| General Information |
| MoonProt ID | 199 |
| First appeared in release | 1.0 |
| Name(s) | DNA replication factor Cdt1
Double parked homolog
DUP
Gene Name:CDT1 |
| UniProt ID | Q9H211 (CDT1_HUMAN), Reviewed |
| GO terms | GO:0000076 DNA replication checkpoint
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006260 DNA replication
GO:0007049 cell cycle
GO:0030174 regulation of DNA-dependent DNA replication initiation
GO:0033262 regulation of nuclear cell cycle DNA replication
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol |
| Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal, OMIM number 605525 Meier-Gorlin Syndrome) |
| Sequence length | 546 |
| FASTA sequence | >sp|Q9H211|CDT1_HUMAN DNA replication factor Cdt1 OS=Homo sapiens GN=CDT1 PE=1 SV=3
MEQRRVTDFFARRRPGPPRIAPPKLACRTPSPARPALRAPASATSGSRKRARPPAAPGRDQARPPARRRLRLSVDEVSSPSTPEAPDIPACPSPGQKIKKSTPAAGQPPHLTSAQDQDTISELASCLQRARELGARVRALKASAQDAGESCTPEAEGRPEEPCGEKAPAYQRFHALAQPGLPGLVLPYKYQVLAEMFRSMDTIVGMLHNRSETPTFAKVQRGVQDMMRRRFEECNVGQIKTVYPASYRFRQERSVPTFKDGTRRSDYQLTIEPLLEQEADGAAPQLTASRLLQRRQIFSQKLVEHVKEHHKAFLASLSPAMVVPEDQLTRWHPRFNVDEVPDIEPAALPQPPATEKLTTAQEVLARARNLISPRMEKALSQLALRSAAPSSPGSPRPALPATPPATPPAASPSALKGVSQDLLERIRAKEAQKQLAQMTRCPEQEQRLQRLERLPELARVLRSVFVSERKPALSMEVACARMVGSCCTIMSPGEMEKHLLLLSELLPDWLSLHRIRTDTYVKLDKAADLAHITARLAHQTRAEEGL
|
| Structure Information |
| PDB ID | 2WVR |
| Quaternary structure | |
| SCOP | NA |
| CATH | 1.20.5.1180 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-122, 135-167, 260-261, |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | helps load proteins onto chromatin to create the pre-replication complex for initiating DNA replication
|
| References for function | |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | nucleus |
| Comments | |
| Function 2 |
| Function description | role in mitosis
localizes to kinetochores through binding to the Hec1 component of the Ndc80 complex
|
| References for function | Varma D, Chandrasekaran S, Sundin LJ, Reidy KT, Wan X, Chasse DA, Nevis KR, DeLuca JG, Salmon ED, Cook JG. Recruitment of the human Cdt1 replication licensing protein by the loop domain of Hec1 is required for stable kinetochore-microtubule attachment. Nat Cell Biol. 2012 May 13. PMID: 22581055 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm, on kinetochores during mitosis |
| Comments | |