| General Information |
| MoonProt ID | 20 |
| First appeared in release | 1.0 |
| Name(s) | DnaK
Hsp70
Chaperone protein DnaK
Heat shock 70 kDa protein
Heat shock protein 70
Gene Name: dnaK
|
| UniProt ID | A9M296 (DNAK_NEIM0), Reviewed |
| GO terms | GO:0006457 protein folding
GO:0006950 response to stress
GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0051082 unfolded protein binding |
| Organisms for which functions have been demonstrated | Neisseria meningitidis (Gram negative bacterium, causes meningitis) |
| Sequence length | 642 |
| FASTA sequence | >sp|A9M296|DNAK_NEIM0 Chaperone protein DnaK OS=Neisseria meningitidis serogroup C (strain 053442) GN=dnaK PE=3 SV=1
MAKVIGIDLGTTNSCLAISENGQTKVIENAEGARTTPSVIAYLDGGEILVGAPAKRQAVTNAKNTIYAAKRLIGHKFEDKEVQRDIESMPFEIIKANNGDAWVKAQGKELSPPQISAEVLRKMKEAAEAYLGEKVTEAVITVPAYFNDSQRQATKDAGRIAGLDVKRIINEPTAAALAFGMDKGDNKDRKVAVYDLGGGTFDISIIEIANLDGDKQFEVLATNGDTFLGGEDFDQRLIDYIIDEFKKEQGIDLKQDVMALQRLKEAAEKAKIELSSGQQTEINLPYITMDATGPKHLAMKITRAKFESLVEDLIARSIEPCRTALKDAGLSTGDIDDVILVGGQSRMPKVQEAVKAFFGKEPRKDVNPDEAVAVGAAIQGEVLSGGRSDVLLLDVTPLSLGIETMGGVMTKLIQKNTTIPTKASQVFSTAEDNQSAVTIHVLQGERERASANKSLGQFNLGDIAPAPRGMPQIEVTFDIDANGILHVSAKDKGTGKAANITIQGSSGLSEEEIERMVKDAEANAEEDKKLTELVASRNQAEALIHSVKKSLADYGDKLDAAEKEKIEAALKEAEEAVKGDDKTAIDAKAEALGTASQKLGEMVYAQAQAEAQAGESEQANASAKKDDDVVDADFEEVKDDKK |
| Structure Information |
| PDB ID | Closest homologue is 2KHO_A (72.61%) |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1,272-275,501-510,515-531,552-562,603-628, 636-642 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | chaperone |
| References for function | |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | plasminogen binding protein |
| References for function | Knaust A, Weber MV, Hammerschmidt S, Bergmann S, Frosch M, Kurzai O. Cytosolic proteins contribute to surface plasminogen recruitment of Neisseria meningitidis. J Bacteriol. 2007 Apr;189(14):5404. PMID: 17307854 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |