| General Information |
| MoonProt ID | 233 |
| First appeared in release | 1.0 |
| Name(s) | Cytochrome c iso-1
Gene Name: CYC1 |
| UniProt ID | P00044 (CYC1_YEAST), Reviewed |
| GO terms | GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c
GO:0006123 mitochondrial electron transport, cytochrome c to oxygen
GO:0055114 oxidation-reduction process
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0009055 electron carrier activity
GO:0020037 heme binding
GO:0046872 metal ion binding
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0070469 respiratory chain |
| Organisms for which functions have been demonstrated | Saccharomyces cerevisiae (yeast, fungi) |
| Sequence length | 109 |
| FASTA sequence | >sp|P00044|CYC1_YEAST Cytochrome c iso-1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CYC1 PE=1 SV=2
MTEFKAGSAKKGATLFKTRCLQCHTVEKGGPHKVGPNLHGIFGRHSGQAEGYSYTDANIKKNVLWDENNMSEYLTNPKKYIPGTKMAFGGLKKEKDRNDLITYLKKACE
|
| Structure Information |
| PDB ID | 2PCC, 2GB8, 2B12, 2JTI, 1KYO, 3CX5, 1YCC, 2B0Z, 2B11, 1U74, 2BCN, 1NMI, 2HV4, 2ORL, 3TYI, 2B10, 1YIC, 1YCC, 1CRH, 1CSW, 1IRV, 1CTY, 1CTZ, 1CHH, 1JQR |
| Quaternary structure | |
| SCOP | Cytochrome c |
| CATH | 1.10.760.10 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-3, 6, 108-109 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Electron carrier protein component of the mitochondrial electron-transport chain |
| References for function | |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | mitochondrion |
| Comments | |
| Function 2 |
| Function description | binding to apoptosis protease activation factor-1 (Apaf-1) promotes apoptosis release from mitochondria allows interaction with apoptosis proteins |
| References for function | Yu T, Wang X, PurringKoch C, Wei Y, McLendon GL. A mutational epitope for cytochrome C binding to the apoptosis protease activation factor-1. J Biol Chem. 2001 Apr 20. PMID: 11112785.
Lim ML, Lum MG, Hansen TM, Roucou X, Nagley P. On the release of cytochrome c from mitochondria during cell death signaling. J Biomed Sci. 2002 0. PMID: 12372987. |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |