| General Information |
| MoonProt ID | 223 |
| First appeared in release | 1.0 |
| Name(s) | Serine hydroxymethyltransferase, cytosolic
SHMT
Glycine hydroxymethyltransferase
Serine methylase
Gene Name:SHMT1 |
| UniProt ID | P34896 (GLYC_HUMAN), Reviewed |
| GO terms | GO:0006544 glycine metabolic process
GO:0006545 glycine biosynthetic process
GO:0006563 L-serine metabolic process
GO:0006565 L-serine catabolic process
GO:0006730 one-carbon metabolic process
GO:0006766 vitamin metabolic process
GO:0006767 water-soluble vitamin metabolic process
GO:0009113 purine nucleobase biosynthetic process
GO:0019264 glycine biosynthetic process from serine
GO:0034641 cellular nitrogen compound metabolic process
GO:0035999 tetrahydrofolate interconversion
GO:0044281 small molecule metabolic process
GO:0045329 carnitine biosynthetic process
GO:0046655 folic acid metabolic process
GO:0051262 protein tetramerization
GO:0051289 protein homotetramerization
GO:0003824 catalytic activity
GO:0004372 glycine hydroxymethyltransferase activity
GO:0008732 L-allo-threonine aldolase activity
GO:0016597 amino acid binding
GO:0016740 transferase activity
GO:0030170 pyridoxal phosphate binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome |
| Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal) |
| Sequence length | 483 |
| FASTA sequence | >sp|P34896|GLYC_HUMAN Serine hydroxymethyltransferase, cytosolic OS=Homo sapiens GN=SHMT1 PE=1 SV=1
MTMPVNGAHKDADLWSSHDKMLAQPLKDSDVEVYNIIKKESNRQRVGLELIASENFASRAVLEALGSCLNNKYSEGYPGQRYYGGTEFIDELETLCQKRALQAYKLDPQCWGVNVQPYSGSPANFAVYTALVEPHGRIMGLDLPDGGHLTHGFMTDKKKISATSIFFESMPYKVNPDTGYINYDQLEENARLFHPKLIIAGTSCYSRNLEYARLRKIADENGAYLMADMAHISGLVAAGVVPSPFEHCHVVTTTTHKTLRGCRAGMIFYRKGVKSVDPKTGKEILYNLESLINSAVFPGLQGGPHNHAIAGVAVALKQAMTLEFKVYQHQVVANCRALSEALTELGYKIVTGGSDNHLILVDLRSKGTDGGRAEKVLEACSIACNKNTCPGDRSALRPSGLRLGTPALTSRGLLEKDFQKVAHFIHRGIELTLQIQSDTGVRATLKEFKERLAGDKYQAAVQALREEVESFASLFPLPGLPDF
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| Structure Information |
| PDB ID | 1BJ4 |
| Quaternary structure | |
| SCOP | PLP-dependent transferase-like |
| CATH | 3.40.640.10, 3.90.1150.10 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1 to 21, 481-483 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | serine hydroxymethyltransferase, enzyme
5,10-methylenetetrahydrofolate + glycine + H2O <=> tetrahydrofolate + L-serine
One-carbon metabolism, tetrahydrofolate interconversion |
| References for function | |
| E.C. number | 2.1.2.1 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | binds mRNA
binds the 5' untranslated region (UTR) of its own mRNA
|
| References for function | Liu X, Reig B, Nasrallah IM, Stover PJ. Human cytoplasmic serine hydroxymethyltransferase is an mRNA binding protein. Biochemistry. 2000 Sep 26. PMID: 10995219 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |