| General Information |
| MoonProt ID | 230 |
| First appeared in release | 1.0 |
| Name(s) | 60 kDa chaperonin 1
GroEL1
GroEL protein 1
Cpn60.1
Protein Cpn60-1
Gene Name: groEL1 |
| UniProt ID | P9WPE9 (CH601_MYCTU), Reviewed |
| GO terms | GO:0006457 protein folding
GO:0042026 protein refolding
GO:0044267 cellular protein metabolic process
GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0051082 unfolded protein binding
GO:0005737 cytoplasm
|
| Organisms for which functions have been demonstrated | Mycobacterium tuberculosis (mycobacterium, causes tuberculosis) |
| Sequence length | 539 |
| FASTA sequence | >sp|P9WPE9|CH601_MYCTU 60 kDa chaperonin 1 OS=Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) GN=groEL1 PE=1 SV=1
MSKLIEYDETARRAMEVGMDKLADTVRVTLGPRGRHVVLAKAFGGPTVTNDGVTVAREIELEDPFEDLGAQLVKSVATKTNDVAGDGTTTATILAQALIKGGLRLVAAGVNPIALGVGIGKAADAVSEALLASATPVSGKTGIAQVATVSSRDEQIGDLVGEAMSKVGHDGVVSVEESSTLGTELEFTEGIGFDKGFLSAYFVTDFDNQQAVLEDALILLHQDKISSLPDLLPLLEKVAGTGKPLLIVAEDVEGEALATLVVNAIRKTLKAVAVKGPYFGDRRKAFLEDLAVVTGGQVVNPDAGMVLREVGLEVLGSARRVVVSKDDTVIVDGGGTAEAVANRAKHLRAEIDKSDSDWDREKLGERLAKLAGGVAVIKVGAATETALKERKESVEDAVAAAKAAVEEGIVPGGGASLIHQARKALTELRASLTGDEVLGVDVFSEALAAPLFWIAANAGLDGSVVVNKVSELPAGHGLNVNTLSYGDLAADGVIDPVKVTRSAVLNASSVARMVLTTETVVVDKPAKAEDHDHHHGHAH
|
| Structure Information |
| PDB ID | |
| Quaternary structure | |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-4, 6-11, 352-357, 525-539 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | protein chaperone
prevents proteins from misfolding, promotes correct refolding and assembly of polypeptides |
| References for function | |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | binds DNA
low specificity but high affinity
nucleoid-associated protein
condenses DNA into a compact structure
|
| References for function | Basu D, Khare G, Singh S, Tyagi A, Khosla S, Mande SC. A novel nucleoid-associated protein of Mycobacterium tuberculosis is a sequence homolog of GroEL. Nucleic Acids Res. 2009 Aug. PMID: 19528065 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | nucleoid |
| Comments | |