| General Information |
| MoonProt ID | 251 |
| First appeared in release | 1.0 |
| Name(s) | Epidermal retinol dehydrogenase 2
hRoDH-E2
EPHD-2
RDH-E2
Retinal short-chain dehydrogenase reductase 2
retSDR2
Short-chain dehydrogenase/reductase family 16C member 5
Gene Name: SDR16C5 |
| UniProt ID | Q8N3Y7 (RDHE2_HUMAN), Reviewed |
| GO terms | GO:0008152 metabolic process
GO:0042572 retinol metabolic process
GO:0042574 retinal metabolic process
GO:0043616 keratinocyte proliferation
GO:0050908 detection of light stimulus involved in visual perception
GO:0055114 oxidation-reduction process
GO:0004745 retinol dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane |
| Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal) |
| Sequence length | 309 |
| FASTA sequence | >sp|Q8N3Y7|RDHE2_HUMAN Epidermal retinol dehydrogenase 2 OS=Homo sapiens GN=SDR16C5 PE=2 SV=2
MSFNLQSSKKLFIFLGKSLFSLLEAMIFALLPKPRKNVAGEIVLITGAGSGLGRLLALQFARLGSVLVLWDINKEGNEETCKMAREAGATRVHAYTCDCSQKEGVYRVADQVKKEVGDVSILINNAGIVTGKKFLDCPDELMEKSFDVNFKAHLWTYKAFLPAMIANDHGHLVCISSSAGLSGVNGLADYCASKFAAFGFAESVFVETFVQKQKGIKTTIVCPFFIKTGMFEGCTTGCPSLLPILEPKYAVEKIVEAILQEKMYLYMPKLLYFMMFLKSFLPLKTGLLIADYLGILHAMDGFVDQKKKL
|
| Structure Information |
| PDB ID | |
| Quaternary structure | |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-6, 305-309 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | retinol dehydrogenase, enzyme
all-trans-retinol + NAD+ <=> all-trans-retinal + NADH.
Cofactor metabolism, retinol metabolism
|
| References for function | |
| E.C. number | 1.1.1.105 |
| Location of functional site(s) | |
| Cellular location of function | Endoplasmic reticulum, transmembrane protein |
| Comments | |
| Function 2 |
| Function description | transcriptional repressor
represses profilaggrin promoter activity by adjusting the activity of Sp1 and other activators
|
| References for function | Markova NG, PinkasSarafova A, Simon M. A metabolic enzyme of the short-chain dehydrogenase/reductase superfamily may moonlight in the nucleus as a repressor of promoter activity. J Invest Dermatol. 2006 Sep. PMID: 16691198 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | nucleus |
| Comments | |