| General Information |
| MoonProt ID | 211 |
| First appeared in release | 1.0 |
| Name(s) | Maltose/maltodextrin import ATP-binding protein MalK
Gene Name:malK |
| UniProt ID | P68187 (MALK_ECOLI), Reviewed |
| GO terms | GO:0006200 ATP catabolic process
GO:0006810 transport
GO:0008152 metabolic process
GO:0008643 carbohydrate transport
GO:0015768 maltose transport
GO:0042956 maltodextrin transport
GO:0055085 transmembrane transport
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005524 ATP binding
GO:0015423 maltose-transporting ATPase activity
GO:0015609 maltooligosaccharide-importing ATPase activity GO:0016787 hydrolase activity
GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0016887 ATPase activity
GO:0017111 nucleoside-triphosphatase activity
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043190 ATP-binding cassette (ABC) transporter complex |
| Organisms for which functions have been demonstrated | Escherichia coli (Gram negative bacterium) |
| Sequence length | 371 |
| FASTA sequence | >sp|P68187|MALK_ECOLI Maltose/maltodextrin import ATP-binding protein MalK OS=Escherichia coli (strain K12) GN=malK PE=1 SV=1
MASVQLQNVTKAWGEVVVSKDINLDIHEGEFVVFVGPSGCGKSTLLRMIAGLETITSGDLFIGEKRMNDTPPAERGVGMVFQSYALYPHLSVAENMSFGLKLAGAKKEVINQRVNQVAEVLQLAHLLDRKPKALSGGQRQRVAIGRTLVAEPSVFLLDEPLSNLDAALRVQMRIEISRLHKRLGRTMIYVTHDQVEAMTLADKIVVLDAGRVAQVGKPLELYHYPADRFVAGFIGSPKMNFLPVKVTATAIDQVQVELPMPNRQQVWLPVESRDVQVGANMSLGIRPEHLLPSDIADVILEGEVQVVEQLGNETQIHIQIPSIRQNLVYRQNDVVLVEEGATFAIGLPPERCHLFREDGTACRRLHKEPGV
|
| Structure Information |
| PDB ID | 1Q12
1Q1E
2AWN
2AWO
3FH6
3PUY
3PUZ
3PV0
3PUV
3PUW
3PUX
3RLF
4JBW
4KHZ
4KI0
1Q1B
2R6G |
| Quaternary structure | |
| SCOP | OB-fold, P-loop containing nucleoside triphosphate hydrolases |
| CATH | 3.40.50.300, 2.40.50.140, 2.40.50.100 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-2, 364-371 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | ATP binding/hydrolysis protein of MalEFGK maltose/maltodextrin transporter (importer)
an ABC transporter
ATP + H2O = ADP + phosphate
|
| References for function | Davidson AL, Nikaido H. Purification and characterization of the membrane-associated components of the maltose transport system from Escherichia coli. J Biol Chem. 1991 May 15. PMID: 2026607.
K?hnau S, Reyes M, Sievertsen A, Shuman HA, Boos W. The activities of the Escherichia coli MalK protein in maltose transport, regulation, and inducer exclusion can be separated by mutations. J Bacteriol. 1991 Apr. PMID: 2007546. |
| E.C. number | 3.6.3.19 |
| Location of functional site(s) | |
| Cellular location of function | inner membrane, peripheral membrane protein |
| Comments | |
| Function 2 |
| Function description | transcription regulation
binds to MalT activator of mal regulon and prevents its action |
| References for function | Panagiotidis CH, Boos W, Shuman HA. The ATP-binding cassette subunit of the maltose transporter MalK antagonizes MalT, the activator of the Escherichia coli mal regulon. Mol Microbiol. 1998 Nov. PMID: 9822819.
K?hnau S, Reyes M, Sievertsen A, Shuman HA, Boos W. The activities of the Escherichia coli MalK protein in maltose transport, regulation, and inducer exclusion can be separated by mutations. J Bacteriol. 1991 Apr. PMID: 2007546. |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | inner membrane, peripheral membrane protein |
| Comments | |