| General Information |
| MoonProt ID | 220 |
| First appeared in release | 1.0 |
| Name(s) | Bifunctional dihydrofolate reductase-thymidylate synthase
DHFR-TS
|
| UniProt ID | P13922 (DRTS_PLAFK), Reviewed |
| GO terms | GO:0006231 dTMP biosynthetic process
GO:0006545 glycine biosynthetic process
GO:0006730 one-carbon metabolic process
GO:0008152 metabolic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation
GO:0046654 tetrahydrofolate biosynthetic process
GO:0055114 oxidation-reduction process
GO:0003824 catalytic activity
GO:0004146 dihydrofolate reductase activity
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0016491 oxidoreductase activity
GO:0016740 transferase activity |
| Organisms for which functions have been demonstrated | Plasmodium falciparum |
| Sequence length | 608 |
| FASTA sequence | >sp|P13922|DRTS_PLAFK Bifunctional dihydrofolate reductase-thymidylate synthase OS=Plasmodium falciparum (isolate K1 / Thailand) PE=1 SV=2
MMEQVCDVFDIYAICACCKVESKNEGKKNEVFNNYTFRGLGNKGVLPWKCNSLDMKYFRAVTTYVNESKYEKLKYKRCKYLNKETVDNVNDMPNSKKLQNVVVMGRTNWESIPKKFKPLSNRINVILSRTLKKEDFDEDVYIINKVEDLIVLLGKLNYYKCFIIGGSVVYQEFLEKKLIKKIYFTRINSTYECDVFFPEINENEYQIISVSDVYTSNNTTLDFIIYKKTNNKMLNEQNCIKGEEKNNDMPLKNDDKDTCHMKKLTEFYKNVDKYKINYENDDDDEEEDDFVYFNFNKEKEEKNKNSIHPNDFQIYNSLKYKYHPEYQYLNIIYDIMMNGNKQSDRTGVGVLSKFGYIMKFDLSQYFPLLTTKKLFLRGIIEELLWFIRGETNGNTLLNKNVRIWEANGTREFLDNRKLFHREVNDLGPIYGFQWRHFGAEYTNMYDNYENKGVDQLKNIINLIKNDPTSRRILLCAWNVKDLDQMALPPCHILCQFYVFDGKLSCIMYQRSCDLGLGVPFNIASYSIFTHMIAQVCNLQPAQFIHVLGNAHVYNNHIDSLKIQLNRIPYPFPTLKLNPDIKNIEDFTISDFTIQNYVHHEKISMDMAA
|
| Structure Information |
| PDB ID | 3JSU,
3QG2,
4DP3,
4DPH,
3QGT,
3UM8,
4DPD,
3UM5,
3UM6,
1J3I,
1J3J,
1J3K,
3DG8,
3DGA |
| Quaternary structure | |
| SCOP | NA |
| CATH | 3.40.430.10, 6.10.250.2210, 3.30.572.10 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-5, 82-92, 233-290, 294-315, 605-608 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Dihydrofolate reductase and Thymidylate synthase, enzyme
5,6,7,8-tetrahydrofolate + NADP+ <=> 7,8-dihydrofolate + NADPH
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP
Tetrahydrofolate biosynthesis |
| References for function | |
| E.C. number | 1.5.1.3 and EC=2.1.1.45 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | mRNA translation inhibition
regulation of plasmodium TS-DHFR mRNA translation |
| References for function | Zhang K, Rathod PK. Divergent regulation of dihydrofolate reductase between malaria parasite and human host. Science. 2002 Apr 19. PMID: 11964483 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |