| General Information |
| MoonProt ID | 22 |
| First appeared in release | 1.0 |
| Name(s) | Elongation factor Tu
EF-Tu
Gene Name: tuf
|
| UniProt ID | Q74JU6 (EFTU_LACJO), Reviewed |
| GO terms | GO:0006184 GTP catabolic process
GO:0006412 translation
GO:0006414 translational elongation
GO:0000166 nucleotide binding
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0005622 intracellular
GO:0005737 cytoplasm |
| Organisms for which functions have been demonstrated | Lactobacillus johnsonii NCC533 (La1) (Gram positive bacterium) |
| Sequence length | 396 |
| FASTA sequence | >sp|Q74JU6|EFTU_LACJO Elongation factor Tu OS=Lactobacillus johnsonii (strain CNCM I-12250 / La1 / NCC 533) GN=tuf PE=3 SV=1
MAEKEHYERTKPHVNIGTIGHVDHGKTTLTAAITTVLAEDGLAQAEDYSQIDAAPEEKERGITINTAHVEYETKNRHYAHMDAPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTREHILLARQVGVQYIVVFLNKVDLVDDPELIDLVEMEVRDLLSEYDYPGDDVPVIRGSALKALEGDPEQQDVIRKLMETVDEYIPTPERDTDKPFLMPVEDVFTITGRGTVASGRIDRGTVKVGDEVEIVGLTDKIEKSTVTGLEMFHKTLDLGEAGDNVGVLLRGIDRDQVERGQVLAAPGSIQTHKNFKGQVYILNKDEGGRHTPFFSDYRPQFYFHTTDVTGKIELPEGTEMVMPGDNVEFTVELIKPVAIEKGTKFTIREGGKTVGAGQVTEILD |
| Structure Information |
| PDB ID | Closest homologue is 6GFU (74.8%) |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-9,391-396 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | elongation factor in protein synthesis |
| References for function | during protein biosynthesis: promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | attachment to human cells and mucins |
| References for function | Granato D, Bergonzelli GE, Pridmore RD, Marvin L, Rouvet M, Corth?syTheulaz IE. Cell surface-associated elongation factor Tu mediates the attachment of Lactobacillus johnsonii NCC533 (La1) to human intestinal cells and mucins. Infect Immun. 2004 Apr;72(4):2160-9. PMID: 15039339 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface
|
| Comments | |