| General Information |
| MoonProt ID | 173 |
| First appeared in release | 1.0 |
| Name(s) | Glyceraldehyde-3-phosphate dehydrogenase
GAPDH
Peptidyl-cysteine S-nitrosylase GAPDH
Gene Name: GAPDH |
| UniProt ID | P04406 (G3P_HUMAN), Reviewed |
| GO terms | GO:0000226 microtubule cytoskeleton organization
GO:0005975 carbohydrate metabolic process
GO:0006006 glucose metabolic process
GO:0006094 gluconeogenesis
GO:0006096 glycolysis
GO:0006417 regulation of translation
GO:0006915 apoptotic process
GO:0017148 negative regulation of translation
GO:0035606 peptidyl-cysteine S-trans-nitrosylation
GO:0044281 small molecule metabolic process
GO:0050821 protein stabilization
GO:0051402 neuron apoptotic process
GO:0055114 oxidation-reduction process
GO:0071346 cellular response to interferon-gamma
GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0016740 transferase activity
GO:0035605 peptidyl-cysteine S-nitrosylase activity
GO:0042802 identical protein binding
GO:0050661 NADP binding
GO:0051287 NAD binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005811 lipid particle
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
GO:0097452 GAIT complex |
| Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal, OMIM number 138400) |
| Sequence length | 335 |
| FASTA sequence | >sp|P04406|G3P_HUMAN Glyceraldehyde-3-phosphate dehydrogenase OS=Homo sapiens GN=GAPDH PE=1 SV=3
MGKVKVGVNGFGRIGRLVTRAAFNSGKVDIVAINDPFIDLNYMVYMFQYDSTHGKFHGTVKAENGKLVINGNPITIFQERDPSKIKWGDAGAEYVVESTGVFTTMEKAGAHLQGGAKRVIISAPSADAPMFVMGVNHEKYDNSLKIISNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGALQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTANVSVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEHQVVSSDFNSDTHSSTFDAGAGIALNDHFVKLISWYDNEFGYSNRVVDLMAHMASKE
|
| Structure Information |
| PDB ID | 1ZNQ_O, 1U8F_O |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1 to 3, 332, 335 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | glyceraldehyde-3-phosphate dehydrogenase, enzyme
D-glyceraldehyde 3-phosphate + phosphate + NAD+ => 1,3-bis-phosphogycerate + NADH
Carbohydrate degradation, glycolysis |
| References for function | |
| E.C. number | 1.2.1.12 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | translation inhibition
part of GAIT complex: interferon (IFN)-gamma-activated inhibitor of translation that silences ceruloplasmin mRNA translation
|
| References for function | Sampath P, Mazumder B, Seshadri V, Gerber CA, Chavatte L, Kinter M, Ting SM, Dignam JD, Kim S, Driscoll DM, Fox PL. Noncanonical function of glutamyl-prolyl-tRNA synthetase: gene-specific silencing of translation. Cell. 2004 Oct 15. PMID: 15479637 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |