFAYLGRLAHEVGWKYQAVTATLEEKRKEKAKIHYRKKKQLMRLRKQAEKNVEKKIDKYTEVLKTHGLLV
|
| Structure Information |
| PDB ID | 4v6x |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1 to 3, 60-69, 203 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | ribosome protein,
part of 60S subunit of ribosome
|
| References for function | |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasem, part of ribosome |
| Comments | |
| Function 2 |
| Function description | translation inhibition
Component of the GAIT complex (gamma interferon-activated inhibitor of translation)
|
| References for function | Mazumder B, Sampath P, Seshadri V, Maitra RK, DiCorleto PE, Fox PL. Regulated release of L13a from the 60S ribosomal subunit as a mechanism of transcript-specific translational control. Cell. 2003 Oct 17. PMID: 14567916 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |