General Information |
MoonProt ID | 185 |
First appeared in release | 1.0 |
Name(s) | 60S ribosomal protein L11
CLL-associated antigen KW-12
Gene Name:Rpl11 |
UniProt ID | P62913 (RL11_HUMAN), Reviewed |
GO terms | GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006364 rRNA processing
GO:0006412 translation
GO:0006413 translational initiation
GO:0006414 translational elongation
GO:0006415 translational termination
GO:0006605 protein targeting
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0019058 viral life cycle
GO:0019083 viral transcription
GO:0034504 protein localization to nucleus
GO:0042273 ribosomal large subunit biogenesis
GO:0044267 cellular protein metabolic process
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0019843 rRNA binding
GO:0044822 poly(A) RNA binding
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:0030529 ribonucleoprotein complex
GO:0070062 extracellular vesicular exosome |
Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal) |
Sequence length | 178 |
FASTA sequence | >sp|P62913|RL11_HUMAN 60S ribosomal protein L11 OS=Homo sapiens GN=RPL11 PE=1 SV=2
MAQDQGEKENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVFSKARYTVRSFGIRRNEKIAVHCTVRGAKAEEILEKGLKVREYELRKNNFSDTGNFGFGIQEHIDLGIKYDPSIGIYGLDFYVVLGRPGFSIADKKRRTGCIGAKHRISKEEAMRWFQQKYDGIILPGK
|
Structure Information |
PDB ID | 2ZKR, 3J3B |
Quaternary structure | |
SCOP | NA |
CATH | NA |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | 1 to 9, 177-178 |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | ribosomal protein, part of 60S subunit |
References for function | |
E.C. number | N/A |
Location of functional site(s) | |
Cellular location of function | cytoplasm, part of ribosome |
Comments | |
Function 2 |
Function description | Binds to and inhibits HDM2, a ubiquitin ligase, which results in stabilization of p53 tumor suppressor protein |
References for function | Zhang Y, Wolf GW, Bhat K, Jin A, Allio T, Burkhart WA, Xiong Y. Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway. Mol Cell Biol. 2003 Dec. PMID: 14612427 |
E.C. number | N/A |
Location of functional site(s) | |
Cellular location of function | cytoplasm |
Comments | |