General Information |
MoonProt ID | 209 |
First appeared in release | 1.0 |
Name(s) | Cytosol aminopeptidase
Aminopeptidase A/I
Leucine aminopeptidase
LAP
Leucyl aminopeptidase
Gene Name:pepA |
UniProt ID | P68767 (AMPA_ECOLI), Reviewed |
GO terms | GO:0006276 plasmid maintenance
GO:0006310 DNA recombination
GO:0006351 transcription, DNA-templated
GO:0006508 proteolysis
GO:0019538 protein metabolic process
GO:0031564 transcription antitermination
GO:0042150 plasmid recombination
GO:0043171 peptide catabolic process
GO:0001073 DNA binding transcription antitermination factor activity
GO:0003677 DNA binding
GO:0004177 aminopeptidase activity
GO:0008233 peptidase activity
GO:0008235 metalloexopeptidase activity
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0005622 intracellular
GO:0005737 cytoplasm |
Organisms for which functions have been demonstrated | Escherichia coli (Gram negative bacterium) |
Sequence length | 503 |
FASTA sequence | >sp|P68767|AMPA_ECOLI Cytosol aminopeptidase OS=Escherichia coli (strain K12) GN=pepA PE=1 SV=1
MEFSVKSGSPEKQRSACIVVGVFEPRRLSPIAEQLDKISDGYISALLRRGELEGKPGQTLLLHHVPNVLSERILLIGCGKERELDERQYKQVIQKTINTLNDTGSMEAVCFLTELHVKGRNNYWKVRQAVETAKETLYSFDQLKTNKSEPRRPLRKMVFNVPTRRELTSGERAIQHGLAIAAGIKAAKDLGNMPPNICNAAYLASQARQLADSYSKNVITRVIGEQQMKELGMHSYLAVGQGSQNESLMSVIEYKGNASEDARPIVLVGKGLTFDSGGISIKPSEGMDEMKYDMCGAAAVYGVMRMVAELQLPINVIGVLAGCENMPGGRAYRPGDVLTTMSGQTVEVLNTDAEGRLVLCDVLTYVERFEPEAVIDVATLTGACVIALGHHITGLMANHNPLAHELIAASEQSGDRAWRLPLGDEYQEQLESNFADMANIGGRPGGAITAGCFLSRFTRKYNWAHLDIAGTAWRSGKAKGATGRPVALLAQFLLNRAGFNGEE
|
Structure Information |
PDB ID | 1GYT |
Quaternary structure | |
SCOP | Macro domain-like, Phosphorylase/hydrolase-like |
CATH | 3.40.220.10, 3.40.630.10 |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | 1, 497-503 |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | aminopeptidase, enzyme
removes amino-terminal amino acid, preferentially if it is Leu
|
References for function | Charlier D, Kholti A, Huysveld N, Gigot D, Maes D, ThiaToong TL, Glansdorff N. Mutational analysis of Escherichia coli PepA, a multifunctional DNA-binding aminopeptidase. J Mol Biol. 2000 Sep 15. PMID: 10970742 |
E.C. number | 3.4.11.1 and 3.4.11.10 |
Location of functional site(s) | |
Cellular location of function | cytoplasm |
Comments | |
Function 2 |
Function description | transcriptional repressor
binds DNA, binds car operator DNA
represses the carAB operon
|
References for function | Charlier D, Kholti A, Huysveld N, Gigot D, Maes D, ThiaToong TL, Glansdorff N. Mutational analysis of Escherichia coli PepA, a multifunctional DNA-binding aminopeptidase. J Mol Biol. 2000 Sep 15. PMID: 10970742 |
E.C. number | N/A |
Location of functional site(s) | |
Cellular location of function | cytoplasm, binds to DNA |
Comments | |