| General Information |
| MoonProt ID | 254 |
| First appeared in release | 1.0 |
| Name(s) | Band 3 anion exchanger
Anion exchange protein 1
Band 3 anion transport protein
AE 1
Anion exchanger 1
Solute carrier family 4 member 1
CD_antigen=CD233
Gene Name: SLC4A1 |
| UniProt ID | P02730 (B3AT_HUMAN), Reviewed |
| GO terms | GO:0006810 transport
GO:0006811 ion transport
GO:0006820 anion transport
GO:0006821 chloride transport
GO:0006873 cellular ion homeostasis
GO:0015701 bicarbonate transport
GO:0044281 small molecule metabolic process
GO:0055085 transmembrane transport
GO:1902476 chloride transmembrane transport
GO:0003779 actin binding
GO:0005215 transporter activity
GO:0005452 inorganic anion exchanger activity
GO:0005515 protein binding
GO:0008022 protein C-terminus binding
GO:0008509 anion transmembrane transporter activity
GO:0015106 bicarbonate transmembrane transporter activity
GO:0015108 chloride transmembrane transporter activity
GO:0015301 anion:anion antiporter activity
GO:0030506 ankyrin binding
GO:0042803 protein homodimerization activity
GO:0043495 protein anchor
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0030018 Z disc
GO:0030863 cortical cytoskeleton
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle |
| Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal) |
| Sequence length | 911 |
| FASTA sequence | >sp|P02730|B3AT_HUMAN Band 3 anion transport protein OS=Homo sapiens GN=SLC4A1 PE=1 SV=3
MEELQDDYEDMMEENLEQEEYEDPDIPESQMEEPAAHDTEATATDYHTTSHPGTHKVYVELQELVMDEKNQELRWMEAARWVQLEENLGENGAWGRPHLSHLTFWSLLELRRVFTKGTVLLDLQETSLAGVANQLLDRFIFEDQIRPQDREELLRALLLKHSHAGELEALGGVKPAVLTRSGDPSQPLLPQHSSLETQLFCEQGDGGTEGHSPSGILEKIPPDSEATLVLVGRADFLEQPVLGFVRLQEAAELEAVELPVPIRFLFVLLGPEAPHIDYTQLGRAAATLMSERVFRIDAYMAQSRGELLHSLEGFLDCSLVLPPTDAPSEQALLSLVPVQRELLRRRYQSSPAKPDSSFYKGLDLNGGPDDPLQQTGQLFGGLVRDIRRRYPYYLSDITDAFSPQVLAAVIFIYFAALSPAITFGGLLGEKTRNQMGVSELLISTAVQGILFALLGAQPLLVVGFSGPLLVFEEAFFSFCETNGLEYIVGRVWIGFWLILLVVLVVAFEGSFLVRFISRYTQEIFSFLISLIFIYETFSKLIKIFQDHPLQKTYNYNVLMVPKPQGPLPNTALLSLVLMAGTFFFAMMLRKFKNSSYFPGKLRRVIGDFGVPISILIMVLVDFFIQDTYTQKLSVPDGFKVSNSSARGWVIHPLGLRSEFPIWMMFASALPALLVFILIFLESQITTLIVSKPERKMVKGSGFHLDLLLVVGMGGVAALFGMPWLSATTVRSVTHANALTVMGKASTPGAAAQIQEVKEQRISGLLVAVLVGLSILMEPILSRIPLAVLFGIFLYMGVTSLSGIQLFDRILLLFKPPKYHPDVPYVKRVKTWRMHLFTGIQIICLAVLWVVKSTPASLALPFVLILTVPLRRVLLPLIFRNVELQCLDADDAKATFDEEEGRDEYDEVAMPV
|
| Structure Information |
| PDB ID | 1HYN
4KY9
1BZK
1BH7 |
| Quaternary structure | |
| SCOP | NA |
| CATH | 2.60.40.10 |
| TM Helix Prediction | 11(406-428,449-471,491-513,526-545,565-587,608-625,661-680,701-723,783-805,833-850,855-874) |
| DisProt Annotation | 5.93%,1 to 54 |
| Predicted Disorder Regions | 1-52, 161-218, 324-371, 636-642, 740-753, 893-911 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Band 3 anion exchanger
transports inorganic anions across the plasma membrane in a 1:1 exchange
|
| References for function | |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | plasma membrane, transmembrane protein |
| Comments | |
| Function 2 |
| Function description | scaffold protein providing binding sites for glycolytic enzymes
involved in regulation of catalytic activity of glycolytic enzymes
site of binding is N-terminal cytoplasmic domain of Band 3 |
| References for function | Low PS, Rathinavelu P, Harrison ML. Regulation of glycolysis via reversible enzyme binding to the membrane protein, band 3. J Biol Chem. 1993 Jul 15;268(20):14627-31. PMID: 8325839 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | plasma membrane, transmembrane protein |
| Comments | |