| General Information |
| MoonProt ID | 187 |
| First appeared in release | 1.0 |
| Name(s) | 40S ribosomal protein S7
Gene Name:RPS7 |
| UniProt ID | P62081 (RS7_HUMAN), Reviewed |
| GO terms | GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006364 rRNA processing
GO:0006412 translation
GO:0006413 translational initiation
GO:0006414 translational elongation
GO:0006415 translational termination
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0019058 viral life cycle
GO:0019083 viral transcription
GO:0042274 ribosomal small subunit biogenesis
GO:0044267 cellular protein metabolic process
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005856 cytoskeleton
GO:0022627 cytosolic small ribosomal subunit
GO:0030529 ribonucleoprotein complex
GO:0030686 90S preribosome
GO:0032040 small-subunit processome |
| Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal) |
| Sequence length | 194 |
| FASTA sequence | >sp|P62081|RS7_HUMAN 40S ribosomal protein S7 OS=Homo sapiens GN=RPS7 PE=1 SV=1
MFSSSAKIVKPNGEKPDEFESGISQALLELEMNSDLKAQLRELNITAAKEIEVGGGRKAIIIFVPVPQLKSFQKIQVRLVRELEKKFSGKHVVFIAQRRILPKPTRKSRTKNKQKRPRSRTLTAVHDAILEDLVFPSEIVGKRIRVKLDGSRLIKVHLDKAQQNNVEHKVETFSGVYKKLTGKDVNFEFPEFQL
|
| Structure Information |
| PDB ID | 3J3A,
4KZX,
4KZY,
4KZZ |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1 to 14, 107-115, 193-194 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | ribosomal protein, part of 40S subunit |
| References for function | |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm, part of ribosome |
| Comments | |
| Function 2 |
| Function description | Binds to and inhibits HDM2, a ubiquitin ligase, which results in stabilization of the p53 tumor suppressor protein |
| References for function | Chen D, Zhang Z, Li M, Wang W, Li Y, Rayburn ER, Hill DL, Wang H, Zhang R. Ribosomal protein S7 as a novel modulator of p53-MDM2 interaction: binding to MDM2, stabilization of p53 protein, and activation of p53 function. Oncogene. 2007 Aug 2. PMID: 17310983 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |