Protein Information

General Information
MoonProt ID226
First appeared in release1.0
Name(s)Mevalonate kinase MK cytosolic luteinizing hormone binding protein LHBP-1 Gene Name:Mvk
UniProt IDP17256 (KIME_RAT), Reviewed
GO termsGO:0006629 lipid metabolic process GO:0006694 steroid biosynthetic process GO:0006695 cholesterol biosynthetic process GO:0006720 isoprenoid metabolic process GO:0008152 metabolic process GO:0008202 steroid metabolic process GO:0008203 cholesterol metabolic process GO:0008299 isoprenoid biosynthetic process GO:0016125 sterol metabolic process GO:0016126 sterol biosynthetic process GO:0016310 phosphorylation GO:0017148 negative regulation of translation GO:0019287 isopentenyl diphosphate biosynthetic process, mevalonate pathway GO:0045540 regulation of cholesterol biosynthetic process GO:0000166 nucleotide binding GO:0003729 mRNA binding GO:0004496 mevalonate kinase activity GO:0005524 ATP binding GO:0016301 kinase activity GO:0016740 transferase activity GO:0016773 phosphotransferase activity, alcohol group as acceptor GO:0005737 cytoplasm GO:0005777 peroxisome GO:0005829 cytosol
Organisms for which functions have been demonstratedRattus norvegicus
Sequence length395
FASTA sequence>sp|P17256|KIME_RAT Mevalonate kinase OS=Rattus norvegicus GN=Mvk PE=1 SV=1 MLSEVLLVSAPGKVILHGEHAVVHGKVALAVALNLRTFLVLRPQSNGKVSLNLPNVGIKQVWDVATLQLLDTGFLEQGDVPAPTLEQLEKLKKVAGLPRDCVGNEGLSLLAFLYLYLAICRKQRTLPSLDIMVWSELPPGAGLGSSAAYSVCVAAALLTACEEVTNPLKDRGSIGSWPEEDLKSINKWAYEGERVIHGNPSGVDNSVSTWGGALRYQQGKMSSLKRLPALQILLTNTKVPRSTKALVAGVRSRLIKFPEIMAPLLTSIDAISLECERVLGEMAAAPVPEQYLVLEELMDMNQHHLNALGVGHASLDQLCQVTAAHGLHSKLTGAGGGGCGITLLKPGLERAKVEAAKQALTGCGFDCWETSIGAPGVSMHSATSIEDPVRQALGL
Structure Information
PDB ID1KVK 2R42
Quaternary structure
Function 1
Function descriptionMevalonate kinase, enzyme ATP + (R)-mevalonate => ADP + (R)-5-phosphomevalonate Isoprenoid biosynthesis, mevalonate pathway
References for function
E.C. number2.7.1.36
Location of functional site(s)
Cellular location of functionperoxisome
Comments
Function 2
Function descriptionmRNA binding cytosolic luteinizing hormone receptor mRNA binding protein increases LH receptor mRNA degradation
References for functionNair AK, Kash JC, Peegel H, Menon KM. Post-transcriptional regulation of luteinizing hormone receptor mRNA in the ovary by a novel mRNA-binding protein. J Biol Chem. 2002 Jun 14. PMID: 11940568. Kash JC, Menon KM. Sequence-specific binding of a hormonally regulated mRNA binding protein to cytidine-rich sequences in the lutropin receptor open reading frame. Biochemistry. 1999 Dec 21. PMID: 10606523. Kash JC, Menon KM. Identification of a hormonally regulated luteinizing hormone/human chorionic gonadotropin receptor mRNA binding protein. Increased mrna binding during receptor down-regulation. J Biol Chem. 1998 Apr 24. PMID: 9553128.
E.C. numberN/A
Location of functional site(s)
Cellular location of functioncytoplasm
Comments