General Information |
MoonProt ID | 25 |
First appeared in release | 1.0 |
Name(s) | Enolase
2-phospho-D-glycerate hydro-lyase
2-phosphoglycerate dehydratase
Gene Name: eno |
UniProt ID | Q8GE63 (ENO_AERHY), Reviewed |
GO terms | GO:0006096 glycolysis
GO:0000287 magnesium ion binding
GO:0004634 phosphopyruvate hydratase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0000015 phosphopyruvate hydratase complex
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0009986 cell surface |
Organisms for which functions have been demonstrated | Aeromonas hydrophila (soft-tissue infections, with cellulitis being most frequent) |
Sequence length | 433 |
FASTA sequence | >gi|25989631|gb|AAN28926.1| enolase [Aeromonas hydrophila]
MSKIVKVIGREIIDSRGNPTVEAEVHLEGGFVGMAAAPSGASTGSREALELRDGDKSRFLGKGVLKALEAVNGPIAQALLGKDAKDQATVDQIMIDLDGTENKSKFGANAILAVSLANAKAAAAAKGMPLYAHIAELNGTPGVYSMPLPMMNIINGGEHADNNVDIQEFMIQPVGAKTLKEAVRMGAEVFHNLAKVLKSKGYNTAVGDEGGFAPNLKSNAEALEVIAEAVAAAGYKLGTDVTLAMDCAASEFYDAEKKEYNLKGEGRVFTSNGFSDFLEELTAKFPIVSIEDGLDESDWEGFAYQTQKLGKKIQIVGDDLFVTNTKILKRGIDNGIANSILIKFNQIGSLTETLAAIKMAKDAGYTAVISHRSGETEDATIADLAVGTAAGQIKTGSMSRSDRVAKYNQLIRIEEALGAKAPFRGLKEVKNQA |
Structure Information |
PDB ID | 6BFY_A |
Quaternary structure | |
SCOP | Enolase N-terminal domain-like, TIM beta/alpha-barrel |
CATH | 3.30.390.10, 3.20.20.120 |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | 1-3,39-43,427-433 |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | enolase, enzyme
2-phospho-D-glycerate => phosphoenolpyruvate + H2O
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate.
Carbohydrate degradation, glycolysis
|
References for function | |
E.C. number | 4.2.1.11 |
Location of functional site(s) | |
Cellular location of function | cytoplasm |
Comments | |
Function 2 |
Function description | plasminogen binding
(binds human plasminogen) |
References for function | Sha J, Erova TE, Alyea RA, Wang S, Olano JP, Pancholi V, Chopra AK. Surface-expressed enolase contributes to the pathogenesis of clinical isolate SSU of Aeromonas hydrophila. J Bacteriol. 2009 May;191(9):3095-107. doi: 10.1128/JB.00005-09. Epub 2009 Mar 6.
PMID: 19270100 |
E.C. number | N/A |
Location of functional site(s) | |
Cellular location of function | cell surface |
Comments | |