General Information |
MoonProt ID | 216 |
First appeared in release | 1.0 |
Name(s) | Sarcosine oxidase, alpha subunit
SOX |
UniProt ID | Q5JFD7 (Q5JFD7_THEKO), Unreviewed |
GO terms | GO:0055114 oxidation-reduction process
GO:0016491 oxidoreductase activity |
Organisms for which functions have been demonstrated | Thermococcus kodakarensis |
Sequence length | 492 |
FASTA sequence | >tr|Q5JFD7|Q5JFD7_THEKO Sarcosine oxidase, alpha subunit OS=Thermococcus kodakaraensis (strain ATCC BAA-918 / JCM 12380 / KOD1) GN=TK0116 PE=4 SV=1
MRPLDLTEKDPSKKITIYLDGEPYEAYEGEKFPVAMLANGVYWLTTSNEGRHRGAFTFGPVPVTVNGVKNINGRKLKLKDGMKIERQRYDEFQEQVEIDEGKPVLRYVVDVAVIGAGPAGLGVVEEIGGKLTVALIEEKGWLGGDMWLKGVEQEGFGNPREAIERLTNFPENVRVFLKTAALGVYDKGEYFLVPAVRNDQLIEFMAKKVVLATGAVDNIMLFENNDWPGVFRRADALEVMNVWGVAPGRKVAVTGAFPEEITAELERWGIEYIIVPNVKRVEGEDRIERVIDENGNVYEVDALIMADGRIPDINPITQAGGKLRFKRGYYMPILDDEHRIRDGIYVAGSAVSIKPHYANYLEGKLVGAYILREFGYESEPCIYEERLKEYEPVARPVPKLPLDNFNGEDVQICGCGVTLKKVDDVVRSGITDLQIIKRLTHLAMGFCQGRFCLFNGALLVSQRSGMGMDRLDIPVARPPIKNVKMKVVAGRD
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Structure Information |
PDB ID | |
Quaternary structure | |
SCOP | |
CATH | |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | 1-11, 88-95, 378-390, 469-471, 488-492 |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | Sarcosine oxidase, enzyme
oxidation of the methyl group in sarcosine and transfer to folate
oxidative demethylation of sarcosine to yield glycine and 5,10-CH2-tetrahydrofolate
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References for function | Lee S, Jia B, Pham BP, Shao Y, Kwak JM, Cheong GW. Architecture and characterization of sarcosine oxidase from Thermococcus kodakarensis KOD1. Extremophiles. 2012 Jan. PMID: 22083128 |
E.C. number | 1.5.3.1 |
Location of functional site(s) | |
Cellular location of function | cytoplasm |
Comments | |
Function 2 |
Function description | NADH dehydrogenase
NADH + H+ + acceptor <=> NAD+ + reduced acceptor
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References for function | Lee S, Jia B, Pham BP, Shao Y, Kwak JM, Cheong GW. Architecture and characterization of sarcosine oxidase from Thermococcus kodakarensis KOD1. Extremophiles. 2012 Jan. PMID: 22083128 |
E.C. number | 1.6.99.3 |
Location of functional site(s) | |
Cellular location of function | cytoplasm |
Comments | |