| General Information |
| MoonProt ID | 250 |
| First appeared in release | 1.0 |
| Name(s) | Ubp6
Ubiquitin carboxyl-terminal hydrolase 6
Deubiquitinating enzyme 6
Ubiquitin thioesterase 6
Ubiquitin-specific-processing protease 6
Gene Name: UBP6 |
| UniProt ID | P43593 (UBP6_YEAST), Reviewed |
| GO terms | GO:0006508 proteolysis
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0016579 protein deubiquitination
GO:1901799 negative regulation of proteasomal protein catabolic process
GO:0004843 ubiquitin-specific protease activity
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0016787 hydrolase activity
GO:0000502 proteasome complex
GO:0005838 proteasome regulatory particle |
| Organisms for which functions have been demonstrated | Saccharomyces cerevisiae (yeast, fungi) |
| Sequence length | 499 |
| FASTA sequence | >sp|P43593|UBP6_YEAST Ubiquitin carboxyl-terminal hydrolase 6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=UBP6 PE=1 SV=1
MSGETFEFNIRHSGKVYPITLSTDATSADLKSKAEELTQVPSARQKYMVKGGLSGEESIKIYPLIKPGSTVMLLGTPDANLISKPAKKNNFIEDLAPEQQVQQFAQLPVGFKNMGNTCYLNATLQALYRVNDLRDMILNYNPSQGVSNSGAQDEEIHKQIVIEMKRCFENLQNKSFKSVLPIVLLNTLRKCYPQFAERDSQGGFYKQQDAEELFTQLFHSMSIVFGDKFSEDFRIQFKTTIKDTANDNDITVKENESDSKLQCHISGTTNFMRNGLLEGLNEKIEKRSDLTGANSIYSVEKKISRLPKFLTVQYVRFFWKRSTNKKSKILRKVVFPFQLDVADMLTPEYAAEKVKVRDELRKVEKEKNEKEREIKRRKFDPSSSENVMTPREQYETQVALNESEKDQWLEEYKKHFPPNLEKGENPSCVYNLIGVITHQGANSESGHYQAFIRDELDENKWYKFNDDKVSVVEKEKIESLAGGGESDSALILMYKGFGL
|
| Structure Information |
| PDB ID | 1VJV |
| Quaternary structure | |
| SCOP | Cysteine proteinases |
| CATH | 3.90.70.10, 6.10.140.1140 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-5, 145-154, 247-252, 353-423, 498-499 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | deubiquitinase, enzyme
associated with proteasome
releases ubiquitin from ubiquitinated proteins that bind to the proteasome
|
| References for function | |
| E.C. number | 3.4.19.12 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm, part of proteasome |
| Comments | |
| Function 2 |
| Function description | inhibits proteasome activity
delays the degradation of ubiquitinated proteins by the proteasome
enables gradual deubiquitination of the substrate
|
| References for function | Hanna J, Hathaway NA, Tone Y, Crosas B, Elsasser S, Kirkpatrick DS, Leggett DS, Gygi SP, King RW, Finley D. Deubiquitinating enzyme Ubp6 functions noncatalytically to delay proteasomal degradation. Cell. 2006 Oct 6. PMID: 17018280 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm, part of proteasome |
| Comments | |