| General Information |
| MoonProt ID | 21 |
| First appeared in release | 1.0 |
| Name(s) | DnaK
Hsp70
molecular chaperone DnaK
Chaperone protein DnaK
Heat shock 70 kDa protein
Heat shock protein 70
Gene Name: dnaK |
| UniProt ID | A0A0H3L5C8 |
| GO terms | GO:0006457 protein folding
GO:0006950 response to stress
GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0051082 unfolded protein binding |
| Organisms for which functions have been demonstrated | Mycobacterium tuberculosis (mycobacterium, causes tuberculosis) |
| Sequence length | 625 |
| FASTA sequence | >tr|A0A0H3L5C8|A0A0H3L5C8_MYCTE Chaperone protein DnaK OS=Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman) GN=dnaK PE=2 SV=1
MARAVGIDLGTTNSVVSVLEGGDPVVVANSEGSRTTPSIVAFARNGEVLVGQPAKNQAVTNVDRTVRSVKRHMGSDWSIEIDGKKYTAPEISARILMKLKRDAEAYLGEDITDAVITTPAYFNDAQRQATKDAGQIAGLNVLRIVNEPTAAALAYGLDKGEKEQRILVFDLGGGTFDVSLLEIGEGVVEVRATSGDNHLGGDDWDQRVVDWLVDKFKGTSGIDLTKDKMAMQRLREAAEKAKIELSSSQSTSINLPYITVDADKNPLFLDEQLTRAEFQRITQDLLDRTRKPFQSVIADTGISVSEIDHVVLVGGSTRMPAVTDLVKELTGGKEPNKGVNPDEVVAVGAALQAGVLKGEVKDVLLLDVTPLSLGIETKGGVMTRLIERNTTIPTKRSETFTTADDNQPSVQIQVYQGEREIAAHNKLLGSFELTGIPPAPRGIPQIEVTFDIDANGIVHVTAKDKGTGKENTIRIQEGSGLSKEDIDRMIKDAEAHAEEDRKRREEADVRNQAETLVYQTEKFVKEQREAEGGSKVPEDTLNKVDAAVAEAKAALGGSDISAIKSAMEKLGQESQALGQAIYEAAQAASQATGAAHPGGEPGGAHPGSADDVVDAEVVDDGREAK |
| Structure Information |
| PDB ID | 4RTF_A |
| Quaternary structure | |
| SCOP | NA |
| CATH | 3.30.420.40, 3.90.640.10 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-2,244-247,470-484,481-511,527-536,584-610,617-625 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | chaperone
|
| References for function | |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | plasminogen binding |
| References for function | Xolalpa W, Vallecillo AJ, Lara M, MendozaHernandez G, Comini M, Spallek R, Singh M, Espitia C. Identification of novel bacterial plasminogen-binding proteins in the human pathogen Mycobacterium tuberculosis. Proteomics. 2007 Sep;7(18):3332-41.
PMID: 17849409 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |