General Information |
MoonProt ID | 189 |
First appeared in release | 1.0 |
Name(s) | Nucleolin
Protein C23
Gene Name:NCL |
UniProt ID | P19338 (NUCL_HUMAN), Reviewed |
GO terms | GO:0001525 angiogenesis
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0042162 telomeric DNA binding
GO:0042802 identical protein binding
GO:0044822 poly(A) RNA binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005938 cell cortex
GO:0030529 ribonucleoprotein complex
GO:0070062 extracellular vesicular exosome |
Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal) |
Sequence length | 710 |
FASTA sequence | >sp|P19338|NUCL_HUMAN Nucleolin OS=Homo sapiens GN=NCL PE=1 SV=3
MVKLAKAGKNQGDPKKMAPPPKEVEEDSEDEEMSEDEEDDSSGEEVVIPQKKGKKAAATSAKKVVVSPTKKVAVATPAKKAAVTPGKKAAATPAKKTVTPAKAVTTPGKKGATPGKALVATPGKKGAAIPAKGAKNGKNAKKEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDEDDDDEDDEEEEEEEEEEPVKEAPGKRKKEMAKQKAAPEAKKQKVEGTEPTTAFNLFVGNLNFNKSAPELKTGISDVFAKNDLAVVDVRIGMTRKFGYVDFESAEDLEKALELTGLKVFGNEIKLEKPKGKDSKKERDARTLLAKNLPYKVTQDELKEVFEDAAEIRLVSKDGKSKGIAYIEFKTEADAEKTFEEKQGTEIDGRSISLYYTGEKGQNQDYRGGKNSTWSGESKTLVLSNLSYSATEETLQEVFEKATFIKVPQNQNGKSKGYAFIEFASFEDAKEALNSCNKREIEGRAIRLELQGPRGSPNARSQPSKTLFVKGLSEDTTEETLKESFDGSVRARIVTDRETGSSKGFGFVDFNSEEDAKAAKEAMEDGEIDGNKVTLDWAKPKGEGGFGGRGGGRGGFGGRGGGRGGRGGFGGRGRGGFGGRGGFRGGRGGGGDHKPQGKKTKFE
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Structure Information |
PDB ID | |
Quaternary structure | |
SCOP | NA |
CATH | NA |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | 1-96, 104-304, 381-389, 466-483, 561-568, 649-710 |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | synthesis and maturation of ribosomes |
References for function | |
E.C. number | N/A |
Location of functional site(s) | |
Cellular location of function | nucleus, nucleolus |
Comments | |
Function 2 |
Function description | regulates (decreases) translation of p53 tumor suppressor protein
binds 5' UTR of p53 mRNA |
References for function | Takagi M, Absalon MJ, McLure KG, Kastan MB. Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell. 2005 Oct 7. PMID: 16213212 |
E.C. number | N/A |
Location of functional site(s) | |
Cellular location of function | cytoplasm |
Comments | |