| General Information |
| MoonProt ID | 23 |
| First appeared in release | 1.0 |
| Name(s) | Ef-Tu
Elongation factor Tu
Gene Name: tuf
|
| UniProt ID | P23568 (EFTU_MYCPN), Reviewed |
| GO terms | GO:0006184 GTP catabolic process
GO:0006412 translation
GO:0006414 translational elongation
GO:0000166 nucleotide binding
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0005622 intracellular
GO:0005737 cytoplasm |
| Organisms for which functions have been demonstrated | Mycoplasma pneumoniae |
| Sequence length | 394 |
| FASTA sequence | >sp|P23568|EFTU_MYCPN Elongation factor Tu OS=Mycoplasma pneumoniae (strain ATCC 29342 / M129) GN=tuf PE=3 SV=2
MAREKFDRSKPHVNVGTIGHIDHGKTTLTAAICTVLAKEGKSAATRYDQIDKAPEEKARGITINSAHVEYSSDKRHYAHVDCPGHADYIKNMITGAAQMDGAILVVSATDSVMPQTREHILLARQVGVPRMVVFLNKCDIATDEEVQELVAEEVRDLLTSYGFDGKNTPIIYGSALKALEGDPKWEAKIHDLMNAVDEWIPTPEREVDKPFLLAIEDTMTITGRGTVVTGRVERGELKVGQEIEIVGLRPIRKAVVTGIEMFKKELDSAMAGDNAGVLLRGVDRKEVERGQVLAKPGSIKPHKKFKAEIYALKKEEGGRHTGFLNGYRPQFYFRTTDVTGSISLPENTEMVLPGDNTSITVELIAPIACEKGSKFSIREGGRTVGAGSVTEVLE |
| Structure Information |
| PDB ID | Closest homologue is 6I8R (74.37%) |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-7,389-394 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | elongation factor in protein synthesis
during protein biosynthesis: promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes |
| References for function | |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | fibronectin binding |
| References for function | Dallo SF, Kannan TR, Blaylock MW, Baseman JB. Elongation factor Tu and E1 beta subunit of pyruvate dehydrogenase complex act as fibronectin binding proteins in Mycoplasma pneumoniae. Mol Microbiol. 2002 Nov;46(4):1041-51. PMID: 12421310 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |