| General Information |
| MoonProt ID | 212 |
| First appeared in release | 1.0 |
| Name(s) | dihydroxyacetone kinase
PTS-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit DhaK
Gene Name:dhaK
|
| UniProt ID | P76015 (DHAK_ECOLI), Reviewed |
| GO terms | GO:0006071 glycerol metabolic process
GO:0006974 cellular response to DNA damage stimulus
GO:0016310 phosphorylation
GO:0019563 glycerol catabolic process
GO:0042182 ketone catabolic process
GO:0046365 monosaccharide catabolic process
GO:0004371 glycerone kinase activity
GO:0005515 protein binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0047324 phosphoenolpyruvate-glycerone phosphotransferase activity
GO:0005829 cytosol |
| Organisms for which functions have been demonstrated | Escherichia coli (Gram negative bacterium) |
| Sequence length | 356 |
| FASTA sequence | >sp|P76015|DHAK_ECOLI PTS-dependent dihydroxyacetone kinase, dihydroxyacetone-binding subunit DhaK OS=Escherichia coli (strain K12) GN=dhaK PE=1 SV=2
MKKLINDVQDVLDEQLAGLAKAHPSLTLHQDPVYVTRADAPVAGKVALLSGGGSGHEPMHCGYIGQGMLSGACPGEIFTSPTPDKIFECAMQVDGGEGVLLIIKNYTGDILNFETATELLHDSGVKVTTVVIDDDVAVKDSLYTAGRRGVANTVLIEKLVGAAAERGDSLDACAELGRKLNNQGHSIGIALGACTVPAAGKPSFTLADNEMEFGVGIHGEPGIDRRPFSSLDQTVDEMFDTLLVNGSYHRTLRFWDYQQGSWQEEQQTKQPLQSGDRVIALVNNLGATPLSELYGVYNRLTTRCQQAGLTIERNLIGAYCTSLDMTGFSITLLKVDDETLALWDAPVHTPALNWGK
|
| Structure Information |
| PDB ID | 1OI2
1OI3
1UID
3PNK
3PNL
4LRY
3PNO
3PNQ
3PNM
1UOE
|
| Quaternary structure | |
| SCOP | NA |
| CATH | |
| TM Helix Prediction | No TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 258-266, 355-356 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | subunit of dihydroxyacetone kinase, enzyme
phosphorylates dihydroxyacetone
contains the Dha binding site
|
| References for function | |
| E.C. number | 2.7.-.- |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | corepressor of DhaR transcription activator
binds to DhaR
affects transcription of the dhaKLM operon
|
| References for function | B?chler C, Schneider P, B?hler P, Lustig A, Erni B. Escherichia coli dihydroxyacetone kinase controls gene expression by binding to transcription factor DhaR. EMBO J. 2005 Jan 26. PMID: 15616579 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |