| General Information |
| MoonProt ID | 232 |
| First appeared in release | 1.0 |
| Name(s) | Cytochrome c
Gene Name: CYCS |
| UniProt ID | P00004 (CYC_HORSE), Reviewed |
| GO terms | GO:0006309 apoptotic DNA fragmentation
GO:0006915 apoptotic process
GO:0055114 oxidation-reduction process
GO:0005506 iron ion binding
GO:0009055 electron carrier activity
GO:0020037 heme binding
GO:0045155 electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity
GO:0046872 metal ion binding
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005829 cytosol
GO:0070469 respiratory chain
|
| Organisms for which functions have been demonstrated | Equus caballus (Horse, a mammal) |
| Sequence length | 105 |
| FASTA sequence | >sp|P00004|CYC_HORSE Cytochrome c OS=Equus caballus GN=CYCS PE=1 SV=2
MGDVEKGKKIFVQKCAQCHTVEKGGKHKTGPNLHGLFGRKTGQAPGFTYTDANKNKGITWKEETLMEYLENPKKYIPGTKMIFAGIKKKTEREDLIAYLKKATNE
|
| Structure Information |
| PDB ID | 1U75
1AKK
1FI7
1FI9
1I5T
1LC1
1LC2
1OCD
2FRC
2GIW
3NBS
3NBT
3WC8
2PCB
1CRC
1HRC
3O1Y
3O20
1WEJ
1GIW |
| Quaternary structure | |
| SCOP | Cytochrome c |
| CATH | 1.10.760.10 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | 99%, 1-104 |
| Predicted Disorder Regions | 1, 103-105 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Electron carrier protein
component of the mitochondrial electron-transport chain
|
| References for function | |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | mitochondrion |
| Comments | |
| Function 2 |
| Function description | binding to apoptosis protease activation factor-1 (Apaf-1)
promotes apoptosis
release from mitochondria allows interaction with apoptosis proteins
|
| References for function | Yu T, Wang X, PurringKoch C, Wei Y, McLendon GL. A mutational epitope for cytochrome C binding to the apoptosis protease activation factor-1. J Biol Chem. 2001 Apr 20. PMID: 11112785.
Lim ML, Lum MG, Hansen TM, Roucou X, Nagley P. On the release of cytochrome c from mitochondria during cell death signaling. J Biomed Sci. 2002 0. PMID: 12372987. |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |