| General Information |
| MoonProt ID | 194 |
| First appeared in release | 1.0 |
| Name(s) | 50S ribosomal protein L4
Gene Name:rplD |
| UniProt ID | P60723 (RL4_ECOLI), Reviewed |
| GO terms | GO:0006351 transcription, DNA-templated
GO:0006353 DNA-templated transcription, termination
GO:0006355 regulation of transcription, DNA-templated
GO:0006412 translation
GO:0006417 regulation of translation
GO:0017148 negative regulation of translation
GO:0046677 response to antibiotic
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding
GO:0030371 translation repressor activity
GO:0005840 ribosome
GO:0022625 cytosolic large ribosomal subunit
GO:0030529 ribonucleoprotein complex |
| Organisms for which functions have been demonstrated | Escherichia coli (Gram negative bacterium) |
| Sequence length | 201 |
| FASTA sequence | >sp|P60723|RL4_ECOLI 50S ribosomal protein L4 OS=Escherichia coli (strain K12) GN=rplD PE=1 SV=1
MELVLKDAQSALTVSETTFGRDFNEALVHQVVVAYAAGARQGTRAQKTRAEVTGSGKKPWRQKGTGRARSGSIKSPIWRSGGVTFAARPQDHSQKVNKKMYRGALKSILSELVRQDRLIVVEKFSVEAPKTKLLAQKLKDMALEDVLIITGELDENLFLAARNLHKVDVRDATGIDPVSLIAFDKVVMTADAVKQVEEMLA
|
| Structure Information |
| PDB ID | 1P85 and many others |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | 31.34%, 41 - 96; 45 - 103, |
| Predicted Disorder Regions | 1 to 11, 43-74 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | ribosomal protein, part of the 50S subunit |
| References for function | |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm, part of the ribosome |
| Comments | |
| Function 2 |
| Function description | transcriptional repressor
causes premature termination of transcription within S10 operon |
| References for function | Zengel JM, Lindahl L. A hairpin structure upstream of the terminator hairpin required for ribosomal protein L4-mediated attenuation control of the S10 operon of Escherichia coli. J Bacteriol. 1996 Apr. PMID: 8636042 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | binding to DNA |
| Comments | |