Protein Information

General Information
MoonProt ID2
First appeared in release1.0
Name(s)Transcription antitermination protein RfaH Gene Name:rfaH
UniProt IDP0AFW0 (RFAH_ECOLI), Reviewed
GO termsGO:0001124 transcription elongation from bacterial-type RNA polymerase promoter GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0031564 transcription antitermination GO:0045727 positive regulation of translation GO:0001000 bacterial-type RNA polymerase core enzyme binding GO:0001073 DNA binding transcription antitermination factor activity GO:0003677 DNA binding GO:0005515 protein binding GO:0008494 translation activator activity
Organisms for which functions have been demonstratedEscherichia coli
Sequence length162
FASTA sequence>sp|P0AFW0|RFAH_ECOLI Transcription antitermination protein RfaH OS=Escherichia coli (strain K12) GN=rfaH PE=1 SV=1 MQSWYLLYCKRGQLQRAQEHLERQAVNCLAPMITLEKIVRGKRTAVSEPLFPNYLFVEFDPEVIHTTTINATRGVSHFVRFGASPAIVPSAVIHQLSVYKPKDIVDPATPYPGDKVIITEGAFEGFQAIFTEPDGEARSMLLLNLINKEIKHSVKNTEFRKL
Structure Information
PDB ID2OUG, 2LCL
Quaternary structure
Function 1
Function descriptionaids in transcription elongation of long RNA chains, reduces pausing and inhibits termination
References for function
E.C. numberN/A
Location of functional site(s)
Cellular location of functionbound to DNA
Comments
Function 2
Function descriptiontranslational regulator
References for functionBurmann BM, Knauer SH, Sevostyanova A, Schweimer K, Mooney RA, Landick R, Artsimovitch I, R?sch P. An a helix to ? barrel domain switch transforms the transcription factor RfaH into a translation factor. Cell. 2012 Jul 20. PMID: 22817892
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments